U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rhabdomyosarcoma of the cervix uteri

MedGen UID:
927341
•Concept ID:
C4289809
•
Neoplastic Process
Synonyms: CERMS; Cervical Rhabdomyosarcoma; Cervical rhabdomyosarcoma; cervical rhabdomyosarcoma; rhabdomyosarcoma (disease) of uterine cervix; Rhabdomyosarcoma of cervix uteri; rhabdomyosarcoma of the cervix uteri; uterine cervix rhabdomyosarcoma; uterine cervix rhabdomyosarcoma (disease)
SNOMED CT: Rhabdomyosarcoma of cervix uteri (763408003); Cervical rhabdomyosarcoma (763408003)
 
Monarch Initiative: MONDO:0016282
Orphanet: ORPHA213802

Definition

A rare highly malignant soft tissue sarcoma located in the uterine cervix and arising from primitive mesenchymal cells displaying skeletal muscle differentiation. It most often presents with abnormal vaginal discharge or dysfunctional uterine bleeding, abdominal pain and/or a cervical mass protruding into the vagina. Association with DICER1 syndrome has been reported. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRhabdomyosarcoma of the cervix uteri

Professional guidelines

PubMed

Local treatment of rhabdomyosarcoma of the female genital tract: Expert consensus from the Children's Oncology Group, the European Soft-Tissue Sarcoma Group, and the Cooperative Weichteilsarkom Studiengruppe.
Lautz TB, Martelli H, Fuchs J, Chargari C, Smeulders N, Granberg CF, Wolden SL, Sparber-Sauer M, Hawkins DS, Bisogno G, Koscielniak E, Rodeberg DA, Seitz G; INSTRuCT group
Pediatr Blood Cancer 2023 May;70(5):e28601. Epub 2020 Aug 6 doi: 10.1002/pbc.28601. PMID: 32762004
Embryonal Rhabdomyosarcoma of the Uterine Cervix: A Clinicopathologic Study of 94 Cases Emphasizing Issues in Differential Diagnosis Staging, and Prognostic Factors.
Devins KM, Young RH, Ghioni M, Burandt E, Bennett JA, Oliva E
Am J Surg Pathol 2022 Nov 1;46(11):1477-1489. Epub 2022 Aug 9 doi: 10.1097/PAS.0000000000001933. PMID: 35941719
Sarcomas of uterine cervix: clinicopathological features, treatment, and outcome.
Khosla D, Gupta R, Srinivasan R, Patel FD, Rajwanshi A
Int J Gynecol Cancer 2012 Jul;22(6):1026-30. doi: 10.1097/IGC.0b013e31825a97f6. PMID: 22740005

Recent clinical studies

Therapy

Local treatment of rhabdomyosarcoma of the female genital tract: Expert consensus from the Children's Oncology Group, the European Soft-Tissue Sarcoma Group, and the Cooperative Weichteilsarkom Studiengruppe.
Lautz TB, Martelli H, Fuchs J, Chargari C, Smeulders N, Granberg CF, Wolden SL, Sparber-Sauer M, Hawkins DS, Bisogno G, Koscielniak E, Rodeberg DA, Seitz G; INSTRuCT group
Pediatr Blood Cancer 2023 May;70(5):e28601. Epub 2020 Aug 6 doi: 10.1002/pbc.28601. PMID: 32762004
Radiation cystitis: A late effect of radiotherapy in a patient with cervical rhabdomyosarcoma.
Upadhyay R, Carthikeyan SM, Pathy S
J Cancer Res Ther 2021 Apr-Jun;17(2):580-583. doi: 10.4103/jcrt.JCRT_500_19. PMID: 34121713
Is fertility-preservation safe for adult non-metastatic gynecologic rhabdomyosarcoma patients? Systematic review and pooled survival analysis of 137 patients.
Elsebaie MA, Elsayed Z
Arch Gynecol Obstet 2018 Mar;297(3):559-572. Epub 2017 Nov 20 doi: 10.1007/s00404-017-4591-6. PMID: 29159540
Embryonal rhabdomyosarcoma of the uterine cervix in adults: a case report and literature review.
Ditto A, Martinelli F, Carcangiu M, Solima E, de Carrillo KJ, Sanfilippo R, Haeusler E, Raspagliesi F
J Low Genit Tract Dis 2013 Oct;17(4):e12-7. doi: 10.1097/LGT.0b013e31827a8b8c. PMID: 23903199
Embryonal rhabdomyosarcoma of the cervix and appendiceal carcinoid tumor.
Adams BN, Brandt JS, Loukeris K, Holcomb K
Obstet Gynecol 2011 Feb;117(2 Pt 2):482-484. doi: 10.1097/AOG.0b013e3182051dd0. PMID: 21252797

Prognosis

Successful pregnancy in a female with embryonal rhabdomyosarcoma of the cervix who received biopsy and chemotherapy alone without recurrence after 16 years: a case report and literature review.
Yu X, Qie M, Huang L, Hou M
BMC Womens Health 2023 Sep 1;23(1):466. doi: 10.1186/s12905-023-02623-6. PMID: 37658404Free PMC Article
Local treatment of rhabdomyosarcoma of the female genital tract: Expert consensus from the Children's Oncology Group, the European Soft-Tissue Sarcoma Group, and the Cooperative Weichteilsarkom Studiengruppe.
Lautz TB, Martelli H, Fuchs J, Chargari C, Smeulders N, Granberg CF, Wolden SL, Sparber-Sauer M, Hawkins DS, Bisogno G, Koscielniak E, Rodeberg DA, Seitz G; INSTRuCT group
Pediatr Blood Cancer 2023 May;70(5):e28601. Epub 2020 Aug 6 doi: 10.1002/pbc.28601. PMID: 32762004
Embryonal Rhabdomyosarcoma of the Uterine Cervix: A Clinicopathologic Study of 94 Cases Emphasizing Issues in Differential Diagnosis Staging, and Prognostic Factors.
Devins KM, Young RH, Ghioni M, Burandt E, Bennett JA, Oliva E
Am J Surg Pathol 2022 Nov 1;46(11):1477-1489. Epub 2022 Aug 9 doi: 10.1097/PAS.0000000000001933. PMID: 35941719
Rhabdomyosarcoma of the Cervix in a Post-Menopausal Woman-An Unparalleled Phenomenon.
Pawlik J, Pawlik W, Branecka-Woźniak D, Kotrych K, Cymbaluk-Płoska A
Int J Environ Res Public Health 2021 Jul 24;18(15) doi: 10.3390/ijerph18157851. PMID: 34360144Free PMC Article
HPV infection and p16(INK4A) and TP53 expression in rare cancers of the uterine cervix.
Missaoui N, Mestiri S, Bdioui A, Zahmoul T, Hamchi H, Mokni M, Hmissa S
Pathol Res Pract 2018 Apr;214(4):498-506. Epub 2018 Mar 6 doi: 10.1016/j.prp.2018.03.004. PMID: 29572122

Clinical prediction guides

Embryonal Rhabdomyosarcoma of the Uterine Cervix: A Clinicopathologic Study of 94 Cases Emphasizing Issues in Differential Diagnosis Staging, and Prognostic Factors.
Devins KM, Young RH, Ghioni M, Burandt E, Bennett JA, Oliva E
Am J Surg Pathol 2022 Nov 1;46(11):1477-1489. Epub 2022 Aug 9 doi: 10.1097/PAS.0000000000001933. PMID: 35941719
Is fertility-preservation safe for adult non-metastatic gynecologic rhabdomyosarcoma patients? Systematic review and pooled survival analysis of 137 patients.
Elsebaie MA, Elsayed Z
Arch Gynecol Obstet 2018 Mar;297(3):559-572. Epub 2017 Nov 20 doi: 10.1007/s00404-017-4591-6. PMID: 29159540

Recent systematic reviews

Is fertility-preservation safe for adult non-metastatic gynecologic rhabdomyosarcoma patients? Systematic review and pooled survival analysis of 137 patients.
Elsebaie MA, Elsayed Z
Arch Gynecol Obstet 2018 Mar;297(3):559-572. Epub 2017 Nov 20 doi: 10.1007/s00404-017-4591-6. PMID: 29159540

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...