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Small cell carcinoma

MedGen UID:
90748
•Concept ID:
C0334239
•
Neoplastic Process
Synonyms: intermediate cell small cell carcinoma; oat cell cancer; oat cell carcinoma; small cell cancer; small cell car. (extrapulmonary); small cell carcinoma; small cell carcinoma (extrapulmonary); small cell carcinoma - intermediate cell; Small cell carcinoma, intermediate cell; small cell carcinoma, intermediate cell; small cell carcinoma, intermediate cell (morphologic abnormality); Small Cell Intermediate Cell Carcinoma; small cell NEC; small cell neuroendocrine carcinoma
SNOMED CT: Small cell carcinoma, intermediate cell (5958006)
 
Monarch Initiative: MONDO:0000402

Definition

A neuroendocrine carcinoma composed of malignant small cells of intermediate shape. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall cell carcinoma

Professional guidelines

PubMed

Radiotherapy treatment for lung cancer: Current status and future directions.
Vinod SK, Hau E
Respirology 2020 Nov;25 Suppl 2:61-71. Epub 2020 Jun 9 doi: 10.1111/resp.13870. PMID: 32516852
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Recent clinical studies

Etiology

Global variations in lung cancer incidence by histological subtype in 2020: a population-based study.
Zhang Y, Vaccarella S, Morgan E, Li M, Etxeberria J, Chokunonga E, Manraj SS, Kamate B, Omonisi A, Bray F
Lancet Oncol 2023 Nov;24(11):1206-1218. Epub 2023 Oct 11 doi: 10.1016/S1470-2045(23)00444-8. PMID: 37837979
The prognosis of patients with small cell carcinoma of the cervix: a retrospective study of the SEER database and a Chinese multicentre registry.
Chu T, Meng Y, Wu P, Li Z, Wen H, Ren F, Zou D, Lu H, Wu L, Zhou S, Chen Y, Li J, Xu M, Wu X, Xiong X, Wang Z, He M, Zhang Y, Lin S, Cao C, Ding W, Chen Y, Zhi W, Peng T, Wei Y, Liu B, Xu Y, Ma D, Wang J, Sun C, Wu P
Lancet Oncol 2023 Jun;24(6):701-708. doi: 10.1016/S1470-2045(23)00185-7. PMID: 37269846
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705
Pathology of epithelial tumors.
Young RH, Scully RE
Hematol Oncol Clin North Am 1992 Aug;6(4):739-60. PMID: 1500384
What to do when an x-ray film suggests lung cancer.
Petty TL
Postgrad Med 1991 Mar;89(4):101-4. doi: 10.1080/00325481.1991.11700861. PMID: 1848004

Diagnosis

Liver Mass: Thinking Out of the Box.
Karachaliou GS, Shi C, Abdelmalek MF
Gastroenterology 2022 Jul;163(1):e10-e12. Epub 2022 Jan 5 doi: 10.1053/j.gastro.2021.12.283. PMID: 34995531
Lung Cancer Pathology: Current Concepts.
Travis WD
Clin Chest Med 2020 Mar;41(1):67-85. Epub 2020 Jan 2 doi: 10.1016/j.ccm.2019.11.001. PMID: 32008630
Pulmonary Neuroendocrine Tumors.
Borczuk AC
Surg Pathol Clin 2020 Mar;13(1):35-55. Epub 2019 Nov 29 doi: 10.1016/j.path.2019.10.002. PMID: 32005434
The Missing Link in the Diagnostic Pathway of Prostate Cancer.
Wøyen AV, Laczkó G, Høyer S, Hegyi L
Pathol Oncol Res 2017 Apr;23(2):447-450. Epub 2017 Jan 4 doi: 10.1007/s12253-016-0183-1. PMID: 28054315
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Therapy

Small-cell lung cancer: defying targets?
Lancet Oncol 2008 Apr;9(4):305. doi: 10.1016/S1470-2045(08)70079-2. PMID: 18374281
Small cell lung cancer: have we made any progress over the last 25 years?
Lally BE, Urbanic JJ, Blackstock AW, Miller AA, Perry MC
Oncologist 2007 Sep;12(9):1096-104. doi: 10.1634/theoncologist.12-9-1096. PMID: 17914079
Chemotherapy for small cell lung cancer.
Sandler AB
Semin Oncol 2003 Feb;30(1):9-25. doi: 10.1053/sonc.2003.50012. PMID: 12635086
Surgery in small cell lung cancer.
Graham BL Jr, Balducci L, Khansur T, Dalton ML, Lambuth B
Ann Thorac Surg 1988 Jun;45(6):687-92. doi: 10.1016/s0003-4975(10)64783-2. PMID: 2837153
Small-cell lung cancer. A curable disease.
Oldham RK, Greco FA
Cancer Chemother Pharmacol 1980;4(3):173-7. doi: 10.1007/BF00254014. PMID: 6249514

Prognosis

Global variations in lung cancer incidence by histological subtype in 2020: a population-based study.
Zhang Y, Vaccarella S, Morgan E, Li M, Etxeberria J, Chokunonga E, Manraj SS, Kamate B, Omonisi A, Bray F
Lancet Oncol 2023 Nov;24(11):1206-1218. Epub 2023 Oct 11 doi: 10.1016/S1470-2045(23)00444-8. PMID: 37837979
Thermal ablation of malignant lung tumors.
Schneider T, Heussel CP, Herth FJ, Dienemann H
Dtsch Arztebl Int 2013 May;110(22):394-400. Epub 2013 May 31 doi: 10.3238/arztebl.2013.0394. PMID: 23826028Free PMC Article
Small cell lung cancer: have we made any progress over the last 25 years?
Lally BE, Urbanic JJ, Blackstock AW, Miller AA, Perry MC
Oncologist 2007 Sep;12(9):1096-104. doi: 10.1634/theoncologist.12-9-1096. PMID: 17914079
Lung cancer.
Ginsberg MS, Grewal RK, Heelan RT
Radiol Clin North Am 2007 Jan;45(1):21-43. doi: 10.1016/j.rcl.2006.10.004. PMID: 17157622
Epidemiology of lung cancer.
Osann KE
Curr Opin Pulm Med 1998 Jul;4(4):198-204. doi: 10.1097/00063198-199807000-00002. PMID: 10813232

Clinical prediction guides

The prognosis of patients with small cell carcinoma of the cervix: a retrospective study of the SEER database and a Chinese multicentre registry.
Chu T, Meng Y, Wu P, Li Z, Wen H, Ren F, Zou D, Lu H, Wu L, Zhou S, Chen Y, Li J, Xu M, Wu X, Xiong X, Wang Z, He M, Zhang Y, Lin S, Cao C, Ding W, Chen Y, Zhi W, Peng T, Wei Y, Liu B, Xu Y, Ma D, Wang J, Sun C, Wu P
Lancet Oncol 2023 Jun;24(6):701-708. doi: 10.1016/S1470-2045(23)00185-7. PMID: 37269846
Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Neuroendocrine neoplasms of the lung: Concepts and terminology.
Wick MR, Marchevsky AM
Semin Diagn Pathol 2015 Nov;32(6):445-55. Epub 2015 Sep 25 doi: 10.1053/j.semdp.2015.09.012. PMID: 26500079
Hyponatremia in cancer patients.
Platania M, Verzoni E, Vitali M
Tumori 2015 Mar-Apr;101(2):246-8. Epub 2015 Apr 16 doi: 10.5301/tj.5000257. PMID: 25908038
Updates in oncology.
Sculier JP, Meert AP, Berghmans T
Eur Respir Rev 2014 Mar 1;23(131):69-78. doi: 10.1183/09059180.00009013. PMID: 24591664Free PMC Article

Recent systematic reviews

A rare rarity: Neuroendocrine tumor of the esophagus.
Giannetta E, Guarnotta V, Rota F, de Cicco F, Grillo F, Colao A, Faggiano A; NIKE
Crit Rev Oncol Hematol 2019 May;137:92-107. Epub 2019 Mar 2 doi: 10.1016/j.critrevonc.2019.02.012. PMID: 31014519
Palinacousis--evidence to suggest a post-ictal phenomenon.
Mohamed W, Ahuja N, Shah A
J Neurol Sci 2012 Jun 15;317(1-2):6-12. Epub 2012 Mar 11 doi: 10.1016/j.jns.2012.02.016. PMID: 22414800
Chemotherapy versus best supportive care for extensive small cell lung cancer.
Pelayo Alvarez M, Gallego Rubio O, Bonfill Cosp X, Agra Varela Y
Cochrane Database Syst Rev 2009 Oct 7;(4):CD001990. doi: 10.1002/14651858.CD001990.pub2. PMID: 19821287
What has the meta-analysis contributed to today's standard of care in the treatment of thoracic malignancies?
Meert AP, Sculier JP
Lung Cancer 2008 Aug;61(2):141-51. Epub 2008 Apr 29 doi: 10.1016/j.lungcan.2008.03.014. PMID: 18448189
Pulmonary metastasectomy for colorectal cancer: weak evidence and no randomised trials.
Treasure T
Eur J Cardiothorac Surg 2008 Feb;33(2):300-2. Epub 2007 Dec 11 doi: 10.1016/j.ejcts.2007.10.015. PMID: 18065234

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