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Respiratory acidosis

MedGen UID:
91
•Concept ID:
C0001127
•
Disease or Syndrome
Synonyms: Acidoses, Respiratory; Acidosis, Respiratory; Respiratory Acidoses; Respiratory Acidosis
SNOMED CT: Respiratory acidosis (12326000)
 
HPO: HP:0005972

Definition

Acidosis because of respiratory retention of carbon dioxide. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRespiratory acidosis

Conditions with this feature

Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome
MedGen UID:
1388385
•Concept ID:
C4518785
•
Disease or Syndrome
Junctional epidermolysis bullosa-7 with interstitial lung disease and nephrotic syndrome (JEB7), also known as ILNEB, is an autosomal recessive multiorgan disorder that includes congenital interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease (summary by Has et al., 2012).
See: Condition Record
Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome

Professional guidelines

PubMed

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Clinical Practice Guidelines for Sustained Neuromuscular Blockade in the Adult Critically Ill Patient.
Murray MJ, DeBlock H, Erstad B, Gray A, Jacobi J, Jordan C, McGee W, McManus C, Meade M, Nix S, Patterson A, Sands MK, Pino R, Tescher A, Arbour R, Rochwerg B, Murray CF, Mehta S
Crit Care Med 2016 Nov;44(11):2079-2103. doi: 10.1097/CCM.0000000000002027. PMID: 27755068
Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness.
Leaf DE, Goldfarb DS
J Appl Physiol (1985) 2007 Apr;102(4):1313-22. Epub 2006 Oct 5 doi: 10.1152/japplphysiol.01572.2005. PMID: 17023566

Recent clinical studies

Etiology

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Sodium bicarbonate therapy for acute respiratory acidosis.
Chand R, Swenson ER, Goldfarb DS
Curr Opin Nephrol Hypertens 2021 Mar 1;30(2):223-230. doi: 10.1097/MNH.0000000000000687. PMID: 33395037
Benefits of non-invasive ventilation in acute hypercapnic respiratory failure.
Comellini V, Pacilli AMG, Nava S
Respirology 2019 Apr;24(4):308-317. Epub 2019 Jan 12 doi: 10.1111/resp.13469. PMID: 30636373
Clinical Practice Guidelines for Sustained Neuromuscular Blockade in the Adult Critically Ill Patient.
Murray MJ, DeBlock H, Erstad B, Gray A, Jacobi J, Jordan C, McGee W, McManus C, Meade M, Nix S, Patterson A, Sands MK, Pino R, Tescher A, Arbour R, Rochwerg B, Murray CF, Mehta S
Crit Care Med 2016 Nov;44(11):2079-2103. doi: 10.1097/CCM.0000000000002027. PMID: 27755068
Respiratory acidosis.
Epstein SK, Singh N
Respir Care 2001 Apr;46(4):366-83. PMID: 11262556

Diagnosis

Respiratory Acidosis and Respiratory Alkalosis: Core Curriculum 2023.
Palmer BF, Clegg DJ
Am J Kidney Dis 2023 Sep;82(3):347-359. Epub 2023 Jun 21 doi: 10.1053/j.ajkd.2023.02.004. PMID: 37341662
Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Acid-Base Disorders in the Critically Ill Patient.
Achanti A, Szerlip HM
Clin J Am Soc Nephrol 2023 Jan 1;18(1):102-112. Epub 2022 Aug 23 doi: 10.2215/CJN.04500422. PMID: 35998977Free PMC Article
Malignant Hyperthermia Update.
Ellinas H, Albrecht MA
Anesthesiol Clin 2020 Mar;38(1):165-181. doi: 10.1016/j.anclin.2019.10.010. PMID: 32008650
Respiratory acidosis.
Epstein SK, Singh N
Respir Care 2001 Apr;46(4):366-83. PMID: 11262556

Therapy

Sodium bicarbonate therapy for acute respiratory acidosis.
Chand R, Swenson ER, Goldfarb DS
Curr Opin Nephrol Hypertens 2021 Mar 1;30(2):223-230. doi: 10.1097/MNH.0000000000000687. PMID: 33395037
Alkali Therapy for Respiratory Acidosis: A Medical Controversy.
Adrogué HJ, Madias NE
Am J Kidney Dis 2020 Feb;75(2):265-271. Epub 2019 Aug 28 doi: 10.1053/j.ajkd.2019.05.029. PMID: 31473018
Benefits of non-invasive ventilation in acute hypercapnic respiratory failure.
Comellini V, Pacilli AMG, Nava S
Respirology 2019 Apr;24(4):308-317. Epub 2019 Jan 12 doi: 10.1111/resp.13469. PMID: 30636373
Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness.
Leaf DE, Goldfarb DS
J Appl Physiol (1985) 2007 Apr;102(4):1313-22. Epub 2006 Oct 5 doi: 10.1152/japplphysiol.01572.2005. PMID: 17023566
Respiratory acidosis.
Epstein SK, Singh N
Respir Care 2001 Apr;46(4):366-83. PMID: 11262556

Prognosis

Case 327.
Decavèle M, Pichon J, Fajac A, Milon A, Antoine M, Gibelin A, Parrot A, Fartoukh M
Radiology 2024 Mar;310(3):e222275. doi: 10.1148/radiol.222275. PMID: 38530173
Potentially (near) fatal asthma.
Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):403-405. doi: 10.2500/aap.2019.40.4257. PMID: 31690380
Clinical Practice Guidelines for Sustained Neuromuscular Blockade in the Adult Critically Ill Patient.
Murray MJ, DeBlock H, Erstad B, Gray A, Jacobi J, Jordan C, McGee W, McManus C, Meade M, Nix S, Patterson A, Sands MK, Pino R, Tescher A, Arbour R, Rochwerg B, Murray CF, Mehta S
Crit Care Med 2016 Nov;44(11):2079-2103. doi: 10.1097/CCM.0000000000002027. PMID: 27755068
Chronic oxygen therapy.
Flick MR, Block AJ
Med Clin North Am 1977 Nov;61(6):1397-406. doi: 10.1016/s0025-7125(16)31268-8. PMID: 412017
Exercise-induced asthma.
Anderson SD, Silverman M, König P, Godfrey S
Br J Dis Chest 1975 Jan;69(1):1-39. doi: 10.1016/0007-0971(75)90053-4. PMID: 237526

Clinical prediction guides

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Extracorporeal carbondioxide removal (ECCO2R): case series and review of literature.
Bozkuş F, Bilal B, Öksüz H
Tuberk Toraks 2018 Sep;66(3):258-265. doi: 10.5578/tt.26368. PMID: 30479235
Clinical Practice Guidelines for Sustained Neuromuscular Blockade in the Adult Critically Ill Patient.
Murray MJ, DeBlock H, Erstad B, Gray A, Jacobi J, Jordan C, McGee W, McManus C, Meade M, Nix S, Patterson A, Sands MK, Pino R, Tescher A, Arbour R, Rochwerg B, Murray CF, Mehta S
Crit Care Med 2016 Nov;44(11):2079-2103. doi: 10.1097/CCM.0000000000002027. PMID: 27755068
Laparoscopic surgery during pregnancy.
O'Rourke N, Kodali BS
Curr Opin Anaesthesiol 2006 Jun;19(3):254-9. doi: 10.1097/01.aco.0000192817.30612.b3. PMID: 16735807
Acidosis and bone.
Bushinsky DA
Miner Electrolyte Metab 1994;20(1-2):40-52. PMID: 8202051

Recent systematic reviews

High flow through nasal cannula in exacerbated COPD patients: a systematic review.
Pisani L, Astuto M, Prediletto I, Longhini F
Pulmonology 2019 Nov-Dec;25(6):348-354. Epub 2019 Oct 5 doi: 10.1016/j.pulmoe.2019.08.001. PMID: 31591056
Acute Systemic Complications of Convulsive Status Epilepticus-A Systematic Review.
Sutter R, Dittrich T, Semmlack S, Rüegg S, Marsch S, Kaplan PW
Crit Care Med 2018 Jan;46(1):138-145. doi: 10.1097/CCM.0000000000002843. PMID: 29099419
Nasal continuous positive airways pressure immediately after extubation for preventing morbidity in preterm infants.
Davis PG, Henderson-Smart DJ
Cochrane Database Syst Rev 2003;(2):CD000143. doi: 10.1002/14651858.CD000143. PMID: 12804388
Nasal continuous positive airways pressure immediately after extubation for preventing morbidity in preterm infants.
Davis PG, Henderson-Smart DJ
Cochrane Database Syst Rev 2000;(3):CD000143. doi: 10.1002/14651858.CD000143. PMID: 10908461
Nasal continuous positive airways pressure immediately after extubation for preventing morbidity in preterm infants.
Davis PG, Henderson-Smart DJ
Cochrane Database Syst Rev 2000;(2):CD000143. doi: 10.1002/14651858.CD000143. PMID: 10796307

Supplemental Content

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