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Deep cerebral white matter hyperintensities

MedGen UID:
927594
•Concept ID:
C4293685
•
Finding
Synonym: Deep cerebral white matter hyperdensities
 
HPO: HP:0030892

Definition

Areas of brighter than expected signal on magnetic resonance imaging emanating from locations distant from the ventricular system. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDeep cerebral white matter hyperintensities

Professional guidelines

PubMed

Primary central nervous system lymphoma: Imaging features and differential diagnosis.
Ribas GA, de Mori LH, Freddi TAL, Oliveira LDS, de Souza SR, Corrêa DG
Neuroradiol J 2024 Dec;37(6):705-722. Epub 2024 May 4 doi: 10.1177/19714009241252625. PMID: 38703015Free PMC Article
Diagnosis and Treatment Effect of Convolutional Neural Network-Based Magnetic Resonance Image Features on Severe Stroke and Mental State.
Han L, Liu L, Hao Y, Zhang L
Contrast Media Mol Imaging 2021;2021:8947789. Epub 2021 Jul 26 doi: 10.1155/2021/8947789. PMID: 34385898Free PMC Article
Seoul criteria for PiB(-) subcortical vascular dementia based on clinical and MRI variables.
Kim GH, Lee JH, Seo SW, Ye BS, Cho H, Kim HJ, Noh Y, Yoon CW, Chin JH, Oh SJ, Kim JS, Choe YS, Lee KH, Kim ST, Jeong JH, Na DL
Neurology 2014 Apr 29;82(17):1529-35. Epub 2014 Mar 28 doi: 10.1212/WNL.0000000000000360. PMID: 24682969

Recent clinical studies

Etiology

Cerebral small vessel disease: A review.
Chojdak-Łukasiewicz J, Dziadkowiak E, Zimny A, Paradowski B
Adv Clin Exp Med 2021 Mar;30(3):349-356. doi: 10.17219/acem/131216. PMID: 33768739
White Matter Lesions in Migraine.
Eikermann-Haerter K, Huang SY
Am J Pathol 2021 Nov;191(11):1955-1962. Epub 2021 Feb 24 doi: 10.1016/j.ajpath.2021.02.007. PMID: 33636178
Diabetes mellitus and white matter hyperintensity.
Tamura Y, Araki A
Geriatr Gerontol Int 2015 Dec;15 Suppl 1:34-42. doi: 10.1111/ggi.12666. PMID: 26671155
White matter integrity and cognitive dysfunction: Radiological and neuropsychological correlations.
Tomimoto H
Geriatr Gerontol Int 2015 Dec;15 Suppl 1:3-9. doi: 10.1111/ggi.12661. PMID: 26671151
MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging.
Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA
AJR Am J Roentgenol 1987 Aug;149(2):351-6. doi: 10.2214/ajr.149.2.351. PMID: 3496763

Diagnosis

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
HTLV-1 encephalitis.
King-Robson J, Hampton T, Rosadas C, Taylor GP, Stanton B
Pract Neurol 2022 Feb;22(1):60-63. Epub 2021 Aug 30 doi: 10.1136/practneurol-2021-003053. PMID: 34462338
Cerebral small vessel disease: A review.
Chojdak-Łukasiewicz J, Dziadkowiak E, Zimny A, Paradowski B
Adv Clin Exp Med 2021 Mar;30(3):349-356. doi: 10.17219/acem/131216. PMID: 33768739
MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders.
Shahriari M, Sotirchos ES, Newsome SD, Yousem DM
AJR Am J Roentgenol 2021 Apr;216(4):1031-1039. Epub 2021 Feb 17 doi: 10.2214/AJR.20.24061. PMID: 32755221
MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging.
Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA
AJR Am J Roentgenol 1987 Aug;149(2):351-6. doi: 10.2214/ajr.149.2.351. PMID: 3496763

Therapy

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis.
Wu TS, Wu PH, Lin HF, Chen WC, Huang TH, Lin MY, Chuang YS, Yang FG, Chiu YW, Chang JM, Kuo MC, Lin YT
Ann Med 2024 Dec;56(1):2310142. Epub 2024 Feb 7 doi: 10.1080/07853890.2024.2310142. PMID: 38324920Free PMC Article
White matter hyperintensities in patients with Parkinson's disease: A systematic review and meta-analysis.
Butt A, Kamtchum-Tatuene J, Khan K, Shuaib A, Jickling GC, Miyasaki JM, Smith EE, Camicioli R
J Neurol Sci 2021 Jul 15;426:117481. Epub 2021 May 4 doi: 10.1016/j.jns.2021.117481. PMID: 33975191
Age differences in periventricular and deep white matter lesions.
Nyquist PA, Bilgel M, Gottesman R, Yanek LR, Moy TF, Becker LC, Cuzzocreo JL, Prince J, Wasserman BA, Yousem DM, Becker DM, Kral BG, Vaidya D
Neurobiol Aging 2015 Apr;36(4):1653-1658. Epub 2015 Jan 7 doi: 10.1016/j.neurobiolaging.2015.01.005. PMID: 25659858Free PMC Article
Factors associated with cerebral white matter hyperintensities in haemodialysis patients.
Naganuma T, Takemoto Y, Shoji T, Shima H, Ishimura E, Okamura M, Nakatani T
Nephrology (Carlton) 2012 Aug;17(6):561-8. doi: 10.1111/j.1440-1797.2012.01596.x. PMID: 22429518

Prognosis

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study.
Sleight E, Stringer MS, Clancy U, Arteaga C, Jaime Garcia D, Hewins W, Jochems ACC, Hamilton OKL, Manning C, Morgan AG, Locherty R, Cheng Y, Liu X, Zhang J, Hamilton I, Jardine C, Brown R, Sakka E, Kampaite A, Wiseman S, Valdés-Hernández MC, Chappell FM, Doubal FN, Marshall I, Thrippleton MJ, Wardlaw JM
Stroke 2023 Nov;54(11):2776-2784. Epub 2023 Oct 10 doi: 10.1161/STROKEAHA.123.042656. PMID: 37814956Free PMC Article
MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders.
Shahriari M, Sotirchos ES, Newsome SD, Yousem DM
AJR Am J Roentgenol 2021 Apr;216(4):1031-1039. Epub 2021 Feb 17 doi: 10.2214/AJR.20.24061. PMID: 32755221
Diabetes mellitus and white matter hyperintensity.
Tamura Y, Araki A
Geriatr Gerontol Int 2015 Dec;15 Suppl 1:34-42. doi: 10.1111/ggi.12666. PMID: 26671155
White matter integrity and cognitive dysfunction: Radiological and neuropsychological correlations.
Tomimoto H
Geriatr Gerontol Int 2015 Dec;15 Suppl 1:3-9. doi: 10.1111/ggi.12661. PMID: 26671151

Clinical prediction guides

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
Genetic and Clinical Correlates of AI-Based Brain Aging Patterns in Cognitively Unimpaired Individuals.
Skampardoni I, Nasrallah IM, Abdulkadir A, Wen J, Melhem R, Mamourian E, Erus G, Doshi J, Singh A, Yang Z, Cui Y, Hwang G, Ren Z, Pomponio R, Srinivasan D, Govindarajan ST, Parmpi P, Wittfeld K, Grabe HJ, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Marcus DS, LaMontagne P, Heckbert SR, Austin TR, Launer LJ, Sotiras A, Espeland MA, Masters CL, Maruff P, Fripp J, Johnson SC, Morris JC, Albert MS, Bryan RN, Yaffe K, Völzke H, Ferrucci L, Benzinger TLS, Ezzati A, Shinohara RT, Fan Y, Resnick SM, Habes M, Wolk D, Shou H, Nikita K, Davatzikos C
JAMA Psychiatry 2024 May 1;81(5):456-467. doi: 10.1001/jamapsychiatry.2023.5599. PMID: 38353984Free PMC Article
Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study.
Sleight E, Stringer MS, Clancy U, Arteaga C, Jaime Garcia D, Hewins W, Jochems ACC, Hamilton OKL, Manning C, Morgan AG, Locherty R, Cheng Y, Liu X, Zhang J, Hamilton I, Jardine C, Brown R, Sakka E, Kampaite A, Wiseman S, Valdés-Hernández MC, Chappell FM, Doubal FN, Marshall I, Thrippleton MJ, Wardlaw JM
Stroke 2023 Nov;54(11):2776-2784. Epub 2023 Oct 10 doi: 10.1161/STROKEAHA.123.042656. PMID: 37814956Free PMC Article
Deep-Learning-Based Segmentation and Localization of White Matter Hyperintensities on Magnetic Resonance Images.
Jiang W, Lin F, Zhang J, Zhan T, Cao P, Wang S
Interdiscip Sci 2020 Dec;12(4):438-446. Epub 2020 Nov 2 doi: 10.1007/s12539-020-00398-0. PMID: 33140170
MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging.
Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA
AJR Am J Roentgenol 1987 Aug;149(2):351-6. doi: 10.2214/ajr.149.2.351. PMID: 3496763

Recent systematic reviews

White matter hyperintensities and post-stroke depression: A systematic review and meta-analysis.
Zhang F, Ping Y, Jin X, Hou X, Song J
J Affect Disord 2023 Jan 1;320:370-380. Epub 2022 Oct 6 doi: 10.1016/j.jad.2022.09.166. PMID: 36209775
White matter hyperintensities in patients with Parkinson's disease: A systematic review and meta-analysis.
Butt A, Kamtchum-Tatuene J, Khan K, Shuaib A, Jickling GC, Miyasaki JM, Smith EE, Camicioli R
J Neurol Sci 2021 Jul 15;426:117481. Epub 2021 May 4 doi: 10.1016/j.jns.2021.117481. PMID: 33975191
White matter lesions and depression: a systematic review and meta-analysis.
Wang L, Leonards CO, Sterzer P, Ebinger M
J Psychiatr Res 2014 Sep;56:56-64. Epub 2014 Jun 9 doi: 10.1016/j.jpsychires.2014.05.005. PMID: 24948437
Systematic review of structural and functional neuroimaging findings in children and adults with CKD.
Moodalbail DG, Reiser KA, Detre JA, Schultz RT, Herrington JD, Davatzikos C, Doshi JJ, Erus G, Liu HS, Radcliffe J, Furth SL, Hooper SR
Clin J Am Soc Nephrol 2013 Aug;8(8):1429-48. Epub 2013 May 30 doi: 10.2215/CJN.11601112. PMID: 23723341Free PMC Article
White matter hyperintensities in late life depression: a systematic review.
Herrmann LL, Le Masurier M, Ebmeier KP
J Neurol Neurosurg Psychiatry 2008 Jun;79(6):619-24. Epub 2007 Aug 23 doi: 10.1136/jnnp.2007.124651. PMID: 17717021

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