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t(15;17)

MedGen UID:
925478
Concept ID:
C4287946
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that involves a translocation between chromosomes 15 and 17. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(15;17)

Professional guidelines

PubMed

Ferrara F, Molica M, Bernardi M
Expert Opin Pharmacother 2022 Jan;23(1):117-127. Epub 2021 Aug 5 doi: 10.1080/14656566.2021.1961744. PMID: 34348549
Salhotra A, Mei M
Cancer Treat Res 2021;181:45-55. doi: 10.1007/978-3-030-78311-2_3. PMID: 34626354
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article

Recent clinical studies

Etiology

Natal RA, Carneiro HC, de Carvalho Barra FF, Pagnano KBB, Soares FA, Vassallo J
Hum Pathol 2022 Aug;126:55-62. Epub 2022 May 10 doi: 10.1016/j.humpath.2022.05.007. PMID: 35550832
Salhotra A, Mei M
Cancer Treat Res 2021;181:45-55. doi: 10.1007/978-3-030-78311-2_3. PMID: 34626354
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diáz MG, Malec M, Langerak AW, San Miguel JF, Biondi A
Leukemia 1999 Dec;13(12):1901-28. doi: 10.1038/sj.leu.2401592. PMID: 10602411

Diagnosis

Ling VY, Lane SW
Haematologica 2023 Feb 1;108(2):295-296. doi: 10.3324/haematol.2022.282577. PMID: 36722400Free PMC Article
Salhotra A, Mei M
Cancer Treat Res 2021;181:45-55. doi: 10.1007/978-3-030-78311-2_3. PMID: 34626354
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diáz MG, Malec M, Langerak AW, San Miguel JF, Biondi A
Leukemia 1999 Dec;13(12):1901-28. doi: 10.1038/sj.leu.2401592. PMID: 10602411

Therapy

Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Thirman MJ, Larson RA
Hematol Oncol Clin North Am 1996 Apr;10(2):293-320. doi: 10.1016/s0889-8588(05)70340-3. PMID: 8707757
Gillard EF, Solomon E
Semin Cancer Biol 1993 Dec;4(6):359-67. PMID: 8142621

Prognosis

Liu L, Wang J, Xu H, Zhao S, Wang L, Huang J, Wang H, Tong H, Jin J
Hematology 2024 Dec;29(1):2293513. Epub 2023 Dec 27 doi: 10.1080/16078454.2023.2293513. PMID: 38149662
Natal RA, Carneiro HC, de Carvalho Barra FF, Pagnano KBB, Soares FA, Vassallo J
Hum Pathol 2022 Aug;126:55-62. Epub 2022 May 10 doi: 10.1016/j.humpath.2022.05.007. PMID: 35550832
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Mirro J Jr
Leukemia 1992 Nov;6 Suppl 4:13-5. PMID: 1434816

Clinical prediction guides

Liu L, Wang J, Xu H, Zhao S, Wang L, Huang J, Wang H, Tong H, Jin J
Hematology 2024 Dec;29(1):2293513. Epub 2023 Dec 27 doi: 10.1080/16078454.2023.2293513. PMID: 38149662
Eckardt JN, Schmittmann T, Riechert S, Kramer M, Sulaiman AS, Sockel K, Kroschinsky F, Schetelig J, Wagenführ L, Schuler U, Platzbecker U, Thiede C, Stölzel F, Röllig C, Bornhäuser M, Wendt K, Middeke JM
BMC Cancer 2022 Feb 22;22(1):201. doi: 10.1186/s12885-022-09307-8. PMID: 35193533Free PMC Article
Fenwarth L, Fournier E, Cheok M, Boyer T, Gonzales F, Castaigne S, Boissel N, Lambert J, Dombret H, Preudhomme C, Duployez N
Int J Mol Sci 2020 Aug 6;21(16) doi: 10.3390/ijms21165626. PMID: 32781546Free PMC Article
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Mitani K
Int J Hematol 1996 Feb;63(2):81-93. doi: 10.1016/0925-5710(96)00440-9. PMID: 8867720

Recent systematic reviews

Rashidi A, Fisher SI
Med Oncol 2013;30(3):625. Epub 2013 Jun 15 doi: 10.1007/s12032-013-0625-5. PMID: 23771799

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