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Hepatorenal syndrome

MedGen UID:
9224
Concept ID:
C0019212
Disease or Syndrome
Synonyms: Hepatorenal Syndrome; Syndrome, Hepatorenal
SNOMED CT: HRF - Hepatorenal failure (51292008); Hepatorenal failure (51292008); Hepatorenal syndrome (51292008)
 
Monarch Initiative: MONDO:0001382

Definition

A syndrome characterized by progressive kidney failure in a patient with cirrhosis or fulminant liver failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatorenal syndrome

Professional guidelines

PubMed

Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Biggins SW, Angeli P, Garcia-Tsao G, Ginès P, Ling SC, Nadim MK, Wong F, Kim WR
Hepatology 2021 Aug;74(2):1014-1048. doi: 10.1002/hep.31884. PMID: 33942342
Simonetto DA, Gines P, Kamath PS
BMJ 2020 Sep 14;370:m2687. doi: 10.1136/bmj.m2687. PMID: 32928750

Recent clinical studies

Etiology

Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Wong F, Pappas SC, Curry MP, Reddy KR, Rubin RA, Porayko MK, Gonzalez SA, Mumtaz K, Lim N, Simonetto DA, Sharma P, Sanyal AJ, Mayo MJ, Frederick RT, Escalante S, Jamil K; CONFIRM Study Investigators
N Engl J Med 2021 Mar 4;384(9):818-828. doi: 10.1056/NEJMoa2008290. PMID: 33657294
Simonetto DA, Gines P, Kamath PS
BMJ 2020 Sep 14;370:m2687. doi: 10.1136/bmj.m2687. PMID: 32928750
Ginès P, Solà E, Angeli P, Wong F, Nadim MK, Kamath PS
Nat Rev Dis Primers 2018 Sep 13;4(1):23. doi: 10.1038/s41572-018-0022-7. PMID: 30213943
Wang H, Liu A, Bo W, Feng X, Hu Y
Medicine (Baltimore) 2018 Apr;97(16):e0431. doi: 10.1097/MD.0000000000010431. PMID: 29668606Free PMC Article

Diagnosis

Belcher JM
Med Clin North Am 2023 Jul;107(4):781-792. Epub 2023 Apr 20 doi: 10.1016/j.mcna.2023.03.009. PMID: 37258014
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Buccheri S, Da BL
Clin Liver Dis 2022 May;26(2):181-201. Epub 2022 Apr 1 doi: 10.1016/j.cld.2022.01.002. PMID: 35487604
Biggins SW, Angeli P, Garcia-Tsao G, Ginès P, Ling SC, Nadim MK, Wong F, Kim WR
Hepatology 2021 Aug;74(2):1014-1048. doi: 10.1002/hep.31884. PMID: 33942342
Simonetto DA, Gines P, Kamath PS
BMJ 2020 Sep 14;370:m2687. doi: 10.1136/bmj.m2687. PMID: 32928750

Therapy

Belcher JM
Med Clin North Am 2023 Jul;107(4):781-792. Epub 2023 Apr 20 doi: 10.1016/j.mcna.2023.03.009. PMID: 37258014
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Jung CY, Chang JW
Clin Mol Hepatol 2023 Oct;29(4):891-908. Epub 2023 Apr 13 doi: 10.3350/cmh.2023.0024. PMID: 37050843Free PMC Article
Buccheri S, Da BL
Clin Liver Dis 2022 May;26(2):181-201. Epub 2022 Apr 1 doi: 10.1016/j.cld.2022.01.002. PMID: 35487604
Amin AA, Alabsawy EI, Jalan R, Davenport A
Semin Nephrol 2019 Jan;39(1):17-30. doi: 10.1016/j.semnephrol.2018.10.002. PMID: 30606404

Prognosis

Pose E, Piano S, Juanola A, Ginès P
Gastroenterology 2024 Apr;166(4):588-604.e1. Epub 2024 Jan 19 doi: 10.1053/j.gastro.2023.11.306. PMID: 38246506
Gupta K, Bhurwal A, Law C, Ventre S, Minacapelli CD, Kabaria S, Li Y, Tait C, Catalano C, Rustgi VK
World J Gastroenterol 2021 Jul 14;27(26):3984-4003. doi: 10.3748/wjg.v27.i26.3984. PMID: 34326609Free PMC Article
Hasan I, Rashid T, Chirila RM, Ghali P, Wadei HM
Rom J Intern Med 2021 Sep 1;59(3):227-261. Epub 2021 Aug 26 doi: 10.2478/rjim-2021-0006. PMID: 33544554
Francoz C, Durand F, Kahn JA, Genyk YS, Nadim MK
Clin J Am Soc Nephrol 2019 May 7;14(5):774-781. Epub 2019 Apr 17 doi: 10.2215/CJN.12451018. PMID: 30996046Free PMC Article
Amin AA, Alabsawy EI, Jalan R, Davenport A
Semin Nephrol 2019 Jan;39(1):17-30. doi: 10.1016/j.semnephrol.2018.10.002. PMID: 30606404

Clinical prediction guides

Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Abraldes JG, Caraceni P, Ghabril M, Garcia-Tsao G
Clin Gastroenterol Hepatol 2023 Jul;21(8):2100-2109. Epub 2023 Mar 25 doi: 10.1016/j.cgh.2023.03.019. PMID: 36972759
Im GY
Clin Liver Dis 2019 Feb;23(1):81-98. Epub 2018 Oct 26 doi: 10.1016/j.cld.2018.09.005. PMID: 30454835
Cavallin M, Kamath PS, Merli M, Fasolato S, Toniutto P, Salerno F, Bernardi M, Romanelli RG, Colletta C, Salinas F, Di Giacomo A, Ridola L, Fornasiere E, Caraceni P, Morando F, Piano S, Gatta A, Angeli P; Italian Association for the Study of the Liver Study Group on Hepatorenal Syndrome
Hepatology 2015 Aug;62(2):567-74. Epub 2015 Feb 13 doi: 10.1002/hep.27709. PMID: 25644760
Gatta A, Verardo A, Bolognesi M
Intern Emerg Med 2012 Oct;7 Suppl 3:S193-9. doi: 10.1007/s11739-012-0802-0. PMID: 23073857

Recent systematic reviews

Bai Z, Wang L, Wang R, Zou M, Méndez-Sánchez N, Romeiro FG, Cheng G, Qi X
Hepatol Int 2022 Dec;16(6):1468-1483. Epub 2022 Sep 1 doi: 10.1007/s12072-022-10374-z. PMID: 36048318
Pitre T, Kiflen M, Helmeczi W, Dionne JC, Rewa O, Bagshaw SM, Needham-Nethercott N, Alhazzani W, Zeraatkar D, Rochwerg B
Crit Care Med 2022 Oct 1;50(10):1419-1429. Epub 2022 Sep 12 doi: 10.1097/CCM.0000000000005595. PMID: 35777925
Wang H, Liu A, Bo W, Feng X, Hu Y
Medicine (Baltimore) 2018 Apr;97(16):e0431. doi: 10.1097/MD.0000000000010431. PMID: 29668606Free PMC Article
Song T, Rössle M, He F, Liu F, Guo X, Qi X
Dig Liver Dis 2018 Apr;50(4):323-330. Epub 2018 Feb 17 doi: 10.1016/j.dld.2018.01.123. PMID: 29422242
Dobre M, Demirjian S, Sehgal AR, Navaneethan SD
Int Urol Nephrol 2011 Mar;43(1):175-84. Epub 2010 Mar 20 doi: 10.1007/s11255-010-9725-8. PMID: 20306131Free PMC Article

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