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Delayed AND/OR secondary postpartum hemorrhage

MedGen UID:
96876
Concept ID:
C0473508
Pathologic Function
Synonyms: Delayed Postpartum Hemorrhage; Hemorrhage, Delayed Postpartum; Postpartum Hemorrhage, Delayed
SNOMED CT: Delayed postpartum hemorrhage (23171006); Delayed AND/OR secondary postpartum hemorrhage (23171006); Hemorrhage after first 24 hours following delivery of placenta (23171006); Postpartum hemorrhage specified as delayed or secondary (23171006); Postpartum hemorrhage, delayed AND/OR secondary (23171006)

Definition

Excessive blood loss between 24 hours after delivery through four weeks that requires intervention. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDelayed AND/OR secondary postpartum hemorrhage

Professional guidelines

PubMed

Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE
J Clin Endocrinol Metab 2023 Sep 18;108(10):2447-2469. doi: 10.1210/clinem/dgad463. PMID: 37580314Free PMC Article
Faraone SV, Banaschewski T, Coghill D, Zheng Y, Biederman J, Bellgrove MA, Newcorn JH, Gignac M, Al Saud NM, Manor I, Rohde LA, Yang L, Cortese S, Almagor D, Stein MA, Albatti TH, Aljoudi HF, Alqahtani MMJ, Asherson P, Atwoli L, Bölte S, Buitelaar JK, Crunelle CL, Daley D, Dalsgaard S, Döpfner M, Espinet S, Fitzgerald M, Franke B, Gerlach M, Haavik J, Hartman CA, Hartung CM, Hinshaw SP, Hoekstra PJ, Hollis C, Kollins SH, Sandra Kooij JJ, Kuntsi J, Larsson H, Li T, Liu J, Merzon E, Mattingly G, Mattos P, McCarthy S, Mikami AY, Molina BSG, Nigg JT, Purper-Ouakil D, Omigbodun OO, Polanczyk GV, Pollak Y, Poulton AS, Rajkumar RP, Reding A, Reif A, Rubia K, Rucklidge J, Romanos M, Ramos-Quiroga JA, Schellekens A, Scheres A, Schoeman R, Schweitzer JB, Shah H, Solanto MV, Sonuga-Barke E, Soutullo C, Steinhausen HC, Swanson JM, Thapar A, Tripp G, van de Glind G, van den Brink W, Van der Oord S, Venter A, Vitiello B, Walitza S, Wang Y
Neurosci Biobehav Rev 2021 Sep;128:789-818. Epub 2021 Feb 4 doi: 10.1016/j.neubiorev.2021.01.022. PMID: 33549739Free PMC Article
Vuurberg G, Hoorntje A, Wink LM, van der Doelen BFW, van den Bekerom MP, Dekker R, van Dijk CN, Krips R, Loogman MCM, Ridderikhof ML, Smithuis FF, Stufkens SAS, Verhagen EALM, de Bie RA, Kerkhoffs GMMJ
Br J Sports Med 2018 Aug;52(15):956. Epub 2018 Mar 7 doi: 10.1136/bjsports-2017-098106. PMID: 29514819

Recent clinical studies

Etiology

Gallos I, Devall A, Martin J, Middleton L, Beeson L, Galadanci H, Alwy Al-Beity F, Qureshi Z, Hofmeyr GJ, Moran N, Fawcus S, Sheikh L, Gwako G, Osoti A, Aswat A, Mammoliti KM, Sindhu KN, Podesek M, Horne I, Timms R, Yunas I, Okore J, Singata-Madliki M, Arends E, Wakili AA, Mwampashi A, Nausheen S, Muhammad S, Latthe P, Evans C, Akter S, Forbes G, Lissauer D, Meher S, Weeks A, Shennan A, Ammerdorffer A, Williams E, Roberts T, Widmer M, Oladapo OT, Lorencatto F, Bohren MA, Miller S, Althabe F, Gülmezoglu M, Smith JM, Hemming K, Coomarasamy A
N Engl J Med 2023 Jul 6;389(1):11-21. Epub 2023 May 9 doi: 10.1056/NEJMoa2303966. PMID: 37158447
Bienstock JL, Eke AC, Hueppchen NA
N Engl J Med 2021 Apr 29;384(17):1635-1645. doi: 10.1056/NEJMra1513247. PMID: 33913640Free PMC Article
Gonzalez-Brown V, Schneider P
Semin Fetal Neonatal Med 2020 Oct;25(5):101129. Epub 2020 Jul 15 doi: 10.1016/j.siny.2020.101129. PMID: 32782215
Andrikopoulou M, D'Alton ME
Semin Perinatol 2019 Feb;43(1):11-17. Epub 2018 Nov 14 doi: 10.1053/j.semperi.2018.11.003. PMID: 30503400
Evensen A, Anderson JM, Fontaine P
Am Fam Physician 2017 Apr 1;95(7):442-449. PMID: 28409600

Diagnosis

Post SE, Rood KM, Kiefer MK
Clin Obstet Gynecol 2023 Jun 1;66(2):367-383. Epub 2023 May 5 doi: 10.1097/GRF.0000000000000785. PMID: 37204172
Gallos I, Devall A, Martin J, Middleton L, Beeson L, Galadanci H, Alwy Al-Beity F, Qureshi Z, Hofmeyr GJ, Moran N, Fawcus S, Sheikh L, Gwako G, Osoti A, Aswat A, Mammoliti KM, Sindhu KN, Podesek M, Horne I, Timms R, Yunas I, Okore J, Singata-Madliki M, Arends E, Wakili AA, Mwampashi A, Nausheen S, Muhammad S, Latthe P, Evans C, Akter S, Forbes G, Lissauer D, Meher S, Weeks A, Shennan A, Ammerdorffer A, Williams E, Roberts T, Widmer M, Oladapo OT, Lorencatto F, Bohren MA, Miller S, Althabe F, Gülmezoglu M, Smith JM, Hemming K, Coomarasamy A
N Engl J Med 2023 Jul 6;389(1):11-21. Epub 2023 May 9 doi: 10.1056/NEJMoa2303966. PMID: 37158447
Federspiel JJ, Eke AC, Eppes CS
Am J Obstet Gynecol MFM 2023 Feb;5(2S):100740. Epub 2022 Sep 2 doi: 10.1016/j.ajogmf.2022.100740. PMID: 36058518Free PMC Article
Andrikopoulou M, D'Alton ME
Semin Perinatol 2019 Feb;43(1):11-17. Epub 2018 Nov 14 doi: 10.1053/j.semperi.2018.11.003. PMID: 30503400
Evensen A, Anderson JM, Fontaine P
Am Fam Physician 2017 Apr 1;95(7):442-449. PMID: 28409600

Therapy

Gallos I, Devall A, Martin J, Middleton L, Beeson L, Galadanci H, Alwy Al-Beity F, Qureshi Z, Hofmeyr GJ, Moran N, Fawcus S, Sheikh L, Gwako G, Osoti A, Aswat A, Mammoliti KM, Sindhu KN, Podesek M, Horne I, Timms R, Yunas I, Okore J, Singata-Madliki M, Arends E, Wakili AA, Mwampashi A, Nausheen S, Muhammad S, Latthe P, Evans C, Akter S, Forbes G, Lissauer D, Meher S, Weeks A, Shennan A, Ammerdorffer A, Williams E, Roberts T, Widmer M, Oladapo OT, Lorencatto F, Bohren MA, Miller S, Althabe F, Gülmezoglu M, Smith JM, Hemming K, Coomarasamy A
N Engl J Med 2023 Jul 6;389(1):11-21. Epub 2023 May 9 doi: 10.1056/NEJMoa2303966. PMID: 37158447
Pacheco LD, Clifton RG, Saade GR, Weiner SJ, Parry S, Thorp JM Jr, Longo M, Salazar A, Dalton W, Tita ATN, Gyamfi-Bannerman C, Chauhan SP, Metz TD, Rood K, Rouse DJ, Bailit JL, Grobman WA, Simhan HN, Macones GA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network
N Engl J Med 2023 Apr 13;388(15):1365-1375. doi: 10.1056/NEJMoa2207419. PMID: 37043652Free PMC Article
D'Alton ME, Rood KM, Smid MC, Simhan HN, Skupski DW, Subramaniam A, Gibson KS, Rosen T, Clark SM, Dudley D, Iqbal SN, Paglia MJ, Duzyj CM, Chien EK, Gibbins KJ, Wine KD, Bentum NAA, Kominiarek MA, Tuuli MG, Goffman D
Obstet Gynecol 2020 Nov;136(5):882-891. doi: 10.1097/AOG.0000000000004138. PMID: 32909970Free PMC Article
Evensen A, Anderson JM, Fontaine P
Am Fam Physician 2017 Apr 1;95(7):442-449. PMID: 28409600
Sentilhes L, Merlot B, Madar H, Sztark F, Brun S, Deneux-Tharaux C
Expert Rev Hematol 2016 Nov;9(11):1043-1061. Epub 2016 Oct 20 doi: 10.1080/17474086.2016.1245135. PMID: 27701915

Prognosis

Patek K, Friedman P
Clin Obstet Gynecol 2023 Jun 1;66(2):344-356. Epub 2023 May 1 doi: 10.1097/GRF.0000000000000782. PMID: 37130373
Omotayo MO, Abioye AI, Kuyebi M, Eke AC
J Obstet Gynaecol Res 2021 Aug;47(8):2565-2576. Epub 2021 May 17 doi: 10.1111/jog.14834. PMID: 34002432Free PMC Article
Gonzalez-Brown V, Schneider P
Semin Fetal Neonatal Med 2020 Oct;25(5):101129. Epub 2020 Jul 15 doi: 10.1016/j.siny.2020.101129. PMID: 32782215
Sentilhes L, Merlot B, Madar H, Sztark F, Brun S, Deneux-Tharaux C
Expert Rev Hematol 2016 Nov;9(11):1043-1061. Epub 2016 Oct 20 doi: 10.1080/17474086.2016.1245135. PMID: 27701915
Oyelese Y, Ananth CV
Clin Obstet Gynecol 2010 Mar;53(1):147-56. doi: 10.1097/GRF.0b013e3181cc406d. PMID: 20142652

Clinical prediction guides

Angarita AM, Cochrane E, Bianco A, Berghella V
Eur J Obstet Gynecol Reprod Biol 2023 Jan;280:112-119. Epub 2022 Nov 24 doi: 10.1016/j.ejogrb.2022.11.021. PMID: 36455391
Miller HE, Ansari JR
Curr Opin Obstet Gynecol 2022 Apr 1;34(2):82-89. doi: 10.1097/GCO.0000000000000776. PMID: 35102109
Omotayo MO, Abioye AI, Kuyebi M, Eke AC
J Obstet Gynaecol Res 2021 Aug;47(8):2565-2576. Epub 2021 May 17 doi: 10.1111/jog.14834. PMID: 34002432Free PMC Article
Committee on Practice Bulletins-Obstetrics
Obstet Gynecol 2017 Oct;130(4):e168-e186. doi: 10.1097/AOG.0000000000002351. PMID: 28937571
Sentilhes L, Merlot B, Madar H, Sztark F, Brun S, Deneux-Tharaux C
Expert Rev Hematol 2016 Nov;9(11):1043-1061. Epub 2016 Oct 20 doi: 10.1080/17474086.2016.1245135. PMID: 27701915

Recent systematic reviews

Omotayo MO, Abioye AI, Kuyebi M, Eke AC
J Obstet Gynaecol Res 2021 Aug;47(8):2565-2576. Epub 2021 May 17 doi: 10.1111/jog.14834. PMID: 34002432Free PMC Article
Ende HB, Lozada MJ, Chestnut DH, Osmundson SS, Walden RL, Shotwell MS, Bauchat JR
Obstet Gynecol 2021 Feb 1;137(2):305-323. doi: 10.1097/AOG.0000000000004228. PMID: 33417319Free PMC Article
Thul TA, Corwin EJ, Carlson NS, Brennan PA, Young LJ
Psychoneuroendocrinology 2020 Oct;120:104793. Epub 2020 Jul 6 doi: 10.1016/j.psyneuen.2020.104793. PMID: 32683141Free PMC Article
Feduniw S, Warzecha D, Szymusik I, Wielgos M
Ginekol Pol 2020;91(1):38-44. doi: 10.5603/GP.2020.0009. PMID: 32039467
Beta J, Khan N, Khalil A, Fiolna M, Ramadan G, Akolekar R
Ultrasound Obstet Gynecol 2019 Sep;54(3):308-318. Epub 2019 Aug 2 doi: 10.1002/uog.20279. PMID: 30938004

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