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Cervical Microglandular Hyperplasia

MedGen UID:
927344
•Concept ID:
C4289812
•
Pathologic Function

Definition

A benign endocervical gland proliferation characterized by the presence of closely packed glands composed of columnar to cuboidal cells with subnuclear mucin vacuoles. It is associated with progestins or pregnancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Microglandular Hyperplasia

Professional guidelines

PubMed

Mitotically active microglandular hyperplasia of the cervix: a case series with implications for the differential diagnosis.
Abi-Raad R, Alomari A, Hui P, Buza N
Int J Gynecol Pathol 2014 Sep;33(5):524-30. doi: 10.1097/PGP.0000000000000086. PMID: 25083971
Immunohistochemical staining for Ki-67 antigen, carcinoembryonic antigen, and p53 in the differential diagnosis of glandular lesions of the cervix.
Cina SJ, Richardson MS, Austin RM, Kurman RJ
Mod Pathol 1997 Mar;10(3):176-80. PMID: 9071723

Recent clinical studies

Therapy

Association of Cervical Microglandular Hyperplasia With Exogenous Progestin Exposure.
Heller DS, Nguyen L, Goldsmith LT
J Low Genit Tract Dis 2016 Apr;20(2):162-4. doi: 10.1097/LGT.0000000000000176. PMID: 26796659
Cervical cytology and immunohistochemical features in endometrial adenocarcinoma simulating microglandular hyperplasia. A case report.
Shidham VB, Dayer AM, Basir Z, Kajdacsy-Balla A
Acta Cytol 2000 Jul-Aug;44(4):661-6. doi: 10.1159/000328544. PMID: 10934963

Prognosis

Utility of p63 and PTEN staining in distinguishing cervical microglandular hyperplasia from endometrial endometrioid carcinoma with microglandular/mucinous features.
Aoun BA, Skala SL
Histopathology 2022 Jun;80(7):1102-1111. Epub 2022 May 5 doi: 10.1111/his.14655. PMID: 35347751Free PMC Article

Clinical prediction guides

Utility of p63 and PTEN staining in distinguishing cervical microglandular hyperplasia from endometrial endometrioid carcinoma with microglandular/mucinous features.
Aoun BA, Skala SL
Histopathology 2022 Jun;80(7):1102-1111. Epub 2022 May 5 doi: 10.1111/his.14655. PMID: 35347751Free PMC Article
Association of Cervical Microglandular Hyperplasia With Exogenous Progestin Exposure.
Heller DS, Nguyen L, Goldsmith LT
J Low Genit Tract Dis 2016 Apr;20(2):162-4. doi: 10.1097/LGT.0000000000000176. PMID: 26796659

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