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Abnormal circulating interferon concentration

MedGen UID:
892854
•Concept ID:
C4072898
•
Finding
Synonyms: Abnormal serum interferon level; Abnormality of interferon secretion
 
HPO: HP:0011116

Definition

The concentration of an interferon is outside the limits of normal. [from HPO]

Professional guidelines

PubMed

The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation.
Van de Wijer L, van der Heijden WA, Ter Horst R, Jaeger M, Trypsteen W, Rutsaert S, van Cranenbroek B, van Rijssen E, Joosten I, Joosten L, Vandekerckhove L, Schoofs T, van Lunzen J, Netea MG, Koenen HJPM, van der Ven AJAM, de Mast Q
Front Immunol 2021;12:661990. Epub 2021 Apr 19 doi: 10.3389/fimmu.2021.661990. PMID: 33953724Free PMC Article
Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.
Christensen MH, Pedersen EK, Nordbø Y, Varhaug JE, Midttun Ø, Ueland PM, Nygård OK, Mellgren G, Lien EA
J Intern Med 2012 Dec;272(6):583-91. Epub 2012 Aug 5 doi: 10.1111/j.1365-2796.2012.02570.x. PMID: 22757621

Recent clinical studies

Etiology

Preeclampsia at term: evidence of disease heterogeneity based on the profile of circulating cytokines and angiogenic factors.
Chaiworapongsa T, Romero R, Gomez-Lopez N, Suksai M, Gallo DM, Jung E, Berry SM, Awonuga A, Tarca AL, Bryant DR
Am J Obstet Gynecol 2024 Apr;230(4):450.e1-450.e18. Epub 2023 Oct 6 doi: 10.1016/j.ajog.2023.10.002. PMID: 37806612Free PMC Article
Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56, and monotypic Ig light chain.
Bergsagel PL, Smith AM, Szczepek A, Mant MJ, Belch AR, Pilarski LM
Blood 1995 Jan 15;85(2):436-47. PMID: 7529064
Elevated pyrogenic cytokines in heatstroke.
Bouchama A, al-Sedairy S, Siddiqui S, Shail E, Rezeig M
Chest 1993 Nov;104(5):1498-502. doi: 10.1378/chest.104.5.1498. PMID: 8222814
Soluble HLA-DR molecules in patients with HLA class II versus class I associated disorders.
Weyand CM, Jendro M, Goronzy JJ
Autoimmunity 1991;8(4):281-7. doi: 10.3109/08916939109007635. PMID: 1932512

Diagnosis

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Changes in Aqueous Concentrations of Various Cytokines after Intravitreal Bevacizumab Injection for Chronic Central Serous Chorioretinopathy.
Park J, Hwang SH, Nam DH, Lee DY
Korean J Ophthalmol 2023 Dec;37(6):453-461. Epub 2023 Oct 25 doi: 10.3341/kjo.2023.0005. PMID: 37899289Free PMC Article
IFN-α and TNF-α serum levels and their association with disease severity in Egyptian children and adults with alopecia areata.
Omar SI, Hamza AM, Eldabah N, Habiba DA
Int J Dermatol 2021 Nov;60(11):1397-1404. Epub 2021 May 18 doi: 10.1111/ijd.15658. PMID: 34008204
Comparison of RT-qPCR and Nanostring in the measurement of blood interferon response for the diagnosis of type I interferonopathies.
Pescarmona R, Belot A, Villard M, Besson L, Lopez J, Mosnier I, Mathieu AL, Lombard C, Garnier L, Frachette C, Walzer T, Viel S
Cytokine 2019 Jan;113:446-452. Epub 2018 Nov 7 doi: 10.1016/j.cyto.2018.10.023. PMID: 30413290
Serum levels of tumor necrosis factor-alpha, interleukin-1, and interferon-gamma in beta(o)-thalassemia/HbE and their clinical significance.
Wanachiwanawin W, Wiener E, Siripanyaphinyo U, Chinprasertsuk S, Mawas F, Fucharoen S, Wickramasinghe SN, Pootrakul P, Visudhiphan S
J Interferon Cytokine Res 1999 Feb;19(2):105-11. doi: 10.1089/107999099314243. PMID: 10090395

Therapy

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation.
Van de Wijer L, van der Heijden WA, Ter Horst R, Jaeger M, Trypsteen W, Rutsaert S, van Cranenbroek B, van Rijssen E, Joosten I, Joosten L, Vandekerckhove L, Schoofs T, van Lunzen J, Netea MG, Koenen HJPM, van der Ven AJAM, de Mast Q
Front Immunol 2021;12:661990. Epub 2021 Apr 19 doi: 10.3389/fimmu.2021.661990. PMID: 33953724Free PMC Article
Safety and efficacy of REP 2139 and pegylated interferon alfa-2a for treatment-naive patients with chronic hepatitis B virus and hepatitis D virus co-infection (REP 301 and REP 301-LTF): a non-randomised, open-label, phase 2 trial.
Bazinet M, Pântea V, Cebotarescu V, Cojuhari L, Jimbei P, Albrecht J, Schmid P, Le Gal F, Gordien E, Krawczyk A, Mijočević H, Karimzadeh H, Roggendorf M, Vaillant A
Lancet Gastroenterol Hepatol 2017 Dec;2(12):877-889. Epub 2017 Sep 28 doi: 10.1016/S2468-1253(17)30288-1. PMID: 28964701
Macromolecular therapeutics: advantages and prospects with special emphasis on solid tumour targeting.
Greish K, Fang J, Inutsuka T, Nagamitsu A, Maeda H
Clin Pharmacokinet 2003;42(13):1089-105. doi: 10.2165/00003088-200342130-00002. PMID: 14531722
In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56, and monotypic Ig light chain.
Bergsagel PL, Smith AM, Szczepek A, Mant MJ, Belch AR, Pilarski LM
Blood 1995 Jan 15;85(2):436-47. PMID: 7529064

Prognosis

Comparison of RT-qPCR and Nanostring in the measurement of blood interferon response for the diagnosis of type I interferonopathies.
Pescarmona R, Belot A, Villard M, Besson L, Lopez J, Mosnier I, Mathieu AL, Lombard C, Garnier L, Frachette C, Walzer T, Viel S
Cytokine 2019 Jan;113:446-452. Epub 2018 Nov 7 doi: 10.1016/j.cyto.2018.10.023. PMID: 30413290
Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids.
Ward SE, Loutfy MR, Blatt LM, Siminovitch KA, Chen J, Hinek A, Wolff B, Pham DH, Deif H, LaMere EA, Kain KC, Farcas GA, Ferguson P, Latchford M, Levy G, Fung L, Dennis JW, Lai EK, Fish EN
Antivir Ther 2005;10(2):263-75. PMID: 15865221
In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56, and monotypic Ig light chain.
Bergsagel PL, Smith AM, Szczepek A, Mant MJ, Belch AR, Pilarski LM
Blood 1995 Jan 15;85(2):436-47. PMID: 7529064
Cytokine network and acute primary HIV-1 infection.
Sinicco A, Biglino A, Sciandra M, Forno B, Pollono AM, Raiteri R, Gioannini P
AIDS 1993 Sep;7(9):1167-72. doi: 10.1097/00002030-199309000-00003. PMID: 8216972
Effects of recombinant alpha and gamma interferons on the in vitro growth of circulating hematopoietic progenitor cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM) from patients with myelofibrosis with myeloid metaplasia.
Carlo-Stella C, Cazzola M, Gasner A, Barosi G, Dezza L, Meloni F, Pedrazzoli P, Hoelzer D, Ascari E
Blood 1987 Oct;70(4):1014-9. PMID: 3115331

Clinical prediction guides

Preeclampsia at term: evidence of disease heterogeneity based on the profile of circulating cytokines and angiogenic factors.
Chaiworapongsa T, Romero R, Gomez-Lopez N, Suksai M, Gallo DM, Jung E, Berry SM, Awonuga A, Tarca AL, Bryant DR
Am J Obstet Gynecol 2024 Apr;230(4):450.e1-450.e18. Epub 2023 Oct 6 doi: 10.1016/j.ajog.2023.10.002. PMID: 37806612Free PMC Article
Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury.
Liu Q, Wu J, Zhang X, Li X, Wu X, Zhao Y, Ren J
Cell Death Dis 2021 Jul 3;12(7):673. doi: 10.1038/s41419-021-03961-9. PMID: 34218252Free PMC Article
Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome.
Kong XF, Worley L, Rinchai D, Bondet V, Jithesh PV, Goulet M, Nonnotte E, Rebillat AS, Conte M, Mircher C, Gürtler N, Liu L, Migaud M, Elanbari M, Habib T, Ma CS, Bustamante J, Abel L, Ravel A, Lyonnet S, Munnich A, Duffy D, Chaussabel D, Casanova JL, Tangye SG, Boisson-Dupuis S, Puel A
J Clin Immunol 2020 Aug;40(6):807-819. Epub 2020 Jun 22 doi: 10.1007/s10875-020-00803-9. PMID: 32572726Free PMC Article
Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.
Christensen MH, Pedersen EK, Nordbø Y, Varhaug JE, Midttun Ø, Ueland PM, Nygård OK, Mellgren G, Lien EA
J Intern Med 2012 Dec;272(6):583-91. Epub 2012 Aug 5 doi: 10.1111/j.1365-2796.2012.02570.x. PMID: 22757621
Elevated pyrogenic cytokines in heatstroke.
Bouchama A, al-Sedairy S, Siddiqui S, Shail E, Rezeig M
Chest 1993 Nov;104(5):1498-502. doi: 10.1378/chest.104.5.1498. PMID: 8222814

Recent systematic reviews

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118

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