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t(12;21)

MedGen UID:
925480
•Concept ID:
C4287948
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that involves a translocation between chromosomes 12 and 21. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(12;21)

Professional guidelines

PubMed

Connectivity between the anterior insula and dorsolateral prefrontal cortex links early symptom improvement to treatment response.
Yuan H, Zhu X, Tang W, Cai Y, Shi S, Luo Q
J Affect Disord 2020 Jan 1;260:490-497. Epub 2019 Sep 9 doi: 10.1016/j.jad.2019.09.041. PMID: 31539685
Down's syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment.
Chessells JM, Harrison G, Richards SM, Bailey CC, Hill FG, Gibson BE, Hann IM
Arch Dis Child 2001 Oct;85(4):321-5. doi: 10.1136/adc.85.4.321. PMID: 11567943Free PMC Article
Recent advances in the treatment of acute leukemia.
Berman E
Curr Opin Hematol 1997 Jul;4(4):256-60. doi: 10.1097/00062752-199704040-00006. PMID: 9260053

Recent clinical studies

Etiology

The Landscape of Secondary Genetic Rearrangements in Pediatric Patients with B-Cell Acute Lymphoblastic Leukemia with t(12;21).
Kaczmarska A, Derebas J, Pinkosz M, Niedźwiecki M, Lejman M
Cells 2023 Jan 18;12(3) doi: 10.3390/cells12030357. PMID: 36766699Free PMC Article
Molecular processes involved in B cell acute lymphoblastic leukaemia.
Malouf C, Ottersbach K
Cell Mol Life Sci 2018 Feb;75(3):417-446. Epub 2017 Aug 17 doi: 10.1007/s00018-017-2620-z. PMID: 28819864Free PMC Article
ETV6-RUNX1 (+) Acute Lymphoblastic Leukaemia in Identical Twins.
Ford AM, Greaves M
Adv Exp Med Biol 2017;962:217-228. doi: 10.1007/978-981-10-3233-2_14. PMID: 28299660
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Acute lymphoblastic leukaemia.
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871

Diagnosis

Targeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia.
Bwanika HC, Leo IR, Struyf N, Talanti A, Aswad L, Konnur A, Björklund AC, Heyman M, Rassidakis G, Erkers T, Seashore-Ludlow B, Jafari R, Pokrovskaja Tamm K
Sci Rep 2024 Feb 18;14(1):4000. doi: 10.1038/s41598-024-54400-6. PMID: 38369625Free PMC Article
Molecular processes involved in B cell acute lymphoblastic leukaemia.
Malouf C, Ottersbach K
Cell Mol Life Sci 2018 Feb;75(3):417-446. Epub 2017 Aug 17 doi: 10.1007/s00018-017-2620-z. PMID: 28819864Free PMC Article
ETV6-RUNX1 (+) Acute Lymphoblastic Leukaemia in Identical Twins.
Ford AM, Greaves M
Adv Exp Med Biol 2017;962:217-228. doi: 10.1007/978-981-10-3233-2_14. PMID: 28299660
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Leukemia: genetics and prognostic factors.
Hamerschlak N
J Pediatr (Rio J) 2008 Aug;84(4 Suppl):S52-7. doi: 10.2223/JPED.1785. PMID: 18830516

Therapy

Blinatumomab as postremission therapy replaces consolidation and substantial parts of maintenance chemotherapy and results in stable MRD negativity in children with newly diagnosed B-lineage ALL.
Mikhailova E, Popov A, Roumiantseva J, Budanov O, Lagoyko S, Zharikova L, Miakova N, Litvinov D, Khachatryan L, Pshonkin A, Ponomareva N, Boichenko E, Varfolomeeva S, Dinikina J, Novichkova G, Henze G, Karachunskiy A
J Immunother Cancer 2024 Jun 6;12(6) doi: 10.1136/jitc-2023-008213. PMID: 38844406Free PMC Article
Targeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia.
Bwanika HC, Leo IR, Struyf N, Talanti A, Aswad L, Konnur A, Björklund AC, Heyman M, Rassidakis G, Erkers T, Seashore-Ludlow B, Jafari R, Pokrovskaja Tamm K
Sci Rep 2024 Feb 18;14(1):4000. doi: 10.1038/s41598-024-54400-6. PMID: 38369625Free PMC Article
Oligo-based aCGH analysis reveals cryptic unbalanced der(6)t(X;6) in pediatric t(12;21)-positive acute lymphoblastic leukemia.
Kjeldsen E
Exp Mol Pathol 2016 Aug;101(1):38-43. Epub 2016 May 20 doi: 10.1016/j.yexmp.2016.05.010. PMID: 27215399
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Molecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia.
Matherly LH, Taub JW
Leuk Lymphoma 1999 Sep;35(1-2):1-20. doi: 10.3109/10428199909145701. PMID: 10512159

Prognosis

Molecular processes involved in B cell acute lymphoblastic leukaemia.
Malouf C, Ottersbach K
Cell Mol Life Sci 2018 Feb;75(3):417-446. Epub 2017 Aug 17 doi: 10.1007/s00018-017-2620-z. PMID: 28819864Free PMC Article
ETV6-RUNX1 (+) Acute Lymphoblastic Leukaemia in Identical Twins.
Ford AM, Greaves M
Adv Exp Med Biol 2017;962:217-228. doi: 10.1007/978-981-10-3233-2_14. PMID: 28299660
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Leukemia: genetics and prognostic factors.
Hamerschlak N
J Pediatr (Rio J) 2008 Aug;84(4 Suppl):S52-7. doi: 10.2223/JPED.1785. PMID: 18830516
Acute lymphoblastic leukaemia.
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871

Clinical prediction guides

ETV6-RUNX1 (+) Acute Lymphoblastic Leukaemia in Identical Twins.
Ford AM, Greaves M
Adv Exp Med Biol 2017;962:217-228. doi: 10.1007/978-981-10-3233-2_14. PMID: 28299660
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Learning anatomy enhances spatial ability.
Vorstenbosch MA, Klaassen TP, Donders AR, Kooloos JG, Bolhuis SM, Laan RF
Anat Sci Educ 2013 Jul-Aug;6(4):257-62. Epub 2013 Jan 24 doi: 10.1002/ase.1346. PMID: 23349122
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694
Detection of the Der (21)t(12;21) chromosome forming the TEL-AML1 fusion gene in childhood acute lymphoblastic leukemia.
Kobayashi H, Satake N, Kaneko Y
Leuk Lymphoma 1997 Dec;28(1-2):43-50. doi: 10.3109/10428199709058329. PMID: 9498702

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