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Reduced euglobulin clot lysis time

MedGen UID:
908297
Concept ID:
C4280701
Finding
HPO: HP:0040247

Definition

Abnormally decreased length of time required for an in vitro clot to dissolve in the absence of the normal plasmin inhibitors. This test is a clinical assay used to measure fibrinolysis. The euglobulin fraction of plasma is precipitated and used to form clot by addition of thrombin; after clot forms the rate of clot breakdown (fibrinolysis) can be monitored. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced euglobulin clot lysis time

Professional guidelines

PubMed

Dias JD, Butwick AJ, Hartmann J, Waters JH
Anaesthesia 2022 Jun;77(6):700-711. Epub 2022 Feb 22 doi: 10.1111/anae.15662. PMID: 35194779
Hvas CL, Hvas AM
Semin Thromb Hemost 2022 Apr;48(3):356-381. Epub 2021 Jul 14 doi: 10.1055/s-0041-1730346. PMID: 34261149
Kanji R, Kubica J, Navarese EP, Gorog DA
Eur J Clin Invest 2021 Apr;51(4):e13471. Epub 2020 Dec 16 doi: 10.1111/eci.13471. PMID: 33296082

Recent clinical studies

Etiology

Kanji R, Kubica J, Navarese EP, Gorog DA
Eur J Clin Invest 2021 Apr;51(4):e13471. Epub 2020 Dec 16 doi: 10.1111/eci.13471. PMID: 33296082
Sidelmann JJ, Gram JB, Rasmussen JJ, Kistorp C
Semin Thromb Hemost 2021 Feb;47(1):11-17. Epub 2020 Oct 5 doi: 10.1055/s-0040-1714398. PMID: 33017849
Undas A
Europace 2020 Feb 1;22(2):185-194. doi: 10.1093/europace/euz271. PMID: 31625555
Longstaff C
J Thromb Haemost 2018 Apr;16(4):652-662. Epub 2018 Feb 17 doi: 10.1111/jth.13957. PMID: 29363269Free PMC Article
Karasu A, Baglin TP, Luddington R, Baglin CA, van Hylckama Vlieg A
Br J Haematol 2016 Mar;172(6):947-53. Epub 2016 Jan 15 doi: 10.1111/bjh.13911. PMID: 26773756

Diagnosis

Bønløkke ST, Fenger-Eriksen C, Ommen HB, Hvas AM
Blood Adv 2023 Nov 28;7(22):7056-7066. doi: 10.1182/bloodadvances.2023011379. PMID: 37756519Free PMC Article
Dias JD, Butwick AJ, Hartmann J, Waters JH
Anaesthesia 2022 Jun;77(6):700-711. Epub 2022 Feb 22 doi: 10.1111/anae.15662. PMID: 35194779
Undas A
Europace 2020 Feb 1;22(2):185-194. doi: 10.1093/europace/euz271. PMID: 31625555
Longstaff C
J Thromb Haemost 2018 Apr;16(4):652-662. Epub 2018 Feb 17 doi: 10.1111/jth.13957. PMID: 29363269Free PMC Article
Kornblith LZ, Kutcher ME, Redick BJ, Calfee CS, Vilardi RF, Cohen MJ
J Trauma Acute Care Surg 2014 Feb;76(2):255-6; discussion 262-3. doi: 10.1097/TA.0000000000000108. PMID: 24458031Free PMC Article

Therapy

Piróg M, Kacalska-Janssen O, Jach R, Wyroba J, Chrostowski B, Ząbczyk M, Natorska J
Reprod Sci 2022 Dec;29(12):3521-3531. Epub 2022 Jul 12 doi: 10.1007/s43032-022-01026-6. PMID: 35821349
Dias JD, Butwick AJ, Hartmann J, Waters JH
Anaesthesia 2022 Jun;77(6):700-711. Epub 2022 Feb 22 doi: 10.1111/anae.15662. PMID: 35194779
Chen S, Chen D, Liu Y, Xu Y, Lin H, Cheng Y, Li J, Meng C, Liang M, Yuan C, Huang M
Br J Haematol 2022 Feb;196(4):1076-1085. Epub 2021 Nov 16 doi: 10.1111/bjh.17942. PMID: 34783361
Sidelmann JJ, Gram JB, Rasmussen JJ, Kistorp C
Semin Thromb Hemost 2021 Feb;47(1):11-17. Epub 2020 Oct 5 doi: 10.1055/s-0040-1714398. PMID: 33017849
Amadio P, Porro B, Sandrini L, Fiorelli S, Bonomi A, Cavalca V, Brambilla M, Camera M, Veglia F, Tremoli E, Barbieri SS
Sci Rep 2019 Jan 23;9(1):389. doi: 10.1038/s41598-018-37117-1. PMID: 30674980Free PMC Article

Prognosis

Dias JD, Butwick AJ, Hartmann J, Waters JH
Anaesthesia 2022 Jun;77(6):700-711. Epub 2022 Feb 22 doi: 10.1111/anae.15662. PMID: 35194779
Mitrovic M, Sabljic N, Cvetkovic Z, Pantic N, Zivkovic Dakic A, Bukumiric Z, Libek V, Savic N, Milenkovic B, Virijevic M, Vucinic V, Milosevic I, Pravdic Z, Suvajdzic N, Fareed J, Antic D
Platelets 2021 Jul 4;32(5):690-696. Epub 2021 Feb 9 doi: 10.1080/09537104.2021.1881949. PMID: 33561381
Kanji R, Kubica J, Navarese EP, Gorog DA
Eur J Clin Invest 2021 Apr;51(4):e13471. Epub 2020 Dec 16 doi: 10.1111/eci.13471. PMID: 33296082
Undas A
Europace 2020 Feb 1;22(2):185-194. doi: 10.1093/europace/euz271. PMID: 31625555
Longstaff C
J Thromb Haemost 2018 Apr;16(4):652-662. Epub 2018 Feb 17 doi: 10.1111/jth.13957. PMID: 29363269Free PMC Article

Clinical prediction guides

Kanji R, Kubica J, Navarese EP, Gorog DA
Eur J Clin Invest 2021 Apr;51(4):e13471. Epub 2020 Dec 16 doi: 10.1111/eci.13471. PMID: 33296082
Sidelmann JJ, Gram JB, Rasmussen JJ, Kistorp C
Semin Thromb Hemost 2021 Feb;47(1):11-17. Epub 2020 Oct 5 doi: 10.1055/s-0040-1714398. PMID: 33017849
Undas A
Europace 2020 Feb 1;22(2):185-194. doi: 10.1093/europace/euz271. PMID: 31625555
Longstaff C
J Thromb Haemost 2018 Apr;16(4):652-662. Epub 2018 Feb 17 doi: 10.1111/jth.13957. PMID: 29363269Free PMC Article
Karasu A, Baglin TP, Luddington R, Baglin CA, van Hylckama Vlieg A
Br J Haematol 2016 Mar;172(6):947-53. Epub 2016 Jan 15 doi: 10.1111/bjh.13911. PMID: 26773756

Recent systematic reviews

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