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t(15;17)

MedGen UID:
925478
•Concept ID:
C4287946
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that involves a translocation between chromosomes 15 and 17. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(15;17)

Professional guidelines

PubMed

Drug treatment options for acute promyelocytic leukemia.
Ferrara F, Molica M, Bernardi M
Expert Opin Pharmacother 2022 Jan;23(1):117-127. Epub 2021 Aug 5 doi: 10.1080/14656566.2021.1961744. PMID: 34348549
Acute Promyelocytic Leukemia: Update on Risk Stratification and Treatment Practices.
Salhotra A, Mei M
Cancer Treat Res 2021;181:45-55. doi: 10.1007/978-3-030-78311-2_3. PMID: 34626354
Acute promyelocytic leukemia current treatment algorithms.
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article

Recent clinical studies

Etiology

Acute Promyelocytic Leukemia: Update on Risk Stratification and Treatment Practices.
Salhotra A, Mei M
Cancer Treat Res 2021;181:45-55. doi: 10.1007/978-3-030-78311-2_3. PMID: 34626354
10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial.
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694
Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia.
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diáz MG, Malec M, Langerak AW, San Miguel JF, Biondi A
Leukemia 1999 Dec;13(12):1901-28. doi: 10.1038/sj.leu.2401592. PMID: 10602411

Diagnosis

Acute Promyelocytic Leukemia: Update on Risk Stratification and Treatment Practices.
Salhotra A, Mei M
Cancer Treat Res 2021;181:45-55. doi: 10.1007/978-3-030-78311-2_3. PMID: 34626354
Acute promyelocytic leukemia current treatment algorithms.
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694
Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia.
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diáz MG, Malec M, Langerak AW, San Miguel JF, Biondi A
Leukemia 1999 Dec;13(12):1901-28. doi: 10.1038/sj.leu.2401592. PMID: 10602411

Therapy

Acute promyelocytic leukemia current treatment algorithms.
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial.
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Therapy-related myeloid leukemia.
Thirman MJ, Larson RA
Hematol Oncol Clin North Am 1996 Apr;10(2):293-320. doi: 10.1016/s0889-8588(05)70340-3. PMID: 8707757
Acute promyelocytic leukaemia and the t(15;17) translocation.
Gillard EF, Solomon E
Semin Cancer Biol 1993 Dec;4(6):359-67. PMID: 8142621

Prognosis

Mast cell neoplasm: a challenging pathological diagnosis.
Natal RA, Carneiro HC, de Carvalho Barra FF, Pagnano KBB, Soares FA, Vassallo J
Hum Pathol 2022 Aug;126:55-62. Epub 2022 May 10 doi: 10.1016/j.humpath.2022.05.007. PMID: 35550832
Acute promyelocytic leukemia current treatment algorithms.
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
Biomarkers of Gemtuzumab Ozogamicin Response for Acute Myeloid Leukemia Treatment.
Fenwarth L, Fournier E, Cheok M, Boyer T, Gonzales F, Castaigne S, Boissel N, Lambert J, Dombret H, Preudhomme C, Duployez N
Int J Mol Sci 2020 Aug 6;21(16) doi: 10.3390/ijms21165626. PMID: 32781546Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694

Clinical prediction guides

Biomarkers of Gemtuzumab Ozogamicin Response for Acute Myeloid Leukemia Treatment.
Fenwarth L, Fournier E, Cheok M, Boyer T, Gonzales F, Castaigne S, Boissel N, Lambert J, Dombret H, Preudhomme C, Duployez N
Int J Mol Sci 2020 Aug 6;21(16) doi: 10.3390/ijms21165626. PMID: 32781546Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Identification of parental chromosomes involved in translocations BCR-ABL, t(9;22) and PML-RARA, t(15;17).
Chaudhuri JP, Karamanov S, Paulraj P, McGill JR, Walther J
Anticancer Res 2008 Nov-Dec;28(6A):3573-8. PMID: 19189637
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694
Chromosomal abnormalities and oncogenes.
Mitani K
Int J Hematol 1996 Feb;63(2):81-93. doi: 10.1016/0925-5710(96)00440-9. PMID: 8867720

Recent systematic reviews

Therapy-related acute promyelocytic leukemia: a systematic review.
Rashidi A, Fisher SI
Med Oncol 2013;30(3):625. Epub 2013 Jun 15 doi: 10.1007/s12032-013-0625-5. PMID: 23771799

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