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Abnormal platelet granule secretion

MedGen UID:
892815
Concept ID:
C4072929
Finding
HPO: HP:0030396

Definition

Platelets are replete with secretory granules, which are critical to normal platelet function. Among the three types of platelet secretory granules - alpha-granules, dense granules, and lysosomes - the alpha-granule is the most abundant. Granule contents must be released from their intracellular repository in order to achieve their physiologic function, and this term refers to a functional defect in granule secretion. [from HPO]

Professional guidelines

PubMed

Reményi G, Szász R, Debreceni IB, Szarvas M, Batár P, Nagy B Jr, Kappelmayer J, Udvardy M
Platelets 2013;24(6):486-92. Epub 2012 Dec 5 doi: 10.3109/09537104.2012.731112. PMID: 23216455
Diamandis M, Veljkovic DK, Maurer-Spurej E, Rivard GE, Hayward CP
Blood Coagul Fibrinolysis 2008 Mar;19(2):109-19. doi: 10.1097/MBC.0b013e3282f41e3e. PMID: 18277131
Schutgens RB, Wanders RJ, Heymans HS, Schram AW, Tager JM, Schrakamp G, van den Bosch H
J Inherit Metab Dis 1987;10 Suppl 1:33-45. doi: 10.1007/BF01812845. PMID: 3119940

Recent clinical studies

Etiology

Zini G, d'Onofrio G
Br J Haematol 2023 Feb;200(4):404-419. Epub 2022 Oct 6 doi: 10.1111/bjh.18489. PMID: 36203344Free PMC Article
Geranpayehvaghei M, Dabirmanesh B, Khaledi M, Atabakhshi-Kashi M, Gao C, Taleb M, Zhang Y, Khajeh K, Nie G
Wiley Interdiscip Rev Nanomed Nanobiotechnol 2021 Sep;13(5):e1702. Epub 2021 Feb 3 doi: 10.1002/wnan.1702. PMID: 33538125
Karampini E, Bierings R, Voorberg J
Arterioscler Thromb Vasc Biol 2020 Jun;40(6):1441-1453. Epub 2020 May 7 doi: 10.1161/ATVBAHA.120.314245. PMID: 32375545
Hayward CPM, Moffat KA, Brunet J, Carlino SA, Plumhoff E, Meijer P, Zehnder JL
Int J Lab Hematol 2019 May;41 Suppl 1:26-32. doi: 10.1111/ijlh.12995. PMID: 31069975
Dell'Angelica EC, Mullins C, Caplan S, Bonifacino JS
FASEB J 2000 Jul;14(10):1265-78. doi: 10.1096/fj.14.10.1265. PMID: 10877819

Diagnosis

Collins JH, Mayer L, Guerrero Lopez JA
J Thromb Haemost 2023 Jun;21(6):1409-1419. Epub 2023 Apr 5 doi: 10.1016/j.jtha.2023.03.032. PMID: 37028650
Chen CH, Lo RW, Urban D, Pluthero FG, Kahr WH
Platelets 2017 Mar;28(2):147-154. Epub 2017 Feb 22 doi: 10.1080/09537104.2017.1280599. PMID: 28277061
Rao AK
Hematol Oncol Clin North Am 2013 Jun;27(3):585-611. doi: 10.1016/j.hoc.2013.02.005. PMID: 23714313
Handin RI
Hematology Am Soc Hematol Educ Program 2005:396-402. doi: 10.1182/asheducation-2005.1.396. PMID: 16304410
Rand ML, Leung R, Packham MA
Transfus Apher Sci 2003 Jun;28(3):307-17. doi: 10.1016/S1473-0502(03)00050-8. PMID: 12725958

Therapy

Wang XB, Cui NH, Fang ZQ, Gao MJ, Cai D
Redox Biol 2024 Jun;72:103146. Epub 2024 Apr 2 doi: 10.1016/j.redox.2024.103146. PMID: 38579589Free PMC Article
Geranpayehvaghei M, Dabirmanesh B, Khaledi M, Atabakhshi-Kashi M, Gao C, Taleb M, Zhang Y, Khajeh K, Nie G
Wiley Interdiscip Rev Nanomed Nanobiotechnol 2021 Sep;13(5):e1702. Epub 2021 Feb 3 doi: 10.1002/wnan.1702. PMID: 33538125
Brunet JG, Sharma T, Tasneem S, Liang M, Wilson MD, Rivard GE, Hayward CPM
Int J Lab Hematol 2020 Dec;42(6):801-809. Epub 2020 Aug 6 doi: 10.1111/ijlh.13302. PMID: 32761872Free PMC Article
Cakir B, Liegl R, Hellgren G, Lundgren P, Sun Y, Klevebro S, Löfqvist C, Mannheimer C, Cho S, Poblete A, Duran R, Hallberg B, Canas J, Lorenz V, Liu ZJ, Sola-Visner MC, Smith LE, Hellström A
JCI Insight 2018 Oct 4;3(19) doi: 10.1172/jci.insight.99448. PMID: 30282834Free PMC Article
Barak Y, Nir E
Am J Pediatr Hematol Oncol 1987 Spring;9(1):42-55. doi: 10.1097/00043426-198721000-00008. PMID: 3296821

Prognosis

Sharma T, Brunet JG, Tasneem S, Smith SA, Morrissey JH, Hayward CPM
Int J Lab Hematol 2021 Dec;43(6):1557-1565. Epub 2021 Jun 29 doi: 10.1111/ijlh.13638. PMID: 34185390Free PMC Article
Aryal B, Yamakuchi M, Shimizu T, Kadono J, Furoi A, Gejima K, Komokata T, Hashiguchi T, Imoto Y
Can J Gastroenterol Hepatol 2018;2018:9142672. Epub 2018 Jun 27 doi: 10.1155/2018/9142672. PMID: 30050894Free PMC Article
Mumford AD, Frelinger AL 3rd, Gachet C, Gresele P, Noris P, Harrison P, Mezzano D
Thromb Haemost 2015 Jul;114(1):14-25. Epub 2015 Apr 16 doi: 10.1160/TH14-11-0999. PMID: 25879272
Zvetkova E, Antonova N, Ivanov I, Savov Y, Gluhcheva Y
Clin Hemorheol Microcirc 2010;45(2-4):245-51. doi: 10.3233/CH-2010-1305. PMID: 20675906
Finazzi G, Budde U, Michiels JJ
Leuk Lymphoma 1996 Sep;22 Suppl 1:71-8. doi: 10.3109/10428199609074363. PMID: 8951775

Clinical prediction guides

Sims MC, Mayer L, Collins JH, Bariana TK, Megy K, Lavenu-Bombled C, Seyres D, Kollipara L, Burden FS, Greene D, Lee D, Rodriguez-Romera A, Alessi MC, Astle WJ, Bahou WF, Bury L, Chalmers E, Da Silva R, De Candia E, Deevi SVV, Farrow S, Gomez K, Grassi L, Greinacher A, Gresele P, Hart D, Hurtaud MF, Kelly AM, Kerr R, Le Quellec S, Leblanc T, Leinøe EB, Mapeta R, McKinney H, Michelson AD, Morais S, Nugent D, Papadia S, Park SJ, Pasi J, Podda GM, Poon MC, Reed R, Sekhar M, Shalev H, Sivapalaratnam S, Steinberg-Shemer O, Stephens JC, Tait RC, Turro E, Wu JKM, Zieger B; NIHR BioResource, Kuijpers TW, Whetton AD, Sickmann A, Freson K, Downes K, Erber WN, Frontini M, Nurden P, Ouwehand WH, Favier R, Guerrero JA
Blood 2020 Oct 22;136(17):1956-1967. doi: 10.1182/blood.2019004776. PMID: 32693407Free PMC Article
Pluthero FG, Di Paola J, Carcao MD, Kahr WHA
Platelets 2018 Sep;29(6):632-635. Epub 2018 Jun 5 doi: 10.1080/09537104.2018.1478405. PMID: 29869935
Mumford AD, Frelinger AL 3rd, Gachet C, Gresele P, Noris P, Harrison P, Mezzano D
Thromb Haemost 2015 Jul;114(1):14-25. Epub 2015 Apr 16 doi: 10.1160/TH14-11-0999. PMID: 25879272
van Es N, Sturk A, Middeldorp S, Nieuwland R
Semin Oncol 2014 Jun;41(3):311-8. Epub 2014 Apr 24 doi: 10.1053/j.seminoncol.2014.04.015. PMID: 25023347
Dell'Angelica EC, Mullins C, Caplan S, Bonifacino JS
FASEB J 2000 Jul;14(10):1265-78. doi: 10.1096/fj.14.10.1265. PMID: 10877819

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