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Eyelid melanoma

MedGen UID:
90937
•Concept ID:
C0339116
•
Neoplastic Process
Synonyms: Eyelid Melanoma; eyelid melanoma; eyelid melanoma (disease); Malignant Eyelid Melanoma; malignant eyelid melanoma; Malignant melanoma of eyelid; Malignant Melanoma of Eyelid; malignant melanoma of eyelid; Malignant Melanoma of the Eyelid; malignant melanoma of the eyelid; melanoma (disease) of eyelid; Melanoma of Eyelid; melanoma of eyelid; Melanoma of the Eyelid; melanoma of the eyelid
SNOMED CT: Malignant melanoma of eyelid (231834005)
 
Monarch Initiative: MONDO:0000928

Definition

A melanoma that arises from the upper or lower eyelid. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEyelid melanoma

Professional guidelines

PubMed

Head and neck melanoma: the eyelid region has a better prognosis and easier management. A retrospective survey and systematic review.
Dini F, Susini P, Zuccaro B, Nisi G, Cuomo R, Grimaldi L, Perillo G, Tinunin L, Antonini P, Innocenti A, Cecchi G, Gambale E, Doni L, Mazzini C, Santoro N, De Giorgi V
Melanoma Res 2024 Oct 1;34(5):429-438. Epub 2024 Jun 3 doi: 10.1097/CMR.0000000000000984. PMID: 38833343

Recent clinical studies

Etiology

Surgical margins and outcomes for eyelid melanoma: a systematic review and meta-analysis.
Pisano CE, Trager MH, Fan W, Samie FH
Arch Dermatol Res 2024 Mar 15;316(4):106. doi: 10.1007/s00403-024-02834-3. PMID: 38489027
Pediatric ocular melanoma: a collaborative multicenter study and meta-analysis.
Masoomian B, Dalvin LA, Riazi-Esfahani H, Ghassemi F, Azizkhani M, Mirghorbani M, Khorrami-Nejad M, Sajjadi Z, Kaliki S, Sagoo MS, Al Harby L, Al-Jamal RT, Kivelä TT, Giblin M, Lim LS, Shields CL
J AAPOS 2023 Dec;27(6):316-324. Epub 2023 Nov 8 doi: 10.1016/j.jaapos.2023.08.021. PMID: 37949393
Long-term outcomes of margin-controlled excision for eyelid melanoma.
Bladen JC, Malhotra R, Litwin A
Eye (Lond) 2023 Apr;37(5):1009-1013. Epub 2023 Feb 24 doi: 10.1038/s41433-023-02428-9. PMID: 36828958Free PMC Article
Clinicopathologic Characteristics and Prognostic Factors Impacting Survival in Melanoma of the Eyelid.
Go CC, Kim DH, Go BC, McGeehan B, Briceño CA
Am J Ophthalmol 2022 Feb;234:71-80. Epub 2021 Jul 31 doi: 10.1016/j.ajo.2021.07.031. PMID: 34343490
Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.
Mancera N, Smalley KSM, Margo CE
Surv Ophthalmol 2019 May-Jun;64(3):272-288. Epub 2018 Dec 20 doi: 10.1016/j.survophthal.2018.12.002. PMID: 30578807

Diagnosis

Clinicopathologic Characteristics and Prognostic Factors Impacting Survival in Melanoma of the Eyelid.
Go CC, Kim DH, Go BC, McGeehan B, Briceño CA
Am J Ophthalmol 2022 Feb;234:71-80. Epub 2021 Jul 31 doi: 10.1016/j.ajo.2021.07.031. PMID: 34343490
Cutaneous eyelid melanoma in an African American child.
Ulloa-Padilla JP, Khararjian A, Choi CJ
Orbit 2021 Oct;40(5):415-418. Epub 2020 Jul 30 doi: 10.1080/01676830.2020.1799419. PMID: 32731781
Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.
Mancera N, Smalley KSM, Margo CE
Surv Ophthalmol 2019 May-Jun;64(3):272-288. Epub 2018 Dec 20 doi: 10.1016/j.survophthal.2018.12.002. PMID: 30578807
Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.
Ford J, Thakar S, Thuro B, Esmaeli B
Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):317-324. doi: 10.1097/IOP.0000000000000901. PMID: 28350693
Sentinel lymph node biopsy for ocular adnexal melanoma.
Pfeiffer ML, Ozgur OK, Myers JN, Peng A, Ning J, Zafereo ME, Thakar S, Thuro B, Prieto VG, Ross MI, Esmaeli B
Acta Ophthalmol 2017 Jun;95(4):e323-e328. Epub 2016 Oct 24 doi: 10.1111/aos.13252. PMID: 27775232

Therapy

Surgical margins and outcomes for eyelid melanoma: a systematic review and meta-analysis.
Pisano CE, Trager MH, Fan W, Samie FH
Arch Dermatol Res 2024 Mar 15;316(4):106. doi: 10.1007/s00403-024-02834-3. PMID: 38489027
Conjunctival Melanoma Responsive to Combined Systemic BRAF/MEK Inhibitors.
Dagi Glass LR, Lawrence DP, Jakobiec FA, Freitag SK
Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):e114-e116. doi: 10.1097/IOP.0000000000000833. PMID: 27893585
Desmoplastic melanoma of the eyelid and conjunctival melanoma in neurofibromatosis type 1: a clinical pathological correlation.
Rubinstein TJ, Plesec TP, Singh AD
Surv Ophthalmol 2015 Jan-Feb;60(1):72-7. Epub 2014 Aug 12 doi: 10.1016/j.survophthal.2014.08.001. PMID: 25233828
Ocular effects of imiquimod with treatment of eyelid melanoma in situ.
Murchison AP, Washington CV, Soloman AR, Bernardino CR
Dermatol Surg 2007 Sep;33(9):1136-8. doi: 10.1111/j.1524-4725.2007.33232.x. PMID: 17760609
Irradiation of malignant eyelid melanoma with iodine 125 plaque.
Stanowsky A, Krey HF, Kopp J, Kanitz W, Wagner T
Am J Ophthalmol 1990 Jul 15;110(1):44-8. doi: 10.1016/s0002-9394(14)76936-3. PMID: 2368820

Prognosis

Pediatric ocular melanoma: a collaborative multicenter study and meta-analysis.
Masoomian B, Dalvin LA, Riazi-Esfahani H, Ghassemi F, Azizkhani M, Mirghorbani M, Khorrami-Nejad M, Sajjadi Z, Kaliki S, Sagoo MS, Al Harby L, Al-Jamal RT, Kivelä TT, Giblin M, Lim LS, Shields CL
J AAPOS 2023 Dec;27(6):316-324. Epub 2023 Nov 8 doi: 10.1016/j.jaapos.2023.08.021. PMID: 37949393
Clinicopathologic Characteristics and Prognostic Factors Impacting Survival in Melanoma of the Eyelid.
Go CC, Kim DH, Go BC, McGeehan B, Briceño CA
Am J Ophthalmol 2022 Feb;234:71-80. Epub 2021 Jul 31 doi: 10.1016/j.ajo.2021.07.031. PMID: 34343490
Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.
Mancera N, Smalley KSM, Margo CE
Surv Ophthalmol 2019 May-Jun;64(3):272-288. Epub 2018 Dec 20 doi: 10.1016/j.survophthal.2018.12.002. PMID: 30578807
Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.
Ford J, Thakar S, Thuro B, Esmaeli B
Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):317-324. doi: 10.1097/IOP.0000000000000901. PMID: 28350693
Sentinel lymph node biopsy for ocular adnexal melanoma.
Pfeiffer ML, Ozgur OK, Myers JN, Peng A, Ning J, Zafereo ME, Thakar S, Thuro B, Prieto VG, Ross MI, Esmaeli B
Acta Ophthalmol 2017 Jun;95(4):e323-e328. Epub 2016 Oct 24 doi: 10.1111/aos.13252. PMID: 27775232

Clinical prediction guides

Long-term outcomes of margin-controlled excision for eyelid melanoma.
Bladen JC, Malhotra R, Litwin A
Eye (Lond) 2023 Apr;37(5):1009-1013. Epub 2023 Feb 24 doi: 10.1038/s41433-023-02428-9. PMID: 36828958Free PMC Article
Clinicopathologic Characteristics and Prognostic Factors Impacting Survival in Melanoma of the Eyelid.
Go CC, Kim DH, Go BC, McGeehan B, Briceño CA
Am J Ophthalmol 2022 Feb;234:71-80. Epub 2021 Jul 31 doi: 10.1016/j.ajo.2021.07.031. PMID: 34343490
Eyelid Melanoma in the United States: A National Cancer Database Analysis.
Oliver JD, Boczar D, Sisti A, Huayllani MT, Restrepo DJ, Spaulding AC, Gabriel E, Bagaria S, Rinker BD, Forte AJ
J Craniofac Surg 2019 Nov-Dec;30(8):2412-2415. doi: 10.1097/SCS.0000000000005673. PMID: 31233000
Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.
Mancera N, Smalley KSM, Margo CE
Surv Ophthalmol 2019 May-Jun;64(3):272-288. Epub 2018 Dec 20 doi: 10.1016/j.survophthal.2018.12.002. PMID: 30578807
Sentinel lymph node biopsy for ocular adnexal melanoma.
Pfeiffer ML, Ozgur OK, Myers JN, Peng A, Ning J, Zafereo ME, Thakar S, Thuro B, Prieto VG, Ross MI, Esmaeli B
Acta Ophthalmol 2017 Jun;95(4):e323-e328. Epub 2016 Oct 24 doi: 10.1111/aos.13252. PMID: 27775232

Recent systematic reviews

Head and neck melanoma: the eyelid region has a better prognosis and easier management. A retrospective survey and systematic review.
Dini F, Susini P, Zuccaro B, Nisi G, Cuomo R, Grimaldi L, Perillo G, Tinunin L, Antonini P, Innocenti A, Cecchi G, Gambale E, Doni L, Mazzini C, Santoro N, De Giorgi V
Melanoma Res 2024 Oct 1;34(5):429-438. Epub 2024 Jun 3 doi: 10.1097/CMR.0000000000000984. PMID: 38833343
Surgical margins and outcomes for eyelid melanoma: a systematic review and meta-analysis.
Pisano CE, Trager MH, Fan W, Samie FH
Arch Dermatol Res 2024 Mar 15;316(4):106. doi: 10.1007/s00403-024-02834-3. PMID: 38489027
Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.
Ford J, Thakar S, Thuro B, Esmaeli B
Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):317-324. doi: 10.1097/IOP.0000000000000901. PMID: 28350693

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