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Gastroesophageal Junction Large Cell Neuroendocrine Carcinoma

MedGen UID:
926577
•Concept ID:
C4289045
•
Neoplastic Process

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastroesophageal Junction Large Cell Neuroendocrine Carcinoma

Recent clinical studies

Diagnosis

High-grade mixed neuroendocrine non-neuroendocrine neoplasm of the gastroesophageal junction: A rare case report and review of literature.
Sulaiman M, Agarwal S, Mandal A, Kumar S, Das P
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):918-920. doi: 10.4103/ijpm.ijpm_143_21. PMID: 36308207
A case of large cell neuroendocrine carcinoma exhibiting rhabdoid features in the esophagogastric junction.
Ichimata S, Aoyagi D, Takehana T, Uehara T, Shiozawa S
Pathol Int 2019 Aug;69(8):481-487. Epub 2019 Jun 24 doi: 10.1111/pin.12807. PMID: 31237049
New model for gastroenteropancreatic large-cell neuroendocrine carcinoma: establishment of two clinically relevant cell lines.
Krieg A, Mersch S, Boeck I, Dizdar L, Weihe E, Hilal Z, Krausch M, Möhlendick B, Topp SA, Piekorz RP, Huckenbeck W, Stoecklein NH, Anlauf M, Knoefel WT
PLoS One 2014;9(2):e88713. Epub 2014 Feb 14 doi: 10.1371/journal.pone.0088713. PMID: 24551139Free PMC Article
Unusual case of small cell gastric carcinoma: case report and literature review.
Richards D, Davis D, Yan P, Guha S
Dig Dis Sci 2011 Apr;56(4):951-7. Epub 2010 Sep 18 doi: 10.1007/s10620-010-1404-1. PMID: 20848201

Therapy

New model for gastroenteropancreatic large-cell neuroendocrine carcinoma: establishment of two clinically relevant cell lines.
Krieg A, Mersch S, Boeck I, Dizdar L, Weihe E, Hilal Z, Krausch M, Möhlendick B, Topp SA, Piekorz RP, Huckenbeck W, Stoecklein NH, Anlauf M, Knoefel WT
PLoS One 2014;9(2):e88713. Epub 2014 Feb 14 doi: 10.1371/journal.pone.0088713. PMID: 24551139Free PMC Article
Unusual case of small cell gastric carcinoma: case report and literature review.
Richards D, Davis D, Yan P, Guha S
Dig Dis Sci 2011 Apr;56(4):951-7. Epub 2010 Sep 18 doi: 10.1007/s10620-010-1404-1. PMID: 20848201

Prognosis

Large cell neuroendocrine carcinoma at the esophagogastric junction. An extremely rare entity.
García-Redondo M, Ruiz Pardo J, Sánchez Fuentes PA, Vidaña Márquez E, Belda Lozano R, Pérez-Rodríguez Á, Gorostiaga Í, Reina Duarte Á
Rev Esp Enferm Dig 2023 Dec;115(12):719-720. doi: 10.17235/reed.2023.9505/2023. PMID: 36809887
Unusual case of small cell gastric carcinoma: case report and literature review.
Richards D, Davis D, Yan P, Guha S
Dig Dis Sci 2011 Apr;56(4):951-7. Epub 2010 Sep 18 doi: 10.1007/s10620-010-1404-1. PMID: 20848201

Clinical prediction guides

A case of large cell neuroendocrine carcinoma exhibiting rhabdoid features in the esophagogastric junction.
Ichimata S, Aoyagi D, Takehana T, Uehara T, Shiozawa S
Pathol Int 2019 Aug;69(8):481-487. Epub 2019 Jun 24 doi: 10.1111/pin.12807. PMID: 31237049
New model for gastroenteropancreatic large-cell neuroendocrine carcinoma: establishment of two clinically relevant cell lines.
Krieg A, Mersch S, Boeck I, Dizdar L, Weihe E, Hilal Z, Krausch M, Möhlendick B, Topp SA, Piekorz RP, Huckenbeck W, Stoecklein NH, Anlauf M, Knoefel WT
PLoS One 2014;9(2):e88713. Epub 2014 Feb 14 doi: 10.1371/journal.pone.0088713. PMID: 24551139Free PMC Article

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