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Endometrial stromal nodule

MedGen UID:
90790
•Concept ID:
C0334485
•
Neoplastic Process
Synonyms: Endometrial Stromal Nodule; endometrial stromal nodule
SNOMED CT: Endometrial stromal nodule (70971005)
 
Monarch Initiative: MONDO:0001783

Definition

A non-infiltrating, benign mesenchymal neoplasm arising from the uterine corpus. It is characterized by the presence of neoplastic cells that resemble the cells of the proliferative phase of endometrial stroma and numerous thin-walled small vessels. It usually presents with abnormal uterine bleeding and menorrhagia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial stromal nodule

Professional guidelines

PubMed

Prognostic value of the diagnostic criteria distinguishing endometrial stromal sarcoma, low grade from undifferentiated endometrial sarcoma, 2 entities within the invasive endometrial stromal neoplasia family.
Feng W, Malpica A, Robboy SJ, Gudlaugsson E, Hua K, Zhou X, Baak JP
Int J Gynecol Pathol 2013 May;32(3):299-306. doi: 10.1097/PGP.0b013e318229adfb. PMID: 23545579

Recent clinical studies

Therapy

Recurrence after fertility-preserving surgery for low-grade endometrial stromal sarcoma.
Chin TH, Lin G, Wu RC, Lai CH
J Obstet Gynaecol Res 2018 Sep;44(9):1836-1842. Epub 2018 Jul 5 doi: 10.1111/jog.13695. PMID: 29974555
Hyperhaploid uterine mesenchymal tumors-a novel genetic subgroup?
Holzmann C, Löning T, Bullerdiek J
Cancer Genet 2016 Jun;209(6):278-81. Epub 2016 Mar 8 doi: 10.1016/j.cancergen.2016.02.005. PMID: 27397601
Simultaneous occurrence of hepatic focal nodular hyperplasia and uterine endometrial stromal nodule in a patient having treated breast infiltrating ductal carcinoma.
Chen CA, Chen M
Acta Obstet Gynecol Scand 2003 Jun;82(6):585-6. doi: 10.1034/j.1600-0412.2003.00142.x. PMID: 12780434
Hormonal treatment of an endometrial stromal nodule followed by local excision.
Schilder JM, Hurd WW, Roth LM, Sutton GP
Obstet Gynecol 1999 May;93(5 Pt 2):805-7. doi: 10.1016/s0029-7844(98)00332-9. PMID: 10912400

Prognosis

Endometrial stromal tumors: A clinico-histomorphological spectrum of endometrial stromal tumors with review of literature.
Verma A, Tomar R, Chaturvedi A, Dhankar N, Mallya V, Khurana N
J Cancer Res Ther 2024 Jan 1;20(1):150-155. Epub 2023 Apr 7 doi: 10.4103/jcrt.jcrt_741_22. PMID: 38554313
Uterine sarcoma Part II-Uterine endometrial stromal sarcoma: The TAG systematic review.
Horng HC, Wen KC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):472-9. doi: 10.1016/j.tjog.2016.04.034. PMID: 27590366
Endometrial stromal tumours revisited: an update based on the 2014 WHO classification.
Ali RH, Rouzbahman M
J Clin Pathol 2015 May;68(5):325-32. Epub 2015 Jan 16 doi: 10.1136/jclinpath-2014-202829. PMID: 25595274
Endometrial stromal tumors: the new WHO classification.
Conklin CM, Longacre TA
Adv Anat Pathol 2014 Nov;21(6):383-93. doi: 10.1097/PAP.0000000000000046. PMID: 25299308
Endometrial stromal sarcomas: a review of potential prognostic factors.
Chew I, Oliva E
Adv Anat Pathol 2010 Mar;17(2):113-21. doi: 10.1097/PAP.0b013e3181cfb7c2. PMID: 20179433

Clinical prediction guides

Endometrial stromal tumors: A clinico-histomorphological spectrum of endometrial stromal tumors with review of literature.
Verma A, Tomar R, Chaturvedi A, Dhankar N, Mallya V, Khurana N
J Cancer Res Ther 2024 Jan 1;20(1):150-155. Epub 2023 Apr 7 doi: 10.4103/jcrt.jcrt_741_22. PMID: 38554313
Immunohistochemical Expression of Lymphoid Enhancer-binding Factor 1 in Low-grade Endometrial Stromal Tumors.
Niu S, Lu H, Li W, Hou Y
Int J Gynecol Pathol 2024 Sep 1;43(5):487-493. Epub 2023 Nov 10 doi: 10.1097/PGP.0000000000001001. PMID: 38085960
SATB2 Expression in Uterine Sarcoma: A Multicenter Retrospective Study.
Le Page C, Almadani N, Turashvili G, Bataillon G, Portelance L, Provencher D, Mes-Masson AM, Gilks B, Hoang L, Rahimi K
Int J Gynecol Pathol 2021 Sep 1;40(5):487-494. doi: 10.1097/PGP.0000000000000730. PMID: 33720083
Endometrial stromal tumours revisited: an update based on the 2014 WHO classification.
Ali RH, Rouzbahman M
J Clin Pathol 2015 May;68(5):325-32. Epub 2015 Jan 16 doi: 10.1136/jclinpath-2014-202829. PMID: 25595274
Endometrial stromal tumors: the new WHO classification.
Conklin CM, Longacre TA
Adv Anat Pathol 2014 Nov;21(6):383-93. doi: 10.1097/PAP.0000000000000046. PMID: 25299308

Recent systematic reviews

Uterine sarcoma Part II-Uterine endometrial stromal sarcoma: The TAG systematic review.
Horng HC, Wen KC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):472-9. doi: 10.1016/j.tjog.2016.04.034. PMID: 27590366

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