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t(16;16)

MedGen UID:
925477
•Concept ID:
C4287945
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that involves a translocation occurring within chromosome 16. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(16;16)

Professional guidelines

PubMed

Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management.
Rajkumar SV
Am J Hematol 2024 Sep;99(9):1802-1824. Epub 2024 Jun 28 doi: 10.1002/ajh.27422. PMID: 38943315Free PMC Article
Multiple myeloma: 2022 update on diagnosis, risk stratification, and management.
Rajkumar SV
Am J Hematol 2022 Aug;97(8):1086-1107. Epub 2022 May 23 doi: 10.1002/ajh.26590. PMID: 35560063Free PMC Article
Diagnosis and Management of Multiple Myeloma: A Review.
Cowan AJ, Green DJ, Kwok M, Lee S, Coffey DG, Holmberg LA, Tuazon S, Gopal AK, Libby EN
JAMA 2022 Feb 1;327(5):464-477. doi: 10.1001/jama.2022.0003. PMID: 35103762

Recent clinical studies

Etiology

AML with inv(16)/t(16;16) and high-risk cytogenetic abnormalities: atypical features and unfavorable outcome.
Assaf N, Lefebvre C, Raggueneau V, Guignedoux G, Marceau-Renaut A, Chevalier S, Tondeur S, Bories D, Benramdane R, Rousselot P, Terré C
Hematology 2022 Dec;27(1):636-641. doi: 10.1080/16078454.2022.2078027. PMID: 35622005
Comprehensive Mutation Profile in Acute Myeloid Leukemia Patients with RUNX1-RUNX1T1 or CBFB-MYH11 Fusions.
Qin W, Chen X, Shen HJ, Wang Z, Cai X, Jiang N, Hua H
Turk J Haematol 2022 Jun 1;39(2):84-93. Epub 2022 Apr 21 doi: 10.4274/tjh.galenos.2022.2021.0641. PMID: 35445594Free PMC Article
Core binding factor acute myelogenous leukemia-2021 treatment algorithm.
Borthakur G, Kantarjian H
Blood Cancer J 2021 Jun 16;11(6):114. doi: 10.1038/s41408-021-00503-6. PMID: 34135311Free PMC Article
Core-binding factor acute myeloid leukemia.
Sangle NA, Perkins SL
Arch Pathol Lab Med 2011 Nov;135(11):1504-9. doi: 10.5858/arpa.2010-0482-RS. PMID: 22032582
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Diagnosis

AML with inv(16)/t(16;16) and high-risk cytogenetic abnormalities: atypical features and unfavorable outcome.
Assaf N, Lefebvre C, Raggueneau V, Guignedoux G, Marceau-Renaut A, Chevalier S, Tondeur S, Bories D, Benramdane R, Rousselot P, Terré C
Hematology 2022 Dec;27(1):636-641. doi: 10.1080/16078454.2022.2078027. PMID: 35622005
Measurable residual disease testing for personalized treatment of acute myeloid leukemia.
Ehinger M, Pettersson L
APMIS 2019 May;127(5):337-351. Epub 2019 Mar 28 doi: 10.1111/apm.12926. PMID: 30919505
Emerging diagnostic and therapeutic approaches in core binding factor acute myeloid leukaemia.
Ustun C, Marcucci G
Curr Opin Hematol 2015 Mar;22(2):85-91. doi: 10.1097/MOH.0000000000000124. PMID: 25635758
Core-binding factor acute myeloid leukemia.
Sangle NA, Perkins SL
Arch Pathol Lab Med 2011 Nov;135(11):1504-9. doi: 10.5858/arpa.2010-0482-RS. PMID: 22032582
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Therapy

Core binding factor acute myelogenous leukemia-2021 treatment algorithm.
Borthakur G, Kantarjian H
Blood Cancer J 2021 Jun 16;11(6):114. doi: 10.1038/s41408-021-00503-6. PMID: 34135311Free PMC Article
Biomarkers of Gemtuzumab Ozogamicin Response for Acute Myeloid Leukemia Treatment.
Fenwarth L, Fournier E, Cheok M, Boyer T, Gonzales F, Castaigne S, Boissel N, Lambert J, Dombret H, Preudhomme C, Duployez N
Int J Mol Sci 2020 Aug 6;21(16) doi: 10.3390/ijms21165626. PMID: 32781546Free PMC Article
Hippocampal volume and vasculature before and after exercise in treatment-resistant schizophrenia.
Woodward ML, Gicas KM, Warburton DE, White RF, Rauscher A, Leonova O, Su W, Smith GN, Thornton AE, Vertinsky AT, Phillips AA, Goghari VM, Honer WG, Lang DJ
Schizophr Res 2018 Dec;202:158-165. Epub 2018 Jun 29 doi: 10.1016/j.schres.2018.06.054. PMID: 30539767
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Prognosis of inv(16)/t(16;16) acute myeloid leukemia (AML): a survey of 110 cases from the French AML Intergroup.
Delaunay J, Vey N, Leblanc T, Fenaux P, Rigal-Huguet F, Witz F, Lamy T, Auvrignon A, Blaise D, Pigneux A, Mugneret F, Bastard C, Dastugue N, Van den Akker J, Fière D, Reiffers J, Castaigne S, Leverger G, Harousseau JL, Dombret H; French Acute Myeloid Leukemia Intergroup; Groupe Ouest-Est des Leucémies Aiguës Myéoblastiques; Leucémies Aiguës Myéoblastiques de l'Enfant; Acute Leukemia French Association; Bordeaux-Grenoble-Marseille-Toulouse cooperative groups
Blood 2003 Jul 15;102(2):462-9. Epub 2003 Mar 20 doi: 10.1182/blood-2002-11-3527. PMID: 12649129

Prognosis

AML with inv(16)/t(16;16) and high-risk cytogenetic abnormalities: atypical features and unfavorable outcome.
Assaf N, Lefebvre C, Raggueneau V, Guignedoux G, Marceau-Renaut A, Chevalier S, Tondeur S, Bories D, Benramdane R, Rousselot P, Terré C
Hematology 2022 Dec;27(1):636-641. doi: 10.1080/16078454.2022.2078027. PMID: 35622005
Core binding factor acute myelogenous leukemia-2021 treatment algorithm.
Borthakur G, Kantarjian H
Blood Cancer J 2021 Jun 16;11(6):114. doi: 10.1038/s41408-021-00503-6. PMID: 34135311Free PMC Article
Measurable residual disease testing for personalized treatment of acute myeloid leukemia.
Ehinger M, Pettersson L
APMIS 2019 May;127(5):337-351. Epub 2019 Mar 28 doi: 10.1111/apm.12926. PMID: 30919505
Core-binding factor acute myeloid leukemia.
Sangle NA, Perkins SL
Arch Pathol Lab Med 2011 Nov;135(11):1504-9. doi: 10.5858/arpa.2010-0482-RS. PMID: 22032582
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Clinical prediction guides

Comprehensive Mutation Profile in Acute Myeloid Leukemia Patients with RUNX1-RUNX1T1 or CBFB-MYH11 Fusions.
Qin W, Chen X, Shen HJ, Wang Z, Cai X, Jiang N, Hua H
Turk J Haematol 2022 Jun 1;39(2):84-93. Epub 2022 Apr 21 doi: 10.4274/tjh.galenos.2022.2021.0641. PMID: 35445594Free PMC Article
Biomarkers of Gemtuzumab Ozogamicin Response for Acute Myeloid Leukemia Treatment.
Fenwarth L, Fournier E, Cheok M, Boyer T, Gonzales F, Castaigne S, Boissel N, Lambert J, Dombret H, Preudhomme C, Duployez N
Int J Mol Sci 2020 Aug 6;21(16) doi: 10.3390/ijms21165626. PMID: 32781546Free PMC Article
Emerging diagnostic and therapeutic approaches in core binding factor acute myeloid leukaemia.
Ustun C, Marcucci G
Curr Opin Hematol 2015 Mar;22(2):85-91. doi: 10.1097/MOH.0000000000000124. PMID: 25635758
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Prognosis of inv(16)/t(16;16) acute myeloid leukemia (AML): a survey of 110 cases from the French AML Intergroup.
Delaunay J, Vey N, Leblanc T, Fenaux P, Rigal-Huguet F, Witz F, Lamy T, Auvrignon A, Blaise D, Pigneux A, Mugneret F, Bastard C, Dastugue N, Van den Akker J, Fière D, Reiffers J, Castaigne S, Leverger G, Harousseau JL, Dombret H; French Acute Myeloid Leukemia Intergroup; Groupe Ouest-Est des Leucémies Aiguës Myéoblastiques; Leucémies Aiguës Myéoblastiques de l'Enfant; Acute Leukemia French Association; Bordeaux-Grenoble-Marseille-Toulouse cooperative groups
Blood 2003 Jul 15;102(2):462-9. Epub 2003 Mar 20 doi: 10.1182/blood-2002-11-3527. PMID: 12649129

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