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Insulin coma

MedGen UID:: 9496
•Concept ID:: C0021645
•: Disease or Syndrome

Synonyms:	Coma, Insulin; Insulin Coma
SNOMED CT:	Insulin coma (111558006)

Definition

A hypoglycemia-induced comatose state resulting from a large dose of exogenous insulin. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVInsulin coma

Clinical finding
- Finding by Site or System
  - Neurological finding
    - Level of consciousness
      - Depressed Level Of Consciousness
        Coma
        Insulin coma

Professional guidelines

PubMed

Practical management of diabetic ketoacidosis and hyperosmolar coma.

Hamblin PS, Topliss DJ, Stockigt JR
Aust N Z J Med 1990 Dec;20(6):836-41. doi: 10.1111/j.1445-5994.1990.tb00437.x. PMID: 2127177

Effectiveness of insulin coma in the treatment of schizopbrenia; a control study.

PATTERSON ES
AMA Arch Neurol Psychiatry 1958 Apr;79(4):460-7. doi: 10.1001/archneurpsyc.1958.02340040104011. PMID: 13519949

The treatment and theory of prolonged insulin coma with a case presentation.

KALICHMAN N
Psychiatr Q 1948 Apr;22(2):213-30. PMID: 18874311

See all (22)

Recent clinical studies

Etiology

Improving Current Treatments for Schizophrenia.

Maric NP, Jovicic MJ, Mihaljevic M, Miljevic C
Drug Dev Res 2016 Nov;77(7):357-367. Epub 2016 Sep 16 doi: 10.1002/ddr.21337. PMID: 27633376

Severity of symptoms in chronically institutionalized geriatric schizophrenic patients.

Davidson M, Harvey PD, Powchik P, Parrella M, White L, Knobler HY, Losonczy MF, Keefe RS, Katz S, Frecska E
Am J Psychiatry 1995 Feb;152(2):197-207. doi: 10.1176/ajp.152.2.197. PMID: 7840352

Increasing incidence of hypoglycemic coma in children with IDDM.

Egger M, Gschwend S, Smith GD, Zuppinger K
Diabetes Care 1991 Nov;14(11):1001-5. doi: 10.2337/diacare.14.11.1001. PMID: 1797479

Factitious brittle diabetes mellitus.

Schade DS, Drumm DA, Eaton RP, Sterling WA
Am J Med 1985 May;78(5):777-84. doi: 10.1016/0002-9343(85)90283-9. PMID: 3922220

Insulin coma and group psychotherapy.

MORROW TF, LAUCKS SP, MCKNIGHT WK
AMA Arch Neurol Psychiatry 1952 Oct;68(4):491-7. doi: 10.1001/archneurpsyc.1952.02320220068007. PMID: 12975892

See all (36)

Diagnosis

Atropine coma: a historical note.

Gazdag G, Bitter I, Ungvári G, Gerevich J
J ECT 2005 Dec;21(4):203-6. doi: 10.1097/01.yct.0000180041.13962.e4. PMID: 16301877

The diabetic dental patient.

Rees TD
Dent Clin North Am 1994 Jul;38(3):447-63. PMID: 7926197

Insulin-induced factitious hypoglycemic coma.

Price WA, Zimmer B, Conway R, Szekely B
Gen Hosp Psychiatry 1986 Jul;8(4):291-3. doi: 10.1016/0163-8343(86)90012-5. PMID: 3527869

Hypoglycemia: an overview.

Leggett J, Favazza AR
J Clin Psychiatry 1978 Jan;39(1):51-7. PMID: 204622

ELECTROENCEPHALOGRAMS DURING COMA.

LOEB C
Acta Neurochir (Wien) 1964;12:270-81. doi: 10.1007/BF01402098. PMID: 14293381

See all (38)

Therapy

'A landmark in psychiatric progress'? The role of evidence in the rise and fall of insulin coma therapy.

Freudenthal R, Moncrieff J
Hist Psychiatry 2022 Mar;33(1):65-78. Epub 2021 Dec 22 doi: 10.1177/0957154X211062538. PMID: 34935541 Free PMC Article

Improving Current Treatments for Schizophrenia.

Maric NP, Jovicic MJ, Mihaljevic M, Miljevic C
Drug Dev Res 2016 Nov;77(7):357-367. Epub 2016 Sep 16 doi: 10.1002/ddr.21337. PMID: 27633376

Hypoglycemic neuropathy.

Mohseni S
Acta Neuropathol 2001 Nov;102(5):413-21. doi: 10.1007/s004010100459. PMID: 11699552

Electroconvulsive therapy for schizophrenia.

Tharyan P
Cochrane Database Syst Rev 2000;(2):CD000076. doi: 10.1002/14651858.CD000076. PMID: 10796292

Diabetic and insulin coma.

NABARRO JD
Br Med J 1955 Apr 9;1(4918):902-4. doi: 10.1136/bmj.1.4918.902. PMID: 14363747 Free PMC Article

See all (87)

Prognosis

Can delirium relieve psychosis?

Malur C, Fink M, Francis A
Compr Psychiatry 2000 Nov-Dec;41(6):450-3. doi: 10.1053/comp.2000.16565. PMID: 11086151

Increasing incidence of hypoglycemic coma in children with IDDM.

Egger M, Gschwend S, Smith GD, Zuppinger K
Diabetes Care 1991 Nov;14(11):1001-5. doi: 10.2337/diacare.14.11.1001. PMID: 1797479

Factitious brittle diabetes mellitus.

Schade DS, Drumm DA, Eaton RP, Sterling WA
Am J Med 1985 May;78(5):777-84. doi: 10.1016/0002-9343(85)90283-9. PMID: 3922220

The effect of insulin coma and E.C.T. on the three-year prognosis of schizophrenia.

LEIBERMAN DM, HOENIG J, AUERBACH I
J Neurol Neurosurg Psychiatry 1957 May;20(2):108-13. doi: 10.1136/jnnp.20.2.108. PMID: 13429378 Free PMC Article

Observations on the relation between insulin coma dosage and prognosis in schizophrenia.

FREUDENBERG RK
J Ment Sci 1952 Jul;98(412):441-9. doi: 10.1192/bjp.98.412.441. PMID: 14938888

See all (28)

Clinical prediction guides

Pyrotherapy for the Treatment of Psychosis in the 21st Century: A Case Report and Literature Review.

Zuschlag ZD, Lalich CJ, Short EB, Hamner M, Kahn DA
J Psychiatr Pract 2016 Sep;22(5):410-5. doi: 10.1097/PRA.0000000000000181. PMID: 27648506

Hypoglycemic neuropathy.

Mohseni S
Acta Neuropathol 2001 Nov;102(5):413-21. doi: 10.1007/s004010100459. PMID: 11699552

Severity of symptoms in chronically institutionalized geriatric schizophrenic patients.

Davidson M, Harvey PD, Powchik P, Parrella M, White L, Knobler HY, Losonczy MF, Keefe RS, Katz S, Frecska E
Am J Psychiatry 1995 Feb;152(2):197-207. doi: 10.1176/ajp.152.2.197. PMID: 7840352

Increasing incidence of hypoglycemic coma in children with IDDM.

Egger M, Gschwend S, Smith GD, Zuppinger K
Diabetes Care 1991 Nov;14(11):1001-5. doi: 10.2337/diacare.14.11.1001. PMID: 1797479

Observations on the relation between insulin coma dosage and prognosis in schizophrenia.

FREUDENBERG RK
J Ment Sci 1952 Jul;98(412):441-9. doi: 10.1192/bjp.98.412.441. PMID: 14938888

See all (16)