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Chronic lymphocytic inflammation

MedGen UID:
90705
•Concept ID:
C0333386
•
Pathologic Function
Synonym: Lymphocytic infiltrate
SNOMED CT: Chronic lymphocytic inflammation (54727009); Lymphocytic infiltrate (54727009); Lymphocytic inflammatory cell infiltrate (54727009)

Definition

A morphologic finding referring to the presence of a cellular infiltrate that is composed of non-neoplastic or neoplastic lymphocytes in a tissue sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic lymphocytic inflammation

Professional guidelines

PubMed

Clinical characteristics, management, and outcomes of CLIPPERS: A comprehensive systematic review of 140 patients from 100 studies.
Al-Chalabi M, DelCimmuto NR, Beran A, Devarasetty PP, Mhanna A, Mahfooz N, Sheikh A
Mult Scler Relat Disord 2022 Dec;68:104112. Epub 2022 Aug 18 doi: 10.1016/j.msard.2022.104112. PMID: 36029706
CLIPPERS and its mimics: evaluation of new criteria for the diagnosis of CLIPPERS.
Taieb G, Mulero P, Psimaras D, van Oosten BW, Seebach JD, Marignier R, Pico F, Rigau V, Ueno Y, Duflos C, Fominykh V, Guiraud V, Lebrun-Frénay C, Camdessanché JP, Kerschen P, Ahle G, Téllez N, Rovira A, Hoang-Xuan K, Pelletier J, Labauge P; in cooperation with the French CLIPPERS group
J Neurol Neurosurg Psychiatry 2019 Sep;90(9):1027-1038. Epub 2019 May 9 doi: 10.1136/jnnp-2018-318957. PMID: 31072955
Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS).
Tobin WO, Guo Y, Krecke KN, Parisi JE, Lucchinetti CF, Pittock SJ, Mandrekar J, Dubey D, Debruyne J, Keegan BM
Brain 2017 Sep 1;140(9):2415-2425. doi: 10.1093/brain/awx200. PMID: 29050399

Recent clinical studies

Etiology

Hemophagocytic Lymphohistiocytosis Gene Mutations in Adult Patients Presenting With CLIPPERS-Like Syndrome.
Taieb G, Kaphan E, Duflos C, Lebrun-Frénay C, Rigau V, Thouvenot E, Duhin-Gand E, Lefaucheur R, Hoang-Xuan K, Coulette S, Ouallet JC, Menjot de Champfleur N, Tranchant C, Picard C, Fusaro M, Sepulveda FE, Labauge P, de Saint Basile G
Neurol Neuroimmunol Neuroinflamm 2021 May;8(3) Epub 2021 Mar 3 doi: 10.1212/NXI.0000000000000970. PMID: 33658321Free PMC Article
Clinical spectrum of central nervous system myelin oligodendrocyte glycoprotein autoimmunity in adults.
Cobo-Calvo A, Vukusic S, Marignier R
Curr Opin Neurol 2019 Jun;32(3):459-466. doi: 10.1097/WCO.0000000000000681. PMID: 30762607
CLIPPERS syndrome responsive to Leflunomide: A case report.
Didier PJ, Adrián ML, Paola SA, Mauricio FS, Omar CS, Liset RY, Luis RJ
Mult Scler Relat Disord 2018 Oct;25:265-267. Epub 2018 Aug 8 doi: 10.1016/j.msard.2018.07.048. PMID: 30149302
Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS).
Tobin WO, Guo Y, Krecke KN, Parisi JE, Lucchinetti CF, Pittock SJ, Mandrekar J, Dubey D, Debruyne J, Keegan BM
Brain 2017 Sep 1;140(9):2415-2425. doi: 10.1093/brain/awx200. PMID: 29050399
Immune-mediated disorders.
Höftberger R, Lassmann H
Handb Clin Neurol 2017;145:285-299. doi: 10.1016/B978-0-12-802395-2.00020-1. PMID: 28987176

Diagnosis

Neurofilament light chain in serum of cancer patients with acute neurological complications.
Gottiparthy A, Lam K, Kundu S, Yang Z, Tremont-Lukats I, Tummala S
CNS Oncol 2024 Dec 31;13(1):2386233. Epub 2024 Aug 13 doi: 10.1080/20450907.2024.2386233. PMID: 39136375Free PMC Article
Clinical spectrum of central nervous system myelin oligodendrocyte glycoprotein autoimmunity in adults.
Cobo-Calvo A, Vukusic S, Marignier R
Curr Opin Neurol 2019 Jun;32(3):459-466. doi: 10.1097/WCO.0000000000000681. PMID: 30762607
CLIPPERS.
Zalewski NL, Tobin WO
Curr Neurol Neurosci Rep 2017 Sep;17(9):65. doi: 10.1007/s11910-017-0773-7. PMID: 28726127
CLIPPERS and the need for long-term immunosuppression.
Abkur TM, Kearney H, Hennessy MJ
Scott Med J 2017 Feb;62(1):28-33. Epub 2017 Jan 22 doi: 10.1177/0036933016689006. PMID: 28110629
CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Review of an increasingly recognized entity within the spectrum of inflammatory central nervous system disorders.
Dudesek A, Rimmele F, Tesar S, Kolbaske S, Rommer PS, Benecke R, Zettl UK
Clin Exp Immunol 2014 Mar;175(3):385-96. doi: 10.1111/cei.12204. PMID: 24028073Free PMC Article

Therapy

Asymptomatic brainstem lesions and pachymeningeal enhancement after anti-PD-1 therapy.
Yuen CA, Rezania K, Park DM, Reder AT
Immunotherapy 2021 Jan;13(1):11-17. Epub 2020 Oct 6 doi: 10.2217/imt-2020-0186. PMID: 33023359
Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS).
Tobin WO, Guo Y, Krecke KN, Parisi JE, Lucchinetti CF, Pittock SJ, Mandrekar J, Dubey D, Debruyne J, Keegan BM
Brain 2017 Sep 1;140(9):2415-2425. doi: 10.1093/brain/awx200. PMID: 29050399
CLIPPERS.
Zalewski NL, Tobin WO
Curr Neurol Neurosci Rep 2017 Sep;17(9):65. doi: 10.1007/s11910-017-0773-7. PMID: 28726127
CLIPPERS and the need for long-term immunosuppression.
Abkur TM, Kearney H, Hennessy MJ
Scott Med J 2017 Feb;62(1):28-33. Epub 2017 Jan 22 doi: 10.1177/0036933016689006. PMID: 28110629
CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Review of an increasingly recognized entity within the spectrum of inflammatory central nervous system disorders.
Dudesek A, Rimmele F, Tesar S, Kolbaske S, Rommer PS, Benecke R, Zettl UK
Clin Exp Immunol 2014 Mar;175(3):385-96. doi: 10.1111/cei.12204. PMID: 24028073Free PMC Article

Prognosis

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): contemporary advances and current controversies.
Li EC, Lai QL, Cai MT, Fang GL, Fang W, Zheng Y, Du Y, Du BQ, Shen CH, Qiao S, Ding MP, Zhang YX
J Neurol 2024 Apr;271(4):1747-1766. Epub 2024 Jan 29 doi: 10.1007/s00415-024-12189-4. PMID: 38286842
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) associated with or without lymphoma: Comparison of clinical features and risk factors suggestive of underlying lymphomas.
Zhang L, Liu XH, Jin F, Liu MX, Zhang M, Zhang Y, Zhou DB, Zhang W
J Clin Neurosci 2019 Aug;66:156-164. Epub 2019 May 11 doi: 10.1016/j.jocn.2019.04.022. PMID: 31088767
Clinical spectrum of central nervous system myelin oligodendrocyte glycoprotein autoimmunity in adults.
Cobo-Calvo A, Vukusic S, Marignier R
Curr Opin Neurol 2019 Jun;32(3):459-466. doi: 10.1097/WCO.0000000000000681. PMID: 30762607
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS).
Pittock SJ, Debruyne J, Krecke KN, Giannini C, van den Ameele J, De Herdt V, McKeon A, Fealey RD, Weinshenker BG, Aksamit AJ, Krueger BR, Shuster EA, Keegan BM
Brain 2010 Sep;133(9):2626-34. Epub 2010 Jul 17 doi: 10.1093/brain/awq164. PMID: 20639547
Juvenile dermatomyositis: recognition and treatment.
Reed AM, Lopez M
Paediatr Drugs 2002;4(5):315-21. doi: 10.2165/00128072-200204050-00004. PMID: 11994036

Clinical prediction guides

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): contemporary advances and current controversies.
Li EC, Lai QL, Cai MT, Fang GL, Fang W, Zheng Y, Du Y, Du BQ, Shen CH, Qiao S, Ding MP, Zhang YX
J Neurol 2024 Apr;271(4):1747-1766. Epub 2024 Jan 29 doi: 10.1007/s00415-024-12189-4. PMID: 38286842
The pathogenesis hypothesis and research progress of CLIPPERS: A literature review.
Cao L, Liu M, Guo L, Li M, Xu M, Wang R
Medicine (Baltimore) 2023 Mar 17;102(11):e33211. doi: 10.1097/MD.0000000000033211. PMID: 36930124Free PMC Article
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) associated with or without lymphoma: Comparison of clinical features and risk factors suggestive of underlying lymphomas.
Zhang L, Liu XH, Jin F, Liu MX, Zhang M, Zhang Y, Zhou DB, Zhang W
J Clin Neurosci 2019 Aug;66:156-164. Epub 2019 May 11 doi: 10.1016/j.jocn.2019.04.022. PMID: 31088767
Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS).
Tobin WO, Guo Y, Krecke KN, Parisi JE, Lucchinetti CF, Pittock SJ, Mandrekar J, Dubey D, Debruyne J, Keegan BM
Brain 2017 Sep 1;140(9):2415-2425. doi: 10.1093/brain/awx200. PMID: 29050399
Diabetes insipidus caused by lymphocytic infundibuloneurohypophysitis.
Kojima H, Nojima T, Nagashima K, Ono Y, Kudo M, Ishikura M
Arch Pathol Lab Med 1989 Dec;113(12):1399-401. PMID: 2589955

Recent systematic reviews

Clinical characteristics, management, and outcomes of CLIPPERS: A comprehensive systematic review of 140 patients from 100 studies.
Al-Chalabi M, DelCimmuto NR, Beran A, Devarasetty PP, Mhanna A, Mahfooz N, Sheikh A
Mult Scler Relat Disord 2022 Dec;68:104112. Epub 2022 Aug 18 doi: 10.1016/j.msard.2022.104112. PMID: 36029706
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) associated with or without lymphoma: Comparison of clinical features and risk factors suggestive of underlying lymphomas.
Zhang L, Liu XH, Jin F, Liu MX, Zhang M, Zhang Y, Zhou DB, Zhang W
J Clin Neurosci 2019 Aug;66:156-164. Epub 2019 May 11 doi: 10.1016/j.jocn.2019.04.022. PMID: 31088767

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