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Rhabdomyosarcoma of the cervix uteri

MedGen UID:
927341
Concept ID:
C4289809
Neoplastic Process
Synonyms: CERMS; Cervical Rhabdomyosarcoma; Cervical rhabdomyosarcoma; cervical rhabdomyosarcoma; rhabdomyosarcoma (disease) of uterine cervix; Rhabdomyosarcoma of cervix uteri; rhabdomyosarcoma of the cervix uteri; uterine cervix rhabdomyosarcoma; uterine cervix rhabdomyosarcoma (disease)
SNOMED CT: Rhabdomyosarcoma of cervix uteri (763408003); Cervical rhabdomyosarcoma (763408003)
 
Monarch Initiative: MONDO:0016282
Orphanet: ORPHA213802

Definition

A rare highly malignant soft tissue sarcoma located in the uterine cervix and arising from primitive mesenchymal cells displaying skeletal muscle differentiation. It most often presents with abnormal vaginal discharge or dysfunctional uterine bleeding, abdominal pain and/or a cervical mass protruding into the vagina. Association with DICER1 syndrome has been reported. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRhabdomyosarcoma of the cervix uteri

Professional guidelines

PubMed

Lautz TB, Martelli H, Fuchs J, Chargari C, Smeulders N, Granberg CF, Wolden SL, Sparber-Sauer M, Hawkins DS, Bisogno G, Koscielniak E, Rodeberg DA, Seitz G; INSTRuCT group
Pediatr Blood Cancer 2023 May;70(5):e28601. Epub 2020 Aug 6 doi: 10.1002/pbc.28601. PMID: 32762004
Devins KM, Young RH, Ghioni M, Burandt E, Bennett JA, Oliva E
Am J Surg Pathol 2022 Nov 1;46(11):1477-1489. Epub 2022 Aug 9 doi: 10.1097/PAS.0000000000001933. PMID: 35941719
Khosla D, Gupta R, Srinivasan R, Patel FD, Rajwanshi A
Int J Gynecol Cancer 2012 Jul;22(6):1026-30. doi: 10.1097/IGC.0b013e31825a97f6. PMID: 22740005

Recent clinical studies

Therapy

Lautz TB, Martelli H, Fuchs J, Chargari C, Smeulders N, Granberg CF, Wolden SL, Sparber-Sauer M, Hawkins DS, Bisogno G, Koscielniak E, Rodeberg DA, Seitz G; INSTRuCT group
Pediatr Blood Cancer 2023 May;70(5):e28601. Epub 2020 Aug 6 doi: 10.1002/pbc.28601. PMID: 32762004
Upadhyay R, Carthikeyan SM, Pathy S
J Cancer Res Ther 2021 Apr-Jun;17(2):580-583. doi: 10.4103/jcrt.JCRT_500_19. PMID: 34121713
Elsebaie MA, Elsayed Z
Arch Gynecol Obstet 2018 Mar;297(3):559-572. Epub 2017 Nov 20 doi: 10.1007/s00404-017-4591-6. PMID: 29159540
Ditto A, Martinelli F, Carcangiu M, Solima E, de Carrillo KJ, Sanfilippo R, Haeusler E, Raspagliesi F
J Low Genit Tract Dis 2013 Oct;17(4):e12-7. doi: 10.1097/LGT.0b013e31827a8b8c. PMID: 23903199
Adams BN, Brandt JS, Loukeris K, Holcomb K
Obstet Gynecol 2011 Feb;117(2 Pt 2):482-484. doi: 10.1097/AOG.0b013e3182051dd0. PMID: 21252797

Prognosis

Yu X, Qie M, Huang L, Hou M
BMC Womens Health 2023 Sep 1;23(1):466. doi: 10.1186/s12905-023-02623-6. PMID: 37658404Free PMC Article
Lautz TB, Martelli H, Fuchs J, Chargari C, Smeulders N, Granberg CF, Wolden SL, Sparber-Sauer M, Hawkins DS, Bisogno G, Koscielniak E, Rodeberg DA, Seitz G; INSTRuCT group
Pediatr Blood Cancer 2023 May;70(5):e28601. Epub 2020 Aug 6 doi: 10.1002/pbc.28601. PMID: 32762004
Devins KM, Young RH, Ghioni M, Burandt E, Bennett JA, Oliva E
Am J Surg Pathol 2022 Nov 1;46(11):1477-1489. Epub 2022 Aug 9 doi: 10.1097/PAS.0000000000001933. PMID: 35941719
Pawlik J, Pawlik W, Branecka-Woźniak D, Kotrych K, Cymbaluk-Płoska A
Int J Environ Res Public Health 2021 Jul 24;18(15) doi: 10.3390/ijerph18157851. PMID: 34360144Free PMC Article
Missaoui N, Mestiri S, Bdioui A, Zahmoul T, Hamchi H, Mokni M, Hmissa S
Pathol Res Pract 2018 Apr;214(4):498-506. Epub 2018 Mar 6 doi: 10.1016/j.prp.2018.03.004. PMID: 29572122

Clinical prediction guides

Devins KM, Young RH, Ghioni M, Burandt E, Bennett JA, Oliva E
Am J Surg Pathol 2022 Nov 1;46(11):1477-1489. Epub 2022 Aug 9 doi: 10.1097/PAS.0000000000001933. PMID: 35941719
Elsebaie MA, Elsayed Z
Arch Gynecol Obstet 2018 Mar;297(3):559-572. Epub 2017 Nov 20 doi: 10.1007/s00404-017-4591-6. PMID: 29159540

Recent systematic reviews

Elsebaie MA, Elsayed Z
Arch Gynecol Obstet 2018 Mar;297(3):559-572. Epub 2017 Nov 20 doi: 10.1007/s00404-017-4591-6. PMID: 29159540

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