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t(11;22)

MedGen UID:
925481
Concept ID:
C4287949
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that involves a translocation between chromosomes 11 and 22. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(11;22)

Professional guidelines

PubMed

Piwowarczyk P, Massalska D, Obodzińska I, Gawlik Zawiślak S, Bijok J, Kucińska-Chahwan A, Roszkowski T
J Obstet Gynaecol 2022 Oct;42(7):2615-2620. Epub 2022 Sep 1 doi: 10.1080/01443615.2022.2114331. PMID: 36048922
Hao X, Wu J, Fu W, Zhang R, Zhong S, Deng Y, Zhu Y, Ye Y, Fang Q
Prenat Diagn 2022 Apr;42(4):469-477. Epub 2022 Jan 31 doi: 10.1002/pd.6098. PMID: 35043432
Hendricks A, Boerner K, Germer CT, Wiegering A
Cancer Treat Rev 2021 Feb;93:102140. Epub 2020 Dec 24 doi: 10.1016/j.ctrv.2020.102140. PMID: 33388539

Recent clinical studies

Etiology

Cilio Arroyuelo M, Tenorio-Castano J, García-Moya LF, Parra A, Cazalla M, Gallego N, Miranda L, Mori MÁ, García-Gueretta L, Labrandero C, Mansilla E, Rikeros E, García-Santiago F, Vallcorba I, Arias P, Silván C, Deiros Bronte L, Nevado J, Lapunzina P
Genes (Basel) 2024 Aug 30;15(9) doi: 10.3390/genes15091146. PMID: 39336737Free PMC Article
Zenagui R, Bernicot I, Ranisavljevic N, Haquet E, Ferrieres-Hoa A, Pellestor F, Anahory T
Reprod Biomed Online 2019 Jul;39(1):40-48. Epub 2019 Mar 12 doi: 10.1016/j.rbmo.2019.02.010. PMID: 31097322
Schoemaker MJ, Jones ME, Higgins CD, Wright AF; UK Clinical Cytogenetics Group, Swerdlow AJ
Int J Cancer 2019 Sep 15;145(6):1493-1498. Epub 2019 Jan 11 doi: 10.1002/ijc.32031. PMID: 30496607Free PMC Article
Kurahashi H, Inagaki H, Ohye T, Kogo H, Kato T, Emanuel BS
DNA Repair (Amst) 2006 Sep 8;5(9-10):1136-45. Epub 2006 Jul 10 doi: 10.1016/j.dnarep.2006.05.035. PMID: 16829213Free PMC Article
Biederman BM, Lin CC, Lowry RB, Somerville R
Hum Genet 1980 Feb;53(2):173-7. doi: 10.1007/BF00273491. PMID: 7358384

Diagnosis

Piwowarczyk P, Massalska D, Obodzińska I, Gawlik Zawiślak S, Bijok J, Kucińska-Chahwan A, Roszkowski T
J Obstet Gynaecol 2022 Oct;42(7):2615-2620. Epub 2022 Sep 1 doi: 10.1080/01443615.2022.2114331. PMID: 36048922
Han LM, VandenBussche CJ, Abildtrup M, Chandra A, Vohra P
Acta Cytol 2022;66(4):336-346. Epub 2021 Jul 2 doi: 10.1159/000516497. PMID: 34218227
Gorthi A, Romero JC, Loranc E, Cao L, Lawrence LA, Goodale E, Iniguez AB, Bernard X, Masamsetti VP, Roston S, Lawlor ER, Toretsky JA, Stegmaier K, Lessnick SL, Chen Y, Bishop AJR
Nature 2018 Mar 15;555(7696):387-391. Epub 2018 Mar 7 doi: 10.1038/nature25748. PMID: 29513652Free PMC Article
Zöllner S, Dirksen U, Jürgens H, Ranft A
Ann Oncol 2013 Sep;24(9):2455-61. Epub 2013 Jun 11 doi: 10.1093/annonc/mdt215. PMID: 23761687
Sankar S, Lessnick SL
Cancer Genet 2011 Jul;204(7):351-65. doi: 10.1016/j.cancergen.2011.07.008. PMID: 21872822Free PMC Article

Therapy

Jiao D, Xu K, Liu Y, Li Z, Wang Y, Ren J, Han X
Sci Rep 2022 Oct 14;12(1):17215. doi: 10.1038/s41598-022-22120-4. PMID: 36241689Free PMC Article
Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG
Cell Chem Biol 2022 Aug 18;29(8):1325-1332.e4. Epub 2022 Jul 7 doi: 10.1016/j.chembiol.2022.06.002. PMID: 35803262Free PMC Article
Smith RS, Odintsov I, Liu Z, Lui AJ, Hayashi T, Vojnic M, Suehara Y, Delasos L, Mattar MS, Hmeljak J, Ramirez HA, Shaw M, Bui G, Hartono AB, Gladstone E, Kunte S, Magnan H, Khodos I, De Stanchina E, La Quaglia MP, Yao J, Laé M, Lee SB, Spraggon L, Pratilas CA, Ladanyi M, Somwar R
Dis Model Mech 2022 Jan 1;15(1) Epub 2022 Jan 27 doi: 10.1242/dmm.047621. PMID: 34841430Free PMC Article
Hendricks A, Boerner K, Germer CT, Wiegering A
Cancer Treat Rev 2021 Feb;93:102140. Epub 2020 Dec 24 doi: 10.1016/j.ctrv.2020.102140. PMID: 33388539
Zöllner S, Dirksen U, Jürgens H, Ranft A
Ann Oncol 2013 Sep;24(9):2455-61. Epub 2013 Jun 11 doi: 10.1093/annonc/mdt215. PMID: 23761687

Prognosis

Han LM, VandenBussche CJ, Abildtrup M, Chandra A, Vohra P
Acta Cytol 2022;66(4):336-346. Epub 2021 Jul 2 doi: 10.1159/000516497. PMID: 34218227
Gargallo P, Juan A, Yáñez Y, Dolz S, Segura V, Castel V, Cañete A
Clin Transl Oncol 2020 Sep;22(9):1440-1454. Epub 2020 Feb 5 doi: 10.1007/s12094-020-02298-7. PMID: 32026343
Schoemaker MJ, Jones ME, Higgins CD, Wright AF; UK Clinical Cytogenetics Group, Swerdlow AJ
Int J Cancer 2019 Sep 15;145(6):1493-1498. Epub 2019 Jan 11 doi: 10.1002/ijc.32031. PMID: 30496607Free PMC Article
Thway K, Noujaim J, Zaidi S, Miah AB, Benson C, Messiou C, Jones RL, Fisher C
Int J Surg Pathol 2016 Dec;24(8):672-684. Epub 2016 Sep 12 doi: 10.1177/1066896916668637. PMID: 27621277
Khoury JD
Adv Anat Pathol 2005 Jul;12(4):212-20. doi: 10.1097/01.pap.0000175114.55541.52. PMID: 16096383

Clinical prediction guides

Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG
Cell Chem Biol 2022 Aug 18;29(8):1325-1332.e4. Epub 2022 Jul 7 doi: 10.1016/j.chembiol.2022.06.002. PMID: 35803262Free PMC Article
Sole A, Grossetête S, Heintzé M, Babin L, Zaïdi S, Revy P, Renouf B, De Cian A, Giovannangeli C, Pierre-Eugène C, Janoueix-Lerosey I, Couronné L, Kaltenbach S, Tomishima M, Jasin M, Grünewald TGP, Delattre O, Surdez D, Brunet E
Cancer Res 2021 Oct 1;81(19):4994-5006. Epub 2021 Aug 2 doi: 10.1158/0008-5472.CAN-20-3837. PMID: 34341072Free PMC Article
Schoemaker MJ, Jones ME, Higgins CD, Wright AF; UK Clinical Cytogenetics Group, Swerdlow AJ
Int J Cancer 2019 Sep 15;145(6):1493-1498. Epub 2019 Jan 11 doi: 10.1002/ijc.32031. PMID: 30496607Free PMC Article
Ohye T, Inagaki H, Kato T, Tsutsumi M, Kurahashi H
Pediatr Int 2014 Aug;56(4):462-6. doi: 10.1111/ped.12437. PMID: 24980921
Zöllner S, Dirksen U, Jürgens H, Ranft A
Ann Oncol 2013 Sep;24(9):2455-61. Epub 2013 Jun 11 doi: 10.1093/annonc/mdt215. PMID: 23761687

Recent systematic reviews

Adams LE, Chapman A, Cormack CL, Campbell K, Ebanks AH, Annibale DJ, Hollinger LE
J Pediatr Surg 2022 Sep;57(9):24-28. Epub 2021 Nov 20 doi: 10.1016/j.jpedsurg.2021.11.005. PMID: 34865829

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