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Pregnancy associated osteoporosis

MedGen UID:
977013
•Concept ID:
CN294816
•
Disease or Syndrome
Synonyms: pregnancy and lactation-associated osteoporosis; pregnancy associated osteoporosis
 
Monarch Initiative: MONDO:0100194

Definition

A severe early presentation of osteoporosis in which young women experience low trauma or spontaneous fractures, most commonly vertebral fractures, during late pregnancy or lactation. [from MONDO]

Professional guidelines

PubMed

Clinical Features, Incidence and Treatment Outcome in Pregnancy-Associated Osteoporosis: A Single-Centre Experience over Two Decades.
Orhadje E, Berg K, Hauser B, Ralston SH
Calcif Tissue Int 2023 Dec;113(6):591-596. Epub 2023 Oct 11 doi: 10.1007/s00223-023-01139-3. PMID: 37819437Free PMC Article
Risk factors, fractures, and management of pregnancy-associated osteoporosis: a retrospective study of 14 Turkish patients.
Tuna F, Akleylek C, Özdemir H, Demirbağ Kabayel D
Gynecol Endocrinol 2020 Mar;36(3):238-242. Epub 2019 Aug 6 doi: 10.1080/09513590.2019.1648417. PMID: 31385717
Osteoporosis during pregnancy and its management.
Smith R, Phillips AJ
Scand J Rheumatol Suppl 1998;107:66-7. doi: 10.1080/03009742.1998.11720768. PMID: 9759136

Recent clinical studies

Etiology

"Pregnancy and Lactation Associated Osteoporosis".
Hardcastle SA
Calcif Tissue Int 2022 May;110(5):531-545. Epub 2021 Feb 23 doi: 10.1007/s00223-021-00815-6. PMID: 33620518
Pregnancy-associated osteoporosis: a UK case series and literature review.
Hardcastle SA, Yahya F, Bhalla AK
Osteoporos Int 2019 May;30(5):939-948. Epub 2019 Jan 23 doi: 10.1007/s00198-019-04842-w. PMID: 30671611
Osteoporosis in premenopausal women.
Langdahl BL
Curr Opin Rheumatol 2017 Jul;29(4):410-415. doi: 10.1097/BOR.0000000000000400. PMID: 28394826
Pregnancy-associated osteoporosis: a case-control study.
Hadji P, Boekhoff J, Hahn M, Hellmeyer L, Hars O, Kyvernitakis I
Osteoporos Int 2017 Apr;28(4):1393-1399. Epub 2017 Jan 10 doi: 10.1007/s00198-016-3897-8. PMID: 28074248
Pregnancy-associated osteoporosis.
Smith R, Athanasou NA, Ostlere SJ, Vipond SE
QJM 1995 Dec;88(12):865-78. PMID: 8593546

Diagnosis

Clinical Features, Incidence and Treatment Outcome in Pregnancy-Associated Osteoporosis: A Single-Centre Experience over Two Decades.
Orhadje E, Berg K, Hauser B, Ralston SH
Calcif Tissue Int 2023 Dec;113(6):591-596. Epub 2023 Oct 11 doi: 10.1007/s00223-023-01139-3. PMID: 37819437Free PMC Article
Osteoporosis in premenopausal women.
Langdahl BL
Curr Opin Rheumatol 2017 Jul;29(4):410-415. doi: 10.1097/BOR.0000000000000400. PMID: 28394826
Pregnancy-associated osteoporosis: a case-control study.
Hadji P, Boekhoff J, Hahn M, Hellmeyer L, Hars O, Kyvernitakis I
Osteoporos Int 2017 Apr;28(4):1393-1399. Epub 2017 Jan 10 doi: 10.1007/s00198-016-3897-8. PMID: 28074248
Pregnancy-associated osteoporosis.
Rizzoli R, Bonjour JP
Lancet 1996 May 11;347(9011):1274-6. doi: 10.1016/s0140-6736(96)90932-0. PMID: 8622498
Pregnancy-associated osteoporosis.
Chung HC, Lim SK, Lee MK, Lee MH, Huh KB
Yonsei Med J 1988;29(3):286-94. doi: 10.3349/ymj.1988.29.3.286. PMID: 2973689

Therapy

Clinical Features, Incidence and Treatment Outcome in Pregnancy-Associated Osteoporosis: A Single-Centre Experience over Two Decades.
Orhadje E, Berg K, Hauser B, Ralston SH
Calcif Tissue Int 2023 Dec;113(6):591-596. Epub 2023 Oct 11 doi: 10.1007/s00223-023-01139-3. PMID: 37819437Free PMC Article
The experience of pregnancy associated osteoporosis: An international survey with implications for midwifery care.
Condon SB, Veitch M
Midwifery 2022 Dec;115:103468. Epub 2022 Aug 24 doi: 10.1016/j.midw.2022.103468. PMID: 36108340
"Pregnancy and Lactation Associated Osteoporosis".
Hardcastle SA
Calcif Tissue Int 2022 May;110(5):531-545. Epub 2021 Feb 23 doi: 10.1007/s00223-021-00815-6. PMID: 33620518
Pregnancy-associated osteoporosis: a UK case series and literature review.
Hardcastle SA, Yahya F, Bhalla AK
Osteoporos Int 2019 May;30(5):939-948. Epub 2019 Jan 23 doi: 10.1007/s00198-019-04842-w. PMID: 30671611
Osteoporosis in premenopausal women.
Langdahl BL
Curr Opin Rheumatol 2017 Jul;29(4):410-415. doi: 10.1097/BOR.0000000000000400. PMID: 28394826

Prognosis

Clinical Features, Incidence and Treatment Outcome in Pregnancy-Associated Osteoporosis: A Single-Centre Experience over Two Decades.
Orhadje E, Berg K, Hauser B, Ralston SH
Calcif Tissue Int 2023 Dec;113(6):591-596. Epub 2023 Oct 11 doi: 10.1007/s00223-023-01139-3. PMID: 37819437Free PMC Article
The experience of pregnancy associated osteoporosis: An international survey with implications for midwifery care.
Condon SB, Veitch M
Midwifery 2022 Dec;115:103468. Epub 2022 Aug 24 doi: 10.1016/j.midw.2022.103468. PMID: 36108340
Pregnancy-associated osteoporosis: does the skeleton recover?
Phillips AJ, Ostlere SJ, Smith R
Osteoporos Int 2000;11(5):449-54. doi: 10.1007/s001980070113. PMID: 10912848
Pregnancy-associated osteoporosis.
Smith R, Athanasou NA, Ostlere SJ, Vipond SE
QJM 1995 Dec;88(12):865-78. PMID: 8593546
Osteoporosis of pregnancy.
Smith R, Stevenson JC, Winearls CG, Woods CG, Wordsworth BP
Lancet 1985 May 25;1(8439):1178-80. doi: 10.1016/s0140-6736(85)92861-2. PMID: 2860385

Clinical prediction guides

Risk factors, fractures, and management of pregnancy-associated osteoporosis: a retrospective study of 14 Turkish patients.
Tuna F, Akleylek C, Özdemir H, Demirbağ Kabayel D
Gynecol Endocrinol 2020 Mar;36(3):238-242. Epub 2019 Aug 6 doi: 10.1080/09513590.2019.1648417. PMID: 31385717
Mutational analysis uncovers monogenic bone disorders in women with pregnancy-associated osteoporosis: three novel mutations in LRP5, COL1A1, and COL1A2.
Butscheidt S, Delsmann A, Rolvien T, Barvencik F, Al-Bughaili M, Mundlos S, Schinke T, Amling M, Kornak U, Oheim R
Osteoporos Int 2018 Jul;29(7):1643-1651. Epub 2018 Mar 29 doi: 10.1007/s00198-018-4499-4. PMID: 29594386
Pregnancy associated osteoporosis--a case report.
Dytfeld J, Horst-Sikorska W
Ginekol Pol 2012 May;83(5):377-9. PMID: 22708337
Pregnancy-associated osteoporosis: an underestimated and underdiagnosed severe disease. A review of two cases in short- and long-term follow-up.
Stumpf UC, Kurth AA, Windolf J, Fassbender WJ
Adv Med Sci 2007;52:94-7. PMID: 18217397
Pregnancy-associated osteoporosis: does the skeleton recover?
Phillips AJ, Ostlere SJ, Smith R
Osteoporos Int 2000;11(5):449-54. doi: 10.1007/s001980070113. PMID: 10912848

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