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t(15;17)

MedGen UID:
925478
•Concept ID:
C4287946
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that involves a translocation between chromosomes 15 and 17. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(15;17)

Professional guidelines

PubMed

Drug treatment options for acute promyelocytic leukemia.
Ferrara F, Molica M, Bernardi M
Expert Opin Pharmacother 2022 Jan;23(1):117-127. Epub 2021 Aug 5 doi: 10.1080/14656566.2021.1961744. PMID: 34348549
Acute Promyelocytic Leukemia: Update on Risk Stratification and Treatment Practices.
Salhotra A, Mei M
Cancer Treat Res 2021;181:45-55. doi: 10.1007/978-3-030-78311-2_3. PMID: 34626354
Acute promyelocytic leukemia current treatment algorithms.
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article

Recent clinical studies

Etiology

How retinoic acid and arsenic transformed acute promyelocytic leukemia therapy.
Korsos V, Miller WH Jr
J Mol Endocrinol 2022 Nov 1;69(4):T69-T83. Epub 2022 Oct 11 doi: 10.1530/JME-22-0141. PMID: 36112505
Acute Promyelocytic Leukemia: Update on Risk Stratification and Treatment Practices.
Salhotra A, Mei M
Cancer Treat Res 2021;181:45-55. doi: 10.1007/978-3-030-78311-2_3. PMID: 34626354
10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial.
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
What is the role of arsenic in newly diagnosed APL?
Tallman MS
Best Pract Res Clin Haematol 2008 Dec;21(4):659-66. doi: 10.1016/j.beha.2008.09.002. PMID: 19041605

Diagnosis

t(15;17) in acute promyelocytc leukemia.
Ling VY, Lane SW
Haematologica 2023 Feb 1;108(2):295-296. doi: 10.3324/haematol.2022.282577. PMID: 36722400Free PMC Article
Acute Promyelocytic Leukemia: Update on Risk Stratification and Treatment Practices.
Salhotra A, Mei M
Cancer Treat Res 2021;181:45-55. doi: 10.1007/978-3-030-78311-2_3. PMID: 34626354
Acute promyelocytic leukemia current treatment algorithms.
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
Therapy-Related Myeloid Neoplasms.
Bueso-Ramos CE, Kanagal-Shamanna R, Routbort MJ, Hanson CA
Am J Clin Pathol 2015 Aug;144(2):207-18. doi: 10.1309/AJCPU1JO2LYTWUAV. PMID: 26185306
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Therapy

Acute promyelocytic leukemia current treatment algorithms.
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial.
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Topoisomerase II and leukemia.
Pendleton M, Lindsey RH Jr, Felix CA, Grimwade D, Osheroff N
Ann N Y Acad Sci 2014 Mar;1310(1):98-110. Epub 2014 Feb 3 doi: 10.1111/nyas.12358. PMID: 24495080Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Therapy-related myeloid leukemia.
Thirman MJ, Larson RA
Hematol Oncol Clin North Am 1996 Apr;10(2):293-320. doi: 10.1016/s0889-8588(05)70340-3. PMID: 8707757

Prognosis

Prognosis influence of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia with t(15;17)(q24;q21).
Liu L, Wang J, Xu H, Zhao S, Wang L, Huang J, Wang H, Tong H, Jin J
Hematology 2024 Dec;29(1):2293513. Epub 2023 Dec 27 doi: 10.1080/16078454.2023.2293513. PMID: 38149662
Acute promyelocytic leukemia current treatment algorithms.
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
Biomarkers of Gemtuzumab Ozogamicin Response for Acute Myeloid Leukemia Treatment.
Fenwarth L, Fournier E, Cheok M, Boyer T, Gonzales F, Castaigne S, Boissel N, Lambert J, Dombret H, Preudhomme C, Duployez N
Int J Mol Sci 2020 Aug 6;21(16) doi: 10.3390/ijms21165626. PMID: 32781546Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Chromosome changes in hematologic malignancies.
Larson RA, Golomb HM, Rowley JD
CA Cancer J Clin 1981 Jul-Aug;31(4):222-38. doi: 10.3322/canjclin.31.4.222. PMID: 6796217

Clinical prediction guides

A complex t(15;22;17)(q22;q11.2;q21) variant of APL.
Ak B, Güngör Ö, Karaca E, Durmaz B, Bozer DS, Töbü M, Akın H
Cancer Genet 2024 Aug;286-287:48-51. Epub 2024 Jul 24 doi: 10.1016/j.cancergen.2024.07.003. PMID: 39111247
Biomarkers of Gemtuzumab Ozogamicin Response for Acute Myeloid Leukemia Treatment.
Fenwarth L, Fournier E, Cheok M, Boyer T, Gonzales F, Castaigne S, Boissel N, Lambert J, Dombret H, Preudhomme C, Duployez N
Int J Mol Sci 2020 Aug 6;21(16) doi: 10.3390/ijms21165626. PMID: 32781546Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Chromosomal abnormalities and oncogenes.
Mitani K
Int J Hematol 1996 Feb;63(2):81-93. doi: 10.1016/0925-5710(96)00440-9. PMID: 8867720
Acute promyelocytic leukemia.
Kingsley EC, Durie BG, Garewal HS
West J Med 1987 Mar;146(3):322-7. PMID: 3472414Free PMC Article

Recent systematic reviews

Therapy-related acute promyelocytic leukemia: a systematic review.
Rashidi A, Fisher SI
Med Oncol 2013;30(3):625. Epub 2013 Jun 15 doi: 10.1007/s12032-013-0625-5. PMID: 23771799

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