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Upper limb muscle hypertrophy

MedGen UID:
898044
•Concept ID:
C4280687
•
Finding
HPO: HP:0040265

Definition

Abnormal increase in muscle size and mass of one or both arms not due to training. [from HPO]

Professional guidelines

PubMed

Bradykinin type 2 receptor -9/-9 genotype is associated with triceps brachii muscle hypertrophy following strength training in young healthy men.
Popadic Gacesa JZ, Momcilovic M, Veselinovic I, Brodie DA, Grujic NG
BMC Musculoskelet Disord 2012 Nov 6;13:217. doi: 10.1186/1471-2474-13-217. PMID: 23127247Free PMC Article
Relation between cardiac hypertrophy and forearm vascular structural changes before and during long-term antihypertensive treatment.
Agabiti-Rosei E, Muiesan ML, Geri A, Romanelli G, Montani G, Muiesan G
Am J Med 1988 Mar 11;84(3A):125-8. doi: 10.1016/0002-9343(88)90217-3. PMID: 2975461

Recent clinical studies

Etiology

Free-Weight and Machine-Based Training Are Equally Effective on Strength and Hypertrophy: Challenging a Traditional Myth.
Hernández-Belmonte A, Martínez-Cava A, Buendía-Romero Á, Franco-López F, Pallarés JG
Med Sci Sports Exerc 2023 Dec 1;55(12):2316-2327. Epub 2023 Aug 2 doi: 10.1249/MSS.0000000000003271. PMID: 37535335
An Overview of Blood Flow Restriction Physiology and Clinical Considerations.
Martin PM, Bart RM, Ashley RL, Velasco T, Wise SR
Curr Sports Med Rep 2022 Apr 1;21(4):123-128. doi: 10.1249/JSR.0000000000000948. PMID: 35394953
How many times per week should a muscle be trained to maximize muscle hypertrophy? A systematic review and meta-analysis of studies examining the effects of resistance training frequency.
Schoenfeld BJ, Grgic J, Krieger J
J Sports Sci 2019 Jun;37(11):1286-1295. Epub 2018 Dec 17 doi: 10.1080/02640414.2018.1555906. PMID: 30558493
Longer Interset Rest Periods Enhance Muscle Strength and Hypertrophy in Resistance-Trained Men.
Schoenfeld BJ, Pope ZK, Benik FM, Hester GM, Sellers J, Nooner JL, Schnaiter JA, Bond-Williams KE, Carter AS, Ross CL, Just BL, Henselmans M, Krieger JW
J Strength Cond Res 2016 Jul;30(7):1805-12. doi: 10.1519/JSC.0000000000001272. PMID: 26605807
Effects of Low- vs. High-Load Resistance Training on Muscle Strength and Hypertrophy in Well-Trained Men.
Schoenfeld BJ, Peterson MD, Ogborn D, Contreras B, Sonmez GT
J Strength Cond Res 2015 Oct;29(10):2954-63. doi: 10.1519/JSC.0000000000000958. PMID: 25853914

Diagnosis

Can muscle typology explain the inter-individual variability in resistance training adaptations?
Van Vossel K, Hardeel J, Van de Casteele F, Van der Stede T, Weyns A, Boone J, Blemker SS, Lievens E, Derave W
J Physiol 2023 Jun;601(12):2307-2327. Epub 2023 Apr 26 doi: 10.1113/JP284442. PMID: 37038845
Upper limb congenital muscular hypertrophy and aberrant muscle syndrome in children.
Dahan E, Chaves C, Bachy M, Fitoussi F
J Hand Surg Eur Vol 2018 Sep;43(7):751-755. Epub 2018 May 14 doi: 10.1177/1753193418774459. PMID: 29759027
Vascular injuries in the upper extremity in athletes.
de Mooij T, Duncan AA, Kakar S
Hand Clin 2015 Feb;31(1):39-52. Epub 2014 Nov 25 doi: 10.1016/j.hcl.2014.09.004. PMID: 25455355
Focal shoulder-elevation dystonia.
Wright RA, Ahlskog JE
Mov Disord 2000 Jul;15(4):709-13. doi: 10.1002/1531-8257(200007)15:4<709::aid-mds1017>3.0.co;2-4. PMID: 10928583
Vibration white finger.
Palmer RA, Collin J
Br J Surg 1993 Jun;80(6):705-9. doi: 10.1002/bjs.1800800608. PMID: 8330150

Therapy

Partial Range of Motion Exercise Is Effective for Facilitating Muscle Hypertrophy and Function Through Sustained Intramuscular Hypoxia in Young Trained Men.
Goto M, Maeda C, Hirayama T, Terada S, Nirengi S, Kurosawa Y, Nagano A, Hamaoka T
J Strength Cond Res 2019 May;33(5):1286-1294. doi: 10.1519/JSC.0000000000002051. PMID: 31034463
Creatine supplementation elicits greater muscle hypertrophy in upper than lower limbs and trunk in resistance-trained men.
Nunes JP, Ribeiro AS, Schoenfeld BJ, Tomeleri CM, Avelar A, Trindade MC, Nabuco HC, Cavalcante EF, Junior PS, Fernandes RR, Carvalho FO, Cyrino ES
Nutr Health 2017 Dec;23(4):223-229. doi: 10.1177/0260106017737013. PMID: 29214923
Longer Interset Rest Periods Enhance Muscle Strength and Hypertrophy in Resistance-Trained Men.
Schoenfeld BJ, Pope ZK, Benik FM, Hester GM, Sellers J, Nooner JL, Schnaiter JA, Bond-Williams KE, Carter AS, Ross CL, Just BL, Henselmans M, Krieger JW
J Strength Cond Res 2016 Jul;30(7):1805-12. doi: 10.1519/JSC.0000000000001272. PMID: 26605807
Effects of Low- vs. High-Load Resistance Training on Muscle Strength and Hypertrophy in Well-Trained Men.
Schoenfeld BJ, Peterson MD, Ogborn D, Contreras B, Sonmez GT
J Strength Cond Res 2015 Oct;29(10):2954-63. doi: 10.1519/JSC.0000000000000958. PMID: 25853914
Effects of different volume-equated resistance training loading strategies on muscular adaptations in well-trained men.
Schoenfeld BJ, Ratamess NA, Peterson MD, Contreras B, Sonmez GT, Alvar BA
J Strength Cond Res 2014 Oct;28(10):2909-18. doi: 10.1519/JSC.0000000000000480. PMID: 24714538

Prognosis

Sensitivity Analysis of Upper Limb Musculoskeletal Models During Isometric and Isokinetic Tasks.
Diaz MT, Harley JB, Nichols JA
J Biomech Eng 2024 Feb 1;146(2) doi: 10.1115/1.4064056. PMID: 37978046Free PMC Article
Accessory heads of biceps brachii muscle its embryogenesis and clinical implications: Cadaveric study.
Chakravarthi KK, Sarvepalli A, Siddegowda SK, Nelluri V
Ann Afr Med 2023 Jul-Sep;22(3):359-364. doi: 10.4103/aam.aam_93_22. PMID: 37417026Free PMC Article
Less common upper limb mononeuropathies.
Williams FH, Kumiga B
PM R 2013 May;5(5 Suppl):S22-30. Epub 2013 Mar 21 doi: 10.1016/j.pmrj.2013.03.021. PMID: 23523706
Clinical and morphological phenotype of the filamin myopathy: a study of 31 German patients.
Kley RA, Hellenbroich Y, van der Ven PF, Fürst DO, Huebner A, Bruchertseifer V, Peters SA, Heyer CM, Kirschner J, Schröder R, Fischer D, Müller K, Tolksdorf K, Eger K, Germing A, Brodherr T, Reum C, Walter MC, Lochmüller H, Ketelsen UP, Vorgerd M
Brain 2007 Dec;130(Pt 12):3250-64. doi: 10.1093/brain/awm271. PMID: 18055494
Ulnar neuropathy of the elbow.
Norkus SA, Meyers MC
Sports Med 1994 Mar;17(3):189-99. doi: 10.2165/00007256-199417030-00005. PMID: 8191176

Clinical prediction guides

Sensitivity Analysis of Upper Limb Musculoskeletal Models During Isometric and Isokinetic Tasks.
Diaz MT, Harley JB, Nichols JA
J Biomech Eng 2024 Feb 1;146(2) doi: 10.1115/1.4064056. PMID: 37978046Free PMC Article
Upper-extremity blood flow restriction: the proximal, distal, and contralateral effects-a randomized controlled trial.
Bowman EN, Elshaar R, Milligan H, Jue G, Mohr K, Brown P, Watanabe DM, Limpisvasti O
J Shoulder Elbow Surg 2020 Jun;29(6):1267-1274. doi: 10.1016/j.jse.2020.02.003. PMID: 32423577
Upper limb congenital muscular hypertrophy and aberrant muscle syndrome in children.
Dahan E, Chaves C, Bachy M, Fitoussi F
J Hand Surg Eur Vol 2018 Sep;43(7):751-755. Epub 2018 May 14 doi: 10.1177/1753193418774459. PMID: 29759027
Creatine supplementation elicits greater muscle hypertrophy in upper than lower limbs and trunk in resistance-trained men.
Nunes JP, Ribeiro AS, Schoenfeld BJ, Tomeleri CM, Avelar A, Trindade MC, Nabuco HC, Cavalcante EF, Junior PS, Fernandes RR, Carvalho FO, Cyrino ES
Nutr Health 2017 Dec;23(4):223-229. doi: 10.1177/0260106017737013. PMID: 29214923
Effects of grip width on muscle strength and activation in the lat pull-down.
Andersen V, Fimland MS, Wiik E, Skoglund A, Saeterbakken AH
J Strength Cond Res 2014 Apr;28(4):1135-42. doi: 10.1097/JSC.0000000000000232. PMID: 24662157

Recent systematic reviews

Strength Training in Climbing: A Systematic Review.
Langer K, Simon C, Wiemeyer J
J Strength Cond Res 2023 Mar 1;37(3):751-767. Epub 2022 Jun 1 doi: 10.1519/JSC.0000000000004286. PMID: 36820707
Does Beef Protein Supplementation Improve Body Composition and Exercise Performance? A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Valenzuela PL, Mata F, Morales JS, Castillo-García A, Lucia A
Nutrients 2019 Jun 25;11(6) doi: 10.3390/nu11061429. PMID: 31242624Free PMC Article
How many times per week should a muscle be trained to maximize muscle hypertrophy? A systematic review and meta-analysis of studies examining the effects of resistance training frequency.
Schoenfeld BJ, Grgic J, Krieger J
J Sports Sci 2019 Jun;37(11):1286-1295. Epub 2018 Dec 17 doi: 10.1080/02640414.2018.1555906. PMID: 30558493
The compatibility of concurrent high intensity interval training and resistance training for muscular strength and hypertrophy: a systematic review and meta-analysis.
Sabag A, Najafi A, Michael S, Esgin T, Halaki M, Hackett D
J Sports Sci 2018 Nov;36(21):2472-2483. Epub 2018 Apr 16 doi: 10.1080/02640414.2018.1464636. PMID: 29658408
The Prevalence of Anatomical Variations of the Median Nerve in the Carpal Tunnel: A Systematic Review and Meta-Analysis.
Henry BM, Zwinczewska H, Roy J, Vikse J, Ramakrishnan PK, Walocha JA, Tomaszewski KA
PLoS One 2015;10(8):e0136477. Epub 2015 Aug 25 doi: 10.1371/journal.pone.0136477. PMID: 26305098Free PMC Article

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