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Hypospermatogenesis

MedGen UID:
889565
Concept ID:
C4048572
Finding
Synonym: HYPOSPERMATOGENESIS
SNOMED CT: Hypospermatogenesis (713919009)
 
HPO: HP:0034813
OMIM®: 400042

Definition

A morphological abnormality visible upon biopsy of the germinal epithelium of the testis in which the cellularity of the germinal epithelium is reduced in general, so that all stages of germ cells (spermatogonia, spermatocytes, and spermatids) are present but reduced in number. This term applies to biopsies with some tubules showing diminished amounts of qualitatively complete spermatogenesis in combination with a vast majority of tubules that lack germ cells. [from HPO]

Professional guidelines

PubMed

Dai Y, Kong X, Yao C, Xiong C, Li Z, Li H
Andrology 2022 May;10(4):749-757. Epub 2022 Mar 29 doi: 10.1111/andr.13173. PMID: 35266640
Drabovich AP, Dimitromanolakis A, Saraon P, Soosaipillai A, Batruch I, Mullen B, Jarvi K, Diamandis EP
Sci Transl Med 2013 Nov 20;5(212):212ra160. doi: 10.1126/scitranslmed.3006260. PMID: 24259048
Adamopoulos DA
Asian J Androl 2000 Mar;2(1):25-32. PMID: 11228933

Recent clinical studies

Etiology

Kang C, Punjani N, Kashanian JA, Schlegel PN
J Urol 2024 Jan;211(1):163-169. Epub 2023 Oct 24 doi: 10.1097/JU.0000000000003737. PMID: 37873937
Sujit KM, Pallavi S, Singh V, Andrabi SW, Trivedi S, Sankhwar SN, Gupta G, Rajender S
Andrologia 2022 Nov;54(10):e14548. Epub 2022 Aug 3 doi: 10.1111/and.14548. PMID: 36177775
Spahovic H, Alic J, Göktolga Ü, Lepara Z, Lepara O, Rama A, Suljevic I
Med Arch 2020 Aug;74(4):279-284. doi: 10.5455/medarh.2020.74.279-284. PMID: 33041445Free PMC Article
Shpunt I, Leibovici D, Ikher S, Kovalyonok A, Avda Y, Jaber M, Bercovich A, Lindner U
Isr Med Assoc J 2018 Oct;20(10):642-644. PMID: 30324783
Cheng YS, Lu CW, Lin TY, Lin PY, Lin YM
Urology 2017 Jul;105:62-68. Epub 2017 Mar 22 doi: 10.1016/j.urology.2017.03.026. PMID: 28342926

Diagnosis

Winters SJ
J Clin Endocrinol Metab 2022 Sep 28;107(10):e3974-e3989. doi: 10.1210/clinem/dgac421. PMID: 35913018
Spahovic H, Alic J, Göktolga Ü, Lepara Z, Lepara O, Rama A, Suljevic I
Med Arch 2020 Aug;74(4):279-284. doi: 10.5455/medarh.2020.74.279-284. PMID: 33041445Free PMC Article
Lei B, Xie L, Zhang S, Lv D, Shu F, Deng Y
Andrologia 2020 Feb;52(1):e13474. Epub 2019 Nov 11 doi: 10.1111/and.13474. PMID: 31710394
Arafat M, Har-Vardi I, Harlev A, Levitas E, Zeadna A, Abofoul-Azab M, Dyomin V, Sheffield VC, Lunenfeld E, Huleihel M, Parvari R
J Med Genet 2017 Sep;54(9):633-639. Epub 2017 May 23 doi: 10.1136/jmedgenet-2017-104514. PMID: 28536242
Cheng YS, Lu CW, Lin TY, Lin PY, Lin YM
Urology 2017 Jul;105:62-68. Epub 2017 Mar 22 doi: 10.1016/j.urology.2017.03.026. PMID: 28342926

Therapy

Winters SJ
J Clin Endocrinol Metab 2022 Sep 28;107(10):e3974-e3989. doi: 10.1210/clinem/dgac421. PMID: 35913018
Lantsberg D, Mizrachi Y, Katz DJ
Aust N Z J Obstet Gynaecol 2022 Apr;62(2):300-305. Epub 2022 Feb 2 doi: 10.1111/ajo.13477. PMID: 35112341
Jindarak S, Nilprapha K, Atikankul T, Angspatt A, Pungrasmi P, Iamphongsai S, Promniyom P, Suwajo P, Selvaggi G, Tiewtranon P
Biomed Res Int 2018;2018:7919481. Epub 2018 Apr 2 doi: 10.1155/2018/7919481. PMID: 29808166Free PMC Article
Garolla A, Selice R, Engl B, Bertoldo A, Menegazzo M, Finos L, Lenzi A, Foresta C
Reprod Biomed Online 2014 Jul;29(1):102-12. Epub 2014 Mar 15 doi: 10.1016/j.rbmo.2014.02.014. PMID: 24816256
Foresta C, Bettella A, Merico M, Garolla A, Plebani M, Ferlin A, Rossato M
Mol Cell Endocrinol 2000 Mar 30;161(1-2):89-97. doi: 10.1016/s0303-7207(99)00228-2. PMID: 10773396

Prognosis

Fantus RJ, Lin JS, Chang C, Pham M, Dubin JM, Brannigan RE, Halpern JA
Urology 2023 Apr;174:99-103. Epub 2023 Jan 28 doi: 10.1016/j.urology.2023.01.015. PMID: 36716824
Shpunt I, Leibovici D, Ikher S, Kovalyonok A, Avda Y, Jaber M, Bercovich A, Lindner U
Isr Med Assoc J 2018 Oct;20(10):642-644. PMID: 30324783
Cheng YS, Wee SK, Lin TY, Lin YM
Hum Reprod 2017 Dec 1;32(12):2373-2381. doi: 10.1093/humrep/dex329. PMID: 29095993
Garolla A, Selice R, Engl B, Bertoldo A, Menegazzo M, Finos L, Lenzi A, Foresta C
Reprod Biomed Online 2014 Jul;29(1):102-12. Epub 2014 Mar 15 doi: 10.1016/j.rbmo.2014.02.014. PMID: 24816256
Colpi GM, Piediferro G, Nerva F, Giacchetta D, Colpi EM, Piatti E
Minerva Urol Nefrol 2005 Jun;57(2):99-107. PMID: 15951734

Clinical prediction guides

Shpunt I, Leibovici D, Ikher S, Kovalyonok A, Avda Y, Jaber M, Bercovich A, Lindner U
Isr Med Assoc J 2018 Oct;20(10):642-644. PMID: 30324783
Winters SJ, Moore JP Jr, Clark BJ
Andrology 2018 Mar;6(2):262-271. Epub 2018 Feb 6 doi: 10.1111/andr.12459. PMID: 29409132
Cheng YS, Wee SK, Lin TY, Lin YM
Hum Reprod 2017 Dec 1;32(12):2373-2381. doi: 10.1093/humrep/dex329. PMID: 29095993
Arafat M, Har-Vardi I, Harlev A, Levitas E, Zeadna A, Abofoul-Azab M, Dyomin V, Sheffield VC, Lunenfeld E, Huleihel M, Parvari R
J Med Genet 2017 Sep;54(9):633-639. Epub 2017 May 23 doi: 10.1136/jmedgenet-2017-104514. PMID: 28536242
Cheng YS, Lu CW, Lin TY, Lin PY, Lin YM
Urology 2017 Jul;105:62-68. Epub 2017 Mar 22 doi: 10.1016/j.urology.2017.03.026. PMID: 28342926

Recent systematic reviews

Zhang F, Dai M, Yang X, Cheng Y, Ye L, Huang W, Chen X, Yin T, Sha Y
Andrology 2024 Jan;12(1):30-44. Epub 2023 May 22 doi: 10.1111/andr.13448. PMID: 37172416
Deruyver Y, Vanderschueren D, Van der Aa F
Andrology 2014 Jan;2(1):20-4. Epub 2013 Nov 6 doi: 10.1111/j.2047-2927.2013.00148.x. PMID: 24193894

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