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Verrucous cell carcinoma of the tongue

MedGen UID:
892992
•Concept ID:
C4072937
•
Neoplastic Process
HPO: HP:0030414

Definition

A low-grade variant of squamous cell carcinoma of the tongue with a warty (verrucous) appearance. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVerrucous cell carcinoma of the tongue

Professional guidelines

PubMed

Low prevalence of high risk genotypes of human papilloma virus in normal oral mucosa, oral leukoplakia and verrucous carcinoma.
Saghravanian N, Ghazvini K, Babakoohi S, Firooz A, Mohtasham N
Acta Odontol Scand 2011 Nov;69(6):406-9. Epub 2011 Apr 5 doi: 10.3109/00016357.2011.572560. PMID: 21466259
Oral cancer. The importance of early diagnosis and treatment.
Sciubba JJ
Am J Clin Dermatol 2001;2(4):239-51. doi: 10.2165/00128071-200102040-00005. PMID: 11705251

Recent clinical studies

Etiology

Progression to malignancy in oral potentially malignant disorders: a retrospective study of 5,036 patients in Ontario, Canada.
McCord C, Achita P, Kiss A, Magalhaes MA, Darling M, Bradley G
Oral Surg Oral Med Oral Pathol Oral Radiol 2023 Oct;136(4):466-477. Epub 2023 Jun 13 doi: 10.1016/j.oooo.2023.06.006. PMID: 37563059
The Spectrum of Oral Lesions Presenting Clinically With Papillary-Verrucous Features.
Whitefield S, Raiser V, Shuster A, Kleinman S, Shlomi B, Kaplan I
J Oral Maxillofac Surg 2018 Mar;76(3):545-552. Epub 2017 Aug 24 doi: 10.1016/j.joms.2017.08.030. PMID: 28923272
Multiple primary squamous cell carcinomas of the oral cavity.
Qaisi M, Vorrasi J, Lubek J, Ord R
J Oral Maxillofac Surg 2014 Aug;72(8):1511-6. Epub 2014 Mar 31 doi: 10.1016/j.joms.2014.03.012. PMID: 24813779
Verrucous carcinoma of the tongue.
Vilela FA, Trope BM, Gurfinkel PC, Piñeiro-Maceira JM, Ramos-e-Silva M
Skinmed 2012 May-Jun;10(3):188-90. PMID: 22779105
Oral cancer. The importance of early diagnosis and treatment.
Sciubba JJ
Am J Clin Dermatol 2001;2(4):239-51. doi: 10.2165/00128071-200102040-00005. PMID: 11705251

Diagnosis

Atypical Squamous Verrucous Lesions of the Oral Cavity: Challenges in Interpretation of Small Incisional Biopsies.
Richards R, Agarwal S
Head Neck Pathol 2023 Sep;17(3):607-617. Epub 2023 May 19 doi: 10.1007/s12105-023-01558-6. PMID: 37204686Free PMC Article
Carcinoma Cuniculatum of the Oral Cavity: A Series of 6 Cases and Review of Literature.
Yadav S, Bal M, Rane S, Mittal N, Janu A, Patil A
Head Neck Pathol 2022 Mar;16(1):213-223. Epub 2021 Jun 2 doi: 10.1007/s12105-021-01340-6. PMID: 34076846Free PMC Article
The Spectrum of Oral Lesions Presenting Clinically With Papillary-Verrucous Features.
Whitefield S, Raiser V, Shuster A, Kleinman S, Shlomi B, Kaplan I
J Oral Maxillofac Surg 2018 Mar;76(3):545-552. Epub 2017 Aug 24 doi: 10.1016/j.joms.2017.08.030. PMID: 28923272
Multiple primary squamous cell carcinomas of the oral cavity.
Qaisi M, Vorrasi J, Lubek J, Ord R
J Oral Maxillofac Surg 2014 Aug;72(8):1511-6. Epub 2014 Mar 31 doi: 10.1016/j.joms.2014.03.012. PMID: 24813779
Verrucous carcinoma of the tongue.
Vilela FA, Trope BM, Gurfinkel PC, Piñeiro-Maceira JM, Ramos-e-Silva M
Skinmed 2012 May-Jun;10(3):188-90. PMID: 22779105

Therapy

Unusual Papillary Squamous Cell Carcinoma of the Tip of Tongue Presenting in a Patient Status Post Heart Transplant.
Alotaiby F, Song F, Boyce BJ, Cao D, Zhao Y, Lai J
Anticancer Res 2018 Jul;38(7):4203-4206. doi: 10.21873/anticanres.12715. PMID: 29970551
Potentially malignant disorders revisited-The lichenoid lesion/proliferative verrucous leukoplakia conundrum.
Thomson PJ, Goodson ML, Smith DR
J Oral Pathol Med 2018 Jul;47(6):557-565. Epub 2018 Apr 29 doi: 10.1111/jop.12716. PMID: 29663518
Oral field cancerization.
Fortuna G, Mignogna MD
CMAJ 2011 Oct 4;183(14):1622. Epub 2011 Jul 11 doi: 10.1503/cmaj.110172. PMID: 21746821Free PMC Article
Verrucous carcinoma of the oral cavity: a clinico-pathologic appraisal of 133 cases in Indians.
Rekha KP, Angadi PV
Oral Maxillofac Surg 2010 Dec;14(4):211-8. doi: 10.1007/s10006-010-0222-0. PMID: 20396919
Proliferative verrucous leukoplakia: high incidence of gingival squamous cell carcinoma.
Bagan JV, Jimenez Y, Sanchis JM, Poveda R, Milian MA, Murillo J, Scully C
J Oral Pathol Med 2003 Aug;32(7):379-82. doi: 10.1034/j.1600-0714.2003.00167.x. PMID: 12846783

Prognosis

Multiple primary squamous cell carcinomas of the oral cavity.
Qaisi M, Vorrasi J, Lubek J, Ord R
J Oral Maxillofac Surg 2014 Aug;72(8):1511-6. Epub 2014 Mar 31 doi: 10.1016/j.joms.2014.03.012. PMID: 24813779
The prognostic importance of midline involvement in oral tongue cancer.
Lloyd S, Yu JB, Wilson LD, Judson BL, Decker RH
Am J Clin Oncol 2012 Oct;35(5):468-73. doi: 10.1097/COC.0b013e3182195619. PMID: 21701377Free PMC Article
Verrucous carcinoma of the oral cavity: a clinico-pathologic appraisal of 133 cases in Indians.
Rekha KP, Angadi PV
Oral Maxillofac Surg 2010 Dec;14(4):211-8. doi: 10.1007/s10006-010-0222-0. PMID: 20396919
Oral cancer. The importance of early diagnosis and treatment.
Sciubba JJ
Am J Clin Dermatol 2001;2(4):239-51. doi: 10.2165/00128071-200102040-00005. PMID: 11705251
Oral verrucous carcinoma.
Tornes K, Bang G, Strømme Koppang H, Pedersen KN
Int J Oral Surg 1985 Dec;14(6):485-92. doi: 10.1016/s0300-9785(85)80054-5. PMID: 3936796

Clinical prediction guides

Proliferative verrucous/multifocal leukoplakia: Updates and literature review "case report".
Alsoghier A, AlBagieh H, AlSahman L, Alshagroud R, AlSahman R
Medicine (Baltimore) 2023 May 26;102(21):e33783. doi: 10.1097/MD.0000000000033783. PMID: 37233434Free PMC Article
Atypical Squamous Verrucous Lesions of the Oral Cavity: Challenges in Interpretation of Small Incisional Biopsies.
Richards R, Agarwal S
Head Neck Pathol 2023 Sep;17(3):607-617. Epub 2023 May 19 doi: 10.1007/s12105-023-01558-6. PMID: 37204686Free PMC Article
Carcinoma Cuniculatum of the Oral Cavity: A Series of 6 Cases and Review of Literature.
Yadav S, Bal M, Rane S, Mittal N, Janu A, Patil A
Head Neck Pathol 2022 Mar;16(1):213-223. Epub 2021 Jun 2 doi: 10.1007/s12105-021-01340-6. PMID: 34076846Free PMC Article
Multiple primary squamous cell carcinomas of the oral cavity.
Qaisi M, Vorrasi J, Lubek J, Ord R
J Oral Maxillofac Surg 2014 Aug;72(8):1511-6. Epub 2014 Mar 31 doi: 10.1016/j.joms.2014.03.012. PMID: 24813779
Oral cancer. The importance of early diagnosis and treatment.
Sciubba JJ
Am J Clin Dermatol 2001;2(4):239-51. doi: 10.2165/00128071-200102040-00005. PMID: 11705251

Recent systematic reviews

Clinical manifestations of oral proliferative verrucous leukoplakia: A systematic review.
Torrejon-Moya A, Jané-Salas E, López-López J
J Oral Pathol Med 2020 May;49(5):404-408. Epub 2020 Feb 9 doi: 10.1111/jop.12999. PMID: 31990082

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