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Endometrial stromal nodule

MedGen UID:
90790
Concept ID:
C0334485
Neoplastic Process
Synonyms: Endometrial Stromal Nodule; endometrial stromal nodule
SNOMED CT: Endometrial stromal nodule (70971005)
 
Monarch Initiative: MONDO:0001783

Definition

A non-infiltrating, benign mesenchymal neoplasm arising from the uterine corpus. It is characterized by the presence of neoplastic cells that resemble the cells of the proliferative phase of endometrial stroma and numerous thin-walled small vessels. It usually presents with abnormal uterine bleeding and menorrhagia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial stromal nodule

Professional guidelines

PubMed

Feng W, Malpica A, Robboy SJ, Gudlaugsson E, Hua K, Zhou X, Baak JP
Int J Gynecol Pathol 2013 May;32(3):299-306. doi: 10.1097/PGP.0b013e318229adfb. PMID: 23545579

Recent clinical studies

Etiology

Li C, Wang C
J Zhejiang Univ Sci B 2021 Aug 15;22(8):633-646. doi: 10.1631/jzus.B2000797. PMID: 34414699Free PMC Article
Le Page C, Almadani N, Turashvili G, Bataillon G, Portelance L, Provencher D, Mes-Masson AM, Gilks B, Hoang L, Rahimi K
Int J Gynecol Pathol 2021 Sep 1;40(5):487-494. doi: 10.1097/PGP.0000000000000730. PMID: 33720083
Moore M, McCluggage WG
Int J Gynecol Pathol 2020 May;39(3):221-226. doi: 10.1097/PGP.0000000000000593. PMID: 30807369
Ferreira J, Félix A, Lennerz JK, Oliva E
Virchows Arch 2018 Dec;473(6):665-678. Epub 2018 Oct 15 doi: 10.1007/s00428-018-2470-6. PMID: 30324234
Horng HC, Wen KC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):472-9. doi: 10.1016/j.tjog.2016.04.034. PMID: 27590366

Diagnosis

Niu S, Zheng W
Semin Diagn Pathol 2022 May;39(3):201-212. Epub 2022 Jan 14 doi: 10.1053/j.semdp.2022.01.004. PMID: 35067405
Hoang L, Chiang S, Lee CH
Pathology 2018 Feb;50(2):162-177. Epub 2017 Dec 22 doi: 10.1016/j.pathol.2017.11.086. PMID: 29275929
Horng HC, Wen KC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):472-9. doi: 10.1016/j.tjog.2016.04.034. PMID: 27590366
Conklin CM, Longacre TA
Adv Anat Pathol 2014 Nov;21(6):383-93. doi: 10.1097/PAP.0000000000000046. PMID: 25299308
Chiang S, Oliva E
Hum Pathol 2011 May;42(5):609-17. Epub 2011 Mar 21 doi: 10.1016/j.humpath.2010.12.005. PMID: 21420714

Therapy

Chin TH, Lin G, Wu RC, Lai CH
J Obstet Gynaecol Res 2018 Sep;44(9):1836-1842. Epub 2018 Jul 5 doi: 10.1111/jog.13695. PMID: 29974555
Holzmann C, Löning T, Bullerdiek J
Cancer Genet 2016 Jun;209(6):278-81. Epub 2016 Mar 8 doi: 10.1016/j.cancergen.2016.02.005. PMID: 27397601
Chen CA, Chen M
Acta Obstet Gynecol Scand 2003 Jun;82(6):585-6. doi: 10.1034/j.1600-0412.2003.00142.x. PMID: 12780434
Schilder JM, Hurd WW, Roth LM, Sutton GP
Obstet Gynecol 1999 May;93(5 Pt 2):805-7. doi: 10.1016/s0029-7844(98)00332-9. PMID: 10912400

Prognosis

Le Page C, Almadani N, Turashvili G, Bataillon G, Portelance L, Provencher D, Mes-Masson AM, Gilks B, Hoang L, Rahimi K
Int J Gynecol Pathol 2021 Sep 1;40(5):487-494. doi: 10.1097/PGP.0000000000000730. PMID: 33720083
Horng HC, Wen KC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):472-9. doi: 10.1016/j.tjog.2016.04.034. PMID: 27590366
Ali RH, Rouzbahman M
J Clin Pathol 2015 May;68(5):325-32. Epub 2015 Jan 16 doi: 10.1136/jclinpath-2014-202829. PMID: 25595274
Conklin CM, Longacre TA
Adv Anat Pathol 2014 Nov;21(6):383-93. doi: 10.1097/PAP.0000000000000046. PMID: 25299308
Chew I, Oliva E
Adv Anat Pathol 2010 Mar;17(2):113-21. doi: 10.1097/PAP.0b013e3181cfb7c2. PMID: 20179433

Clinical prediction guides

Le Page C, Almadani N, Turashvili G, Bataillon G, Portelance L, Provencher D, Mes-Masson AM, Gilks B, Hoang L, Rahimi K
Int J Gynecol Pathol 2021 Sep 1;40(5):487-494. doi: 10.1097/PGP.0000000000000730. PMID: 33720083
Ali RH, Rouzbahman M
J Clin Pathol 2015 May;68(5):325-32. Epub 2015 Jan 16 doi: 10.1136/jclinpath-2014-202829. PMID: 25595274
Conklin CM, Longacre TA
Adv Anat Pathol 2014 Nov;21(6):383-93. doi: 10.1097/PAP.0000000000000046. PMID: 25299308
Parra-Herran CE, Yuan L, Nucci MR, Quade BJ
Mod Pathol 2014 Apr;27(4):569-79. Epub 2013 Sep 27 doi: 10.1038/modpathol.2013.123. PMID: 24072182
Chang KL, Crabtree GS, Lim-Tan SK, Kempson RL, Hendrickson MR
Am J Surg Pathol 1990 May;14(5):415-38. doi: 10.1097/00000478-199005000-00002. PMID: 2327549

Recent systematic reviews

Horng HC, Wen KC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):472-9. doi: 10.1016/j.tjog.2016.04.034. PMID: 27590366

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