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Hepatorenal syndrome

MedGen UID:
9224
•Concept ID:
C0019212
•
Disease or Syndrome
Synonyms: Hepatorenal Syndrome; Syndrome, Hepatorenal
SNOMED CT: HRF - Hepatorenal failure (51292008); Hepatorenal failure (51292008); Hepatorenal syndrome (51292008)
 
Monarch Initiative: MONDO:0001382

Definition

A syndrome characterized by progressive kidney failure in a patient with cirrhosis or fulminant liver failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatorenal syndrome

Professional guidelines

PubMed

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031
Evidence-based clinical practice guidelines for Liver Cirrhosis 2020.
Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, Kawaguchi T, Kurosaki M, Sakaida I, Shimizu M, Taniai M, Terai S, Nishikawa H, Hiasa Y, Hidaka H, Miwa H, Chayama K, Enomoto N, Shimosegawa T, Takehara T, Koike K
J Gastroenterol 2021 Jul;56(7):593-619. Epub 2021 Jul 7 doi: 10.1007/s00535-021-01788-x. PMID: 34231046Free PMC Article
Hepatorenal syndrome: pathophysiology, diagnosis, and management.
Simonetto DA, Gines P, Kamath PS
BMJ 2020 Sep 14;370:m2687. doi: 10.1136/bmj.m2687. PMID: 32928750

Recent clinical studies

Etiology

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031
Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome.
Wong F, Pappas SC, Curry MP, Reddy KR, Rubin RA, Porayko MK, Gonzalez SA, Mumtaz K, Lim N, Simonetto DA, Sharma P, Sanyal AJ, Mayo MJ, Frederick RT, Escalante S, Jamil K; CONFIRM Study Investigators
N Engl J Med 2021 Mar 4;384(9):818-828. doi: 10.1056/NEJMoa2008290. PMID: 33657294
Hepatorenal syndrome: pathophysiology, diagnosis, and management.
Simonetto DA, Gines P, Kamath PS
BMJ 2020 Sep 14;370:m2687. doi: 10.1136/bmj.m2687. PMID: 32928750
Hepatorenal syndrome.
Ginès P, Solà E, Angeli P, Wong F, Nadim MK, Kamath PS
Nat Rev Dis Primers 2018 Sep 13;4(1):23. doi: 10.1038/s41572-018-0022-7. PMID: 30213943
Management of decompensated cirrhosis.
Mansour D, McPherson S
Clin Med (Lond) 2018 Apr 1;18(Suppl 2):s60-s65. doi: 10.7861/clinmedicine.18-2-s60. PMID: 29700095Free PMC Article

Diagnosis

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031
Acute kidney injury and hepatorenal syndrome in cirrhosis.
Gupta K, Bhurwal A, Law C, Ventre S, Minacapelli CD, Kabaria S, Li Y, Tait C, Catalano C, Rustgi VK
World J Gastroenterol 2021 Jul 14;27(26):3984-4003. doi: 10.3748/wjg.v27.i26.3984. PMID: 34326609Free PMC Article
Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome: 2021 Practice Guidance by the American Association for the Study of Liver Diseases.
Biggins SW, Angeli P, Garcia-Tsao G, Ginès P, Ling SC, Nadim MK, Wong F, Kim WR
Hepatology 2021 Aug;74(2):1014-1048. doi: 10.1002/hep.31884. PMID: 33942342
Hepatorenal syndrome: pathophysiology, diagnosis, and management.
Simonetto DA, Gines P, Kamath PS
BMJ 2020 Sep 14;370:m2687. doi: 10.1136/bmj.m2687. PMID: 32928750
Hepatorenal Syndrome.
Francoz C, Durand F, Kahn JA, Genyk YS, Nadim MK
Clin J Am Soc Nephrol 2019 May 7;14(5):774-781. Epub 2019 Apr 17 doi: 10.2215/CJN.12451018. PMID: 30996046Free PMC Article

Therapy

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031
Hepatorenal Syndrome: Definitions, Diagnosis, and Management.
Buccheri S, Da BL
Clin Liver Dis 2022 May;26(2):181-201. Epub 2022 Apr 1 doi: 10.1016/j.cld.2022.01.002. PMID: 35487604
Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome.
Wong F, Pappas SC, Curry MP, Reddy KR, Rubin RA, Porayko MK, Gonzalez SA, Mumtaz K, Lim N, Simonetto DA, Sharma P, Sanyal AJ, Mayo MJ, Frederick RT, Escalante S, Jamil K; CONFIRM Study Investigators
N Engl J Med 2021 Mar 4;384(9):818-828. doi: 10.1056/NEJMoa2008290. PMID: 33657294
Ascites and Hepatorenal Syndrome.
Adebayo D, Neong SF, Wong F
Clin Liver Dis 2019 Nov;23(4):659-682. Epub 2019 Aug 7 doi: 10.1016/j.cld.2019.06.002. PMID: 31563217
Hypoalbuminemia.
Gatta A, Verardo A, Bolognesi M
Intern Emerg Med 2012 Oct;7 Suppl 3:S193-9. doi: 10.1007/s11739-012-0802-0. PMID: 23073857

Prognosis

Acute kidney injury and hepatorenal syndrome in cirrhosis.
Gupta K, Bhurwal A, Law C, Ventre S, Minacapelli CD, Kabaria S, Li Y, Tait C, Catalano C, Rustgi VK
World J Gastroenterol 2021 Jul 14;27(26):3984-4003. doi: 10.3748/wjg.v27.i26.3984. PMID: 34326609Free PMC Article
Hepatorenal Syndrome.
Khemichian S, Francoz C, Durand F, Karvellas CJ, Nadim MK
Crit Care Clin 2021 Apr;37(2):321-334. Epub 2020 Dec 15 doi: 10.1016/j.ccc.2020.11.011. PMID: 33752858
Hepatorenal syndrome: pathophysiology and evidence-based management update.
Hasan I, Rashid T, Chirila RM, Ghali P, Wadei HM
Rom J Intern Med 2021 Sep 1;59(3):227-261. Epub 2021 Aug 26 doi: 10.2478/rjim-2021-0006. PMID: 33544554
Hepatorenal Syndrome.
Francoz C, Durand F, Kahn JA, Genyk YS, Nadim MK
Clin J Am Soc Nephrol 2019 May 7;14(5):774-781. Epub 2019 Apr 17 doi: 10.2215/CJN.12451018. PMID: 30996046Free PMC Article
Hypoalbuminemia.
Gatta A, Verardo A, Bolognesi M
Intern Emerg Med 2012 Oct;7 Suppl 3:S193-9. doi: 10.1007/s11739-012-0802-0. PMID: 23073857

Clinical prediction guides

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031
Acute Renal Failure and Its Complications, Indications for Emergent Dialysis, and Dialysis Modalities.
Muaddi L, Ledgerwood C, Sheridan R, Dumont T, Nashar K
Crit Care Nurs Q 2022 Jul-Sep 01;45(3):258-265. doi: 10.1097/CNQ.0000000000000410. PMID: 35617092
Acute Alcoholic Hepatitis.
Im GY
Clin Liver Dis 2019 Feb;23(1):81-98. Epub 2018 Oct 26 doi: 10.1016/j.cld.2018.09.005. PMID: 30454835
New Developments in Hepatorenal Syndrome.
Mindikoglu AL, Pappas SC
Clin Gastroenterol Hepatol 2018 Feb;16(2):162-177.e1. Epub 2017 Jun 7 doi: 10.1016/j.cgh.2017.05.041. PMID: 28602971Free PMC Article
Hypoalbuminemia.
Gatta A, Verardo A, Bolognesi M
Intern Emerg Med 2012 Oct;7 Suppl 3:S193-9. doi: 10.1007/s11739-012-0802-0. PMID: 23073857

Recent systematic reviews

Use of human albumin infusion in cirrhotic patients: a systematic review and meta-analysis of randomized controlled trials.
Bai Z, Wang L, Wang R, Zou M, Méndez-Sánchez N, Romeiro FG, Cheng G, Qi X
Hepatol Int 2022 Dec;16(6):1468-1483. Epub 2022 Sep 1 doi: 10.1007/s12072-022-10374-z. PMID: 36048318
The Comparative Effectiveness of Vasoactive Treatments for Hepatorenal Syndrome: A Systematic Review and Network Meta-Analysis.
Pitre T, Kiflen M, Helmeczi W, Dionne JC, Rewa O, Bagshaw SM, Needham-Nethercott N, Alhazzani W, Zeraatkar D, Rochwerg B
Crit Care Med 2022 Oct 1;50(10):1419-1429. Epub 2022 Sep 12 doi: 10.1097/CCM.0000000000005595. PMID: 35777925
Treatment for ascites in adults with decompensated liver cirrhosis: a network meta-analysis.
Benmassaoud A, Freeman SC, Roccarina D, Plaz Torres MC, Sutton AJ, Cooper NJ, Iogna Prat L, Cowlin M, Milne EJ, Hawkins N, Davidson BR, Pavlov CS, Thorburn D, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2020 Jan 16;1(1):CD013123. doi: 10.1002/14651858.CD013123.pub2. PMID: 31978257Free PMC Article
Terlipressin in the treatment of hepatorenal syndrome: A systematic review and meta-analysis.
Wang H, Liu A, Bo W, Feng X, Hu Y
Medicine (Baltimore) 2018 Apr;97(16):e0431. doi: 10.1097/MD.0000000000010431. PMID: 29668606Free PMC Article
Terlipressin versus other vasoactive drugs for hepatorenal syndrome.
Israelsen M, Krag A, Allegretti AS, Jovani M, Goldin AH, Winter RW, Gluud LL
Cochrane Database Syst Rev 2017 Sep 27;9(9):CD011532. doi: 10.1002/14651858.CD011532.pub2. PMID: 28953318Free PMC Article

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