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Post-partum hemorrhage

MedGen UID:
18592
Concept ID:
C0032797
Pathologic Function
Synonym: Post-partum bleeding
SNOMED CT: PPH - Postpartum hemorrhage (47821001); Bleeding postpartum (47821001); Postpartum hemorrhage (47821001); Hemorrhage after delivery of fetus (47821001)
 
HPO: HP:0011891

Definition

Significant maternal haemorrhage/blood loss following deilvery of a child. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPost-partum hemorrhage

Conditions with this feature

Autosomal dominant nonsyndromic hearing loss 1
MedGen UID:
343767
Concept ID:
C1852282
Disease or Syndrome
DFNA1 is an autosomal dominant form of progressive hearing loss with onset in the first decade. Some patients have mild thrombocytopenia and enlarged platelets, although most of these individuals do not have significant bleeding tendencies (summary by Neuhaus et al., 2017).
Hermansky-Pudlak syndrome 7
MedGen UID:
481386
Concept ID:
C3279756
Disease or Syndrome
Hermansky-Pudlak syndrome (HPS) is characterized by oculocutaneous albinism, a bleeding diathesis, and, in some individuals, pulmonary fibrosis, granulomatous colitis, or immunodeficiency. Ocular findings include reduced iris pigment with iris transillumination, reduced retinal pigment, foveal hypoplasia with significant reduction in visual acuity (usually in the range of 20/50 to 20/400), nystagmus, and increased crossing of the optic nerve fibers. Hair color ranges from white to brown; skin color ranges from white to olive and is usually a shade lighter than that of other family members. The bleeding diathesis can result in variable bruising, epistaxis, gingival bleeding, postpartum hemorrhage, colonic bleeding, and prolonged bleeding with menses or after tooth extraction, circumcision, and other surgeries. Pulmonary fibrosis, a restrictive lung disease, typically causes symptoms in the early thirties and can progress to death within a decade. Granulomatous colitis is severe in about 15% of affected individuals. Neutropenia and/or immune defects occur primarily in individuals with pathogenic variants in AP3B1 and AP3D1.
Thrombocytopenia 7
MedGen UID:
1768257
Concept ID:
C5436874
Disease or Syndrome
Thrombocytopenia-7 (THC7) is an autosomal dominant disorder characterized by reduced peripheral platelet count. The expression and severity of the disorder is highly variable: some patients have no bleeding symptoms, whereas other have recurrent petechiae, epistaxis, or more severe bleeding episodes. A common finding is decreased alpha-granules in the platelets. There are variable findings on light and electron microscopic analysis: some patients have normal platelet morphology, whereas others show abnormal platelet morphology with cytoskeletal defects. Flow cytometric studies may show reduced expression of platelet membrane glycoproteins and activation markers (summary by Lentaigne et al., 2019 and Leinoe et al., 2021). For a general phenotypic description and a discussion of genetic heterogeneity of thrombocytopenia, see 313900.

Professional guidelines

PubMed

Delgado C, Komatsu R
Best Pract Res Clin Anaesthesiol 2022 Dec;36(3-4):359-369. Epub 2022 Sep 28 doi: 10.1016/j.bpa.2022.09.001. PMID: 36513431
Katz D, Beilin Y
J Matern Fetal Neonatal Med 2021 May;34(9):1487-1493. Epub 2019 Jul 10 doi: 10.1080/14767058.2019.1638360. PMID: 31257973
Pacheco LD, Saade GR, Hankins GDV
Semin Perinatol 2019 Feb;43(1):22-26. Epub 2018 Nov 14 doi: 10.1053/j.semperi.2018.11.005. PMID: 30503399

Recent clinical studies

Etiology

Delgado C, Komatsu R
Best Pract Res Clin Anaesthesiol 2022 Dec;36(3-4):359-369. Epub 2022 Sep 28 doi: 10.1016/j.bpa.2022.09.001. PMID: 36513431
Katz D, Beilin Y
J Matern Fetal Neonatal Med 2021 May;34(9):1487-1493. Epub 2019 Jul 10 doi: 10.1080/14767058.2019.1638360. PMID: 31257973
Gresele P, Falcinelli E, Bury L
Thromb Res 2019 Sep;181 Suppl 1:S54-S59. doi: 10.1016/S0049-3848(19)30368-8. PMID: 31477229
Clark SL
Semin Perinatol 2016 Mar;40(2):109-11. Epub 2015 Dec 22 doi: 10.1053/j.semperi.2015.11.016. PMID: 26726136
Dajani NK, Magann EF
Semin Perinatol 2014 Jun;38(4):201-4. doi: 10.1053/j.semperi.2014.04.005. PMID: 24863025

Diagnosis

Delgado C, Komatsu R
Best Pract Res Clin Anaesthesiol 2022 Dec;36(3-4):359-369. Epub 2022 Sep 28 doi: 10.1016/j.bpa.2022.09.001. PMID: 36513431
Fiszer E, Weiniger CF
Best Pract Res Clin Anaesthesiol 2022 May;36(1):157-164. Epub 2022 Feb 1 doi: 10.1016/j.bpa.2022.01.003. PMID: 35659951
Gresele P, Falcinelli E, Bury L
Thromb Res 2019 Sep;181 Suppl 1:S54-S59. doi: 10.1016/S0049-3848(19)30368-8. PMID: 31477229
Pacheco LD, Saade GR, Hankins GDV
Semin Perinatol 2019 Feb;43(1):22-26. Epub 2018 Nov 14 doi: 10.1053/j.semperi.2018.11.005. PMID: 30503399
Clark SL
Semin Perinatol 2016 Mar;40(2):109-11. Epub 2015 Dec 22 doi: 10.1053/j.semperi.2015.11.016. PMID: 26726136

Therapy

Busnelli A, Schirripa I, Fedele F, Bulfoni A, Levi-Setti PE
Hum Reprod 2022 Jun 30;37(7):1619-1641. doi: 10.1093/humrep/deac073. PMID: 35553678
Bernasconi M, Eggel-Hort B, Horsch A, Vial Y, Denys A, Quibel T, Baud D
Sci Rep 2021 Jul 7;11(1):13990. doi: 10.1038/s41598-021-92847-z. PMID: 34234162Free PMC Article
Pacheco LD, Saade GR, Hankins GDV
Semin Perinatol 2019 Feb;43(1):22-26. Epub 2018 Nov 14 doi: 10.1053/j.semperi.2018.11.005. PMID: 30503399
Meng W, Li R, Zha N, E L
J Obstet Gynaecol Res 2019 Jan;45(1):47-56. Epub 2018 Oct 4 doi: 10.1111/jog.13833. PMID: 30288846
Dajani NK, Magann EF
Semin Perinatol 2014 Jun;38(4):201-4. doi: 10.1053/j.semperi.2014.04.005. PMID: 24863025

Prognosis

Nath SS, Pandey CK, Kumar S
Ann Card Anaesth 2022 Jan-Mar;25(1):1-10. doi: 10.4103/aca.aca_319_20. PMID: 35075014Free PMC Article
Gresele P, Falcinelli E, Bury L
Thromb Res 2019 Sep;181 Suppl 1:S54-S59. doi: 10.1016/S0049-3848(19)30368-8. PMID: 31477229
Pacheco LD, Saade GR, Hankins GDV
Semin Perinatol 2019 Feb;43(1):22-26. Epub 2018 Nov 14 doi: 10.1053/j.semperi.2018.11.005. PMID: 30503399
Clark SL
Semin Perinatol 2016 Mar;40(2):109-11. Epub 2015 Dec 22 doi: 10.1053/j.semperi.2015.11.016. PMID: 26726136
Delotte J, Novellas S, Koh C, Bongain A, Chevallier P
Eur J Obstet Gynecol Reprod Biol 2009 Aug;145(2):129-32. Epub 2009 Apr 23 doi: 10.1016/j.ejogrb.2009.03.013. PMID: 19398259

Clinical prediction guides

Cristina T, Mara T, Arianna S, Gennaro S, Rosaria C, Pantaleo G
Eur J Obstet Gynecol Reprod Biol 2022 Sep;276:26-37. Epub 2022 Jun 23 doi: 10.1016/j.ejogrb.2022.06.016. PMID: 35797821
Paily VP, Raj G R, Sidhik A, Sudhamma A, Neelankavil JJ, Usha MG, George R, Cheriyan S, Ramakrishnan S, John TE, Vishnu D, Pradeep M
Eur J Obstet Gynecol Reprod Biol 2022 May;272:6-15. Epub 2022 Mar 4 doi: 10.1016/j.ejogrb.2022.03.002. PMID: 35276445
Sichitiu J, Baud D, Desseauve D
J Matern Fetal Neonatal Med 2022 Dec;35(25):8114-8117. Epub 2021 Sep 1 doi: 10.1080/14767058.2021.1962841. PMID: 34470143
Feleke BE, Feleke TE, Nigussie AA, Misgan E
BMC Womens Health 2021 Sep 25;21(1):340. doi: 10.1186/s12905-021-01485-0. PMID: 34563190Free PMC Article
Gresele P, Falcinelli E, Bury L
Thromb Res 2019 Sep;181 Suppl 1:S54-S59. doi: 10.1016/S0049-3848(19)30368-8. PMID: 31477229

Recent systematic reviews

Cristina T, Mara T, Arianna S, Gennaro S, Rosaria C, Pantaleo G
Eur J Obstet Gynecol Reprod Biol 2022 Sep;276:26-37. Epub 2022 Jun 23 doi: 10.1016/j.ejogrb.2022.06.016. PMID: 35797821
Busnelli A, Schirripa I, Fedele F, Bulfoni A, Levi-Setti PE
Hum Reprod 2022 Jun 30;37(7):1619-1641. doi: 10.1093/humrep/deac073. PMID: 35553678
Nigussie J, Girma B, Molla A, Tamir T, Tilahun R
Reprod Health 2022 Mar 9;19(1):63. doi: 10.1186/s12978-022-01360-7. PMID: 35264188Free PMC Article
Obeng-Tuudah D, Hussein BA, Hakim A, Gomez K, Abdul Kadir R
Int J Gynaecol Obstet 2021 Sep;154(3):412-426. Epub 2021 Mar 9 doi: 10.1002/ijgo.13632. PMID: 33521972
Samnani AABA, Rizvi N, Ali TS, Abrejo F
Reprod Health 2017 Oct 27;14(1):139. doi: 10.1186/s12978-017-0383-5. PMID: 29078777Free PMC Article

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