U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

t(12;21)

MedGen UID:
925480
•Concept ID:
C4287948
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that involves a translocation between chromosomes 12 and 21. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(12;21)

Professional guidelines

PubMed

Connectivity between the anterior insula and dorsolateral prefrontal cortex links early symptom improvement to treatment response.
Yuan H, Zhu X, Tang W, Cai Y, Shi S, Luo Q
J Affect Disord 2020 Jan 1;260:490-497. Epub 2019 Sep 9 doi: 10.1016/j.jad.2019.09.041. PMID: 31539685
Five most common prognostically important fusion oncogenes are detected in the majority of Pakistani pediatric acute lymphoblastic leukemia patients and are strongly associated with disease biology and treatment outcome.
Awan T, Iqbal Z, Aleem A, Sabir N, Absar M, Rasool M, Tahir AH, Basit S, Khalid AM, Sabar MF, Asad S, Ali AS, Mahmood A, Akram M, Saeed T, Saleem A, Mohsin D, Shah IH, Khalid M, Asif M, Haq R, Iqbal M, Akhtar T
Asian Pac J Cancer Prev 2012;13(11):5469-75. doi: 10.7314/apjcp.2012.13.11.5469. PMID: 23317202
Down's syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment.
Chessells JM, Harrison G, Richards SM, Bailey CC, Hill FG, Gibson BE, Hann IM
Arch Dis Child 2001 Oct;85(4):321-5. doi: 10.1136/adc.85.4.321. PMID: 11567943Free PMC Article

Recent clinical studies

Etiology

Molecular processes involved in B cell acute lymphoblastic leukaemia.
Malouf C, Ottersbach K
Cell Mol Life Sci 2018 Feb;75(3):417-446. Epub 2017 Aug 17 doi: 10.1007/s00018-017-2620-z. PMID: 28819864Free PMC Article
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Acute lymphoblastic leukaemia.
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694
Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia.
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diáz MG, Malec M, Langerak AW, San Miguel JF, Biondi A
Leukemia 1999 Dec;13(12):1901-28. doi: 10.1038/sj.leu.2401592. PMID: 10602411

Diagnosis

New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
Sawińska M, Ładoń D
Leuk Res 2004 Jan;28(1):35-42. doi: 10.1016/s0145-2126(03)00160-7. PMID: 14630078
Acute lymphoblastic leukaemia.
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694
Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia.
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diáz MG, Malec M, Langerak AW, San Miguel JF, Biondi A
Leukemia 1999 Dec;13(12):1901-28. doi: 10.1038/sj.leu.2401592. PMID: 10602411

Therapy

Oligo-based aCGH analysis reveals cryptic unbalanced der(6)t(X;6) in pediatric t(12;21)-positive acute lymphoblastic leukemia.
Kjeldsen E
Exp Mol Pathol 2016 Aug;101(1):38-43. Epub 2016 May 20 doi: 10.1016/j.yexmp.2016.05.010. PMID: 27215399
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
High frequency of t(12;21)(p13;q22) in children with acute lymphoblastic leukemia and known clinical outcome in southern Brazil.
Veiga LB, Cóser VM, Cavalli LR, Cavalli IJ, Rodrigues JN, Pereira WV, Pereira DV, Lafayette TC, Villalba BT, Moreira ME, Haddad BR, de Souza Fonseca Ribeiro EM
Leuk Res 2004 Oct;28(10):1033-8. doi: 10.1016/j.leukres.2004.02.004. PMID: 15289014
Post-induction residual disease in translocation t(12;21)-positive childhood ALL.
Seyfarth J, Madsen HO, Nyvold C, Ryder LP, Clausen N, Jonmundsson GK, Wesenberg F, Schmiegelow K
Med Pediatr Oncol 2003 Feb;40(2):82-7. doi: 10.1002/mpo.10217. PMID: 12461790
Sensitivity to L-asparaginase is not associated with expression levels of asparagine synthetase in t(12;21)+ pediatric ALL.
Stams WA, den Boer ML, Beverloo HB, Meijerink JP, Stigter RL, van Wering ER, Janka-Schaub GE, Slater R, Pieters R
Blood 2003 Apr 1;101(7):2743-7. Epub 2002 Nov 14 doi: 10.1182/blood-2002-08-2446. PMID: 12433682

Prognosis

New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
Sawińska M, Ładoń D
Leuk Res 2004 Jan;28(1):35-42. doi: 10.1016/s0145-2126(03)00160-7. PMID: 14630078
Acute lymphoblastic leukaemia.
Harrison CJ
Best Pract Res Clin Haematol 2001 Sep;14(3):593-607. doi: 10.1053/beha.2001.0156. PMID: 11640871
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694
Detection of the Der (21)t(12;21) chromosome forming the TEL-AML1 fusion gene in childhood acute lymphoblastic leukemia.
Kobayashi H, Satake N, Kaneko Y
Leuk Lymphoma 1997 Dec;28(1-2):43-50. doi: 10.3109/10428199709058329. PMID: 9498702

Clinical prediction guides

ETV6-RUNX1 (+) Acute Lymphoblastic Leukaemia in Identical Twins.
Ford AM, Greaves M
Adv Exp Med Biol 2017;962:217-228. doi: 10.1007/978-981-10-3233-2_14. PMID: 28299660
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
Sawińska M, Ładoń D
Leuk Res 2004 Jan;28(1):35-42. doi: 10.1016/s0145-2126(03)00160-7. PMID: 14630078
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694
Detection of the Der (21)t(12;21) chromosome forming the TEL-AML1 fusion gene in childhood acute lymphoblastic leukemia.
Kobayashi H, Satake N, Kaneko Y
Leuk Lymphoma 1997 Dec;28(1-2):43-50. doi: 10.3109/10428199709058329. PMID: 9498702

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...