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t(6;9)

MedGen UID:
925468
•Concept ID:
C4287936
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that involves a translocation between chromosomes 6 and 9. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(6;9)

Professional guidelines

PubMed

Polarized Polychromatic Noncoherent Light (Bioptron Light) as Adjunctive Treatment in Chronic Oral Mucosal Pain: A Pilot Study.
Petruzzi M, Nardi GM, Cocco F, Della Vella F, Grassi R, Grassi FR
Photobiomodul Photomed Laser Surg 2019 Apr;37(4):227-232. doi: 10.1089/photob.2018.4576. PMID: 31050959
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Head and neck adenoid cystic carcinoma: what is new in biological markers and treatment?
Bell D, Hanna EY
Curr Opin Otolaryngol Head Neck Surg 2013 Apr;21(2):124-9. doi: 10.1097/MOO.0b013e32835c05fd. PMID: 23222122

Recent clinical studies

Etiology

The Relationship Between PSA and Total Testosterone Levels in Men With Prostate Cancer.
Flores JM, Bernie HL, Miranda E, Nascimento B, Schofield E, Benfante N, Carlsson S, Mulhall JP
J Sex Med 2022 Mar;19(3):471-478. Epub 2022 Feb 5 doi: 10.1016/j.jsxm.2022.01.003. PMID: 35135736Free PMC Article
Clinicopathologic and molecular characterization of myeloid neoplasms with isolated t(6;9)(p23;q34).
Visconte V, Shetty S, Przychodzen B, Hirsch C, Bodo J, Maciejewski JP, Hsi ED, Rogers HJ
Int J Lab Hematol 2017 Aug;39(4):409-417. Epub 2017 Mar 20 doi: 10.1111/ijlh.12641. PMID: 28318095Free PMC Article
Non-t(6;9) and Non-Inv(3) Balanced Chromosomal Rearrangements Are Associated With Poor Survival Outcomes in Myelodysplastic Syndromes.
Ai J, Visconte V, Tabarroki A, Hasrouni E, Hamilton BK, Mukherjee S, Kalaycio M, Sobecks R, Advani AS, Sekeres MA, Shetty S, Tiu RV
Clin Lymphoma Myeloma Leuk 2015 Aug;15(8):489-95. Epub 2015 Apr 2 doi: 10.1016/j.clml.2015.03.017. PMID: 25977195
t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients.
Sandahl JD, Coenen EA, Forestier E, Harbott J, Johansson B, Kerndrup G, Adachi S, Auvrignon A, Beverloo HB, Cayuela JM, Chilton L, Fornerod M, de Haas V, Harrison CJ, Inaba H, Kaspers GJ, Liang DC, Locatelli F, Masetti R, Perot C, Raimondi SC, Reinhardt K, Tomizawa D, von Neuhoff N, Zecca M, Zwaan CM, van den Heuvel-Eibrink MM, Hasle H
Haematologica 2014 May;99(5):865-72. Epub 2014 Jan 17 doi: 10.3324/haematol.2013.098517. PMID: 24441146Free PMC Article
The t(6;9)(p22;q34) in myeloid neoplasms: a retrospective study of 16 cases.
Gupta M, Ashok Kumar J, Sitaram U, Neeraj S, Nancy A, Balasubramanian P, Abraham A, Mathews V, Viswabandya A, George B, Chandy M, Srivastava A, Srivastava VM
Cancer Genet Cytogenet 2010 Dec;203(2):297-302. doi: 10.1016/j.cancergencyto.2010.08.012. PMID: 21156248

Diagnosis

Diagnosis of rare subtypes of acute myeloid leukaemia and related neoplasms.
George TI, Bajel A
Pathology 2021 Apr;53(3):312-327. Epub 2021 Mar 4 doi: 10.1016/j.pathol.2021.02.001. PMID: 33676766
Myelodysplastic syndrome with t(6;9)(p22;q34.1)/DEK-NUP214 better classified as acute myeloid leukemia? A multicenter study of 107 cases.
Fang H, Yabe M, Zhang X, Kim Y, Wu X, Wei P, Chi S, Zheng L, Garcia-Manero G, Shao L, Yuan J, Shen Y, Zheng G, Tang G, Wang W, Loghavi S, Shen Q, Yuan Y, He R, Chen D, Medeiros LJ, Hu S
Mod Pathol 2021 Jun;34(6):1143-1152. Epub 2021 Feb 8 doi: 10.1038/s41379-021-00741-w. PMID: 33558656
Clinicopathologic and molecular characterization of myeloid neoplasms with isolated t(6;9)(p23;q34).
Visconte V, Shetty S, Przychodzen B, Hirsch C, Bodo J, Maciejewski JP, Hsi ED, Rogers HJ
Int J Lab Hematol 2017 Aug;39(4):409-417. Epub 2017 Mar 20 doi: 10.1111/ijlh.12641. PMID: 28318095Free PMC Article
t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients.
Sandahl JD, Coenen EA, Forestier E, Harbott J, Johansson B, Kerndrup G, Adachi S, Auvrignon A, Beverloo HB, Cayuela JM, Chilton L, Fornerod M, de Haas V, Harrison CJ, Inaba H, Kaspers GJ, Liang DC, Locatelli F, Masetti R, Perot C, Raimondi SC, Reinhardt K, Tomizawa D, von Neuhoff N, Zecca M, Zwaan CM, van den Heuvel-Eibrink MM, Hasle H
Haematologica 2014 May;99(5):865-72. Epub 2014 Jan 17 doi: 10.3324/haematol.2013.098517. PMID: 24441146Free PMC Article
Acute myelogenous leukemia with t(6;9)(p23;q34) and marrow basophilia: an overview.
Chi Y, Lindgren V, Quigley S, Gaitonde S
Arch Pathol Lab Med 2008 Nov;132(11):1835-7. doi: 10.5858/132.11.1835. PMID: 18976025

Therapy

The Relationship Between PSA and Total Testosterone Levels in Men With Prostate Cancer.
Flores JM, Bernie HL, Miranda E, Nascimento B, Schofield E, Benfante N, Carlsson S, Mulhall JP
J Sex Med 2022 Mar;19(3):471-478. Epub 2022 Feb 5 doi: 10.1016/j.jsxm.2022.01.003. PMID: 35135736Free PMC Article
c-MYB and DMTF1 in Cancer.
Fry EA, Inoue K
Cancer Invest 2019;37(1):46-65. Epub 2019 Jan 2 doi: 10.1080/07357907.2018.1550090. PMID: 30599775Free PMC Article
t(6;9)(p23;q34.1) acute myeloid leukaemia with cup-like blasts.
Bories C, Boyer T
Br J Haematol 2018 Jul;182(1):9. Epub 2018 May 16 doi: 10.1111/bjh.15214. PMID: 29767433
Patients with Fanconi anemia and AML have different cytogenetic clones than de novo cases of AML.
Rochowski A, Olson SB, Alonzo TA, Gerbing RB, Lange BJ, Alter BP
Pediatr Blood Cancer 2012 Nov;59(5):922-4. Epub 2012 Apr 19 doi: 10.1002/pbc.24168. PMID: 22517793Free PMC Article
Syndromes of acute nonlymphocytic leukemia.
Koeffler HP
Ann Intern Med 1987 Nov;107(5):748-58. doi: 10.7326/0003-4819-107-5-748. PMID: 3310797

Prognosis

Activation of signaling pathways in models of t(6;9)-acute myeloid leukemia.
Chiriches C, Khan D, Wieske M, Guillen N, Rokicki M, Guy C, Wilson M, Heesom KJ, Ottmann OG, Ruthardt M
Ann Hematol 2022 Oct;101(10):2179-2193. Epub 2022 Aug 8 doi: 10.1007/s00277-022-04905-9. PMID: 35941390Free PMC Article
Diagnosis of rare subtypes of acute myeloid leukaemia and related neoplasms.
George TI, Bajel A
Pathology 2021 Apr;53(3):312-327. Epub 2021 Mar 4 doi: 10.1016/j.pathol.2021.02.001. PMID: 33676766
t(6;9)(MYB-NFIB) in head and neck adenoid cystic carcinoma: A systematic review with meta-analysis.
de Almeida-Pinto YD, Costa SFDS, de Andrade BAB, Altemani A, Vargas PA, Abreu LG, Fonseca FP
Oral Dis 2019 Jul;25(5):1277-1282. Epub 2019 Jan 1 doi: 10.1111/odi.12984. PMID: 30269389
Histological types of breast cancer: how special are they?
Weigelt B, Geyer FC, Reis-Filho JS
Mol Oncol 2010 Jun;4(3):192-208. Epub 2010 Apr 18 doi: 10.1016/j.molonc.2010.04.004. PMID: 20452298Free PMC Article
Acute myelogenous leukemia with t(6;9)(p23;q34) and marrow basophilia: an overview.
Chi Y, Lindgren V, Quigley S, Gaitonde S
Arch Pathol Lab Med 2008 Nov;132(11):1835-7. doi: 10.5858/132.11.1835. PMID: 18976025

Clinical prediction guides

The Relationship Between PSA and Total Testosterone Levels in Men With Prostate Cancer.
Flores JM, Bernie HL, Miranda E, Nascimento B, Schofield E, Benfante N, Carlsson S, Mulhall JP
J Sex Med 2022 Mar;19(3):471-478. Epub 2022 Feb 5 doi: 10.1016/j.jsxm.2022.01.003. PMID: 35135736Free PMC Article
t(6;9)(MYB-NFIB) in head and neck adenoid cystic carcinoma: A systematic review with meta-analysis.
de Almeida-Pinto YD, Costa SFDS, de Andrade BAB, Altemani A, Vargas PA, Abreu LG, Fonseca FP
Oral Dis 2019 Jul;25(5):1277-1282. Epub 2019 Jan 1 doi: 10.1111/odi.12984. PMID: 30269389
Clinicopathologic and molecular characterization of myeloid neoplasms with isolated t(6;9)(p23;q34).
Visconte V, Shetty S, Przychodzen B, Hirsch C, Bodo J, Maciejewski JP, Hsi ED, Rogers HJ
Int J Lab Hematol 2017 Aug;39(4):409-417. Epub 2017 Mar 20 doi: 10.1111/ijlh.12641. PMID: 28318095Free PMC Article
Non-t(6;9) and Non-Inv(3) Balanced Chromosomal Rearrangements Are Associated With Poor Survival Outcomes in Myelodysplastic Syndromes.
Ai J, Visconte V, Tabarroki A, Hasrouni E, Hamilton BK, Mukherjee S, Kalaycio M, Sobecks R, Advani AS, Sekeres MA, Shetty S, Tiu RV
Clin Lymphoma Myeloma Leuk 2015 Aug;15(8):489-95. Epub 2015 Apr 2 doi: 10.1016/j.clml.2015.03.017. PMID: 25977195
Histological types of breast cancer: how special are they?
Weigelt B, Geyer FC, Reis-Filho JS
Mol Oncol 2010 Jun;4(3):192-208. Epub 2010 Apr 18 doi: 10.1016/j.molonc.2010.04.004. PMID: 20452298Free PMC Article

Recent systematic reviews

t(6;9)(MYB-NFIB) in head and neck adenoid cystic carcinoma: A systematic review with meta-analysis.
de Almeida-Pinto YD, Costa SFDS, de Andrade BAB, Altemani A, Vargas PA, Abreu LG, Fonseca FP
Oral Dis 2019 Jul;25(5):1277-1282. Epub 2019 Jan 1 doi: 10.1111/odi.12984. PMID: 30269389

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