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Deep cerebral white matter hyperintensities

MedGen UID:
927594
Concept ID:
C4293685
Finding
Synonym: Deep cerebral white matter hyperdensities
 
HPO: HP:0030892

Definition

Areas of brighter than expected signal on magnetic resonance imaging emanating from locations distant from the ventricular system. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDeep cerebral white matter hyperintensities

Professional guidelines

PubMed

Han L, Liu L, Hao Y, Zhang L
Contrast Media Mol Imaging 2021;2021:8947789. Epub 2021 Jul 26 doi: 10.1155/2021/8947789. PMID: 34385898Free PMC Article
Matsushima T, Conedera S, Tanaka R, Li Y, Yoshino H, Funayama M, Ikeda A, Hosaka Y, Okuzumi A, Shimada Y, Yamashiro K, Motoi Y, Nishioka K, Hattori N
Neurobiol Aging 2017 Feb;50:169.e7-169.e14. Epub 2016 Nov 2 doi: 10.1016/j.neurobiolaging.2016.10.026. PMID: 27890607
Kim GH, Lee JH, Seo SW, Ye BS, Cho H, Kim HJ, Noh Y, Yoon CW, Chin JH, Oh SJ, Kim JS, Choe YS, Lee KH, Kim ST, Jeong JH, Na DL
Neurology 2014 Apr 29;82(17):1529-35. Epub 2014 Mar 28 doi: 10.1212/WNL.0000000000000360. PMID: 24682969

Recent clinical studies

Etiology

Sleight E, Stringer MS, Clancy U, Arteaga C, Jaime Garcia D, Hewins W, Jochems ACC, Hamilton OKL, Manning C, Morgan AG, Locherty R, Cheng Y, Liu X, Zhang J, Hamilton I, Jardine C, Brown R, Sakka E, Kampaite A, Wiseman S, Valdés-Hernández MC, Chappell FM, Doubal FN, Marshall I, Thrippleton MJ, Wardlaw JM
Stroke 2023 Nov;54(11):2776-2784. Epub 2023 Oct 10 doi: 10.1161/STROKEAHA.123.042656. PMID: 37814956Free PMC Article
Terracciano A, Cenatus B, Zhu X, Karakose S, Stephan Y, Marcolini S, De Deyn PP, Luchetti M, Sutin AR
J Psychiatr Res 2023 Sep;165:174-179. Epub 2023 Jul 21 doi: 10.1016/j.jpsychires.2023.07.026. PMID: 37506413Free PMC Article
Zhang F, Ping Y, Jin X, Hou X, Song J
J Affect Disord 2023 Jan 1;320:370-380. Epub 2022 Oct 6 doi: 10.1016/j.jad.2022.09.166. PMID: 36209775
Chojdak-Łukasiewicz J, Dziadkowiak E, Zimny A, Paradowski B
Adv Clin Exp Med 2021 Mar;30(3):349-356. doi: 10.17219/acem/131216. PMID: 33768739
Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA
AJR Am J Roentgenol 1987 Aug;149(2):351-6. doi: 10.2214/ajr.149.2.351. PMID: 3496763

Diagnosis

Terracciano A, Cenatus B, Zhu X, Karakose S, Stephan Y, Marcolini S, De Deyn PP, Luchetti M, Sutin AR
J Psychiatr Res 2023 Sep;165:174-179. Epub 2023 Jul 21 doi: 10.1016/j.jpsychires.2023.07.026. PMID: 37506413Free PMC Article
King-Robson J, Hampton T, Rosadas C, Taylor GP, Stanton B
Pract Neurol 2022 Feb;22(1):60-63. Epub 2021 Aug 30 doi: 10.1136/practneurol-2021-003053. PMID: 34462338
Chojdak-Łukasiewicz J, Dziadkowiak E, Zimny A, Paradowski B
Adv Clin Exp Med 2021 Mar;30(3):349-356. doi: 10.17219/acem/131216. PMID: 33768739
Shahriari M, Sotirchos ES, Newsome SD, Yousem DM
AJR Am J Roentgenol 2021 Apr;216(4):1031-1039. Epub 2021 Feb 17 doi: 10.2214/AJR.20.24061. PMID: 32755221
Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA
AJR Am J Roentgenol 1987 Aug;149(2):351-6. doi: 10.2214/ajr.149.2.351. PMID: 3496763

Therapy

Tian Y, Yao D, Pan Y, Wang M, Meng X, Zhao X, Liu L, Wang Y, Wang Y
CNS Neurosci Ther 2023 May;29(5):1379-1391. Epub 2023 Feb 14 doi: 10.1111/cns.14111. PMID: 36786131Free PMC Article
Jeong SH, Lee HS, Jung JH, Baik K, Sohn YH, Chung SJ, Lee PH
Parkinsonism Relat Disord 2022 Apr;97:1-7. Epub 2022 Mar 3 doi: 10.1016/j.parkreldis.2022.02.020. PMID: 35276583
Butt A, Kamtchum-Tatuene J, Khan K, Shuaib A, Jickling GC, Miyasaki JM, Smith EE, Camicioli R
J Neurol Sci 2021 Jul 15;426:117481. Epub 2021 May 4 doi: 10.1016/j.jns.2021.117481. PMID: 33975191
Nyquist PA, Bilgel M, Gottesman R, Yanek LR, Moy TF, Becker LC, Cuzzocreo JL, Prince J, Wasserman BA, Yousem DM, Becker DM, Kral BG, Vaidya D
Neurobiol Aging 2015 Apr;36(4):1653-1658. Epub 2015 Jan 7 doi: 10.1016/j.neurobiolaging.2015.01.005. PMID: 25659858Free PMC Article
Herrmann LL, Le Masurier M, Ebmeier KP
J Neurol Neurosurg Psychiatry 2008 Jun;79(6):619-24. Epub 2007 Aug 23 doi: 10.1136/jnnp.2007.124651. PMID: 17717021

Prognosis

Sleight E, Stringer MS, Clancy U, Arteaga C, Jaime Garcia D, Hewins W, Jochems ACC, Hamilton OKL, Manning C, Morgan AG, Locherty R, Cheng Y, Liu X, Zhang J, Hamilton I, Jardine C, Brown R, Sakka E, Kampaite A, Wiseman S, Valdés-Hernández MC, Chappell FM, Doubal FN, Marshall I, Thrippleton MJ, Wardlaw JM
Stroke 2023 Nov;54(11):2776-2784. Epub 2023 Oct 10 doi: 10.1161/STROKEAHA.123.042656. PMID: 37814956Free PMC Article
Tian Y, Yao D, Pan Y, Wang M, Meng X, Zhao X, Liu L, Wang Y, Wang Y
CNS Neurosci Ther 2023 May;29(5):1379-1391. Epub 2023 Feb 14 doi: 10.1111/cns.14111. PMID: 36786131Free PMC Article
Hung SH, Khlif MS, Kramer S, Werden E, Bird LJ, Campbell BCV, Brodtmann A
Med Sci Sports Exerc 2022 Sep 1;54(9):1401-1409. Epub 2022 Apr 25 doi: 10.1249/MSS.0000000000002946. PMID: 35482768
Shahriari M, Sotirchos ES, Newsome SD, Yousem DM
AJR Am J Roentgenol 2021 Apr;216(4):1031-1039. Epub 2021 Feb 17 doi: 10.2214/AJR.20.24061. PMID: 32755221
Tamura Y, Araki A
Geriatr Gerontol Int 2015 Dec;15 Suppl 1:34-42. doi: 10.1111/ggi.12666. PMID: 26671155

Clinical prediction guides

Sleight E, Stringer MS, Clancy U, Arteaga C, Jaime Garcia D, Hewins W, Jochems ACC, Hamilton OKL, Manning C, Morgan AG, Locherty R, Cheng Y, Liu X, Zhang J, Hamilton I, Jardine C, Brown R, Sakka E, Kampaite A, Wiseman S, Valdés-Hernández MC, Chappell FM, Doubal FN, Marshall I, Thrippleton MJ, Wardlaw JM
Stroke 2023 Nov;54(11):2776-2784. Epub 2023 Oct 10 doi: 10.1161/STROKEAHA.123.042656. PMID: 37814956Free PMC Article
Alban SL, Lynch KM, Ringman JM, Toga AW, Chui HC, Sepehrband F, Choupan J; Alzheimer's Disease Neuroimaging Initiative
Neuroimage Clin 2023;38:103383. Epub 2023 Mar 20 doi: 10.1016/j.nicl.2023.103383. PMID: 36965457Free PMC Article
Tian Y, Yao D, Pan Y, Wang M, Meng X, Zhao X, Liu L, Wang Y, Wang Y
CNS Neurosci Ther 2023 May;29(5):1379-1391. Epub 2023 Feb 14 doi: 10.1111/cns.14111. PMID: 36786131Free PMC Article
Thurston RC, Wu M, Chang YF, Aizenstein HJ, Derby CA, Barinas-Mitchell EA, Maki P
Neurology 2023 Jan 10;100(2):e133-e141. Epub 2022 Oct 12 doi: 10.1212/WNL.0000000000201401. PMID: 36224031Free PMC Article
Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA
AJR Am J Roentgenol 1987 Aug;149(2):351-6. doi: 10.2214/ajr.149.2.351. PMID: 3496763

Recent systematic reviews

Zhang F, Ping Y, Jin X, Hou X, Song J
J Affect Disord 2023 Jan 1;320:370-380. Epub 2022 Oct 6 doi: 10.1016/j.jad.2022.09.166. PMID: 36209775
Butt A, Kamtchum-Tatuene J, Khan K, Shuaib A, Jickling GC, Miyasaki JM, Smith EE, Camicioli R
J Neurol Sci 2021 Jul 15;426:117481. Epub 2021 May 4 doi: 10.1016/j.jns.2021.117481. PMID: 33975191
Wang L, Leonards CO, Sterzer P, Ebinger M
J Psychiatr Res 2014 Sep;56:56-64. Epub 2014 Jun 9 doi: 10.1016/j.jpsychires.2014.05.005. PMID: 24948437
Moodalbail DG, Reiser KA, Detre JA, Schultz RT, Herrington JD, Davatzikos C, Doshi JJ, Erus G, Liu HS, Radcliffe J, Furth SL, Hooper SR
Clin J Am Soc Nephrol 2013 Aug;8(8):1429-48. Epub 2013 May 30 doi: 10.2215/CJN.11601112. PMID: 23723341Free PMC Article
Herrmann LL, Le Masurier M, Ebmeier KP
J Neurol Neurosurg Psychiatry 2008 Jun;79(6):619-24. Epub 2007 Aug 23 doi: 10.1136/jnnp.2007.124651. PMID: 17717021

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