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Reduced antithrombin antigen

MedGen UID:
906331
•Concept ID:
C4280702
•
Finding
HPO: HP:0040246

Definition

Reduced antithrombin antigen. A reduced level of antithrombin may lead to an increased risk of thrombus formation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced antithrombin antigen

Professional guidelines

PubMed

HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.
Smits NC, Kobayashi T, Srivastava PK, Skopelja S, Ivy JA, Elwood DJ, Stan RV, Tsongalis GJ, Sellke FW, Gross PL, Cole MD, DeVries JT, Kaplan AV, Robb JF, Williams SM, Shworak NW
Matrix Biol 2017 Nov;63:69-90. Epub 2017 Jan 23 doi: 10.1016/j.matbio.2017.01.003. PMID: 28126521Free PMC Article
The management of heparin-induced thrombocytopenia.
Keeling D, Davidson S, Watson H; Haemostasis and Thrombosis Task Force of the British Committee for Standards in Haematology
Br J Haematol 2006 May;133(3):259-69. doi: 10.1111/j.1365-2141.2006.06018.x. PMID: 16643427
Long-term treatment with growth hormone decreases plasminogen activator inhibitor-1 and tissue plasminogen activator in growth hormone-deficient adults.
Johansson JO, Landin K, Johannsson G, Tengborn L, Bengtsson BA
Thromb Haemost 1996 Sep;76(3):422-8. PMID: 8883281

Recent clinical studies

Etiology

Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation.
Christersson C, Wallentin L, Andersson U, Alexander JH, Alings M, De Caterina R, Gersh BJ, Granger CB, Halvorsen S, Hanna M, Huber K, Hylek EM, Lopes RD, Oh BH, Siegbahn A
Heart 2019 Feb;105(3):235-242. Epub 2018 Sep 12 doi: 10.1136/heartjnl-2018-313351. PMID: 30209126Free PMC Article
Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on α and β forms.
Amiral J, Seghatchian J
Transfus Apher Sci 2018 Apr;57(2):291-297. Epub 2018 Apr 19 doi: 10.1016/j.transci.2018.04.010. PMID: 29784539
The phenotypic and genetic assessment of antithrombin deficiency.
Cooper PC, Coath F, Daly ME, Makris M
Int J Lab Hematol 2011 Jun;33(3):227-37. Epub 2011 Mar 15 doi: 10.1111/j.1751-553X.2011.01307.x. PMID: 21401902
Markers of intravascular coagulation and fibrinolysis in preeclampsia: association with intrauterine growth retardation.
Schjetlein R, Haugen G, Wisløff F
Acta Obstet Gynecol Scand 1997 Jul;76(6):541-6. doi: 10.3109/00016349709024580. PMID: 9246959
Antithrombin III deficiency.
Cucuianu M, Blaga S, Pop S, Olinic D, Olinic N, Colhon D, Cristea A
Rom J Intern Med 1994 Apr-Jun;32(2):119-27. PMID: 7920326

Diagnosis

Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on α and β forms.
Amiral J, Seghatchian J
Transfus Apher Sci 2018 Apr;57(2):291-297. Epub 2018 Apr 19 doi: 10.1016/j.transci.2018.04.010. PMID: 29784539
The phenotypic and genetic assessment of antithrombin deficiency.
Cooper PC, Coath F, Daly ME, Makris M
Int J Lab Hematol 2011 Jun;33(3):227-37. Epub 2011 Mar 15 doi: 10.1111/j.1751-553X.2011.01307.x. PMID: 21401902
Antithrombin III deficiency.
Cucuianu M, Blaga S, Pop S, Olinic D, Olinic N, Colhon D, Cristea A
Rom J Intern Med 1994 Apr-Jun;32(2):119-27. PMID: 7920326
Laboratory diagnosis of antithrombin and heparin cofactor II deficiency.
Tollefsen DM
Semin Thromb Hemost 1990 Apr;16(2):162-8. doi: 10.1055/s-2007-1002664. PMID: 2191430
Blood clotting and fibrinolysis in pregnancy.
Howie PW
Postgrad Med J 1979 May;55(643):362-6. doi: 10.1136/pgmj.55.643.362. PMID: 382169Free PMC Article

Therapy

Rivaroxaban improves vascular response in LPS-induced acute inflammation in experimental models.
Daci A, Da Dalt L, Alaj R, Shurdhiqi S, Neziri B, Ferizi R, Danilo Norata G, Krasniqi S
PLoS One 2020;15(12):e0240669. Epub 2020 Dec 10 doi: 10.1371/journal.pone.0240669. PMID: 33301454Free PMC Article
Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation.
Christersson C, Wallentin L, Andersson U, Alexander JH, Alings M, De Caterina R, Gersh BJ, Granger CB, Halvorsen S, Hanna M, Huber K, Hylek EM, Lopes RD, Oh BH, Siegbahn A
Heart 2019 Feb;105(3):235-242. Epub 2018 Sep 12 doi: 10.1136/heartjnl-2018-313351. PMID: 30209126Free PMC Article
Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on α and β forms.
Amiral J, Seghatchian J
Transfus Apher Sci 2018 Apr;57(2):291-297. Epub 2018 Apr 19 doi: 10.1016/j.transci.2018.04.010. PMID: 29784539
Coagulation Parameters in Wilson Disease.
Schaefer M, Weber L, Gotthardt D, Seessle J, Stremmel W, Pfeiffenberger J, Weiss KH
J Gastrointestin Liver Dis 2015 Jun;24(2):183-8. doi: 10.15403/jgld.2014.1121.242.wls. PMID: 26114178
Microvascular prothrombogenicity and transplant coronary artery disease.
Labarrere CA, Deng MC
Transpl Immunol 2002 May;9(2-4):243-9. doi: 10.1016/s0966-3274(02)00025-4. PMID: 12180838

Prognosis

Optimal Tests to Minimise Bleeding and Ischaemic Complications in Patients on Extracorporeal Membrane Oxygenation.
Kanji R, Vandenbriele C, Arachchillage DRJ, Price S, Gorog DA
Thromb Haemost 2022 Apr;122(4):480-491. Epub 2021 Jun 21 doi: 10.1055/a-1508-8230. [Epub ahead of print] PMID: 33984868
Antithrombin p.Thr147Ala: The First Founder Mutation in People of African Origin Responsible for Inherited Antithrombin Deficiency.
Orlando C, de la Morena-Barrio B, Pareyn I, Vanhoorelbeke K, Martínez-Martínez I, Vicente V, Corral J, Jochmans K, de la Morena-Barrio ME
Thromb Haemost 2021 Feb;121(2):182-191. Epub 2020 Sep 13 doi: 10.1055/s-0040-1716531. PMID: 32920809
Antithrombin and fibrinogen levels as predictors for plasma L-asparaginase activity in children with acute lymphoblastic leukemia.
Merlen C, Bonnefoy A, Afeich C, Théorêt Y, Laverdière C, Leclerc JM, Rivard GE
Pediatr Blood Cancer 2019 Jul;66(7):e27729. Epub 2019 Apr 2 doi: 10.1002/pbc.27729. PMID: 30938058
Coagulation Parameters in Wilson Disease.
Schaefer M, Weber L, Gotthardt D, Seessle J, Stremmel W, Pfeiffenberger J, Weiss KH
J Gastrointestin Liver Dis 2015 Jun;24(2):183-8. doi: 10.15403/jgld.2014.1121.242.wls. PMID: 26114178
Changes in von Willebrand factor and ADAMTS-13 in patients following arthroplasty.
Liu L, Ling J, Ma Z, Yuan Q, Pan J, Yang H
Mol Med Rep 2015 Apr;11(4):3015-20. Epub 2014 Dec 3 doi: 10.3892/mmr.2014.3041. PMID: 25482054

Clinical prediction guides

Rivaroxaban improves vascular response in LPS-induced acute inflammation in experimental models.
Daci A, Da Dalt L, Alaj R, Shurdhiqi S, Neziri B, Ferizi R, Danilo Norata G, Krasniqi S
PLoS One 2020;15(12):e0240669. Epub 2020 Dec 10 doi: 10.1371/journal.pone.0240669. PMID: 33301454Free PMC Article
Coagulation Parameters in Wilson Disease.
Schaefer M, Weber L, Gotthardt D, Seessle J, Stremmel W, Pfeiffenberger J, Weiss KH
J Gastrointestin Liver Dis 2015 Jun;24(2):183-8. doi: 10.15403/jgld.2014.1121.242.wls. PMID: 26114178
Platelets do not express the oxidized or reduced forms of tissue factor.
Bouchard BA, Gissel MT, Whelihan MF, Mann KG, Butenas S
Biochim Biophys Acta 2014 Mar;1840(3):1188-93. Epub 2013 Dec 19 doi: 10.1016/j.bbagen.2013.11.024. PMID: 24361609Free PMC Article
Antithrombin III deficiency.
Cucuianu M, Blaga S, Pop S, Olinic D, Olinic N, Colhon D, Cristea A
Rom J Intern Med 1994 Apr-Jun;32(2):119-27. PMID: 7920326
Neonatal antithrombin III.
Peters M, Jansen E, ten Cate JW, Kahlé LH, Ockelford P, Breederveld C
Br J Haematol 1984 Dec;58(4):579-87. doi: 10.1111/j.1365-2141.1984.tb06104.x. PMID: 6518134

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