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Cervical Microglandular Hyperplasia

MedGen UID:
927344
•Concept ID:
C4289812
•
Pathologic Function

Definition

A benign endocervical gland proliferation characterized by the presence of closely packed glands composed of columnar to cuboidal cells with subnuclear mucin vacuoles. It is associated with progestins or pregnancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Microglandular Hyperplasia

Professional guidelines

PubMed

Mitotically active microglandular hyperplasia of the cervix: a case series with implications for the differential diagnosis.
Abi-Raad R, Alomari A, Hui P, Buza N
Int J Gynecol Pathol 2014 Sep;33(5):524-30. doi: 10.1097/PGP.0000000000000086. PMID: 25083971
Immunohistochemical staining for Ki-67 antigen, carcinoembryonic antigen, and p53 in the differential diagnosis of glandular lesions of the cervix.
Cina SJ, Richardson MS, Austin RM, Kurman RJ
Mod Pathol 1997 Mar;10(3):176-80. PMID: 9071723

Recent clinical studies

Etiology

Morphologic changes in the endometrium associated with the use of the mirena coil: a retrospective study of 106 cases.
Hejmadi RK, Chaudhri S, Ganesan R, Rollason TP
Int J Surg Pathol 2007 Apr;15(2):148-54. doi: 10.1177/1066896906299120. PMID: 17478768
Clinical significance of a cytologic diagnosis of atypical glandular cells, favor endometrial origin, in Pap smears.
Saad RS, Takei H, Liu YL, Silverman JE, Lipscomb JT, Ruiz B
Acta Cytol 2006 Jan-Feb;50(1):48-54. doi: 10.1159/000325894. PMID: 16514840
Surface epithelial changes in endometrial adenocarcinoma: diagnostic pitfalls in curettage specimens.
Jacques SM, Qureshi F, Lawrence WD
Int J Gynecol Pathol 1995 Jul;14(3):191-7. doi: 10.1097/00004347-199507000-00001. PMID: 8600069

Diagnosis

Utility of p63 and PTEN staining in distinguishing cervical microglandular hyperplasia from endometrial endometrioid carcinoma with microglandular/mucinous features.
Aoun BA, Skala SL
Histopathology 2022 Jun;80(7):1102-1111. Epub 2022 May 5 doi: 10.1111/his.14655. PMID: 35347751Free PMC Article
PAX2 and cyclin D1 expression in the distinction between cervical microglandular hyperplasia and endometrial microglandular-like carcinoma: a comparison with p16, vimentin, and Ki67.
Stewart CJ, Crook ML
Int J Gynecol Pathol 2015 Jan;34(1):90-100. doi: 10.1097/PGP.0000000000000107. PMID: 25473758
The expression and diagnostic utility of p63 in the female genital tract.
Houghton O, McCluggage WG
Adv Anat Pathol 2009 Sep;16(5):316-21. doi: 10.1097/PAP.0b013e3181b507c6. PMID: 19700941
Comparison of morphologic and immunohistochemical features of cervical microglandular hyperplasia with low-grade mucinous adenocarcinoma of the endometrium.
Qiu W, Mittal K
Int J Gynecol Pathol 2003 Jul;22(3):261-5. doi: 10.1097/01.PGP.0000071043.12278.8D. PMID: 12819393
Cervical cytology and immunohistochemical features in endometrial adenocarcinoma simulating microglandular hyperplasia. A case report.
Shidham VB, Dayer AM, Basir Z, Kajdacsy-Balla A
Acta Cytol 2000 Jul-Aug;44(4):661-6. doi: 10.1159/000328544. PMID: 10934963

Therapy

Association of Cervical Microglandular Hyperplasia With Exogenous Progestin Exposure.
Heller DS, Nguyen L, Goldsmith LT
J Low Genit Tract Dis 2016 Apr;20(2):162-4. doi: 10.1097/LGT.0000000000000176. PMID: 26796659
Cervical cytology and immunohistochemical features in endometrial adenocarcinoma simulating microglandular hyperplasia. A case report.
Shidham VB, Dayer AM, Basir Z, Kajdacsy-Balla A
Acta Cytol 2000 Jul-Aug;44(4):661-6. doi: 10.1159/000328544. PMID: 10934963

Prognosis

Utility of p63 and PTEN staining in distinguishing cervical microglandular hyperplasia from endometrial endometrioid carcinoma with microglandular/mucinous features.
Aoun BA, Skala SL
Histopathology 2022 Jun;80(7):1102-1111. Epub 2022 May 5 doi: 10.1111/his.14655. PMID: 35347751Free PMC Article

Clinical prediction guides

Utility of p63 and PTEN staining in distinguishing cervical microglandular hyperplasia from endometrial endometrioid carcinoma with microglandular/mucinous features.
Aoun BA, Skala SL
Histopathology 2022 Jun;80(7):1102-1111. Epub 2022 May 5 doi: 10.1111/his.14655. PMID: 35347751Free PMC Article
Association of Cervical Microglandular Hyperplasia With Exogenous Progestin Exposure.
Heller DS, Nguyen L, Goldsmith LT
J Low Genit Tract Dis 2016 Apr;20(2):162-4. doi: 10.1097/LGT.0000000000000176. PMID: 26796659

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