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Refractory Adult Acute Lymphoblastic Leukemia

MedGen UID:
925834
•Concept ID:
C4288302
•
Neoplastic Process

Definition

Acute lymphoblastic leukemia that occurs in adulthood and does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Adult Acute Lymphoblastic Leukemia

Professional guidelines

PubMed

Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA).
Hayden PJ, Roddie C, Bader P, Basak GW, Bonig H, Bonini C, Chabannon C, Ciceri F, Corbacioglu S, Ellard R, Sanchez-Guijo F, Jäger U, Hildebrandt M, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Rees J, Rioufol C, Saccardi R, Snowden JA, Styczynski J, Subklewe M, Thieblemont C, Topp M, Ispizua ÁU, Chen D, Vrhovac R, Gribben JG, Kröger N, Einsele H, Yakoub-Agha I
Ann Oncol 2022 Mar;33(3):259-275. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.003. PMID: 34923107
Adult Acute Lymphoblastic Leukemia: Treatment and Management Updates.
Gregory S
Semin Oncol Nurs 2019 Dec;35(6):150951. Epub 2019 Nov 20 doi: 10.1016/j.soncn.2019.150951. PMID: 31759820

Recent clinical studies

Etiology

Therapeutic approaches for relapsed/refractory adult acute lymphoblastic leukemia (ALL), a review on monoclonal antibodies and targeted therapies.
Hosseini MS, Jafari L, Yami A, Gharehbaghian A
Indian J Cancer 2022 Jan-Mar;59(1):4-11. doi: 10.4103/ijc.IJC_567_19. PMID: 35645049
Fludarabine, cytarabine, and mitoxantrone (FLAM) for the treatment of relapsed and refractory adult acute lymphoblastic leukemia. A phase study by the Polish Adult Leukemia Group (PALG).
Giebel S, Krawczyk-Kulis M, Adamczyk-Cioch M, Jakubas B, Palynyczko G, Lewandowski K, Dmoszynska A, Skotnicki A, Nowak K, Holowiecki J; Polish Adult Leukemia Group
Ann Hematol 2006 Oct;85(10):717-22. Epub 2006 Jul 11 doi: 10.1007/s00277-006-0121-5. PMID: 16832677
A phase II study of high dose ARA-C and mitoxantrone for treatment of relapsed or refractory adult acute lymphoblastic leukemia.
Rosen PJ, Rankin C, Head DR, Boldt DH, Luthardt FW, Norwood T, Pugh RP, Karanes C, Appelbaum FR
Leuk Res 2000 Mar;24(3):183-7. doi: 10.1016/s0145-2126(99)00148-4. PMID: 10738999
Therapy of refractory adult acute lymphoblastic leukemia with vincristine and prednisone plus tandem methotrexate and L-asparaginase. Results of a Cancer and Leukemia Group B Study.
Terebelo HR, Anderson K, Wiernik PH, Cuttner J, Cooper RM, Faso L, Berenberg JL
Am J Clin Oncol 1986 Oct;9(5):411-5. doi: 10.1097/00000421-198610000-00010. PMID: 3465228

Therapy

Therapeutic approaches for relapsed/refractory adult acute lymphoblastic leukemia (ALL), a review on monoclonal antibodies and targeted therapies.
Hosseini MS, Jafari L, Yami A, Gharehbaghian A
Indian J Cancer 2022 Jan-Mar;59(1):4-11. doi: 10.4103/ijc.IJC_567_19. PMID: 35645049
Fludarabine, cytarabine, and mitoxantrone (FLAM) for the treatment of relapsed and refractory adult acute lymphoblastic leukemia. A phase study by the Polish Adult Leukemia Group (PALG).
Giebel S, Krawczyk-Kulis M, Adamczyk-Cioch M, Jakubas B, Palynyczko G, Lewandowski K, Dmoszynska A, Skotnicki A, Nowak K, Holowiecki J; Polish Adult Leukemia Group
Ann Hematol 2006 Oct;85(10):717-22. Epub 2006 Jul 11 doi: 10.1007/s00277-006-0121-5. PMID: 16832677
A phase II study of high dose ARA-C and mitoxantrone for treatment of relapsed or refractory adult acute lymphoblastic leukemia.
Rosen PJ, Rankin C, Head DR, Boldt DH, Luthardt FW, Norwood T, Pugh RP, Karanes C, Appelbaum FR
Leuk Res 2000 Mar;24(3):183-7. doi: 10.1016/s0145-2126(99)00148-4. PMID: 10738999
A phase I trial of a single high dose of idarubicin combined with high-dose cytarabine as induction therapy in relapsed or refractory adult patients with acute lymphoblastic leukemia.
Weiss MA, Drullinsky P, Maslak P, Scheinberg D, Golde DW
Leukemia 1998 Jun;12(6):865-8. doi: 10.1038/sj.leu.2401058. PMID: 9639412
Therapy of refractory adult acute lymphoblastic leukemia with vincristine and prednisone plus tandem methotrexate and L-asparaginase. Results of a Cancer and Leukemia Group B Study.
Terebelo HR, Anderson K, Wiernik PH, Cuttner J, Cooper RM, Faso L, Berenberg JL
Am J Clin Oncol 1986 Oct;9(5):411-5. doi: 10.1097/00000421-198610000-00010. PMID: 3465228

Prognosis

Fludarabine, cytarabine, and mitoxantrone (FLAM) for the treatment of relapsed and refractory adult acute lymphoblastic leukemia. A phase study by the Polish Adult Leukemia Group (PALG).
Giebel S, Krawczyk-Kulis M, Adamczyk-Cioch M, Jakubas B, Palynyczko G, Lewandowski K, Dmoszynska A, Skotnicki A, Nowak K, Holowiecki J; Polish Adult Leukemia Group
Ann Hematol 2006 Oct;85(10):717-22. Epub 2006 Jul 11 doi: 10.1007/s00277-006-0121-5. PMID: 16832677
A phase II study of high dose ARA-C and mitoxantrone for treatment of relapsed or refractory adult acute lymphoblastic leukemia.
Rosen PJ, Rankin C, Head DR, Boldt DH, Luthardt FW, Norwood T, Pugh RP, Karanes C, Appelbaum FR
Leuk Res 2000 Mar;24(3):183-7. doi: 10.1016/s0145-2126(99)00148-4. PMID: 10738999
A phase I trial of a single high dose of idarubicin combined with high-dose cytarabine as induction therapy in relapsed or refractory adult patients with acute lymphoblastic leukemia.
Weiss MA, Drullinsky P, Maslak P, Scheinberg D, Golde DW
Leukemia 1998 Jun;12(6):865-8. doi: 10.1038/sj.leu.2401058. PMID: 9639412

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