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Chromosome 7 Abnormality

MedGen UID:
1698649
•Concept ID:
C5204450
•
Cell or Molecular Dysfunction
Synonyms: Aberrant Chromosome 7; Chromosome 7 Aberration

Definition

A cytogenetic abnormality that refers to any structural irregularity in chromosome 7. [from NCI]

Professional guidelines

PubMed

Prenatal cytogenetic diagnosis in Taiwan: a nationwide population-based study.
Chang HP, Chiou JY, Chen JY, Su PH
J Matern Fetal Neonatal Med 2017 Nov;30(21):2521-2528. Epub 2016 Nov 24 doi: 10.1080/14767058.2016.1255191. PMID: 27806654

Recent clinical studies

Etiology

L-asparaginase as an efficient salvage therapy for refractory acute myeloid leukemia with chromosome 7 abnormalities: a case series.
Noguchi K, Ikawa Y, Takenaka M, Sakai Y, Fujiki T, Kuroda R, Maeba H, Goto H, Kitoh T, Wada T
Int J Hematol 2023 Sep;118(3):406-410. Epub 2023 Apr 6 doi: 10.1007/s12185-023-03591-1. PMID: 37022561
Predictors of clonal evolution and myeloid neoplasia following immunosuppressive therapy in severe aplastic anemia.
Groarke EM, Patel BA, Shalhoub R, Gutierrez-Rodrigues F, Desai P, Leuva H, Zaimoku Y, Paton C, Spitofsky N, Lotter J, Rios O, Childs RW, Young DJ, Dulau-Florea A, Dunbar CE, Calvo KR, Wu CO, Young NS
Leukemia 2022 Sep;36(9):2328-2337. Epub 2022 Jul 27 doi: 10.1038/s41375-022-01636-8. PMID: 35896822Free PMC Article
Prognostic impact of chromosomal changes at relapse after allogeneic hematopoietic cell transplantation for acute myeloid leukemia or myelodysplastic syndrome.
Okada Y, Nakasone H, Nakamura Y, Kawamura M, Kawamura S, Takeshita J, Yoshino N, Misaki Y, Yoshimura K, Matsumi S, Gomyo A, Kawamura T, Akahoshi Y, Kusuda M, Kameda K, Tanihara A, Tamaki M, Kimura SI, Kobayashi S, Kako S, Kimura F, Kanda Y
Bone Marrow Transplant 2022 May;57(5):810-816. Epub 2022 Mar 21 doi: 10.1038/s41409-022-01635-4. PMID: 35314792
Long-term outcomes in patients with severe aplastic anemia treated with immunosuppression and eltrombopag: a phase 2 study.
Patel BA, Groarke EM, Lotter J, Shalhoub R, Gutierrez-Rodrigues F, Rios O, Quinones Raffo D, Wu CO, Young NS
Blood 2022 Jan 6;139(1):34-43. doi: 10.1182/blood.2021012130. PMID: 34525188Free PMC Article
Monosomal karyotype predicts poor survival after allogeneic stem cell transplantation in chromosome 7 abnormal myelodysplastic syndrome and secondary acute myeloid leukemia.
van Gelder M, de Wreede LC, Schetelig J, van Biezen A, Volin L, Maertens J, Robin M, Petersen E, de Witte T, Kröger N; EBMT Chronic Malignancies Working Party
Leukemia 2013 Apr;27(4):879-88. Epub 2012 Oct 16 doi: 10.1038/leu.2012.297. PMID: 23164802

Diagnosis

Prognostic impact of chromosomal changes at relapse after allogeneic hematopoietic cell transplantation for acute myeloid leukemia or myelodysplastic syndrome.
Okada Y, Nakasone H, Nakamura Y, Kawamura M, Kawamura S, Takeshita J, Yoshino N, Misaki Y, Yoshimura K, Matsumi S, Gomyo A, Kawamura T, Akahoshi Y, Kusuda M, Kameda K, Tanihara A, Tamaki M, Kimura SI, Kobayashi S, Kako S, Kimura F, Kanda Y
Bone Marrow Transplant 2022 May;57(5):810-816. Epub 2022 Mar 21 doi: 10.1038/s41409-022-01635-4. PMID: 35314792
Prominent gelatinous bone marrow transformation presenting prior to myelodysplastic syndrome: a case report with review of the literature.
Nakanishi R, Ishida M, Hodohara K, Yoshida T, Yoshii M, Okuno H, Horinouchi A, Iwai M, Yoshida K, Kagotani A, Okabe H
Int J Clin Exp Pathol 2013;6(8):1677-82. Epub 2013 Jul 15 PMID: 23923088Free PMC Article
Inheritance of chromosome 7 is associated with a drug-resistant phenotype in somatic cell hybrids.
de Silva M, Kantharidis P, Wall DM, Campbell L, Vrazas V, Nadalin G, Kaczmarczyk SJ, Hu XF, Parkin JD, Zalcberg JR
Br J Cancer 1996 Jan;73(2):169-74. doi: 10.1038/bjc.1996.31. PMID: 8546902Free PMC Article

Therapy

Prognostic impact of chromosomal changes at relapse after allogeneic hematopoietic cell transplantation for acute myeloid leukemia or myelodysplastic syndrome.
Okada Y, Nakasone H, Nakamura Y, Kawamura M, Kawamura S, Takeshita J, Yoshino N, Misaki Y, Yoshimura K, Matsumi S, Gomyo A, Kawamura T, Akahoshi Y, Kusuda M, Kameda K, Tanihara A, Tamaki M, Kimura SI, Kobayashi S, Kako S, Kimura F, Kanda Y
Bone Marrow Transplant 2022 May;57(5):810-816. Epub 2022 Mar 21 doi: 10.1038/s41409-022-01635-4. PMID: 35314792
Long-term outcomes in patients with severe aplastic anemia treated with immunosuppression and eltrombopag: a phase 2 study.
Patel BA, Groarke EM, Lotter J, Shalhoub R, Gutierrez-Rodrigues F, Rios O, Quinones Raffo D, Wu CO, Young NS
Blood 2022 Jan 6;139(1):34-43. doi: 10.1182/blood.2021012130. PMID: 34525188Free PMC Article
The heterogeneous prognosis of patients with myelodysplastic syndrome and chromosome 5 abnormalities: how does it relate to the original lenalidomide experience in MDS?
Kantarjian H, O'Brien S, Ravandi F, Borthakur G, Faderl S, Bueso-Ramos C, Abruzzo L, Pierce S, Shan J, Issa JP, Garcia-Manero G
Cancer 2009 Nov 15;115(22):5202-9. doi: 10.1002/cncr.24575. PMID: 19691096Free PMC Article
Inheritance of chromosome 7 is associated with a drug-resistant phenotype in somatic cell hybrids.
de Silva M, Kantharidis P, Wall DM, Campbell L, Vrazas V, Nadalin G, Kaczmarczyk SJ, Hu XF, Parkin JD, Zalcberg JR
Br J Cancer 1996 Jan;73(2):169-74. doi: 10.1038/bjc.1996.31. PMID: 8546902Free PMC Article

Prognosis

L-asparaginase as an efficient salvage therapy for refractory acute myeloid leukemia with chromosome 7 abnormalities: a case series.
Noguchi K, Ikawa Y, Takenaka M, Sakai Y, Fujiki T, Kuroda R, Maeba H, Goto H, Kitoh T, Wada T
Int J Hematol 2023 Sep;118(3):406-410. Epub 2023 Apr 6 doi: 10.1007/s12185-023-03591-1. PMID: 37022561
Predictors of clonal evolution and myeloid neoplasia following immunosuppressive therapy in severe aplastic anemia.
Groarke EM, Patel BA, Shalhoub R, Gutierrez-Rodrigues F, Desai P, Leuva H, Zaimoku Y, Paton C, Spitofsky N, Lotter J, Rios O, Childs RW, Young DJ, Dulau-Florea A, Dunbar CE, Calvo KR, Wu CO, Young NS
Leukemia 2022 Sep;36(9):2328-2337. Epub 2022 Jul 27 doi: 10.1038/s41375-022-01636-8. PMID: 35896822Free PMC Article
The prognostic impact of loss of chromosome 7 material detected by fluorescence in situ hybridization (FISH) in myeloid malignancies.
El-Menoufy MAM, Mourad ZI, Farahat NM
J Egypt Natl Canc Inst 2018 Dec;30(4):133-138. Epub 2018 Nov 22 doi: 10.1016/j.jnci.2018.11.001. PMID: 30472199
Monosomal karyotype predicts poor survival after allogeneic stem cell transplantation in chromosome 7 abnormal myelodysplastic syndrome and secondary acute myeloid leukemia.
van Gelder M, de Wreede LC, Schetelig J, van Biezen A, Volin L, Maertens J, Robin M, Petersen E, de Witte T, Kröger N; EBMT Chronic Malignancies Working Party
Leukemia 2013 Apr;27(4):879-88. Epub 2012 Oct 16 doi: 10.1038/leu.2012.297. PMID: 23164802
The heterogeneous prognosis of patients with myelodysplastic syndrome and chromosome 5 abnormalities: how does it relate to the original lenalidomide experience in MDS?
Kantarjian H, O'Brien S, Ravandi F, Borthakur G, Faderl S, Bueso-Ramos C, Abruzzo L, Pierce S, Shan J, Issa JP, Garcia-Manero G
Cancer 2009 Nov 15;115(22):5202-9. doi: 10.1002/cncr.24575. PMID: 19691096Free PMC Article

Clinical prediction guides

Predictors of clonal evolution and myeloid neoplasia following immunosuppressive therapy in severe aplastic anemia.
Groarke EM, Patel BA, Shalhoub R, Gutierrez-Rodrigues F, Desai P, Leuva H, Zaimoku Y, Paton C, Spitofsky N, Lotter J, Rios O, Childs RW, Young DJ, Dulau-Florea A, Dunbar CE, Calvo KR, Wu CO, Young NS
Leukemia 2022 Sep;36(9):2328-2337. Epub 2022 Jul 27 doi: 10.1038/s41375-022-01636-8. PMID: 35896822Free PMC Article
Long-term outcomes in patients with severe aplastic anemia treated with immunosuppression and eltrombopag: a phase 2 study.
Patel BA, Groarke EM, Lotter J, Shalhoub R, Gutierrez-Rodrigues F, Rios O, Quinones Raffo D, Wu CO, Young NS
Blood 2022 Jan 6;139(1):34-43. doi: 10.1182/blood.2021012130. PMID: 34525188Free PMC Article
The prognostic impact of loss of chromosome 7 material detected by fluorescence in situ hybridization (FISH) in myeloid malignancies.
El-Menoufy MAM, Mourad ZI, Farahat NM
J Egypt Natl Canc Inst 2018 Dec;30(4):133-138. Epub 2018 Nov 22 doi: 10.1016/j.jnci.2018.11.001. PMID: 30472199
Monosomal karyotype predicts poor survival after allogeneic stem cell transplantation in chromosome 7 abnormal myelodysplastic syndrome and secondary acute myeloid leukemia.
van Gelder M, de Wreede LC, Schetelig J, van Biezen A, Volin L, Maertens J, Robin M, Petersen E, de Witte T, Kröger N; EBMT Chronic Malignancies Working Party
Leukemia 2013 Apr;27(4):879-88. Epub 2012 Oct 16 doi: 10.1038/leu.2012.297. PMID: 23164802
Chromosome 7 long arm deletion in myeloid disorders: a narrow breakpoint region in 7q22 defined by molecular mapping.
Kere J, Ruutu T, Davies KA, Roninson IB, Watkins PC, Winqvist R, de la Chapelle A
Blood 1989 Jan;73(1):230-4. PMID: 2562922

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