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Abnormal circulating follicle-stimulating hormone concentration

MedGen UID:
892827
•Concept ID:
C4072891
•
Finding
Synonym: Abnormal circulating follicle-stimulating hormone level
 
HPO: HP:0030346

Definition

An anomaly of the circulating level of follicle-stimulating hormone (FSH). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating follicle-stimulating hormone concentration

Conditions with this feature

Spermatogenic failure 2
MedGen UID:
400056
•Concept ID:
C1862459
•
Finding
Spermatogenic failure-2 (SPGF2) is characterized by male infertility due to azoospermia (Tang et al., 2020; Akbari et al., 2021). For a discussion of phenotypic and genetic heterogeneity of spermatogenic failure, see SPGF1 (258150).
See: Condition Record
Spermatogenic failure 15
MedGen UID:
934746
•Concept ID:
C4310779
•
Disease or Syndrome
Any azoospermia in which the cause of the disease is a mutation in the SYCE1 gene.
See: Condition Record
Spermatogenic failure 15
Spermatogenic failure 2

Professional guidelines

PubMed

Circulating gonadotropin pattern in anorchia syndrome. Response to treatment.
Mendoza-Morfin F, Rodríguez-López M, Oliveros-Rodríguez A, Altamirano-Bustamante P, Navarrete-López R, Gutiérrez-Pérez H, Oseguera-Valladares R
Arch Invest Med (Mex) 1980;11(2):239-47. PMID: 6775612

Recent clinical studies

Etiology

Circulating Zinc and Copper Levels are Associated with Sperm Quality in Obese Men after Metabolic Surgery: A Pilot Study.
Calderón B, Gómez-Martín JM, Cuadrado-Ayuso M, Cobeta P, Vega-Piñero B, Mateo R, Galindo J, Botella-Carretero JI
Nutrients 2020 Oct 30;12(11) doi: 10.3390/nu12113354. PMID: 33143218Free PMC Article
Circulating hormones and breast cancer risk in premenopausal women: a randomized trial of low-dose tamoxifen and fenretinide.
Johansson H, Bonanni B, Gandini S, Guerrieri-Gonzaga A, Cazzaniga M, Serrano D, Macis D, Puccio A, Sandri MT, Gulisano M, Formelli F, Decensi A
Breast Cancer Res Treat 2013 Dec;142(3):569-78. Epub 2013 Nov 17 doi: 10.1007/s10549-013-2768-7. PMID: 24241787
Evidence for abnormal granulosa cell responsiveness to follicle-stimulating hormone in women with polycystic ovary syndrome.
Coffler MS, Patel K, Dahan MH, Malcom PJ, Kawashima T, Deutsch R, Chang RJ
J Clin Endocrinol Metab 2003 Apr;88(4):1742-7. doi: 10.1210/jc.2002-021280. PMID: 12679467
3 beta-hydroxysteroid dehydrogenase deficiency in hyperandrogenism.
Azziz R, Bradley EL Jr, Potter HD, Boots LR
Am J Obstet Gynecol 1993 Mar;168(3 Pt 1):889-95. doi: 10.1016/s0002-9378(12)90840-6. PMID: 8456898
The epidemiology and endocrinology of the menarche in relation to breast cancer.
Vihko RK, Apter DL
Cancer Surv 1986;5(3):561-71. PMID: 3555783

Diagnosis

MKRN3 circulating levels in Prader-Willi syndrome: a pilot study.
Mariani M, Fintini D, Cirillo G, Palumbo S, Del Giudice EM, Bocchini S, Manco M, Cappa M, Grandone A
J Endocrinol Invest 2022 Nov;45(11):2165-2170. Epub 2022 Jul 19 doi: 10.1007/s40618-022-01860-0. PMID: 35854182
Clinical and biological characterization of macroprolactinemia with and without prolactin-IgG complexes.
De Schepper J, Schiettecatte J, Velkeniers B, Blumenfeld Z, Shteinberg M, Devroey P, Anckaert E, Smitz J, Verdood P, Hooghe R, Hooghe-Peters E
Eur J Endocrinol 2003 Sep;149(3):201-7. doi: 10.1530/eje.0.1490201. PMID: 12943522
Evidence for abnormal granulosa cell responsiveness to follicle-stimulating hormone in women with polycystic ovary syndrome.
Coffler MS, Patel K, Dahan MH, Malcom PJ, Kawashima T, Deutsch R, Chang RJ
J Clin Endocrinol Metab 2003 Apr;88(4):1742-7. doi: 10.1210/jc.2002-021280. PMID: 12679467
Steroidogenesis in human polycystic ovary.
Mahajan DK
Endocrinol Metab Clin North Am 1988 Dec;17(4):751-69. PMID: 3143567
The epidemiology and endocrinology of the menarche in relation to breast cancer.
Vihko RK, Apter DL
Cancer Surv 1986;5(3):561-71. PMID: 3555783

Therapy

Congenital hypogonadotropic hypogonadism and Kallmann syndrome as models for studying hormonal regulation of human testicular endocrine functions.
Trabado S, Lamothe S, Maione L, Bouvattier C, Sarfati J, Brailly-Tabard S, Young J
Ann Endocrinol (Paris) 2014 May;75(2):79-87. Epub 2014 May 9 doi: 10.1016/j.ando.2014.04.011. PMID: 24815726
Circulating hormones and breast cancer risk in premenopausal women: a randomized trial of low-dose tamoxifen and fenretinide.
Johansson H, Bonanni B, Gandini S, Guerrieri-Gonzaga A, Cazzaniga M, Serrano D, Macis D, Puccio A, Sandri MT, Gulisano M, Formelli F, Decensi A
Breast Cancer Res Treat 2013 Dec;142(3):569-78. Epub 2013 Nov 17 doi: 10.1007/s10549-013-2768-7. PMID: 24241787
Evidence for abnormal granulosa cell responsiveness to follicle-stimulating hormone in women with polycystic ovary syndrome.
Coffler MS, Patel K, Dahan MH, Malcom PJ, Kawashima T, Deutsch R, Chang RJ
J Clin Endocrinol Metab 2003 Apr;88(4):1742-7. doi: 10.1210/jc.2002-021280. PMID: 12679467
A preponderance of circulating basic isoforms is associated with decreased plasma half-life and biological to immunological ratio of gonadotropin-releasing hormone-releasable luteinizing hormone in obese men.
Castro-Fernández C, Olivares A, Söderlund D, López-Alvarenga JC, Zambrano E, Veldhuis JD, Ulloa-Aguirre A, Méndez JP
J Clin Endocrinol Metab 2000 Dec;85(12):4603-10. doi: 10.1210/jcem.85.12.7041. PMID: 11134115
Pituitary dysfunction in recently post-menopausal women. Nottingham EPIC Study Group.
Lyons A, Ng C, Fielding K, Hosking D, Selby C, Lawson N
Clin Endocrinol (Oxf) 1997 Oct;47(4):431-8. doi: 10.1046/j.1365-2265.1997.2761083.x. PMID: 9404441

Prognosis

Circulating Zinc and Copper Levels are Associated with Sperm Quality in Obese Men after Metabolic Surgery: A Pilot Study.
Calderón B, Gómez-Martín JM, Cuadrado-Ayuso M, Cobeta P, Vega-Piñero B, Mateo R, Galindo J, Botella-Carretero JI
Nutrients 2020 Oct 30;12(11) doi: 10.3390/nu12113354. PMID: 33143218Free PMC Article
Follicular fluid soluble receptor for advanced glycation end-products (sRAGE): a potential indicator of ovarian reserve.
Merhi Z, Irani M, Doswell AD, Ambroggio J
J Clin Endocrinol Metab 2014 Feb;99(2):E226-33. Epub 2013 Nov 25 doi: 10.1210/jc.2013-3839. PMID: 24276462
Circulating hormones and breast cancer risk in premenopausal women: a randomized trial of low-dose tamoxifen and fenretinide.
Johansson H, Bonanni B, Gandini S, Guerrieri-Gonzaga A, Cazzaniga M, Serrano D, Macis D, Puccio A, Sandri MT, Gulisano M, Formelli F, Decensi A
Breast Cancer Res Treat 2013 Dec;142(3):569-78. Epub 2013 Nov 17 doi: 10.1007/s10549-013-2768-7. PMID: 24241787
Evidence for abnormal granulosa cell responsiveness to follicle-stimulating hormone in women with polycystic ovary syndrome.
Coffler MS, Patel K, Dahan MH, Malcom PJ, Kawashima T, Deutsch R, Chang RJ
J Clin Endocrinol Metab 2003 Apr;88(4):1742-7. doi: 10.1210/jc.2002-021280. PMID: 12679467
Improvement of pituitary function after surgical decompression for pituitary tumor apoplexy.
Arafah BM, Harrington JF, Madhoun ZT, Selman WR
J Clin Endocrinol Metab 1990 Aug;71(2):323-8. doi: 10.1210/jcem-71-2-323. PMID: 2166068

Clinical prediction guides

MKRN3 circulating levels in Prader-Willi syndrome: a pilot study.
Mariani M, Fintini D, Cirillo G, Palumbo S, Del Giudice EM, Bocchini S, Manco M, Cappa M, Grandone A
J Endocrinol Invest 2022 Nov;45(11):2165-2170. Epub 2022 Jul 19 doi: 10.1007/s40618-022-01860-0. PMID: 35854182
Follicular fluid soluble receptor for advanced glycation end-products (sRAGE): a potential indicator of ovarian reserve.
Merhi Z, Irani M, Doswell AD, Ambroggio J
J Clin Endocrinol Metab 2014 Feb;99(2):E226-33. Epub 2013 Nov 25 doi: 10.1210/jc.2013-3839. PMID: 24276462
Impaired folliculogenesis and ovulation in older reproductive aged women.
Santoro N, Isaac B, Neal-Perry G, Adel T, Weingart L, Nussbaum A, Thakur S, Jinnai H, Khosla N, Barad D
J Clin Endocrinol Metab 2003 Nov;88(11):5502-9. doi: 10.1210/jc.2002-021839. PMID: 14602797
17 beta-Oestradiol, androstenedione and inhibin levels in fluid from individual follicles of normal and polycystic ovaries, and in ovaries from androgen treated female to male transsexuals.
Pache TD, Hop WC, de Jong FH, Leerentveld RA, van Geldorp H, Van de Kamp TM, Gooren LJ, Fauser BC
Clin Endocrinol (Oxf) 1992 Jun;36(6):565-71. doi: 10.1111/j.1365-2265.1992.tb02266.x. PMID: 1424181
Steroidogenesis in human polycystic ovary.
Mahajan DK
Endocrinol Metab Clin North Am 1988 Dec;17(4):751-69. PMID: 3143567

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