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Hypospermatogenesis

MedGen UID:
889565
•Concept ID:
C4048572
•
Finding
Synonym: HYPOSPERMATOGENESIS
SNOMED CT: Hypospermatogenesis (713919009)
 
HPO: HP:0034813
OMIM®: 400042

Definition

A morphological abnormality visible upon biopsy of the germinal epithelium of the testis in which the cellularity of the germinal epithelium is reduced in general, so that all stages of germ cells (spermatogonia, spermatocytes, and spermatids) are present but reduced in number. This term applies to biopsies with some tubules showing diminished amounts of qualitatively complete spermatogenesis in combination with a vast majority of tubules that lack germ cells. [from HPO]

Professional guidelines

PubMed

An integrated approach for improving clinical management of non-obstructive azoospermia.
Shi F, Liu Y, Chen Z, Li D, Yao Y, Zhou M, Zhuo Y, Ma X, Cao D
Andrology 2024 Sep;12(6):1312-1323. Epub 2024 Jan 14 doi: 10.1111/andr.13587. PMID: 38221731
Multi-stage screening cell-free seminal mRNAs to diagnose completion of meiosis and predict testicular sperm retrieval in men with non-obstructive azoospermia.
Dai Y, Kong X, Yao C, Xiong C, Li Z, Li H
Andrology 2022 May;10(4):749-757. Epub 2022 Mar 29 doi: 10.1111/andr.13173. PMID: 35266640
Differential diagnosis of azoospermia with proteomic biomarkers ECM1 and TEX101 quantified in seminal plasma.
Drabovich AP, Dimitromanolakis A, Saraon P, Soosaipillai A, Batruch I, Mullen B, Jarvi K, Diamandis EP
Sci Transl Med 2013 Nov 20;5(212):212ra160. doi: 10.1126/scitranslmed.3006260. PMID: 24259048

Recent clinical studies

Etiology

Research progress on the fanconi anemia signaling pathway in non-obstructive azoospermia.
Xu H, Zhang Y, Wang C, Fu Z, Lv J, Yang Y, Zhang Z, Qi Y, Meng K, Yuan J, Wang X
Front Endocrinol (Lausanne) 2024;15:1393111. Epub 2024 May 23 doi: 10.3389/fendo.2024.1393111. PMID: 38846492Free PMC Article
Age, Sperm Retrieval, and Testicular Histology in Klinefelter Syndrome.
Kang C, Punjani N, Kashanian JA, Schlegel PN
J Urol 2024 Jan;211(1):163-169. Epub 2023 Oct 24 doi: 10.1097/JU.0000000000003737. PMID: 37873937
Compensated Hypospermatogenesis: Elevated Follicle-stimulating Hormone Predicts Decline in Semen Parameters Among Men With Normal Index Semen Analysis.
Fantus RJ, Lin JS, Chang C, Pham M, Dubin JM, Brannigan RE, Halpern JA
Urology 2023 Apr;174:99-103. Epub 2023 Jan 28 doi: 10.1016/j.urology.2023.01.015. PMID: 36716824
SPATA16 promoter hypermethylation and downregulation in male infertility.
Sujit KM, Pallavi S, Singh V, Andrabi SW, Trivedi S, Sankhwar SN, Gupta G, Rajender S
Andrologia 2022 Nov;54(10):e14548. Epub 2022 Aug 3 doi: 10.1111/and.14548. PMID: 36177775
Causes and Clinical Features of Infertile Men With Nonobstructive Azoospermia and Histopathologic Diagnosis of Hypospermatogenesis.
Cheng YS, Lu CW, Lin TY, Lin PY, Lin YM
Urology 2017 Jul;105:62-68. Epub 2017 Mar 22 doi: 10.1016/j.urology.2017.03.026. PMID: 28342926

Diagnosis

Compensated Hypospermatogenesis: Elevated Follicle-stimulating Hormone Predicts Decline in Semen Parameters Among Men With Normal Index Semen Analysis.
Fantus RJ, Lin JS, Chang C, Pham M, Dubin JM, Brannigan RE, Halpern JA
Urology 2023 Apr;174:99-103. Epub 2023 Jan 28 doi: 10.1016/j.urology.2023.01.015. PMID: 36716824
Hypogonadism in Males With Genetic Neurodevelopmental Syndromes.
Winters SJ
J Clin Endocrinol Metab 2022 Sep 28;107(10):e3974-e3989. doi: 10.1210/clinem/dgac421. PMID: 35913018
MicroRNA expression profiles in the seminal plasma of nonobstructive azoospermia patients with different histopathologic patterns.
Zhang W, Zhang Y, Zhao M, Ding N, Yan L, Chen J, Gao L, Zhang G, Sun X, Gu Y, Liu M
Fertil Steril 2021 May;115(5):1197-1211. Epub 2021 Feb 16 doi: 10.1016/j.fertnstert.2020.11.020. PMID: 33602558
UBE2W down-regulation promotes cell apoptosis and correlates with hypospermatogenesis.
Lei B, Xie L, Zhang S, Lv D, Shu F, Deng Y
Andrologia 2020 Feb;52(1):e13474. Epub 2019 Nov 11 doi: 10.1111/and.13474. PMID: 31710394
Causes and Clinical Features of Infertile Men With Nonobstructive Azoospermia and Histopathologic Diagnosis of Hypospermatogenesis.
Cheng YS, Lu CW, Lin TY, Lin PY, Lin YM
Urology 2017 Jul;105:62-68. Epub 2017 Mar 22 doi: 10.1016/j.urology.2017.03.026. PMID: 28342926

Therapy

Hypogonadism in Males With Genetic Neurodevelopmental Syndromes.
Winters SJ
J Clin Endocrinol Metab 2022 Sep 28;107(10):e3974-e3989. doi: 10.1210/clinem/dgac421. PMID: 35913018
Micro-testicular sperm extraction outcomes for non-obstructive azoospermia in a single large clinic in Victoria.
Lantsberg D, Mizrachi Y, Katz DJ
Aust N Z J Obstet Gynaecol 2022 Apr;62(2):300-305. Epub 2022 Feb 2 doi: 10.1111/ajo.13477. PMID: 35112341
Spermatogenesis Abnormalities following Hormonal Therapy in Transwomen.
Jindarak S, Nilprapha K, Atikankul T, Angspatt A, Pungrasmi P, Iamphongsai S, Promniyom P, Suwajo P, Selvaggi G, Tiewtranon P
Biomed Res Int 2018;2018:7919481. Epub 2018 Apr 2 doi: 10.1155/2018/7919481. PMID: 29808166Free PMC Article
Outcome of microdissection TESE compared with conventional TESE in non-obstructive azoospermia: a systematic review.
Deruyver Y, Vanderschueren D, Van der Aa F
Andrology 2014 Jan;2(1):20-4. Epub 2013 Nov 6 doi: 10.1111/j.2047-2927.2013.00148.x. PMID: 24193894
Regulatory T cells and vasectomy.
Rival C, Wheeler K, Jeffrey S, Qiao H, Luu B, Tewalt EF, Engelhard VH, Tardif S, Hardy D, del Rio R, Teuscher C, Tung K
J Reprod Immunol 2013 Nov;100(1):66-75. Epub 2013 Sep 8 doi: 10.1016/j.jri.2013.08.004. PMID: 24080233Free PMC Article

Prognosis

Compensated Hypospermatogenesis: Elevated Follicle-stimulating Hormone Predicts Decline in Semen Parameters Among Men With Normal Index Semen Analysis.
Fantus RJ, Lin JS, Chang C, Pham M, Dubin JM, Brannigan RE, Halpern JA
Urology 2023 Apr;174:99-103. Epub 2023 Jan 28 doi: 10.1016/j.urology.2023.01.015. PMID: 36716824
Spermatogenesis in Testicles with Germ Cell Tumors.
Shpunt I, Leibovici D, Ikher S, Kovalyonok A, Avda Y, Jaber M, Bercovich A, Lindner U
Isr Med Assoc J 2018 Oct;20(10):642-644. PMID: 30324783
MAEL promoter hypermethylation is associated with de-repression of LINE-1 in human hypospermatogenesis.
Cheng YS, Wee SK, Lin TY, Lin YM
Hum Reprod 2017 Dec 1;32(12):2373-2381. doi: 10.1093/humrep/dex329. PMID: 29095993
Spermatid count as a predictor of response to FSH therapy.
Garolla A, Selice R, Engl B, Bertoldo A, Menegazzo M, Finos L, Lenzi A, Foresta C
Reprod Biomed Online 2014 Jul;29(1):102-12. Epub 2014 Mar 15 doi: 10.1016/j.rbmo.2014.02.014. PMID: 24816256
Histological evaluation of the human testis--approaches to optimizing the clinical value of the assessment: mini review.
McLachlan RI, Rajpert-De Meyts E, Hoei-Hansen CE, de Kretser DM, Skakkebaek NE
Hum Reprod 2007 Jan;22(1):2-16. Epub 2006 Aug 3 doi: 10.1093/humrep/del279. PMID: 16887924

Clinical prediction guides

Compensated Hypospermatogenesis: Elevated Follicle-stimulating Hormone Predicts Decline in Semen Parameters Among Men With Normal Index Semen Analysis.
Fantus RJ, Lin JS, Chang C, Pham M, Dubin JM, Brannigan RE, Halpern JA
Urology 2023 Apr;174:99-103. Epub 2023 Jan 28 doi: 10.1016/j.urology.2023.01.015. PMID: 36716824
Leydig cell insufficiency in hypospermatogenesis: a paracrine effect of activin-inhibin signaling?
Winters SJ, Moore JP Jr, Clark BJ
Andrology 2018 Mar;6(2):262-271. Epub 2018 Feb 6 doi: 10.1111/andr.12459. PMID: 29409132
MAEL promoter hypermethylation is associated with de-repression of LINE-1 in human hypospermatogenesis.
Cheng YS, Wee SK, Lin TY, Lin YM
Hum Reprod 2017 Dec 1;32(12):2373-2381. doi: 10.1093/humrep/dex329. PMID: 29095993
Causes and Clinical Features of Infertile Men With Nonobstructive Azoospermia and Histopathologic Diagnosis of Hypospermatogenesis.
Cheng YS, Lu CW, Lin TY, Lin PY, Lin YM
Urology 2017 Jul;105:62-68. Epub 2017 Mar 22 doi: 10.1016/j.urology.2017.03.026. PMID: 28342926
Outcome of microdissection TESE compared with conventional TESE in non-obstructive azoospermia: a systematic review.
Deruyver Y, Vanderschueren D, Van der Aa F
Andrology 2014 Jan;2(1):20-4. Epub 2013 Nov 6 doi: 10.1111/j.2047-2927.2013.00148.x. PMID: 24193894

Recent systematic reviews

Predictors of successful salvage microdissection testicular sperm extraction (mTESE) after failed initial TESE in patients with non-obstructive azoospermia: A systematic review and meta-analysis.
Zhang F, Dai M, Yang X, Cheng Y, Ye L, Huang W, Chen X, Yin T, Sha Y
Andrology 2024 Jan;12(1):30-44. Epub 2023 May 22 doi: 10.1111/andr.13448. PMID: 37172416
Outcome of microdissection TESE compared with conventional TESE in non-obstructive azoospermia: a systematic review.
Deruyver Y, Vanderschueren D, Van der Aa F
Andrology 2014 Jan;2(1):20-4. Epub 2013 Nov 6 doi: 10.1111/j.2047-2927.2013.00148.x. PMID: 24193894

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