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Metabolic bone disorder

MedGen UID:
2699
•Concept ID:
C0005944
•
Disease or Syndrome
Synonyms: Bone Disease, Metabolic; Bone Diseases, Metabolic; Metabolic Bone Disease; Metabolic Bone Diseases
SNOMED CT: Metabolic disorder of bone (50279003); Metabolic bone disease (50279003)
 
Monarch Initiative: MONDO:0800486

Definition

A group of disorders that affect the bones secondary to increased levels of minerals or deficient levels of minerals such as calcium, magnesium, phosphorus, and vitamin D. Representative examples are osteomalacia, osteoporosis, and Paget disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetabolic bone disorder

Professional guidelines

PubMed

Theranostic Approach for the Management of Osteoporosis.
Pant A, Singh J, Barnwal RP, Singh G, Singh B
Crit Rev Ther Drug Carrier Syst 2023;40(3):95-121. doi: 10.1615/CritRevTherDrugCarrierSyst.2022043413. PMID: 36749084
Definition, Assessment, and Management of Vitamin D Inadequacy: Suggestions, Recommendations, and Warnings from the Italian Society for Osteoporosis, Mineral Metabolism and Bone Diseases (SIOMMMS).
Bertoldo F, Cianferotti L, Di Monaco M, Falchetti A, Fassio A, Gatti D, Gennari L, Giannini S, Girasole G, Gonnelli S, Malavolta N, Minisola S, Pedrazzoni M, Rendina D, Rossini M, Chiodini I
Nutrients 2022 Oct 6;14(19) doi: 10.3390/nu14194148. PMID: 36235800Free PMC Article
Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis.
Xiao PL, Cui AY, Hsu CJ, Peng R, Jiang N, Xu XH, Ma YG, Liu D, Lu HD
Osteoporos Int 2022 Oct;33(10):2137-2153. Epub 2022 Jun 10 doi: 10.1007/s00198-022-06454-3. PMID: 35687123

Recent clinical studies

Etiology

Bone fragility and osteoporosis in children and young adults.
Formosa MM, Christou MA, Mäkitie O
J Endocrinol Invest 2024 Feb;47(2):285-298. Epub 2023 Sep 5 doi: 10.1007/s40618-023-02179-0. PMID: 37668887Free PMC Article
Definition, Assessment, and Management of Vitamin D Inadequacy: Suggestions, Recommendations, and Warnings from the Italian Society for Osteoporosis, Mineral Metabolism and Bone Diseases (SIOMMMS).
Bertoldo F, Cianferotti L, Di Monaco M, Falchetti A, Fassio A, Gatti D, Gennari L, Giannini S, Girasole G, Gonnelli S, Malavolta N, Minisola S, Pedrazzoni M, Rendina D, Rossini M, Chiodini I
Nutrients 2022 Oct 6;14(19) doi: 10.3390/nu14194148. PMID: 36235800Free PMC Article
Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis.
Xiao PL, Cui AY, Hsu CJ, Peng R, Jiang N, Xu XH, Ma YG, Liu D, Lu HD
Osteoporos Int 2022 Oct;33(10):2137-2153. Epub 2022 Jun 10 doi: 10.1007/s00198-022-06454-3. PMID: 35687123
"Pregnancy and Lactation Associated Osteoporosis".
Hardcastle SA
Calcif Tissue Int 2022 May;110(5):531-545. Epub 2021 Feb 23 doi: 10.1007/s00223-021-00815-6. PMID: 33620518
Osteoporosis: a review.
Lin JT, Lane JM
Clin Orthop Relat Res 2004 Aug;(425):126-34. PMID: 15292797

Diagnosis

Bone fragility and osteoporosis in children and young adults.
Formosa MM, Christou MA, Mäkitie O
J Endocrinol Invest 2024 Feb;47(2):285-298. Epub 2023 Sep 5 doi: 10.1007/s40618-023-02179-0. PMID: 37668887Free PMC Article
Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis.
Xiao PL, Cui AY, Hsu CJ, Peng R, Jiang N, Xu XH, Ma YG, Liu D, Lu HD
Osteoporos Int 2022 Oct;33(10):2137-2153. Epub 2022 Jun 10 doi: 10.1007/s00198-022-06454-3. PMID: 35687123
Imaging of Paget's Disease of Bone.
Lombardi AF, Aihara AY, Fernandes ADRC, Cardoso FN
Radiol Clin North Am 2022 Jul;60(4):561-573. doi: 10.1016/j.rcl.2022.02.005. PMID: 35672089
Craniosynostosis and metabolic bone disorder. A review.
Di Rocco F, Rothenbuhler A, Cormier Daire V, Bacchetta J, Adamsbaum C, Baujat G, Rossi M, Lingart A
Neurochirurgie 2019 Nov;65(5):258-263. Epub 2019 Sep 25 doi: 10.1016/j.neuchi.2019.09.008. PMID: 31562881
Osteoporosis: a review.
Lin JT, Lane JM
Clin Orthop Relat Res 2004 Aug;(425):126-34. PMID: 15292797

Therapy

Causal relationship between circulating inflammatory factors and osteoporosis: a bidirectional Mendelian randomization study.
Yi KJ, Kang RM, Zhang YY, Li Q
Eur Rev Med Pharmacol Sci 2024 Mar;28(6):2237-2249. doi: 10.26355/eurrev_202403_35728. PMID: 38567587
Hypophosphatasia: presentation and response to asfotase alfa.
Alsarraf F, Ali DS, Almonaei K, Al-Alwani H, Khan AA, Brandi ML
Osteoporos Int 2024 Apr;35(4):717-725. Epub 2023 Nov 23 doi: 10.1007/s00198-023-06943-z. PMID: 37993691
Definition, Assessment, and Management of Vitamin D Inadequacy: Suggestions, Recommendations, and Warnings from the Italian Society for Osteoporosis, Mineral Metabolism and Bone Diseases (SIOMMMS).
Bertoldo F, Cianferotti L, Di Monaco M, Falchetti A, Fassio A, Gatti D, Gennari L, Giannini S, Girasole G, Gonnelli S, Malavolta N, Minisola S, Pedrazzoni M, Rendina D, Rossini M, Chiodini I
Nutrients 2022 Oct 6;14(19) doi: 10.3390/nu14194148. PMID: 36235800Free PMC Article
"Pregnancy and Lactation Associated Osteoporosis".
Hardcastle SA
Calcif Tissue Int 2022 May;110(5):531-545. Epub 2021 Feb 23 doi: 10.1007/s00223-021-00815-6. PMID: 33620518
Paget's disease of bone: an osteoimmunological disorder?
Numan MS, Amiable N, Brown JP, Michou L
Drug Des Devel Ther 2015;9:4695-707. Epub 2015 Aug 14 doi: 10.2147/DDDT.S88845. PMID: 26316708Free PMC Article

Prognosis

Development and validation of a radiomics-based model for predicting osteoporosis in patients with lumbar compression fractures.
Nian S, Zhao Y, Li C, Zhu K, Li N, Li W, Chen J
Spine J 2024 Sep;24(9):1625-1634. Epub 2024 Apr 26 doi: 10.1016/j.spinee.2024.04.016. PMID: 38679078
Development of a quantitative systems pharmacology model of chronic kidney disease: metabolic bone disorder.
Gaweda AE, McBride DE, Lederer ED, Brier ME
Am J Physiol Renal Physiol 2021 Feb 1;320(2):F203-F211. Epub 2020 Dec 14 doi: 10.1152/ajprenal.00159.2020. PMID: 33308018Free PMC Article
Current and Emerging Diagnostic Imaging-Based Techniques for Assessment of Osteoporosis and Fracture Risk.
Areeckal AS, Kocher M, S SD
IEEE Rev Biomed Eng 2019;12:254-268. Epub 2018 Jul 3 doi: 10.1109/RBME.2018.2852620. PMID: 29994405
Paget's disease of bone: an osteoimmunological disorder?
Numan MS, Amiable N, Brown JP, Michou L
Drug Des Devel Ther 2015;9:4695-707. Epub 2015 Aug 14 doi: 10.2147/DDDT.S88845. PMID: 26316708Free PMC Article
Parathyroid hormone and growth in chronic kidney disease.
Waller S
Pediatr Nephrol 2011 Feb;26(2):195-204. Epub 2010 Aug 9 doi: 10.1007/s00467-010-1614-y. PMID: 20694820

Clinical prediction guides

Causal relationship between circulating inflammatory factors and osteoporosis: a bidirectional Mendelian randomization study.
Yi KJ, Kang RM, Zhang YY, Li Q
Eur Rev Med Pharmacol Sci 2024 Mar;28(6):2237-2249. doi: 10.26355/eurrev_202403_35728. PMID: 38567587
Bone fragility and osteoporosis in children and young adults.
Formosa MM, Christou MA, Mäkitie O
J Endocrinol Invest 2024 Feb;47(2):285-298. Epub 2023 Sep 5 doi: 10.1007/s40618-023-02179-0. PMID: 37668887Free PMC Article
Compromised Muscle Properties in a Severe Hypophosphatasia Murine Model.
Pendleton EG, Nichenko AS, Mcfaline-Figueroa J, Raymond-Pope CJ, Schifino AG, Pigg TM, Barrow RP, Greising SM, Call JA, Mortensen LJ
Int J Mol Sci 2023 Nov 2;24(21) doi: 10.3390/ijms242115905. PMID: 37958888Free PMC Article
Current and Emerging Diagnostic Imaging-Based Techniques for Assessment of Osteoporosis and Fracture Risk.
Areeckal AS, Kocher M, S SD
IEEE Rev Biomed Eng 2019;12:254-268. Epub 2018 Jul 3 doi: 10.1109/RBME.2018.2852620. PMID: 29994405
Paget's disease of bone: an osteoimmunological disorder?
Numan MS, Amiable N, Brown JP, Michou L
Drug Des Devel Ther 2015;9:4695-707. Epub 2015 Aug 14 doi: 10.2147/DDDT.S88845. PMID: 26316708Free PMC Article

Recent systematic reviews

Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis.
Xiao PL, Cui AY, Hsu CJ, Peng R, Jiang N, Xu XH, Ma YG, Liu D, Lu HD
Osteoporos Int 2022 Oct;33(10):2137-2153. Epub 2022 Jun 10 doi: 10.1007/s00198-022-06454-3. PMID: 35687123
Comparing the Efficacies of Bisphosphonates' Therapies for Osteoporosis Persistence and Compliance: A Systematic Review.
Almohaileb FI, Rasheed Z
Curr Mol Med 2022;22(3):274-284. doi: 10.2174/1566524021666210414100227. PMID: 33855941
The prevalence of osteoporosis among Iranian postmenopausal women with type 2 diabetes: A systematic review and meta-analysis.
Parizad N, Baghi V, Karimi EB, Ghanei Gheshlagh R
Diabetes Metab Syndr 2019 Jul-Aug;13(4):2607-2612. Epub 2019 Jul 13 doi: 10.1016/j.dsx.2019.07.036. PMID: 31405683

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