U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eyelid melanoma

MedGen UID:
90937
•Concept ID:
C0339116
•
Neoplastic Process
Synonyms: Eyelid Melanoma; eyelid melanoma; eyelid melanoma (disease); Malignant Eyelid Melanoma; malignant eyelid melanoma; Malignant melanoma of eyelid; Malignant Melanoma of Eyelid; malignant melanoma of eyelid; Malignant Melanoma of the Eyelid; malignant melanoma of the eyelid; melanoma (disease) of eyelid; Melanoma of Eyelid; melanoma of eyelid; Melanoma of the Eyelid; melanoma of the eyelid
SNOMED CT: Malignant melanoma of eyelid (231834005)
 
Monarch Initiative: MONDO:0000928

Definition

A melanoma that arises from the upper or lower eyelid. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEyelid melanoma

Professional guidelines

PubMed

Clinical treatment options for early-stage and advanced conjunctival melanoma.
Zeng Y, Hu C, Shu L, Pan Y, Zhao L, Pu X, Wu F
Surv Ophthalmol 2021 May-Jun;66(3):461-470. Epub 2020 Sep 25 doi: 10.1016/j.survophthal.2020.09.004. PMID: 32980421
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796

Recent clinical studies

Etiology

Surgical margins and outcomes for eyelid melanoma: a systematic review and meta-analysis.
Pisano CE, Trager MH, Fan W, Samie FH
Arch Dermatol Res 2024 Mar 15;316(4):106. doi: 10.1007/s00403-024-02834-3. PMID: 38489027
Pediatric ocular melanoma: a collaborative multicenter study and meta-analysis.
Masoomian B, Dalvin LA, Riazi-Esfahani H, Ghassemi F, Azizkhani M, Mirghorbani M, Khorrami-Nejad M, Sajjadi Z, Kaliki S, Sagoo MS, Al Harby L, Al-Jamal RT, Kivelä TT, Giblin M, Lim LS, Shields CL
J AAPOS 2023 Dec;27(6):316-324. Epub 2023 Nov 8 doi: 10.1016/j.jaapos.2023.08.021. PMID: 37949393
Long-term outcomes of margin-controlled excision for eyelid melanoma.
Bladen JC, Malhotra R, Litwin A
Eye (Lond) 2023 Apr;37(5):1009-1013. Epub 2023 Feb 24 doi: 10.1038/s41433-023-02428-9. PMID: 36828958Free PMC Article
Clinicopathologic Characteristics and Prognostic Factors Impacting Survival in Melanoma of the Eyelid.
Go CC, Kim DH, Go BC, McGeehan B, Briceño CA
Am J Ophthalmol 2022 Feb;234:71-80. Epub 2021 Jul 31 doi: 10.1016/j.ajo.2021.07.031. PMID: 34343490
Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.
Mancera N, Smalley KSM, Margo CE
Surv Ophthalmol 2019 May-Jun;64(3):272-288. Epub 2018 Dec 20 doi: 10.1016/j.survophthal.2018.12.002. PMID: 30578807

Diagnosis

Clinicopathologic Characteristics and Prognostic Factors Impacting Survival in Melanoma of the Eyelid.
Go CC, Kim DH, Go BC, McGeehan B, Briceño CA
Am J Ophthalmol 2022 Feb;234:71-80. Epub 2021 Jul 31 doi: 10.1016/j.ajo.2021.07.031. PMID: 34343490
Cutaneous eyelid melanoma in an African American child.
Ulloa-Padilla JP, Khararjian A, Choi CJ
Orbit 2021 Oct;40(5):415-418. Epub 2020 Jul 30 doi: 10.1080/01676830.2020.1799419. PMID: 32731781
Eyelid Melanoma in the United States: A National Cancer Database Analysis.
Oliver JD, Boczar D, Sisti A, Huayllani MT, Restrepo DJ, Spaulding AC, Gabriel E, Bagaria S, Rinker BD, Forte AJ
J Craniofac Surg 2019 Nov-Dec;30(8):2412-2415. doi: 10.1097/SCS.0000000000005673. PMID: 31233000
Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.
Mancera N, Smalley KSM, Margo CE
Surv Ophthalmol 2019 May-Jun;64(3):272-288. Epub 2018 Dec 20 doi: 10.1016/j.survophthal.2018.12.002. PMID: 30578807
Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.
Ford J, Thakar S, Thuro B, Esmaeli B
Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):317-324. doi: 10.1097/IOP.0000000000000901. PMID: 28350693

Therapy

Surgical margins and outcomes for eyelid melanoma: a systematic review and meta-analysis.
Pisano CE, Trager MH, Fan W, Samie FH
Arch Dermatol Res 2024 Mar 15;316(4):106. doi: 10.1007/s00403-024-02834-3. PMID: 38489027
Conjunctival Melanoma Responsive to Combined Systemic BRAF/MEK Inhibitors.
Dagi Glass LR, Lawrence DP, Jakobiec FA, Freitag SK
Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):e114-e116. doi: 10.1097/IOP.0000000000000833. PMID: 27893585
Desmoplastic melanoma of the eyelid and conjunctival melanoma in neurofibromatosis type 1: a clinical pathological correlation.
Rubinstein TJ, Plesec TP, Singh AD
Surv Ophthalmol 2015 Jan-Feb;60(1):72-7. Epub 2014 Aug 12 doi: 10.1016/j.survophthal.2014.08.001. PMID: 25233828
Ocular effects of imiquimod with treatment of eyelid melanoma in situ.
Murchison AP, Washington CV, Soloman AR, Bernardino CR
Dermatol Surg 2007 Sep;33(9):1136-8. doi: 10.1111/j.1524-4725.2007.33232.x. PMID: 17760609
Irradiation of malignant eyelid melanoma with iodine 125 plaque.
Stanowsky A, Krey HF, Kopp J, Kanitz W, Wagner T
Am J Ophthalmol 1990 Jul 15;110(1):44-8. doi: 10.1016/s0002-9394(14)76936-3. PMID: 2368820

Prognosis

Pediatric ocular melanoma: a collaborative multicenter study and meta-analysis.
Masoomian B, Dalvin LA, Riazi-Esfahani H, Ghassemi F, Azizkhani M, Mirghorbani M, Khorrami-Nejad M, Sajjadi Z, Kaliki S, Sagoo MS, Al Harby L, Al-Jamal RT, Kivelä TT, Giblin M, Lim LS, Shields CL
J AAPOS 2023 Dec;27(6):316-324. Epub 2023 Nov 8 doi: 10.1016/j.jaapos.2023.08.021. PMID: 37949393
Clinicopathologic Characteristics and Prognostic Factors Impacting Survival in Melanoma of the Eyelid.
Go CC, Kim DH, Go BC, McGeehan B, Briceño CA
Am J Ophthalmol 2022 Feb;234:71-80. Epub 2021 Jul 31 doi: 10.1016/j.ajo.2021.07.031. PMID: 34343490
Eyelid Melanoma in the United States: A National Cancer Database Analysis.
Oliver JD, Boczar D, Sisti A, Huayllani MT, Restrepo DJ, Spaulding AC, Gabriel E, Bagaria S, Rinker BD, Forte AJ
J Craniofac Surg 2019 Nov-Dec;30(8):2412-2415. doi: 10.1097/SCS.0000000000005673. PMID: 31233000
Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.
Mancera N, Smalley KSM, Margo CE
Surv Ophthalmol 2019 May-Jun;64(3):272-288. Epub 2018 Dec 20 doi: 10.1016/j.survophthal.2018.12.002. PMID: 30578807
Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.
Ford J, Thakar S, Thuro B, Esmaeli B
Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):317-324. doi: 10.1097/IOP.0000000000000901. PMID: 28350693

Clinical prediction guides

Long-term outcomes of margin-controlled excision for eyelid melanoma.
Bladen JC, Malhotra R, Litwin A
Eye (Lond) 2023 Apr;37(5):1009-1013. Epub 2023 Feb 24 doi: 10.1038/s41433-023-02428-9. PMID: 36828958Free PMC Article
Clinicopathologic Characteristics and Prognostic Factors Impacting Survival in Melanoma of the Eyelid.
Go CC, Kim DH, Go BC, McGeehan B, Briceño CA
Am J Ophthalmol 2022 Feb;234:71-80. Epub 2021 Jul 31 doi: 10.1016/j.ajo.2021.07.031. PMID: 34343490
Eyelid Melanoma in the United States: A National Cancer Database Analysis.
Oliver JD, Boczar D, Sisti A, Huayllani MT, Restrepo DJ, Spaulding AC, Gabriel E, Bagaria S, Rinker BD, Forte AJ
J Craniofac Surg 2019 Nov-Dec;30(8):2412-2415. doi: 10.1097/SCS.0000000000005673. PMID: 31233000
Melanoma of the eyelid and periocular skin: Histopathologic classification and molecular pathology.
Mancera N, Smalley KSM, Margo CE
Surv Ophthalmol 2019 May-Jun;64(3):272-288. Epub 2018 Dec 20 doi: 10.1016/j.survophthal.2018.12.002. PMID: 30578807
Clinicopathologic features and behavior of cutaneous eyelid melanoma.
Vaziri M, Buffam FV, Martinka M, Oryschak A, Dhaliwal H, White VA
Ophthalmology 2002 May;109(5):901-8. doi: 10.1016/s0161-6420(02)00962-4. PMID: 11986095

Recent systematic reviews

Surgical margins and outcomes for eyelid melanoma: a systematic review and meta-analysis.
Pisano CE, Trager MH, Fan W, Samie FH
Arch Dermatol Res 2024 Mar 15;316(4):106. doi: 10.1007/s00403-024-02834-3. PMID: 38489027
Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.
Ford J, Thakar S, Thuro B, Esmaeli B
Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):317-324. doi: 10.1097/IOP.0000000000000901. PMID: 28350693

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...