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t(12;21)

MedGen UID:
925480
Concept ID:
C4287948
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that involves a translocation between chromosomes 12 and 21. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(12;21)

Professional guidelines

PubMed

Yuan H, Zhu X, Tang W, Cai Y, Shi S, Luo Q
J Affect Disord 2020 Jan 1;260:490-497. Epub 2019 Sep 9 doi: 10.1016/j.jad.2019.09.041. PMID: 31539685
Chessells JM, Harrison G, Richards SM, Bailey CC, Hill FG, Gibson BE, Hann IM
Arch Dis Child 2001 Oct;85(4):321-5. doi: 10.1136/adc.85.4.321. PMID: 11567943Free PMC Article
Berman E
Curr Opin Hematol 1997 Jul;4(4):256-60. doi: 10.1097/00062752-199704040-00006. PMID: 9260053

Recent clinical studies

Etiology

Malouf C, Ottersbach K
Cell Mol Life Sci 2018 Feb;75(3):417-446. Epub 2017 Aug 17 doi: 10.1007/s00018-017-2620-z. PMID: 28819864Free PMC Article
Ford AM, Greaves M
Adv Exp Med Biol 2017;962:217-228. doi: 10.1007/978-981-10-3233-2_14. PMID: 28299660
Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA
Toxicol Appl Pharmacol 2005 Aug 7;206(2):237-45. doi: 10.1016/j.taap.2004.11.026. PMID: 15967214
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diáz MG, Malec M, Langerak AW, San Miguel JF, Biondi A
Leukemia 1999 Dec;13(12):1901-28. doi: 10.1038/sj.leu.2401592. PMID: 10602411

Diagnosis

Malouf C, Ottersbach K
Cell Mol Life Sci 2018 Feb;75(3):417-446. Epub 2017 Aug 17 doi: 10.1007/s00018-017-2620-z. PMID: 28819864Free PMC Article
Ford AM, Greaves M
Adv Exp Med Biol 2017;962:217-228. doi: 10.1007/978-981-10-3233-2_14. PMID: 28299660
Sawińska M, Ładoń D
Leuk Res 2004 Jan;28(1):35-42. doi: 10.1016/s0145-2126(03)00160-7. PMID: 14630078
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diáz MG, Malec M, Langerak AW, San Miguel JF, Biondi A
Leukemia 1999 Dec;13(12):1901-28. doi: 10.1038/sj.leu.2401592. PMID: 10602411

Therapy

Kjeldsen E
Exp Mol Pathol 2016 Aug;101(1):38-43. Epub 2016 May 20 doi: 10.1016/j.yexmp.2016.05.010. PMID: 27215399
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Veiga LB, Cóser VM, Cavalli LR, Cavalli IJ, Rodrigues JN, Pereira WV, Pereira DV, Lafayette TC, Villalba BT, Moreira ME, Haddad BR, de Souza Fonseca Ribeiro EM
Leuk Res 2004 Oct;28(10):1033-8. doi: 10.1016/j.leukres.2004.02.004. PMID: 15289014
Stams WA, den Boer ML, Beverloo HB, Meijerink JP, Stigter RL, van Wering ER, Janka-Schaub GE, Slater R, Pieters R
Blood 2003 Apr 1;101(7):2743-7. Epub 2002 Nov 14 doi: 10.1182/blood-2002-08-2446. PMID: 12433682
Matherly LH, Taub JW
Leuk Lymphoma 1999 Sep;35(1-2):1-20. doi: 10.3109/10428199909145701. PMID: 10512159

Prognosis

Malouf C, Ottersbach K
Cell Mol Life Sci 2018 Feb;75(3):417-446. Epub 2017 Aug 17 doi: 10.1007/s00018-017-2620-z. PMID: 28819864Free PMC Article
Ford AM, Greaves M
Adv Exp Med Biol 2017;962:217-228. doi: 10.1007/978-981-10-3233-2_14. PMID: 28299660
Sawińska M, Ładoń D
Leuk Res 2004 Jan;28(1):35-42. doi: 10.1016/s0145-2126(03)00160-7. PMID: 14630078
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871
Kobayashi H, Satake N, Kaneko Y
Leuk Lymphoma 1997 Dec;28(1-2):43-50. doi: 10.3109/10428199709058329. PMID: 9498702

Clinical prediction guides

Ford AM, Greaves M
Adv Exp Med Biol 2017;962:217-228. doi: 10.1007/978-981-10-3233-2_14. PMID: 28299660
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Sawińska M, Ładoń D
Leuk Res 2004 Jan;28(1):35-42. doi: 10.1016/s0145-2126(03)00160-7. PMID: 14630078
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694
Kobayashi H, Satake N, Kaneko Y
Leuk Lymphoma 1997 Dec;28(1-2):43-50. doi: 10.3109/10428199709058329. PMID: 9498702

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