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Depressed Level Of Consciousness

MedGen UID:
108194
•Concept ID:
C0549249
•
Finding
Synonyms: Consciousness, Level Depressed; Depressed Level of Consciousness

Definition

A neurologic state characterized by decreased ability to perceive and respond. [from NCI]

Professional guidelines

PubMed

Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus.
Schmiegelow K, Attarbaschi A, Barzilai S, Escherich G, Frandsen TL, Halsey C, Hough R, Jeha S, Kato M, Liang DC, Mikkelsen TS, Möricke A, Niinimäki R, Piette C, Putti MC, Raetz E, Silverman LB, Skinner R, Tuckuviene R, van der Sluis I, Zapotocka E; Ponte di Legno toxicity working group
Lancet Oncol 2016 Jun;17(6):e231-e239. doi: 10.1016/S1470-2045(16)30035-3. PMID: 27299279
Encephalitis diagnosis and management in the real world.
Long SS
Adv Exp Med Biol 2011;697:153-73. doi: 10.1007/978-1-4419-7185-2_11. PMID: 21120725
Nelarabine for the treatment of patients with relapsed or refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma.
DeAngelo DJ
Hematol Oncol Clin North Am 2009 Oct;23(5):1121-35, vii-viii. doi: 10.1016/j.hoc.2009.07.008. PMID: 19825456

Recent clinical studies

Etiology

In-Hospital Depressed Level of Consciousness and Long-Term Functional Outcomes in ICU Survivors.
Mart MF, Thompson JL, Ely EW, Pandharipande PP, Patel MB, Wilson JE, Williams Roberson S, Birdrow CI, Raman R, Brummel NE
Crit Care Med 2022 Nov 1;50(11):1618-1627. Epub 2022 Aug 23 doi: 10.1097/CCM.0000000000005656. PMID: 36005816Free PMC Article
COVID-19 Infection and Neurological Complications: Present Findings and Future Predictions.
Beghi E, Feigin V, Caso V, Santalucia P, Logroscino G
Neuroepidemiology 2020;54(5):364-369. Epub 2020 Jul 1 doi: 10.1159/000508991. PMID: 32610334Free PMC Article
EEG dynamical correlates of focal and diffuse causes of coma.
Kafashan M, Ryu S, Hargis MJ, Laurido-Soto O, Roberts DE, Thontakudi A, Eisenman L, Kummer TT, Ching S
BMC Neurol 2017 Nov 15;17(1):197. doi: 10.1186/s12883-017-0977-0. PMID: 29141595Free PMC Article
Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus.
Schmiegelow K, Attarbaschi A, Barzilai S, Escherich G, Frandsen TL, Halsey C, Hough R, Jeha S, Kato M, Liang DC, Mikkelsen TS, Möricke A, Niinimäki R, Piette C, Putti MC, Raetz E, Silverman LB, Skinner R, Tuckuviene R, van der Sluis I, Zapotocka E; Ponte di Legno toxicity working group
Lancet Oncol 2016 Jun;17(6):e231-e239. doi: 10.1016/S1470-2045(16)30035-3. PMID: 27299279
Cerebrovascular disorders.
Hutchison JS, Ichord R, Guerguerian AM, Deveber G
Semin Pediatr Neurol 2004 Jun;11(2):139-46. doi: 10.1016/j.spen.2004.04.004. PMID: 15259867

Diagnosis

COVID-19 Infection and Neurological Complications: Present Findings and Future Predictions.
Beghi E, Feigin V, Caso V, Santalucia P, Logroscino G
Neuroepidemiology 2020;54(5):364-369. Epub 2020 Jul 1 doi: 10.1159/000508991. PMID: 32610334Free PMC Article
Electrographic Seizures in Patients with Acute Encephalitis.
Viarasilpa T, Panyavachiraporn N, Osman G, Parres C, Varelas P, Van Harn M, Mayer SA
Neurocrit Care 2019 Feb;30(1):207-215. doi: 10.1007/s12028-018-0599-4. PMID: 30203384
EEG dynamical correlates of focal and diffuse causes of coma.
Kafashan M, Ryu S, Hargis MJ, Laurido-Soto O, Roberts DE, Thontakudi A, Eisenman L, Kummer TT, Ching S
BMC Neurol 2017 Nov 15;17(1):197. doi: 10.1186/s12883-017-0977-0. PMID: 29141595Free PMC Article
Cerebrovascular disorders.
Hutchison JS, Ichord R, Guerguerian AM, Deveber G
Semin Pediatr Neurol 2004 Jun;11(2):139-46. doi: 10.1016/j.spen.2004.04.004. PMID: 15259867
Pneumococcal sacroiliitis.
Pinson AG, Jolles PR, Balkissoon AR
South Med J 1997 Jun;90(6):649-52. doi: 10.1097/00007611-199706000-00015. PMID: 9191746

Therapy

A Real-World Pharmacovigilance Study of Ceftazidime/Avibactam: Data Mining of the Food and Drug Administration Adverse Event Reporting System Database.
Yao H, Wang Y, Peng Y, Huang Z, Gan G, Wang Z
J Clin Pharmacol 2024 Jul;64(7):820-827. Epub 2024 Feb 20 doi: 10.1002/jcph.2420. PMID: 38375685
Safety of nelarabine in adults with relapsed or refractory T-cell acute lymphoblastic leukemia/lymphoma.
Candoni A, Lazzarotto D, Petruzzellis G
Expert Opin Drug Saf 2021 Jul;20(7):751-756. Epub 2021 May 17 doi: 10.1080/14740338.2021.1919621. PMID: 33866913
Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus.
Schmiegelow K, Attarbaschi A, Barzilai S, Escherich G, Frandsen TL, Halsey C, Hough R, Jeha S, Kato M, Liang DC, Mikkelsen TS, Möricke A, Niinimäki R, Piette C, Putti MC, Raetz E, Silverman LB, Skinner R, Tuckuviene R, van der Sluis I, Zapotocka E; Ponte di Legno toxicity working group
Lancet Oncol 2016 Jun;17(6):e231-e239. doi: 10.1016/S1470-2045(16)30035-3. PMID: 27299279
Effect of sedation level on the prevalence of delirium when assessed with CAM-ICU and ICDSC.
Haenggi M, Blum S, Brechbuehl R, Brunello A, Jakob SM, Takala J
Intensive Care Med 2013 Dec;39(12):2171-9. Epub 2013 Aug 7 doi: 10.1007/s00134-013-3034-5. PMID: 23921976
Pneumococcal sacroiliitis.
Pinson AG, Jolles PR, Balkissoon AR
South Med J 1997 Jun;90(6):649-52. doi: 10.1097/00007611-199706000-00015. PMID: 9191746

Prognosis

Chemotherapy-induced autoimmune-mediated encephalitis during germinoma treatment.
Yamada N, Yamasaki K, Yamamoto N, Kuki I, Sakuma H, Hara J
Brain Dev 2021 Oct;43(9):967-971. Epub 2021 Jun 3 doi: 10.1016/j.braindev.2021.05.010. PMID: 34092404
COVID-19 Infection and Neurological Complications: Present Findings and Future Predictions.
Beghi E, Feigin V, Caso V, Santalucia P, Logroscino G
Neuroepidemiology 2020;54(5):364-369. Epub 2020 Jul 1 doi: 10.1159/000508991. PMID: 32610334Free PMC Article
Why Physicians Prescribe Prophylactic Seizure Medications after Intracerebral Hemorrhage: An Adaptive Conjoint Analysis.
Pinto D, Prabhakaran S, Tipton E, Naidech AM
J Stroke Cerebrovasc Dis 2020 Apr;29(4):104628. Epub 2020 Feb 6 doi: 10.1016/j.jstrokecerebrovasdis.2019.104628. PMID: 32033905Free PMC Article
Pneumococcal sacroiliitis.
Pinson AG, Jolles PR, Balkissoon AR
South Med J 1997 Jun;90(6):649-52. doi: 10.1097/00007611-199706000-00015. PMID: 9191746
Pharmacology of intravenous sedatives and opioids in critically ill patients.
Levine RL
Crit Care Clin 1994 Oct;10(4):709-31. PMID: 8000923

Clinical prediction guides

In-Hospital Depressed Level of Consciousness and Long-Term Functional Outcomes in ICU Survivors.
Mart MF, Thompson JL, Ely EW, Pandharipande PP, Patel MB, Wilson JE, Williams Roberson S, Birdrow CI, Raman R, Brummel NE
Crit Care Med 2022 Nov 1;50(11):1618-1627. Epub 2022 Aug 23 doi: 10.1097/CCM.0000000000005656. PMID: 36005816Free PMC Article
COVID-19 Infection and Neurological Complications: Present Findings and Future Predictions.
Beghi E, Feigin V, Caso V, Santalucia P, Logroscino G
Neuroepidemiology 2020;54(5):364-369. Epub 2020 Jul 1 doi: 10.1159/000508991. PMID: 32610334Free PMC Article
Effect of sedation level on the prevalence of delirium when assessed with CAM-ICU and ICDSC.
Haenggi M, Blum S, Brechbuehl R, Brunello A, Jakob SM, Takala J
Intensive Care Med 2013 Dec;39(12):2171-9. Epub 2013 Aug 7 doi: 10.1007/s00134-013-3034-5. PMID: 23921976
Acute hydrocephalus after subarachnoid hemorrhage.
Suarez-Rivera O
Surg Neurol 1998 May;49(5):563-5. doi: 10.1016/s0090-3019(97)00342-x. PMID: 9586937
Pharmacology of intravenous sedatives and opioids in critically ill patients.
Levine RL
Crit Care Clin 1994 Oct;10(4):709-31. PMID: 8000923

Recent systematic reviews

Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports.
Kupats E, Vrublevska J, Zvejniece B, Vavers E, Stelfa G, Zvejniece L, Dambrova M
Pharmacopsychiatry 2020 Sep;53(5):201-208. Epub 2020 Apr 27 doi: 10.1055/a-1151-5017. PMID: 32340063
The Full Outline of UnResponsiveness (FOUR) Score and Its Use in Outcome Prediction: A Scoping Systematic Review of the Adult Literature.
Almojuela A, Hasen M, Zeiler FA
Neurocrit Care 2019 Aug;31(1):162-175. doi: 10.1007/s12028-018-0630-9. PMID: 30411302

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