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Non-Neoplastic Brain Disorder

MedGen UID:
474893
•Concept ID:
C3273260
•
Disease or Syndrome

Definition

A non-neoplastic disorder that affects the brain. Representative examples include cerebrovascular disorder, hydrocephalus, and encephalitis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Brain Disorder

Professional guidelines

PubMed

Surgical Management of Brain Tumors with Focused Ultrasound.
Mehkri Y, Pierre K, Woodford SJ, Davidson CG, Urhie O, Sriram S, Hernandez J, Hanna C, Lucke-Wold B
Curr Oncol 2023 May 13;30(5):4990-5002. doi: 10.3390/curroncol30050377. PMID: 37232835Free PMC Article
Postoperative risk of IDH-mutant glioma-associated seizures and their potential management with IDH-mutant inhibitors.
Drumm MR, Wang W, Sears TK, Bell-Burdett K, Javier R, Cotton KY, Webb B, Byrne K, Unruh D, Thirunavu V, Walshon J, Steffens A, McCortney K, Lukas RV, Phillips JJ, Mohamed E, Finan JD, Santana-Santos L, Heimberger AB, Franz CK, Kurz J, Templer JW, Swanson GT, Horbinski C
J Clin Invest 2023 Jun 15;133(12) doi: 10.1172/JCI168035. PMID: 37104042Free PMC Article
Drug repurposing for the treatment of glioblastoma multiforme.
Abbruzzese C, Matteoni S, Signore M, Cardone L, Nath K, Glickson JD, Paggi MG
J Exp Clin Cancer Res 2017 Nov 28;36(1):169. doi: 10.1186/s13046-017-0642-x. PMID: 29179732Free PMC Article

Recent clinical studies

Etiology

In and around the pineal gland: a neuroimaging review.
Zaccagna F, Brown FS, Allinson KSJ, Devadass A, Kapadia A, Massoud TF, Matys T
Clin Radiol 2022 Feb;77(2):e107-e119. Epub 2021 Nov 11 doi: 10.1016/j.crad.2021.09.020. PMID: 34774298
An update on the central nervous system manifestations of neurofibromatosis type 1.
Nix JS, Blakeley J, Rodriguez FJ
Acta Neuropathol 2020 Apr;139(4):625-641. Epub 2019 Apr 8 doi: 10.1007/s00401-019-02002-2. PMID: 30963251Free PMC Article
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article
Insular lesionectomy for refractory epilepsy: management and outcome.
von Lehe M, Wellmer J, Urbach H, Schramm J, Elger CE, Clusmann H
Brain 2009 Apr;132(Pt 4):1048-56. Epub 2009 Mar 18 doi: 10.1093/brain/awp047. PMID: 19297505
Non-tumoral non-infectious intracranial calcifications.
Rózyło-Kalinowska I, Złomaniec J, Jedrzejewski G
Ann Univ Mariae Curie Sklodowska Med 2002;57(2):1-8. PMID: 12898811

Diagnosis

In and around the pineal gland: a neuroimaging review.
Zaccagna F, Brown FS, Allinson KSJ, Devadass A, Kapadia A, Massoud TF, Matys T
Clin Radiol 2022 Feb;77(2):e107-e119. Epub 2021 Nov 11 doi: 10.1016/j.crad.2021.09.020. PMID: 34774298
The neuropathological basis to the functional role of microglia/macrophages in gliomas.
Schiffer D, Mellai M, Bovio E, Annovazzi L
Neurol Sci 2017 Sep;38(9):1571-1577. Epub 2017 Jun 7 doi: 10.1007/s10072-017-3002-x. PMID: 28593528
Imaging diagnosis of brain metastasis.
Barajas RF Jr, Cha S
Prog Neurol Surg 2012;25:55-73. Epub 2012 Jan 6 doi: 10.1159/000331174. PMID: 22236668
Multiple ring-enhancing lesions of the brain.
Garg RK, Sinha MK
J Postgrad Med 2010 Oct-Dec;56(4):307-16. doi: 10.4103/0022-3859.70939. PMID: 20935408
Non-neoplastic pineal cysts.
Fetell MR, Bruce JN, Burke AM, Cross DT, Torres RA, Powers JM, Stein BM
Neurology 1991 Jul;41(7):1034-40. doi: 10.1212/wnl.41.7.1034. PMID: 2067630

Therapy

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article
Native Oligodendrocytes in Astrocytomas Might Inhibit Tumor Proliferation by WIF1 Expression.
Asslaber M, Schauer S, Gogg-Kamerer M, Bernhart E, Quehenberger F, Haybaeck J
J Neuropathol Exp Neurol 2017 Jan 1;76(1):16-26. doi: 10.1093/jnen/nlw098. PMID: 28040794
Convection-enhanced delivery of therapeutic agents into the brain.
Vogelbaum MA, Iannotti CA
Handb Clin Neurol 2012;104:355-62. doi: 10.1016/B978-0-444-52138-5.00023-2. PMID: 22230453
Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation.
Candolfi M, Kroeger KM, Xiong W, Liu C, Puntel M, Yagiz K, Muhammad AG, Mineharu Y, Foulad D, Wibowo M, Assi H, Baker GJ, Lowenstein PR, Castro MG
Anticancer Agents Med Chem 2011 Oct;11(8):729-38. doi: 10.2174/187152011797378689. PMID: 21707497Free PMC Article
Non-neoplastic intrasellar cysts.
Weiss SR, Raskind R
Int Surg 1969 Apr;51(4):282-8. PMID: 5774857

Prognosis

Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma.
DeCordova S, Shastri A, Tsolaki AG, Yasmin H, Klein L, Singh SK, Kishore U
Front Immunol 2020;11:1402. Epub 2020 Jul 17 doi: 10.3389/fimmu.2020.01402. PMID: 32765498Free PMC Article
The neuropathological basis to the functional role of microglia/macrophages in gliomas.
Schiffer D, Mellai M, Bovio E, Annovazzi L
Neurol Sci 2017 Sep;38(9):1571-1577. Epub 2017 Jun 7 doi: 10.1007/s10072-017-3002-x. PMID: 28593528
MRI findings and pathological features in early-stage glioblastoma.
Ideguchi M, Kajiwara K, Goto H, Sugimoto K, Nomura S, Ikeda E, Suzuki M
J Neurooncol 2015 Jun;123(2):289-97. Epub 2015 May 5 doi: 10.1007/s11060-015-1797-y. PMID: 25939441
Insular lesionectomy for refractory epilepsy: management and outcome.
von Lehe M, Wellmer J, Urbach H, Schramm J, Elger CE, Clusmann H
Brain 2009 Apr;132(Pt 4):1048-56. Epub 2009 Mar 18 doi: 10.1093/brain/awp047. PMID: 19297505
p53 and disease: when the guardian angel fails.
Royds JA, Iacopetta B
Cell Death Differ 2006 Jun;13(6):1017-26. doi: 10.1038/sj.cdd.4401913. PMID: 16557268

Clinical prediction guides

Radiotherapy-Induced Astrocyte Senescence Promotes an Immunosuppressive Microenvironment in Glioblastoma to Facilitate Tumor Regrowth.
Ji J, Ding K, Cheng B, Zhang X, Luo T, Huang B, Yu H, Chen Y, Xu X, Lin H, Zhou J, Wang T, Jin M, Liu A, Yan D, Liu F, Wang C, Chen J, Yan F, Wang L, Zhang J, Yan S, Wang J, Li X, Chen G
Adv Sci (Weinh) 2024 Apr;11(15):e2304609. Epub 2024 Feb 11 doi: 10.1002/advs.202304609. PMID: 38342629Free PMC Article
The neuropathological basis to the functional role of microglia/macrophages in gliomas.
Schiffer D, Mellai M, Bovio E, Annovazzi L
Neurol Sci 2017 Sep;38(9):1571-1577. Epub 2017 Jun 7 doi: 10.1007/s10072-017-3002-x. PMID: 28593528
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article
p53 and disease: when the guardian angel fails.
Royds JA, Iacopetta B
Cell Death Differ 2006 Jun;13(6):1017-26. doi: 10.1038/sj.cdd.4401913. PMID: 16557268
Non-neoplastic pineal cysts.
Fetell MR, Bruce JN, Burke AM, Cross DT, Torres RA, Powers JM, Stein BM
Neurology 1991 Jul;41(7):1034-40. doi: 10.1212/wnl.41.7.1034. PMID: 2067630

Recent systematic reviews

Diagnostic windows in non-neoplastic diseases: a systematic review.
Whitfield E, White B, Denaxas S, Lyratzopoulos G
Br J Gen Pract 2023 Sep;73(734):e702-e709. Epub 2023 Aug 31 doi: 10.3399/BJGP.2023.0044. PMID: 37308303Free PMC Article
Xanthogranuloma of the sellar region: a systematic review.
Guerrero-Pérez F, Marengo AP, Vilarrasa N, Vidal N, Ruiz-Roig N, Sánchez-Fernández JJ, Torres-Díaz A, Sanmillán JL, Pérez-Maraver M, Villabona C
Hormones (Athens) 2023 Jun;22(2):199-210. Epub 2023 Jan 25 doi: 10.1007/s42000-023-00432-y. PMID: 36695986
5-Aminolevulinic acid fluorescence in brain non-neoplastic lesions: a systematic review and case series.
Duarte JFS, Jung GS, da Silva EB Jr, de Almeida Teixeira BC, Cavalcanti MS, Ramina R
Neurosurg Rev 2022 Oct;45(5):3139-3148. Epub 2022 Aug 16 doi: 10.1007/s10143-022-01843-y. PMID: 35972631
Diagnostic Yield, Morbidity, and Mortality of Intraventricular Neuroendoscopic Biopsy: Systematic Review and Meta-Analysis.
Somji M, Badhiwala J, McLellan A, Kulkarni AV
World Neurosurg 2016 Jan;85:315-24.e2. Epub 2015 Sep 16 doi: 10.1016/j.wneu.2015.09.011. PMID: 26385114
Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis.
Morris Z, Whiteley WN, Longstreth WT Jr, Weber F, Lee YC, Tsushima Y, Alphs H, Ladd SC, Warlow C, Wardlaw JM, Al-Shahi Salman R
BMJ 2009 Aug 17;339:b3016. doi: 10.1136/bmj.b3016. PMID: 19687093Free PMC Article

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