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Reduced antithrombin antigen

MedGen UID:
906331
•Concept ID:
C4280702
•
Finding
HPO: HP:0040246

Definition

Reduced antithrombin antigen. A reduced level of antithrombin may lead to an increased risk of thrombus formation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced antithrombin antigen

Professional guidelines

PubMed

Perioperative Treatment with Rivaroxaban and Dabigatran on Changes of Coagulation and Platelet Activation Biomarkers following Left Atrial Appendage Closure.
Yao Y, Li Y, Jin Q, Li X, Zhang X, Lv Q
Cardiovasc Ther 2024;2024:4405152. Epub 2024 Mar 12 doi: 10.1155/2024/4405152. PMID: 38505191Free PMC Article
HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.
Smits NC, Kobayashi T, Srivastava PK, Skopelja S, Ivy JA, Elwood DJ, Stan RV, Tsongalis GJ, Sellke FW, Gross PL, Cole MD, DeVries JT, Kaplan AV, Robb JF, Williams SM, Shworak NW
Matrix Biol 2017 Nov;63:69-90. Epub 2017 Jan 23 doi: 10.1016/j.matbio.2017.01.003. PMID: 28126521Free PMC Article
The management of heparin-induced thrombocytopenia.
Keeling D, Davidson S, Watson H; Haemostasis and Thrombosis Task Force of the British Committee for Standards in Haematology
Br J Haematol 2006 May;133(3):259-69. doi: 10.1111/j.1365-2141.2006.06018.x. PMID: 16643427

Recent clinical studies

Etiology

Congenital Hypodysfibrinogenemia due to γ326Cys→Tyr Mutation: Third Ever-Described Case Associated with Recurrent Venous Thrombosis and COVID Vaccine.
Nanthan KR, Pedersen IS, Andersen DT, Bor MV
Acta Haematol 2024;147(5):564-570. Epub 2024 Feb 17 doi: 10.1159/000536562. PMID: 39140696
Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on α and β forms.
Amiral J, Seghatchian J
Transfus Apher Sci 2018 Apr;57(2):291-297. Epub 2018 Apr 19 doi: 10.1016/j.transci.2018.04.010. PMID: 29784539
Natural Hirudin Increases Rat Flap Viability by Anti-Inflammation via PARs/p38/NF-κB Pathway.
Peng L, Pan X, Yin G
Biomed Res Int 2015;2015:597264. Epub 2015 Dec 7 doi: 10.1155/2015/597264. PMID: 26770977Free PMC Article
Reduced thrombin generation and soluble P-selectin after intravenous enoxaparin during PCI.
Kvasnička J, Horák J, Zenáhlíková Z, Kvasnička T, Simek S, Kovárník T, Malíková I, Linhart A, Aschermann M
Cardiovasc Drugs Ther 2011 Jun;25(3):243-50. doi: 10.1007/s10557-011-6301-0. PMID: 21584633
The comparative effects of n-3 and n-6 polyunsaturated fatty acids on plasma fibrinogen levels: a controlled clinical trial in hypertriglyceridemic subjects.
Radack K, Deck C, Huster G
J Am Coll Nutr 1990 Aug;9(4):352-7. doi: 10.1080/07315724.1990.10720392. PMID: 2212394

Diagnosis

Antithrombin Resistance Rescues Clotting Defect of Homozygous Prothrombin-Y510N Dysprothrombinemia.
Lu Y, Villoutreix BO, Biswas I, Ding Q, Wang X, Rezaie AR
Thromb Haemost 2022 May;122(5):679-691. Epub 2021 Sep 5 doi: 10.1055/a-1549-6407. [Epub ahead of print] PMID: 34256393Free PMC Article
Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on α and β forms.
Amiral J, Seghatchian J
Transfus Apher Sci 2018 Apr;57(2):291-297. Epub 2018 Apr 19 doi: 10.1016/j.transci.2018.04.010. PMID: 29784539
The phenotypic and genetic assessment of antithrombin deficiency.
Cooper PC, Coath F, Daly ME, Makris M
Int J Lab Hematol 2011 Jun;33(3):227-37. Epub 2011 Mar 15 doi: 10.1111/j.1751-553X.2011.01307.x. PMID: 21401902
Whole blood tissue factor procoagulant activity is elevated in patients with sickle cell disease.
Key NS, Slungaard A, Dandelet L, Nelson SC, Moertel C, Styles LA, Kuypers FA, Bach RR
Blood 1998 Jun 1;91(11):4216-23. PMID: 9596669
Laboratory diagnosis of antithrombin and heparin cofactor II deficiency.
Tollefsen DM
Semin Thromb Hemost 1990 Apr;16(2):162-8. doi: 10.1055/s-2007-1002664. PMID: 2191430

Therapy

Gene editing of human iPSCs rescues thrombophilia in hereditary antithrombin deficiency in mice.
Tang LV, Tao Y, Feng Y, Ma J, Lin W, Zhang Y, Zhang Y, Wu T, Cai Y, Lu H, Wei J, Corral J, Hu Y
Sci Transl Med 2022 Nov 30;14(673):eabq3202. doi: 10.1126/scitranslmed.abq3202. PMID: 36449603
Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model.
de Souza JG, Morais KL, Anglés-Cano E, Boufleur P, de Mello ES, Maria DA, Origassa CS, de Campos Zampolli H, Câmara NO, Berra CM, Bosch RV, Chudzinski-Tavassi AM
Oncotarget 2016 Sep 20;7(38):62255-62266. doi: 10.18632/oncotarget.11555. PMID: 27566592Free PMC Article
Natural Hirudin Increases Rat Flap Viability by Anti-Inflammation via PARs/p38/NF-κB Pathway.
Peng L, Pan X, Yin G
Biomed Res Int 2015;2015:597264. Epub 2015 Dec 7 doi: 10.1155/2015/597264. PMID: 26770977Free PMC Article
Reduced thrombin generation and soluble P-selectin after intravenous enoxaparin during PCI.
Kvasnička J, Horák J, Zenáhlíková Z, Kvasnička T, Simek S, Kovárník T, Malíková I, Linhart A, Aschermann M
Cardiovasc Drugs Ther 2011 Jun;25(3):243-50. doi: 10.1007/s10557-011-6301-0. PMID: 21584633
Development of idraparinux and idrabiotaparinux for anticoagulant therapy.
Harenberg J
Thromb Haemost 2009 Nov;102(5):811-5. doi: 10.1160/TH09-08-0555. PMID: 19888513

Prognosis

FXa-mediated PAR-2 promotes the efficacy of immunotherapy for hepatocellular carcinoma through immune escape and anoikis resistance by inducing PD-L1 transcription.
Li X, Gao L, Wang B, Hu J, Yu Y, Gu B, Xiang L, Li X, Li H, Zhang T, Wang Y, Ma C, Dong J, Lu J, Lucas A, Chen H
J Immunother Cancer 2024 Jul 25;12(7) doi: 10.1136/jitc-2024-009565. PMID: 39060025Free PMC Article
Optimal Tests to Minimise Bleeding and Ischaemic Complications in Patients on Extracorporeal Membrane Oxygenation.
Kanji R, Vandenbriele C, Arachchillage DRJ, Price S, Gorog DA
Thromb Haemost 2022 Apr;122(4):480-491. Epub 2021 Jun 21 doi: 10.1055/a-1508-8230. [Epub ahead of print] PMID: 33984868
Binding between heparin and the integrin VLA-4.
Schlesinger M, Simonis D, Schmitz P, Fritzsche J, Bendas G
Thromb Haemost 2009 Nov;102(5):816-22. doi: 10.1160/TH09-01-0061. PMID: 19888514
Decreased platelet reactivity in blood anticoagulated with bivalirudin or enoxaparin compared with unfractionated heparin: implications for coronary intervention.
Aggarwal A, Sobel BE, Schneider DJ
J Thromb Thrombolysis 2002 Jun;13(3):161-5. doi: 10.1023/a:1020478923794. PMID: 12355033
Antithrombin Cambridge, 384 Ala to Pro: a new variant identified using the polymerase chain reaction.
Perry DJ, Harper PL, Fairham S, Daly M, Carrell RW
FEBS Lett 1989 Aug 28;254(1-2):174-6. doi: 10.1016/0014-5793(89)81033-6. PMID: 2776881

Clinical prediction guides

Gene editing of human iPSCs rescues thrombophilia in hereditary antithrombin deficiency in mice.
Tang LV, Tao Y, Feng Y, Ma J, Lin W, Zhang Y, Zhang Y, Wu T, Cai Y, Lu H, Wei J, Corral J, Hu Y
Sci Transl Med 2022 Nov 30;14(673):eabq3202. doi: 10.1126/scitranslmed.abq3202. PMID: 36449603
Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model.
de Souza JG, Morais KL, Anglés-Cano E, Boufleur P, de Mello ES, Maria DA, Origassa CS, de Campos Zampolli H, Câmara NO, Berra CM, Bosch RV, Chudzinski-Tavassi AM
Oncotarget 2016 Sep 20;7(38):62255-62266. doi: 10.18632/oncotarget.11555. PMID: 27566592Free PMC Article
Reduced thrombin generation and soluble P-selectin after intravenous enoxaparin during PCI.
Kvasnička J, Horák J, Zenáhlíková Z, Kvasnička T, Simek S, Kovárník T, Malíková I, Linhart A, Aschermann M
Cardiovasc Drugs Ther 2011 Jun;25(3):243-50. doi: 10.1007/s10557-011-6301-0. PMID: 21584633
Whole blood tissue factor procoagulant activity is elevated in patients with sickle cell disease.
Key NS, Slungaard A, Dandelet L, Nelson SC, Moertel C, Styles LA, Kuypers FA, Bach RR
Blood 1998 Jun 1;91(11):4216-23. PMID: 9596669
Antithrombin Cambridge, 384 Ala to Pro: a new variant identified using the polymerase chain reaction.
Perry DJ, Harper PL, Fairham S, Daly M, Carrell RW
FEBS Lett 1989 Aug 28;254(1-2):174-6. doi: 10.1016/0014-5793(89)81033-6. PMID: 2776881

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