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Vaginal Large Cell Neuroendocrine Carcinoma

MedGen UID:
925571
Concept ID:
C4288039
Neoplastic Process

Definition

A rare, aggressive neuroendocrine carcinoma that arises from the vagina and is characterized by the presence of malignant cells with abundant cytoplasm, large nuclei, and prominent nucleoli. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Large Cell Neuroendocrine Carcinoma

Recent clinical studies

Etiology

Patibandla JR, Fehniger JE, Levine DA, Jelinic P
Gynecol Oncol 2018 May;149(2):420-427. Epub 2018 Feb 17 doi: 10.1016/j.ygyno.2018.02.004. PMID: 29458976
Koo YJ, Kim DY, Kim KR, Kim JH, Kim YM, Kim YT, Nam JH
Taiwan J Obstet Gynecol 2014 Sep;53(3):355-9. doi: 10.1016/j.tjog.2013.05.006. PMID: 25286790
Powell JL, McKinney CD
J Low Genit Tract Dis 2008 Jul;12(3):242-4. doi: 10.1097/LGT.0b013e3181641b4f. PMID: 18596468
Conner MG, Richter H, Moran CA, Hameed A, Albores-Saavedra J
Ann Diagn Pathol 2002 Dec;6(6):345-8. doi: 10.1053/adpa.2002.36661. PMID: 12478483
Gilks CB, Young RH, Gersell DJ, Clement PB
Am J Surg Pathol 1997 Aug;21(8):905-14. doi: 10.1097/00000478-199708000-00004. PMID: 9255253

Diagnosis

Okabe A, Ishida M, Noda Y, Okano K, Sandoh K, Fukuda H, Kita M, Okada H, Tsuta K
Diagn Cytopathol 2022 Oct;50(10):E285-E288. Epub 2022 Jun 2 doi: 10.1002/dc.24997. PMID: 35652304
Hardy LE, Chaudry Z, Wan K, Ayres C
BMJ Case Rep 2020 Sep 2;13(9) doi: 10.1136/bcr-2020-234977. PMID: 32878852Free PMC Article
Habeeb A, Habeeb H
BMJ Case Rep 2019 Jan 14;12(1) doi: 10.1136/bcr-2018-225880. PMID: 30642849Free PMC Article
Patibandla JR, Fehniger JE, Levine DA, Jelinic P
Gynecol Oncol 2018 May;149(2):420-427. Epub 2018 Feb 17 doi: 10.1016/j.ygyno.2018.02.004. PMID: 29458976
Rouzbahman M, Clarke B
Semin Diagn Pathol 2013 Aug;30(3):224-33. doi: 10.1053/j.semdp.2013.06.007. PMID: 24144291

Therapy

Hu R, Jiang J, Song G, Zhu C, Chen L, Wang C, Wang X
Medicine (Baltimore) 2019 Jul;98(29):e16433. doi: 10.1097/MD.0000000000016433. PMID: 31335697Free PMC Article
Ling C, Shen Y
J Clin Pathol 2018 Nov;71(11):1030. Epub 2018 Aug 28 doi: 10.1136/jclinpath-2018-205081. PMID: 30154130
Li WW, Yau TN, Leung CW, Pong WM, Chan MY
Hong Kong Med J 2009 Feb;15(1):69-72. PMID: 19197101

Prognosis

Georgescu TA, Bohiltea RE, Munteanu O, Furtunescu F, Lisievici AC, Grigoriu C, Gherghiceanu F, Vlădăreanu EM, Berceanu C, Ducu I, Iordache AM
Medicina (Kaunas) 2021 Dec 7;57(12) doi: 10.3390/medicina57121338. PMID: 34946283Free PMC Article
Gupta P, Gupta N, Suri V, Rai B, Rajwanshi A
Cytopathology 2021 Nov;32(6):813-818. Epub 2021 Jul 19 doi: 10.1111/cyt.13030. PMID: 34241929
Habeeb A, Habeeb H
BMJ Case Rep 2019 Jan 14;12(1) doi: 10.1136/bcr-2018-225880. PMID: 30642849Free PMC Article
Patibandla JR, Fehniger JE, Levine DA, Jelinic P
Gynecol Oncol 2018 May;149(2):420-427. Epub 2018 Feb 17 doi: 10.1016/j.ygyno.2018.02.004. PMID: 29458976
Eichhorn JH, Young RH
Am J Clin Pathol 2001 Jun;115 Suppl:S94-112. doi: 10.1309/64CW-WKGK-49EF-BYD1. PMID: 11993694

Clinical prediction guides

Nishiumi Y, Nishimura T, Kashu I, Aoki T, Itoh R, Tsuta K, Ishida M
Diagn Cytopathol 2018 Sep;46(9):752-755. Epub 2018 Apr 15 doi: 10.1002/dc.23940. PMID: 29656585
Pocrnich CE, Ramalingam P, Euscher ED, Malpica A
Am J Surg Pathol 2016 May;40(5):577-86. doi: 10.1097/PAS.0000000000000633. PMID: 26945341Free PMC Article
Koo YJ, Kim DY, Kim KR, Kim JH, Kim YM, Kim YT, Nam JH
Taiwan J Obstet Gynecol 2014 Sep;53(3):355-9. doi: 10.1016/j.tjog.2013.05.006. PMID: 25286790
Kuroda N, Wada Y, Inoue K, Ohara M, Mizuno K, Toi M, Tanaka A, Wani Y, Yanai H
Diagn Cytopathol 2013 Jul;41(7):636-9. Epub 2011 Oct 11 doi: 10.1002/dc.21834. PMID: 21987295
Albores-Saavedra J, Martinez-Benitez B, Luevano E
Int J Gynecol Pathol 2008 Jul;27(3):333-9. doi: 10.1097/PGP.0b013e31815de006. PMID: 18580310

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