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Polysomy 7

MedGen UID:
925916
•Concept ID:
C4288384
•
Cell or Molecular Dysfunction
Synonym: Chromosome 7 Polysomy

Definition

A numerical chromosomal abnormality characterized by the presence of more than two copies of chromosome 7 in a cell. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolysomy 7

Professional guidelines

PubMed

Clinical utility of fluorescence in situ hybridization (FISH) in nonbrainstem glioblastomas of childhood.
Korshunov A, Sycheva R, Gorelyshev S, Golanov A
Mod Pathol 2005 Sep;18(9):1258-63. doi: 10.1038/modpathol.3800415. PMID: 15832192

Recent clinical studies

Etiology

Clinical, radiological and genomic features and targeted therapy in BRAF V600E mutant adult glioblastoma.
Lim-Fat MJ, Song KW, Iorgulescu JB, Andersen BM, Forst DA, Jordan JT, Gerstner ER, Reardon DA, Wen PY, Arrillaga-Romany I
J Neurooncol 2021 May;152(3):515-522. Epub 2021 Mar 1 doi: 10.1007/s11060-021-03719-5. PMID: 33646525Free PMC Article
Molecular and clinicopathologic features of gliomas harboring NTRK fusions.
Torre M, Vasudevaraja V, Serrano J, DeLorenzo M, Malinowski S, Blandin AF, Pages M, Ligon AH, Dong F, Meredith DM, Nasrallah MP, Horbinski C, Dahiya S, Ligon KL, Santi M, Ramkissoon SH, Filbin MG, Snuderl M, Alexandrescu S
Acta Neuropathol Commun 2020 Jul 14;8(1):107. doi: 10.1186/s40478-020-00980-z. PMID: 32665022Free PMC Article
Molecular-genetic analysis is essential for accurate classification of renal carcinoma resembling Xp11.2 translocation carcinoma.
Hayes M, Peckova K, Martinek P, Hora M, Kalusova K, Straka L, Daum O, Kokoskova B, Rotterova P, Pivovarčikova K, Branzovsky J, Dubova M, Vesela P, Michal M, Hes O
Virchows Arch 2015 Mar;466(3):313-22. Epub 2014 Dec 28 doi: 10.1007/s00428-014-1702-7. PMID: 25544614
Locus/chromosome aberrations in intraductal papillary mucinous neoplasms analyzed by fluorescence in situ hybridization.
Miyabe K, Hori Y, Nakazawa T, Hayashi K, Naitoh I, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Kato A, Ohara H, Joh T, Inagaki H
Am J Surg Pathol 2015 Apr;39(4):512-20. doi: 10.1097/PAS.0000000000000360. PMID: 25517961
C-MET is expressed in the majority of penile squamous cell carcinomas and correlates with polysomy-7 but is not associated with MET oncogene amplification, pertinent histopathologic parameters, or with cancer-specific survival.
Gunia S, Erbersdobler A, Hakenberg OW, Koch S, May M
Pathol Res Pract 2013 Apr;209(4):215-20. Epub 2013 Mar 13 doi: 10.1016/j.prp.2013.02.002. PMID: 23490239

Diagnosis

Clinical, radiological and genomic features and targeted therapy in BRAF V600E mutant adult glioblastoma.
Lim-Fat MJ, Song KW, Iorgulescu JB, Andersen BM, Forst DA, Jordan JT, Gerstner ER, Reardon DA, Wen PY, Arrillaga-Romany I
J Neurooncol 2021 May;152(3):515-522. Epub 2021 Mar 1 doi: 10.1007/s11060-021-03719-5. PMID: 33646525Free PMC Article
Molecular-genetic analysis is essential for accurate classification of renal carcinoma resembling Xp11.2 translocation carcinoma.
Hayes M, Peckova K, Martinek P, Hora M, Kalusova K, Straka L, Daum O, Kokoskova B, Rotterova P, Pivovarčikova K, Branzovsky J, Dubova M, Vesela P, Michal M, Hes O
Virchows Arch 2015 Mar;466(3):313-22. Epub 2014 Dec 28 doi: 10.1007/s00428-014-1702-7. PMID: 25544614
Locus/chromosome aberrations in intraductal papillary mucinous neoplasms analyzed by fluorescence in situ hybridization.
Miyabe K, Hori Y, Nakazawa T, Hayashi K, Naitoh I, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Kato A, Ohara H, Joh T, Inagaki H
Am J Surg Pathol 2015 Apr;39(4):512-20. doi: 10.1097/PAS.0000000000000360. PMID: 25517961
C-MET is expressed in the majority of penile squamous cell carcinomas and correlates with polysomy-7 but is not associated with MET oncogene amplification, pertinent histopathologic parameters, or with cancer-specific survival.
Gunia S, Erbersdobler A, Hakenberg OW, Koch S, May M
Pathol Res Pract 2013 Apr;209(4):215-20. Epub 2013 Mar 13 doi: 10.1016/j.prp.2013.02.002. PMID: 23490239
Identification of novel predictive markers for the prognosis of pancreatic ductal adenocarcinoma.
Luo Y, Qiu Z, Tian L, Zhu G, Feng Y, Yi M, Chen X, Wang L, Li C, Huang Q
Hum Pathol 2013 Jan;44(1):69-76. Epub 2012 Aug 30 doi: 10.1016/j.humpath.2012.04.014. PMID: 22939953

Therapy

Numerical aberrations of chromosome 7 detected in 15 microns paraffin-embedded tissue sections of primary cutaneous melanomas by fluorescence in situ hybridization and confocal laser scanning microscopy.
D'Alessandro I, Zitzelsberger H, Hutzler P, Lehmann L, Braselmann H, Chimenti S, Höfler H
J Cutan Pathol 1997 Feb;24(2):70-5. doi: 10.1111/j.1600-0560.1997.tb01099.x. PMID: 9162738

Prognosis

Mesenchymal-epithelial transition gene amplification and protein overexpression in stage IV pulmonary adenocarcinoma.
Ando R, Fujino M, Kominami-Kiriyama A, Ito A, Koide T, Ito M
Jpn J Clin Oncol 2019 Aug 1;49(8):755-761. doi: 10.1093/jjco/hyz060. PMID: 31329925
Molecular-genetic analysis is essential for accurate classification of renal carcinoma resembling Xp11.2 translocation carcinoma.
Hayes M, Peckova K, Martinek P, Hora M, Kalusova K, Straka L, Daum O, Kokoskova B, Rotterova P, Pivovarčikova K, Branzovsky J, Dubova M, Vesela P, Michal M, Hes O
Virchows Arch 2015 Mar;466(3):313-22. Epub 2014 Dec 28 doi: 10.1007/s00428-014-1702-7. PMID: 25544614
C-MET is expressed in the majority of penile squamous cell carcinomas and correlates with polysomy-7 but is not associated with MET oncogene amplification, pertinent histopathologic parameters, or with cancer-specific survival.
Gunia S, Erbersdobler A, Hakenberg OW, Koch S, May M
Pathol Res Pract 2013 Apr;209(4):215-20. Epub 2013 Mar 13 doi: 10.1016/j.prp.2013.02.002. PMID: 23490239
Identification of novel predictive markers for the prognosis of pancreatic ductal adenocarcinoma.
Luo Y, Qiu Z, Tian L, Zhu G, Feng Y, Yi M, Chen X, Wang L, Li C, Huang Q
Hum Pathol 2013 Jan;44(1):69-76. Epub 2012 Aug 30 doi: 10.1016/j.humpath.2012.04.014. PMID: 22939953
Clinical utility of fluorescence in situ hybridization (FISH) in nonbrainstem glioblastomas of childhood.
Korshunov A, Sycheva R, Gorelyshev S, Golanov A
Mod Pathol 2005 Sep;18(9):1258-63. doi: 10.1038/modpathol.3800415. PMID: 15832192

Clinical prediction guides

Locus/chromosome aberrations in intraductal papillary mucinous neoplasms analyzed by fluorescence in situ hybridization.
Miyabe K, Hori Y, Nakazawa T, Hayashi K, Naitoh I, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Kato A, Ohara H, Joh T, Inagaki H
Am J Surg Pathol 2015 Apr;39(4):512-20. doi: 10.1097/PAS.0000000000000360. PMID: 25517961
C-MET is expressed in the majority of penile squamous cell carcinomas and correlates with polysomy-7 but is not associated with MET oncogene amplification, pertinent histopathologic parameters, or with cancer-specific survival.
Gunia S, Erbersdobler A, Hakenberg OW, Koch S, May M
Pathol Res Pract 2013 Apr;209(4):215-20. Epub 2013 Mar 13 doi: 10.1016/j.prp.2013.02.002. PMID: 23490239
Identification of novel predictive markers for the prognosis of pancreatic ductal adenocarcinoma.
Luo Y, Qiu Z, Tian L, Zhu G, Feng Y, Yi M, Chen X, Wang L, Li C, Huang Q
Hum Pathol 2013 Jan;44(1):69-76. Epub 2012 Aug 30 doi: 10.1016/j.humpath.2012.04.014. PMID: 22939953
MET overexpressing chordomas frequently exhibit polysomy of chromosome 7 but no MET activation through sarcoma-specific gene fusions.
Grabellus F, Konik MJ, Worm K, Sheu SY, van de Nes JA, Bauer S, Paulus W, Egensperger R, Schmid KW
Tumour Biol 2010 Jun;31(3):157-63. Epub 2010 Mar 6 doi: 10.1007/s13277-010-0021-0. PMID: 20512480
Proliferating cell nuclear antigen and epidermal growth factor receptor (EGFr) status in renal cell carcinoma patients with polysomy of chromosome 7.
Amare Kadam PS, Varghese C, Bharde SH, Narasimhamoorthy NK, Desai S, Advani SH, Havaldar R, Kulkarni JN
Cancer Genet Cytogenet 2001 Mar;125(2):139-46. doi: 10.1016/s0165-4608(00)00375-7. PMID: 11369057

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