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t(1;19)

MedGen UID:
925475
•Concept ID:
C4287943
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that involves a translocation between chromosomes 1 and 19. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(1;19)

Professional guidelines

PubMed

Outcomes of blinatumomab based therapy in children with relapsed, persistent, or refractory acute lymphoblastic leukemia: a multicenter study focusing on predictors of response and post-treatment immunoglobulin production.
Essa MF, Abdellatif R, Elimam N, Ballourah W, Alsudairy R, Alkaiyat M, Alsultan A, Jastaniah W
Pediatr Hematol Oncol 2022 Oct;39(7):613-628. Epub 2022 Apr 23 doi: 10.1080/08880018.2022.2049936. PMID: 36200934
Efficacy and safety of induction chemotherapy with daunorubicin or idarubicin in the treatment of an adult with acute lymphoblastic leukemia.
Zhang Q, Zhang CH, Wang ZD, Wang D
Tumori 2022 Apr;108(2):182-188. Epub 2021 Jul 23 doi: 10.1177/03008916211032724. PMID: 34296648
Primary treatment of childhood acute lymphoblastic leukemia of non-T cell lineage (including infants).
Gaynon PS
Hematol Oncol Clin North Am 1990 Oct;4(5):915-36. PMID: 2262485

Recent clinical studies

Etiology

Translocation t(1;19) in acute precursor B-cell lymphoblastic Leukaemia in paediatric patients- Pakistani population.
Rehman P, Qazi R, Hammad-Ur-Rehman M
J Pak Med Assoc 2022 Sep;72(9):1736-1739. doi: 10.47391/JPMA.3591. PMID: 36280966
Pediatric acute lymphoblastic leukemia with t(1;19)/TCF3-PBX1 in Taiwan.
Yen HJ, Chen SH, Chang TY, Yang CP, Lin DT, Hung IJ, Lin KH, Chen JS, Hsiao CC, Chang TT, Chang TK, Peng CT, Lin MT, Jaing TH, Liu HC, Jou ST, Lu MY, Cheng CN, Sheen JM, Chiou SS, Hung GY, Wu KH, Yeh TC, Wang SC, Chen RL, Chang HH, Yang YL, Chen SH, Cheng SN, Chang YH, Chen BW, Hsieh YL, Huang FL, Ho WL, Wang JL, Chang CY, Chao YH, Lin PC, Chen YC, Liao YM, Lin TH, Shih LY, Liang DC
Pediatr Blood Cancer 2017 Oct;64(10) Epub 2017 Apr 24 doi: 10.1002/pbc.26557. PMID: 28436581
Acute lymphoblastic leukaemia.
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694
Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia.
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diáz MG, Malec M, Langerak AW, San Miguel JF, Biondi A
Leukemia 1999 Dec;13(12):1901-28. doi: 10.1038/sj.leu.2401592. PMID: 10602411

Diagnosis

Translocation t(1;19) in acute precursor B-cell lymphoblastic Leukaemia in paediatric patients- Pakistani population.
Rehman P, Qazi R, Hammad-Ur-Rehman M
J Pak Med Assoc 2022 Sep;72(9):1736-1739. doi: 10.47391/JPMA.3591. PMID: 36280966
Myelodysplastic Syndrome with t(1;14),t(1;17),t(1;19) Transforms to AML-M5: A Case Report and Literature Review.
Zhang H, Li G, Chang J, Wang H
Ann Clin Lab Sci 2020 May;50(3):401-403. PMID: 32581034
Acute lymphoblastic leukaemia.
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694
Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia.
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diáz MG, Malec M, Langerak AW, San Miguel JF, Biondi A
Leukemia 1999 Dec;13(12):1901-28. doi: 10.1038/sj.leu.2401592. PMID: 10602411

Therapy

Effectiveness of acceptance and commitment therapy on weight, eating behaviours and psychological outcomes: a systematic review and meta-analysis.
Chew HSJ, Chng S, Rajasegaran NN, Choy KH, Chong YY
Eat Weight Disord 2023 Feb 10;28(1):6. doi: 10.1007/s40519-023-01535-6. PMID: 36763199Free PMC Article
Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.
Watanabe A, Inukai T, Kagami K, Abe M, Takagi M, Fukushima T, Fukushima H, Nanmoku T, Terui K, Ito T, Toki T, Ito E, Fujimura J, Goto H, Endo M, Look T, Kamps M, Minegishi M, Takita J, Inaba T, Takahashi H, Ohara A, Harama D, Shinohara T, Somazu S, Oshiro H, Akahane K, Goi K, Sugita K
Cancer Med 2019 Sep;8(11):5274-5288. Epub 2019 Jul 15 doi: 10.1002/cam4.2356. PMID: 31305009Free PMC Article
Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL.
Chow M, Gao L, MacManiman JD, Bicocca VT, Chang BH, Alumkal JJ, Tyner JW
Oncogene 2018 Sep;37(38):5221-5232. Epub 2018 May 30 doi: 10.1038/s41388-018-0299-8. PMID: 29849118Free PMC Article
Pediatric acute lymphoblastic leukemia with t(1;19)/TCF3-PBX1 in Taiwan.
Yen HJ, Chen SH, Chang TY, Yang CP, Lin DT, Hung IJ, Lin KH, Chen JS, Hsiao CC, Chang TT, Chang TK, Peng CT, Lin MT, Jaing TH, Liu HC, Jou ST, Lu MY, Cheng CN, Sheen JM, Chiou SS, Hung GY, Wu KH, Yeh TC, Wang SC, Chen RL, Chang HH, Yang YL, Chen SH, Cheng SN, Chang YH, Chen BW, Hsieh YL, Huang FL, Ho WL, Wang JL, Chang CY, Chao YH, Lin PC, Chen YC, Liao YM, Lin TH, Shih LY, Liang DC
Pediatr Blood Cancer 2017 Oct;64(10) Epub 2017 Apr 24 doi: 10.1002/pbc.26557. PMID: 28436581
Prognostic impact of t(1;19)/ TCF3-PBX1 in childhood acute lymphoblastic leukemia in the context of Berlin-Frankfurt-Münster-based protocols.
Felice MS, Gallego MS, Alonso CN, Alfaro EM, Guitter MR, Bernasconi AR, Rubio PL, Zubizarreta PA, Rossi JG
Leuk Lymphoma 2011 Jul;52(7):1215-21. Epub 2011 May 3 doi: 10.3109/10428194.2011.565436. PMID: 21534874

Prognosis

Translocation t(1;19)(q23;p13) in adult acute lymphoblastic leukemia - a distinct subtype with favorable prognosis.
Yilmaz M, Kantarjian HM, Toruner G, Yin CC, Kanagal-Shamanna R, Cortes JE, Issa G, Short NJ, Khoury JD, Garcia-Manero G, Ravandi F, Kadia T, Konopleva M, Wierda WG, Jain N, Estrov Z, Sasaki K, Pierce S, O'Brien SM, Jabbour EJ
Leuk Lymphoma 2021 Jan;62(1):224-228. Epub 2020 Sep 21 doi: 10.1080/10428194.2020.1824071. PMID: 32955970
Myelodysplastic Syndrome with t(1;14),t(1;17),t(1;19) Transforms to AML-M5: A Case Report and Literature Review.
Zhang H, Li G, Chang J, Wang H
Ann Clin Lab Sci 2020 May;50(3):401-403. PMID: 32581034
Pediatric acute lymphoblastic leukemia with t(1;19)/TCF3-PBX1 in Taiwan.
Yen HJ, Chen SH, Chang TY, Yang CP, Lin DT, Hung IJ, Lin KH, Chen JS, Hsiao CC, Chang TT, Chang TK, Peng CT, Lin MT, Jaing TH, Liu HC, Jou ST, Lu MY, Cheng CN, Sheen JM, Chiou SS, Hung GY, Wu KH, Yeh TC, Wang SC, Chen RL, Chang HH, Yang YL, Chen SH, Cheng SN, Chang YH, Chen BW, Hsieh YL, Huang FL, Ho WL, Wang JL, Chang CY, Chao YH, Lin PC, Chen YC, Liao YM, Lin TH, Shih LY, Liang DC
Pediatr Blood Cancer 2017 Oct;64(10) Epub 2017 Apr 24 doi: 10.1002/pbc.26557. PMID: 28436581
Acute lymphoblastic leukaemia.
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694

Clinical prediction guides

Oligodendrogliomas: new insights from the genetics and perspectives.
Alentorn A, Sanson M, Idbaih A
Curr Opin Oncol 2012 Nov;24(6):687-93. doi: 10.1097/CCO.0b013e328357f4ea. PMID: 22913971
NOTCH2 is neither rearranged nor mutated in t(1;19) positive oligodendrogliomas.
Benetkiewicz M, Idbaih A, Cousin PY, Boisselier B, Marie Y, Crinière E, Hoang-Xuan K, Delattre JY, Sanson M, Delattre O
PLoS One 2009;4(1):e4107. Epub 2009 Jan 1 doi: 10.1371/journal.pone.0004107. PMID: 19119320Free PMC Article
Interphase cytogenetics for 1p19q and t(1;19)(q10;p10) may distinguish prognostically relevant subgroups in extraventricular neurocytoma.
Rodriguez FJ, Mota RA, Scheithauer BW, Giannini C, Blair H, New KC, Wu KJ, Dickson DW, Jenkins RB
Brain Pathol 2009 Oct;19(4):623-9. Epub 2008 Aug 15 doi: 10.1111/j.1750-3639.2008.00206.x. PMID: 18710393Free PMC Article
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694
A classification of acute leukaemia for the 1990s.
Catovsky D, Matutes E, Buccheri V, Shetty V, Hanslip J, Yoshida N, Morilla R
Ann Hematol 1991 Feb;62(1):16-21. doi: 10.1007/BF01714978. PMID: 2031964

Recent systematic reviews

Effectiveness of acceptance and commitment therapy on weight, eating behaviours and psychological outcomes: a systematic review and meta-analysis.
Chew HSJ, Chng S, Rajasegaran NN, Choy KH, Chong YY
Eat Weight Disord 2023 Feb 10;28(1):6. doi: 10.1007/s40519-023-01535-6. PMID: 36763199Free PMC Article

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