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Basaloid follicular hamartoma

MedGen UID:
96887
•Concept ID:
C0474964
•
Neoplastic Process
Synonyms: Basal cell nevus with comedones; Basal Cell Nevus with Comedones; basal cell nevus with comedones; basaloid follicular hamartoma
SNOMED CT: Basaloid follicular hamartoma (254705003); Basal cell nevus with comedones (254705003)
 
Monarch Initiative: MONDO:0021977

Definition

A type of pilosebaceous hamartoma characterized by basal cell epitheliomata, epidermoid cysts and comedones, and epidermal atrophy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBasaloid follicular hamartoma

Recent clinical studies

Etiology

Basaloid tumors arising from seborrheic keratosis: Malignant basal cell carcinoma or benign basaloid follicular hamartomatous proliferation?
Flordelis JO, Shen YC, Wu YH
J Cutan Pathol 2020 Mar;47(3):207-218. Epub 2019 Dec 3 doi: 10.1111/cup.13607. PMID: 31682281
Cytokeratin 20 expression in basaloid follicular hamartoma and infundibulocystic basal cell carcinoma.
Honarpisheh H, Glusac EJ, Ko CJ
J Cutan Pathol 2014 Dec;41(12):916-21. doi: 10.1111/cup.12410. PMID: 25353070
Linear unilateral hamartomatous basal cell naevus with glandular and follicular differentiation.
Yébenes M, Toll A, Vélez M, Barranco C, Alonso-López NA, Gonzalez-Sarmiento R, Bellosillo B, Pujol RM
Clin Exp Dermatol 2008 Jul;33(4):429-32. Epub 2008 Feb 28 doi: 10.1111/j.1365-2230.2007.02663.x. PMID: 18312461
Basal cell carcinomas in association with basaloid follicular hamartoma.
Yoshida Y, Urabe K, Mashino T, Duan H, Kiryu H, Masuda T, Koga T, Furue M
Dermatology 2003;207(1):57-60. doi: 10.1159/000070944. PMID: 12835551
Congenital non-familial unilateral basaloid follicular hamartoma.
Harman M, Inalöz HS, Akdeniz S, Inalöz SS, Aslan A
J Eur Acad Dermatol Venereol 1999 Nov;13(3):210-3. PMID: 10642058

Diagnosis

Happle-Tinschert syndrome variable phenotype as part of the mosaic hedgehog spectrum: Report of three cases.
Cano R, Abad ME, Schanze D, Zenker M, Serafin E, Larralde M
Pediatr Dermatol 2023 Jul-Aug;40(4):691-694. Epub 2023 Jan 27 doi: 10.1111/pde.15248. PMID: 36707059
A 3-month-old with papules and plaques in a blaschkoid distribution.
Wong CY, Piliang M, Irfan M
Int J Dermatol 2019 Sep;58(9):1037-1039. Epub 2019 Mar 14 doi: 10.1111/ijd.14425. PMID: 30868566
Histologic Mimics of Basal Cell Carcinoma.
Stanoszek LM, Wang GY, Harms PW
Arch Pathol Lab Med 2017 Nov;141(11):1490-1502. doi: 10.5858/arpa.2017-0222-RA. PMID: 29072946
Happle-Tinschert syndrome: report of a case with hemimegalencephaly.
Özgur A, Çabuk G, Arpacı R, Baz K, Katar D
Korean J Radiol 2014 Jul-Aug;15(4):534-7. Epub 2014 Jul 9 doi: 10.3348/kjr.2014.15.4.534. PMID: 25053915Free PMC Article
Basaloid follicular hamartoma.
Mills O, Thomas LB
Arch Pathol Lab Med 2010 Aug;134(8):1215-9. doi: 10.5858/2008-0620-RS.1. PMID: 20670146

Therapy

Basaloid follicular hamartomas associated with autoimmune disease: a possible role for retinoids in therapy.
Smith KJ, Skelton H
J Am Acad Dermatol 2003 Dec;49(6):1067-70. doi: 10.1016/s0190-9622(02)61779-7. PMID: 14639386

Prognosis

Basal cell carcinomas in association with basaloid follicular hamartoma.
Yoshida Y, Urabe K, Mashino T, Duan H, Kiryu H, Masuda T, Koga T, Furue M
Dermatology 2003;207(1):57-60. doi: 10.1159/000070944. PMID: 12835551
Congenital non-familial unilateral basaloid follicular hamartoma.
Harman M, Inalöz HS, Akdeniz S, Inalöz SS, Aslan A
J Eur Acad Dermatol Venereol 1999 Nov;13(3):210-3. PMID: 10642058

Clinical prediction guides

"Kissing" basaloid follicular hamartomas of the eyelid.
Ezemma O, Ragi SD, Ruiz R, Robinson-Bostom L, Enzer Y, DiMarco C
J Cutan Pathol 2022 Oct;49(10):881-884. Epub 2022 Jul 5 doi: 10.1111/cup.14273. PMID: 35699643
Basaloid tumors arising from seborrheic keratosis: Malignant basal cell carcinoma or benign basaloid follicular hamartomatous proliferation?
Flordelis JO, Shen YC, Wu YH
J Cutan Pathol 2020 Mar;47(3):207-218. Epub 2019 Dec 3 doi: 10.1111/cup.13607. PMID: 31682281
Congenital systematized basaloid follicular hamartoma with microphthalmia and hemimegalencephaly.
Boccaletti V, Accorsi P, Pinelli L, Ungari M, Giordano L, Neri I, De Panfilis G
Pediatr Dermatol 2011 Sep-Oct;28(5):555-60. Epub 2010 Nov 9 doi: 10.1111/j.1525-1470.2010.01225.x. PMID: 21062348
Multiple hereditary infundibulocystic basal cell carcinomas: a genodermatosis different from nevoid basal cell carcinoma syndrome.
Requena L, Fariña MC, Robledo M, Sangueza OP, Sanchez E, Villanueva A, Marquina A, Tamarit R
Arch Dermatol 1999 Oct;135(10):1227-35. doi: 10.1001/archderm.135.10.1227. PMID: 10522671
Solitary basaloid follicular hamartoma.
Toyoda M, Kagoura M, Morohashi M
J Dermatol 1998 Jul;25(7):434-7. doi: 10.1111/j.1346-8138.1998.tb02430.x. PMID: 9714975

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