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Third Trimester Antepartum Hemorrhage

MedGen UID:
897740
•Concept ID:
C4086902
•
Pathologic Function
Synonym: Antepartum Hemorrhage, Third Trimester

Definition

Excessive blood loss within the third trimester but prior to onset of labor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThird Trimester Antepartum Hemorrhage

Professional guidelines

PubMed

Implementation of a protocol for management of antepartum iron deficiency anemia: a prospective cohort study.
Hamm RF, Wang EY, Levine LD, Speranza RJ, Srinivas SK
Am J Obstet Gynecol MFM 2022 Mar;4(2):100533. Epub 2021 Nov 20 doi: 10.1016/j.ajogmf.2021.100533. PMID: 34808403Free PMC Article
Management of parturients with Factor XI deficiency-10year case series and review of literature.
Verghese L, Tingi E, Thachil J, Hay C, Byrd L
Eur J Obstet Gynecol Reprod Biol 2017 Aug;215:85-92. Epub 2017 Jun 6 doi: 10.1016/j.ejogrb.2017.06.008. PMID: 28622635
Ultrasound and human-placental-lactogen screening early detection of twin pregnancies.
Grennert L, Persson PH, Gennser G, Kullander S, Thorell J
Lancet 1976 Jan 3;1(7949):4-6. doi: 10.1016/s0140-6736(76)92905-6. PMID: 54540

Recent clinical studies

Etiology

Antepartum and postpartum anemia: a narrative review.
Butwick AJ, McDonnell N
Int J Obstet Anesth 2021 Aug;47:102985. Epub 2021 Mar 29 doi: 10.1016/j.ijoa.2021.102985. PMID: 33893005
Considering delay of cholecystectomy in the third trimester of pregnancy.
Hong J, Yang J, Zhang X, Su J, Tumati A, Garry D, Docimo S, Bates AT, Spaniolas K, Talamini MA, Pryor AD
Surg Endosc 2021 Aug;35(8):4673-4680. Epub 2020 Sep 1 doi: 10.1007/s00464-020-07910-z. PMID: 32875420
Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Smith C, Teng F, Branch E, Chu S, Joseph KS
Obstet Gynecol 2019 Dec;134(6):1234-1244. doi: 10.1097/AOG.0000000000003557. PMID: 31764734Free PMC Article
Antepartum bleeding of unknown origin in the second half of pregnancy: a review.
Magann EF, Cummings JE, Niederhauser A, Rodriguez-Thompson D, McCormack R, Chauhan SP
Obstet Gynecol Surv 2005 Nov;60(11):741-5. doi: 10.1097/01.ogx.0000182881.53139.f7. PMID: 16250922
Pregnancy and delivery in protein C-deficiency.
Sugiura M
Curr Drug Targets 2005 Aug;6(5):577-83. doi: 10.2174/1389450054545971. PMID: 16026278

Diagnosis

Antepartum and postpartum changes in adipokines, endothelial dysfunction, inflammatory markers and other biochemical parameters in preeclamptic women: A prospective observational cohort study.
Talab AY, Aboali Hamza H, Mostafa TM
J Appl Biomed 2021 Mar;19(1):62-72. Epub 2021 Jan 28 doi: 10.32725/jab.2021.004. PMID: 34907717
Antepartum and postpartum anemia: a narrative review.
Butwick AJ, McDonnell N
Int J Obstet Anesth 2021 Aug;47:102985. Epub 2021 Mar 29 doi: 10.1016/j.ijoa.2021.102985. PMID: 33893005
Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Smith C, Teng F, Branch E, Chu S, Joseph KS
Obstet Gynecol 2019 Dec;134(6):1234-1244. doi: 10.1097/AOG.0000000000003557. PMID: 31764734Free PMC Article
Vaginal Bleeding in Late Pregnancy.
Young JS, White LM
Emerg Med Clin North Am 2019 May;37(2):251-264. Epub 2019 Mar 8 doi: 10.1016/j.emc.2019.01.006. PMID: 30940370
Cesarean scar pregnancy is a precursor of morbidly adherent placenta.
Timor-Tritsch IE, Monteagudo A, Cali G, Vintzileos A, Viscarello R, Al-Khan A, Zamudio S, Mayberry P, Cordoba MM, Dar P
Ultrasound Obstet Gynecol 2014 Sep;44(3):346-53. Epub 2014 Jul 31 doi: 10.1002/uog.13426. PMID: 24890256

Therapy

Considering delay of cholecystectomy in the third trimester of pregnancy.
Hong J, Yang J, Zhang X, Su J, Tumati A, Garry D, Docimo S, Bates AT, Spaniolas K, Talamini MA, Pryor AD
Surg Endosc 2021 Aug;35(8):4673-4680. Epub 2020 Sep 1 doi: 10.1007/s00464-020-07910-z. PMID: 32875420
The association between maternal cortisol and depression during pregnancy, a systematic review.
Orta OR, Gelaye B, Bain PA, Williams MA
Arch Womens Ment Health 2018 Feb;21(1):43-53. Epub 2017 Sep 24 doi: 10.1007/s00737-017-0777-y. PMID: 28942465Free PMC Article
Management of parturients with Factor XI deficiency-10year case series and review of literature.
Verghese L, Tingi E, Thachil J, Hay C, Byrd L
Eur J Obstet Gynecol Reprod Biol 2017 Aug;215:85-92. Epub 2017 Jun 6 doi: 10.1016/j.ejogrb.2017.06.008. PMID: 28622635
Cesarean scar pregnancy is a precursor of morbidly adherent placenta.
Timor-Tritsch IE, Monteagudo A, Cali G, Vintzileos A, Viscarello R, Al-Khan A, Zamudio S, Mayberry P, Cordoba MM, Dar P
Ultrasound Obstet Gynecol 2014 Sep;44(3):346-53. Epub 2014 Jul 31 doi: 10.1002/uog.13426. PMID: 24890256
Use of antithrombotic agents during pregnancy: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
Bates SM, Greer IA, Hirsh J, Ginsberg JS
Chest 2004 Sep;126(3 Suppl):627S-644S. doi: 10.1378/chest.126.3_suppl.627S. PMID: 15383488

Prognosis

Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Smith C, Teng F, Branch E, Chu S, Joseph KS
Obstet Gynecol 2019 Dec;134(6):1234-1244. doi: 10.1097/AOG.0000000000003557. PMID: 31764734Free PMC Article
Incidence and outcome of severe ante-partum hemorrhage at the Teaching Hospital Yalgado Ouédraogo in Burkina Faso.
Lankoande M, Bonkoungou P, Ouandaogo S, Dayamba M, Ouedraogo A, Veyckmans F, Ouédraogo N
BMC Emerg Med 2017 May 31;17(1):17. doi: 10.1186/s12873-017-0128-3. PMID: 28569134Free PMC Article
Cesarean scar pregnancy is a precursor of morbidly adherent placenta.
Timor-Tritsch IE, Monteagudo A, Cali G, Vintzileos A, Viscarello R, Al-Khan A, Zamudio S, Mayberry P, Cordoba MM, Dar P
Ultrasound Obstet Gynecol 2014 Sep;44(3):346-53. Epub 2014 Jul 31 doi: 10.1002/uog.13426. PMID: 24890256
Cervical length and risk of antepartum hemorrhage in presence of low-lying placenta.
Curti A, Potti S, Di Donato N, Simonazzi G, Rizzo N, Berghella V
J Matern Fetal Neonatal Med 2013 Apr;26(6):563-5. Epub 2012 Dec 12 doi: 10.3109/14767058.2012.743524. PMID: 23153020
Antepartum bleeding of unknown origin in the second half of pregnancy: a review.
Magann EF, Cummings JE, Niederhauser A, Rodriguez-Thompson D, McCormack R, Chauhan SP
Obstet Gynecol Surv 2005 Nov;60(11):741-5. doi: 10.1097/01.ogx.0000182881.53139.f7. PMID: 16250922

Clinical prediction guides

Antepartum and postpartum changes in adipokines, endothelial dysfunction, inflammatory markers and other biochemical parameters in preeclamptic women: A prospective observational cohort study.
Talab AY, Aboali Hamza H, Mostafa TM
J Appl Biomed 2021 Mar;19(1):62-72. Epub 2021 Jan 28 doi: 10.32725/jab.2021.004. PMID: 34907717
Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Smith C, Teng F, Branch E, Chu S, Joseph KS
Obstet Gynecol 2019 Dec;134(6):1234-1244. doi: 10.1097/AOG.0000000000003557. PMID: 31764734Free PMC Article
The association between maternal cortisol and depression during pregnancy, a systematic review.
Orta OR, Gelaye B, Bain PA, Williams MA
Arch Womens Ment Health 2018 Feb;21(1):43-53. Epub 2017 Sep 24 doi: 10.1007/s00737-017-0777-y. PMID: 28942465Free PMC Article
Maternal Serum Prolactin and Prediction of Postpartum β-Cell Function and Risk of Prediabetes/Diabetes.
Retnakaran R, Ye C, Kramer CK, Connelly PW, Hanley AJ, Sermer M, Zinman B
Diabetes Care 2016 Jul;39(7):1250-8. Epub 2016 Apr 26 doi: 10.2337/dc16-0043. PMID: 27208323
Antepartum bleeding of unknown origin in the second half of pregnancy: a review.
Magann EF, Cummings JE, Niederhauser A, Rodriguez-Thompson D, McCormack R, Chauhan SP
Obstet Gynecol Surv 2005 Nov;60(11):741-5. doi: 10.1097/01.ogx.0000182881.53139.f7. PMID: 16250922

Recent systematic reviews

The association between maternal cortisol and depression during pregnancy, a systematic review.
Orta OR, Gelaye B, Bain PA, Williams MA
Arch Womens Ment Health 2018 Feb;21(1):43-53. Epub 2017 Sep 24 doi: 10.1007/s00737-017-0777-y. PMID: 28942465Free PMC Article

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