U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Reduced antithrombin antigen

MedGen UID:
906331
•Concept ID:
C4280702
•
Finding
HPO: HP:0040246

Definition

Reduced antithrombin antigen. A reduced level of antithrombin may lead to an increased risk of thrombus formation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced antithrombin antigen

Professional guidelines

PubMed

Perioperative Treatment with Rivaroxaban and Dabigatran on Changes of Coagulation and Platelet Activation Biomarkers following Left Atrial Appendage Closure.
Yao Y, Li Y, Jin Q, Li X, Zhang X, Lv Q
Cardiovasc Ther 2024;2024:4405152. Epub 2024 Mar 12 doi: 10.1155/2024/4405152. PMID: 38505191Free PMC Article
HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.
Smits NC, Kobayashi T, Srivastava PK, Skopelja S, Ivy JA, Elwood DJ, Stan RV, Tsongalis GJ, Sellke FW, Gross PL, Cole MD, DeVries JT, Kaplan AV, Robb JF, Williams SM, Shworak NW
Matrix Biol 2017 Nov;63:69-90. Epub 2017 Jan 23 doi: 10.1016/j.matbio.2017.01.003. PMID: 28126521Free PMC Article
The management of heparin-induced thrombocytopenia.
Keeling D, Davidson S, Watson H; Haemostasis and Thrombosis Task Force of the British Committee for Standards in Haematology
Br J Haematol 2006 May;133(3):259-69. doi: 10.1111/j.1365-2141.2006.06018.x. PMID: 16643427

Recent clinical studies

Etiology

Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype.
Natorska J, Corral J, de la Morena-Barrio ME, Bravo-Pérez C, Bagoly Z, Bereczky Z, Treliński J, Witkowski M, Klajmon A, Undas A, Ząbczyk M
Thromb Haemost 2023 Sep;123(9):880-891. Epub 2023 May 18 doi: 10.1055/s-0043-1768712. PMID: 37201530Free PMC Article
Optimal Tests to Minimise Bleeding and Ischaemic Complications in Patients on Extracorporeal Membrane Oxygenation.
Kanji R, Vandenbriele C, Arachchillage DRJ, Price S, Gorog DA
Thromb Haemost 2022 Apr;122(4):480-491. Epub 2021 Jun 21 doi: 10.1055/a-1508-8230. [Epub ahead of print] PMID: 33984868
Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on α and β forms.
Amiral J, Seghatchian J
Transfus Apher Sci 2018 Apr;57(2):291-297. Epub 2018 Apr 19 doi: 10.1016/j.transci.2018.04.010. PMID: 29784539
The phenotypic and genetic assessment of antithrombin deficiency.
Cooper PC, Coath F, Daly ME, Makris M
Int J Lab Hematol 2011 Jun;33(3):227-37. Epub 2011 Mar 15 doi: 10.1111/j.1751-553X.2011.01307.x. PMID: 21401902
Microvascular prothrombogenicity and transplant coronary artery disease.
Labarrere CA, Deng MC
Transpl Immunol 2002 May;9(2-4):243-9. doi: 10.1016/s0966-3274(02)00025-4. PMID: 12180838

Diagnosis

Antithrombin Resistance Rescues Clotting Defect of Homozygous Prothrombin-Y510N Dysprothrombinemia.
Lu Y, Villoutreix BO, Biswas I, Ding Q, Wang X, Rezaie AR
Thromb Haemost 2022 May;122(5):679-691. Epub 2021 Sep 5 doi: 10.1055/a-1549-6407. [Epub ahead of print] PMID: 34256393Free PMC Article
Optimal Tests to Minimise Bleeding and Ischaemic Complications in Patients on Extracorporeal Membrane Oxygenation.
Kanji R, Vandenbriele C, Arachchillage DRJ, Price S, Gorog DA
Thromb Haemost 2022 Apr;122(4):480-491. Epub 2021 Jun 21 doi: 10.1055/a-1508-8230. [Epub ahead of print] PMID: 33984868
Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on α and β forms.
Amiral J, Seghatchian J
Transfus Apher Sci 2018 Apr;57(2):291-297. Epub 2018 Apr 19 doi: 10.1016/j.transci.2018.04.010. PMID: 29784539
The phenotypic and genetic assessment of antithrombin deficiency.
Cooper PC, Coath F, Daly ME, Makris M
Int J Lab Hematol 2011 Jun;33(3):227-37. Epub 2011 Mar 15 doi: 10.1111/j.1751-553X.2011.01307.x. PMID: 21401902
Laboratory diagnosis of antithrombin and heparin cofactor II deficiency.
Tollefsen DM
Semin Thromb Hemost 1990 Apr;16(2):162-8. doi: 10.1055/s-2007-1002664. PMID: 2191430

Therapy

FXa-mediated PAR-2 promotes the efficacy of immunotherapy for hepatocellular carcinoma through immune escape and anoikis resistance by inducing PD-L1 transcription.
Li X, Gao L, Wang B, Hu J, Yu Y, Gu B, Xiang L, Li X, Li H, Zhang T, Wang Y, Ma C, Dong J, Lu J, Lucas A, Chen H
J Immunother Cancer 2024 Jul 25;12(7) doi: 10.1136/jitc-2024-009565. PMID: 39060025Free PMC Article
Gene editing of human iPSCs rescues thrombophilia in hereditary antithrombin deficiency in mice.
Tang LV, Tao Y, Feng Y, Ma J, Lin W, Zhang Y, Zhang Y, Wu T, Cai Y, Lu H, Wei J, Corral J, Hu Y
Sci Transl Med 2022 Nov 30;14(673):eabq3202. doi: 10.1126/scitranslmed.abq3202. PMID: 36449603
Rivaroxaban improves vascular response in LPS-induced acute inflammation in experimental models.
Daci A, Da Dalt L, Alaj R, Shurdhiqi S, Neziri B, Ferizi R, Danilo Norata G, Krasniqi S
PLoS One 2020;15(12):e0240669. Epub 2020 Dec 10 doi: 10.1371/journal.pone.0240669. PMID: 33301454Free PMC Article
Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on α and β forms.
Amiral J, Seghatchian J
Transfus Apher Sci 2018 Apr;57(2):291-297. Epub 2018 Apr 19 doi: 10.1016/j.transci.2018.04.010. PMID: 29784539
Microvascular prothrombogenicity and transplant coronary artery disease.
Labarrere CA, Deng MC
Transpl Immunol 2002 May;9(2-4):243-9. doi: 10.1016/s0966-3274(02)00025-4. PMID: 12180838

Prognosis

FXa-mediated PAR-2 promotes the efficacy of immunotherapy for hepatocellular carcinoma through immune escape and anoikis resistance by inducing PD-L1 transcription.
Li X, Gao L, Wang B, Hu J, Yu Y, Gu B, Xiang L, Li X, Li H, Zhang T, Wang Y, Ma C, Dong J, Lu J, Lucas A, Chen H
J Immunother Cancer 2024 Jul 25;12(7) doi: 10.1136/jitc-2024-009565. PMID: 39060025Free PMC Article
Curcumol, a major terpenoid from Curcumae Rhizoma, attenuates human uterine leiomyoma cell development via the p38MAPK/NF-κB pathway.
Yu YH, Zhang HJ, Yang F, Xu L, Liu H
J Ethnopharmacol 2023 Jun 28;310:116311. Epub 2023 Mar 7 doi: 10.1016/j.jep.2023.116311. PMID: 36894110
Optimal Tests to Minimise Bleeding and Ischaemic Complications in Patients on Extracorporeal Membrane Oxygenation.
Kanji R, Vandenbriele C, Arachchillage DRJ, Price S, Gorog DA
Thromb Haemost 2022 Apr;122(4):480-491. Epub 2021 Jun 21 doi: 10.1055/a-1508-8230. [Epub ahead of print] PMID: 33984868
Coagulation Parameters in Wilson Disease.
Schaefer M, Weber L, Gotthardt D, Seessle J, Stremmel W, Pfeiffenberger J, Weiss KH
J Gastrointestin Liver Dis 2015 Jun;24(2):183-8. doi: 10.15403/jgld.2014.1121.242.wls. PMID: 26114178
Changes in von Willebrand factor and ADAMTS-13 in patients following arthroplasty.
Liu L, Ling J, Ma Z, Yuan Q, Pan J, Yang H
Mol Med Rep 2015 Apr;11(4):3015-20. Epub 2014 Dec 3 doi: 10.3892/mmr.2014.3041. PMID: 25482054

Clinical prediction guides

Fibrinogen dysfunction and fibrinolysis state in patients with hepatitis B-related cirrhosis.
Liu Y, Zhuang Y, Xu G, Wang X, Lin L, Ding Q
Hematology 2024 Dec;29(1):2392028. Epub 2024 Sep 2 doi: 10.1080/16078454.2024.2392028. PMID: 39222052
Gene editing of human iPSCs rescues thrombophilia in hereditary antithrombin deficiency in mice.
Tang LV, Tao Y, Feng Y, Ma J, Lin W, Zhang Y, Zhang Y, Wu T, Cai Y, Lu H, Wei J, Corral J, Hu Y
Sci Transl Med 2022 Nov 30;14(673):eabq3202. doi: 10.1126/scitranslmed.abq3202. PMID: 36449603
Rivaroxaban improves vascular response in LPS-induced acute inflammation in experimental models.
Daci A, Da Dalt L, Alaj R, Shurdhiqi S, Neziri B, Ferizi R, Danilo Norata G, Krasniqi S
PLoS One 2020;15(12):e0240669. Epub 2020 Dec 10 doi: 10.1371/journal.pone.0240669. PMID: 33301454Free PMC Article
Platelets do not express the oxidized or reduced forms of tissue factor.
Bouchard BA, Gissel MT, Whelihan MF, Mann KG, Butenas S
Biochim Biophys Acta 2014 Mar;1840(3):1188-93. Epub 2013 Dec 19 doi: 10.1016/j.bbagen.2013.11.024. PMID: 24361609Free PMC Article
Neonatal antithrombin III.
Peters M, Jansen E, ten Cate JW, Kahlé LH, Ockelford P, Breederveld C
Br J Haematol 1984 Dec;58(4):579-87. doi: 10.1111/j.1365-2141.1984.tb06104.x. PMID: 6518134

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...