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Corticobasal degeneration disorder

MedGen UID:
95979
Concept ID:
C0393570
Disease or Syndrome
Synonyms: Cortical-Basal Ganglionic degeneration; Cortico-Basal Ganglionic Degeneration (CBGD); Corticobasal degeneration
SNOMED CT: Cortical basal ganglionic degeneration (18842008); Corticobasal degeneration (18842008); Corticodentatonigral degeneration with neuronal achromasia (18842008)
 
Monarch Initiative: MONDO:0022308

Definition

A progressive neurodegenerative condition affecting the cerebral cortex and basal ganglia. The disorder is characterized by varying degrees of cognitive and motor impairment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorticobasal degeneration disorder
Follow this link to review classifications for Corticobasal degeneration disorder in Orphanet.

Professional guidelines

PubMed

Meyer PT, Frings L, Rücker G, Hellwig S
J Nucl Med 2017 Dec;58(12):1888-1898. Epub 2017 Sep 14 doi: 10.2967/jnumed.116.186403. PMID: 28912150
Levin J, Kurz A, Arzberger T, Giese A, Höglinger GU
Dtsch Arztebl Int 2016 Feb 5;113(5):61-9. doi: 10.3238/arztebl.2016.0061. PMID: 26900156Free PMC Article
Armstrong MJ, Litvan I, Lang AE, Bak TH, Bhatia KP, Borroni B, Boxer AL, Dickson DW, Grossman M, Hallett M, Josephs KA, Kertesz A, Lee SE, Miller BL, Reich SG, Riley DE, Tolosa E, Tröster AI, Vidailhet M, Weiner WJ
Neurology 2013 Jan 29;80(5):496-503. doi: 10.1212/WNL.0b013e31827f0fd1. PMID: 23359374Free PMC Article

Recent clinical studies

Etiology

Cummings JL, Gonzalez MI, Pritchard MC, May PC, Toledo-Sherman LM, Harris GA
Alzheimers Res Ther 2023 Oct 6;15(1):168. doi: 10.1186/s13195-023-01321-7. PMID: 37803386Free PMC Article
Gallo D, Ruiz A, Sánchez-Juan P
Neuroscience 2023 May 10;518:27-37. Epub 2022 May 21 doi: 10.1016/j.neuroscience.2022.05.022. PMID: 35609758
Höglinger GU, Respondek G, Kovacs GG
Rev Neurol (Paris) 2018 Nov;174(9):664-668. Epub 2018 Aug 8 doi: 10.1016/j.neurol.2018.07.001. PMID: 30098799
Grijalvo-Perez AM, Litvan I
Semin Neurol 2014 Apr;34(2):160-73. Epub 2014 Jun 25 doi: 10.1055/s-0034-1381734. PMID: 24963675
Gilman S
Clin Geriatr Med 2006 Nov;22(4):827-42, vi. doi: 10.1016/j.cger.2006.06.007. PMID: 17000338

Diagnosis

Höglinger GU, Kassubek J, Csoti I, Ehret R, Herbst H, Wellach I, Winkler J, Jost WH
J Neural Transm (Vienna) 2017 Aug;124(8):997-1004. Epub 2017 Feb 27 doi: 10.1007/s00702-017-1700-4. PMID: 28243754
Stamelou M, Bhatia KP
Neurol Clin 2015 Feb;33(1):39-56. doi: 10.1016/j.ncl.2014.09.012. PMID: 25432722
Grijalvo-Perez AM, Litvan I
Semin Neurol 2014 Apr;34(2):160-73. Epub 2014 Jun 25 doi: 10.1055/s-0034-1381734. PMID: 24963675
Stamelou M, Quinn NP, Bhatia KP
Mov Disord 2013 Aug;28(9):1184-99. Epub 2013 May 29 doi: 10.1002/mds.25509. PMID: 23720239
Takeda N, Kishimoto Y, Yokota O
Adv Exp Med Biol 2012;724:300-16. doi: 10.1007/978-1-4614-0653-2_23. PMID: 22411252

Therapy

Gendron TF, Heckman MG, White LJ, Veire AM, Pedraza O, Burch AR, Bozoki AC, Dickerson BC, Domoto-Reilly K, Foroud T, Forsberg LK, Galasko DR, Ghoshal N, Graff-Radford NR, Grossman M, Heuer HW, Huey ED, Hsiung GR, Irwin DJ, Kaufer DI, Leger GC, Litvan I, Masdeu JC, Mendez MF, Onyike CU, Pascual B, Ritter A, Roberson ED, Rojas JC, Tartaglia MC, Wszolek ZK, Rosen H, Boeve BF, Boxer AL; ALLFTD consortium, Petrucelli L
Cell Rep Med 2022 Apr 19;3(4):100607. doi: 10.1016/j.xcrm.2022.100607. PMID: 35492244Free PMC Article
VandeVrede L, Ljubenkov PA, Rojas JC, Welch AE, Boxer AL
Neurotherapeutics 2020 Oct;17(4):1563-1581. doi: 10.1007/s13311-020-00888-5. PMID: 32676851Free PMC Article
VandeVrede L, Boxer AL, Polydoro M
Neurosci Lett 2020 Jul 13;731:134919. Epub 2020 May 4 doi: 10.1016/j.neulet.2020.134919. PMID: 32380145Free PMC Article
Pîrşcoveanu DFV, Pirici I, Tudorică V, Bălşeanu TA, Albu VC, Bondari S, Bumbea AM, Pîrşcoveanu M
Rom J Morphol Embryol 2017;58(4):1141-1150. PMID: 29556602
Wenning GK, Krismer F, Poewe W
Curr Opin Neurol 2011 Aug;24(4):331-8. doi: 10.1097/WCO.0b013e3283480569. PMID: 21577106Free PMC Article

Prognosis

VandeVrede L, Boxer AL, Polydoro M
Neurosci Lett 2020 Jul 13;731:134919. Epub 2020 May 4 doi: 10.1016/j.neulet.2020.134919. PMID: 32380145Free PMC Article
Raposo Rodríguez L, Tovar Salazar DJ, Fernández García N, Pastor Hernández L, Fernández Guinea Ó
Radiologia (Engl Ed) 2018 Nov-Dec;60(6):476-484. Epub 2018 Jun 11 doi: 10.1016/j.rx.2018.04.003. PMID: 29903629
Valli M, Strafella AP
Int Rev Psychiatry 2017 Dec;29(6):628-635. Epub 2017 Dec 5 doi: 10.1080/09540261.2017.1396446. PMID: 29206491
Grijalvo-Perez AM, Litvan I
Semin Neurol 2014 Apr;34(2):160-73. Epub 2014 Jun 25 doi: 10.1055/s-0034-1381734. PMID: 24963675
Gilman S
Clin Geriatr Med 2006 Nov;22(4):827-42, vi. doi: 10.1016/j.cger.2006.06.007. PMID: 17000338

Clinical prediction guides

Sharma AM, Thomas TL, Woodard DR, Kashmer OM, Diamond MI
Elife 2018 Dec 11;7 doi: 10.7554/eLife.37813. PMID: 30526844Free PMC Article
Raposo Rodríguez L, Tovar Salazar DJ, Fernández García N, Pastor Hernández L, Fernández Guinea Ó
Radiologia (Engl Ed) 2018 Nov-Dec;60(6):476-484. Epub 2018 Jun 11 doi: 10.1016/j.rx.2018.04.003. PMID: 29903629
Irwin DJ
Parkinsonism Relat Disord 2016 Jan;22 Suppl 1(0 1):S29-33. Epub 2015 Sep 8 doi: 10.1016/j.parkreldis.2015.09.020. PMID: 26382841Free PMC Article
Defebvre L
Neurophysiol Clin 2006 Sep-Dec;36(5-6):319-25. Epub 2006 Dec 13 doi: 10.1016/j.neucli.2006.11.003. PMID: 17336776
Vanek ZF, Jankovic J
Adv Neurol 2000;82:61-7. PMID: 10624471

Recent systematic reviews

Chang JY, Rukavina K, Lawn T, Chaudhuri KR
J Integr Neurosci 2021 Dec 30;20(4):1067-1078. doi: 10.31083/j.jin2004108. PMID: 34997730
Wittke C, Petkovic S, Dobricic V, Schaake S; MDS‐endorsed PSP Study Group, Respondek G, Weissbach A, Madoev H, Trinh J, Vollstedt EJ, Kuhnke N, Lohmann K, Dulovic Mahlow M, Marras C, König IR, Stamelou M, Bonifati V, Lill CM, Kasten M, Huppertz HJ, Höglinger G, Klein C
Mov Disord 2021 Jul;36(7):1499-1510. Epub 2021 Mar 19 doi: 10.1002/mds.28517. PMID: 34396589Free PMC Article
Pick S, Anderson DG, Asadi-Pooya AA, Aybek S, Baslet G, Bloem BR, Bradley-Westguard A, Brown RJ, Carson AJ, Chalder T, Damianova M, David AS, Edwards MJ, Epstein SA, Espay AJ, Garcin B, Goldstein LH, Hallett M, Jankovic J, Joyce EM, Kanaan RA, Keynejad RC, Kozlowska K, LaFaver K, LaFrance WC Jr, Lang AE, Lehn A, Lidstone S, Maurer CW, Mildon B, Morgante F, Myers L, Nicholson C, Nielsen G, Perez DL, Popkirov S, Reuber M, Rommelfanger KS, Schwingenshuh P, Serranova T, Shotbolt P, Stebbins GT, Stone J, Tijssen MA, Tinazzi M, Nicholson TR
J Neurol Neurosurg Psychiatry 2020 Jun;91(6):638-649. Epub 2020 Feb 28 doi: 10.1136/jnnp-2019-322180. PMID: 32111637Free PMC Article
Moretti DV
CNS Neurosci Ther 2019 Feb;25(2):159-174. Epub 2018 Oct 7 doi: 10.1111/cns.13068. PMID: 30294976Free PMC Article
Clarke CE, Lowry M
Eur J Neurol 2001 Nov;8(6):573-7. doi: 10.1046/j.1468-1331.2001.00308.x. PMID: 11784341

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