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Speckled Oral Leukoplakia

MedGen UID:
97998
•Concept ID:
C0399473
•
Neoplastic Process
Synonyms: Nodular leukoplakia of oral mucosa; Speckled oral leukoplakia
SNOMED CT: Nodular leukoplakia of oral mucosa (235029004); Speckled oral leukoplakia (235029004)

Definition

Non-homogenous leukoplakia on the oral mucosa. It is associated with a high risk for malignant transformation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpeckled Oral Leukoplakia

Professional guidelines

PubMed

Effective management of smoking in an oral dysplasia clinic in London.
Poate TW, Warnakulasuriya S
Oral Dis 2006 Jan;12(1):22-6. doi: 10.1111/j.1601-0825.2005.01146.x. PMID: 16390464
Oral candidiasis--its pleomorphic clinical manifestations, diagnosis and treatment.
Ramanathan K, Han NK, Chelvanayagam PI
Dent J Malays 1985 Jan;8(1):39-45. PMID: 3917209
Utilization of primary health care workers for early detection of oral cancer and precancer cases in Sri Lanka.
Warnakulasuriya KA, Ekanayake AN, Sivayoham S, Stjernswärd J, Pindborg JJ, Sobin LH, Perera KS
Bull World Health Organ 1984;62(2):243-50. PMID: 6610492Free PMC Article

Recent clinical studies

Etiology

Oral potentially malignant disorders: clinical-pathological study of 684 cases diagnosed in a Brazilian population.
Pires FR, Barreto ME, Nunes JG, Carneiro NS, Azevedo AB, Dos Santos TC
Med Oral Patol Oral Cir Bucal 2020 Jan 1;25(1):e84-e88. doi: 10.4317/medoral.23197. PMID: 31880285Free PMC Article
Seventeen New Cases of Chronic Ulcerative Stomatitis with Literature Review.
Reddy R, Fitzpatrick SG, Bhattacharyya I, Cohen DM, Islam MN
Head Neck Pathol 2019 Sep;13(3):386-396. Epub 2018 Oct 29 doi: 10.1007/s12105-018-0982-7. PMID: 30374883Free PMC Article
Oral Leukoplakia: Clinicopathological Correlation and Its Relevance to Regional Tobacco-related Habit Index.
Shetty P, Hegde S, Vinod KS, Kalra S, Goyal P, Patel M
J Contemp Dent Pract 2016 Jul 1;17(7):601-8. PMID: 27595730
Oral erythroplakia and speckled leukoplakia: retrospective analysis of 13 cases.
Hosni ES, Salum FG, Cherubini K, Yurgel LS, Figueiredo MA
Braz J Otorhinolaryngol 2009 Mar-Apr;75(2):295-9. doi: 10.1016/s1808-8694(15)30793-x. PMID: 19575119Free PMC Article
Premalignant oral mucosal diseases.
Melrose RJ
J Calif Dent Assoc 2001 Aug;29(8):593-600. PMID: 11577670

Diagnosis

Oral potentially malignant disorders: clinical-pathological study of 684 cases diagnosed in a Brazilian population.
Pires FR, Barreto ME, Nunes JG, Carneiro NS, Azevedo AB, Dos Santos TC
Med Oral Patol Oral Cir Bucal 2020 Jan 1;25(1):e84-e88. doi: 10.4317/medoral.23197. PMID: 31880285Free PMC Article
Seventeen New Cases of Chronic Ulcerative Stomatitis with Literature Review.
Reddy R, Fitzpatrick SG, Bhattacharyya I, Cohen DM, Islam MN
Head Neck Pathol 2019 Sep;13(3):386-396. Epub 2018 Oct 29 doi: 10.1007/s12105-018-0982-7. PMID: 30374883Free PMC Article
Novel biochemical markers: early detection and prevention of malignant transformation a pilot study.
Nayyar AS
Acta Med Iran 2012;50(9):597-602. PMID: 23165808
Oral erythroplakia and speckled leukoplakia: retrospective analysis of 13 cases.
Hosni ES, Salum FG, Cherubini K, Yurgel LS, Figueiredo MA
Braz J Otorhinolaryngol 2009 Mar-Apr;75(2):295-9. doi: 10.1016/s1808-8694(15)30793-x. PMID: 19575119Free PMC Article
Oral candidiasis--its pleomorphic clinical manifestations, diagnosis and treatment.
Ramanathan K, Han NK, Chelvanayagam PI
Dent J Malays 1985 Jan;8(1):39-45. PMID: 3917209

Therapy

Premalignant oral mucosal diseases.
Melrose RJ
J Calif Dent Assoc 2001 Aug;29(8):593-600. PMID: 11577670
Topical application of vitamin A to oral leukoplakia: A clinical case series.
Epstein JB, Gorsky M
Cancer 1999 Sep 15;86(6):921-7. doi: 10.1002/(sici)1097-0142(19990915)86:6<921::aid-cncr5>3.0.co;2-6. PMID: 10491516
Chewing and smoking habits in relation to precancer and oral cancer.
Mehta FS, Gupta PC, Pindborg JJ
J Cancer Res Clin Oncol 1981;99(1-2):35-9. doi: 10.1007/BF00412440. PMID: 7251636

Prognosis

Oral Leukoplakia: Clinicopathological Correlation and Its Relevance to Regional Tobacco-related Habit Index.
Shetty P, Hegde S, Vinod KS, Kalra S, Goyal P, Patel M
J Contemp Dent Pract 2016 Jul 1;17(7):601-8. PMID: 27595730
Prognostic value of cyclin D1, p27, and p63 in oral leukoplakia.
Kövesi G, Szende B
J Oral Pathol Med 2006 May;35(5):274-7. doi: 10.1111/j.1600-0714.2006.00396.x. PMID: 16630290
Premalignant oral mucosal diseases.
Melrose RJ
J Calif Dent Assoc 2001 Aug;29(8):593-600. PMID: 11577670
Excision of oral leukoplakias by CO2 laser on an out-patient basis: a useful procedure for prevention and early detection of oral carcinomas.
Chiesa F, Sala L, Costa L, Moglia D, Mauri M, Podrecca S, Andreola S, Marchesini R, Bandieramonte G, Bartoli C
Tumori 1986 Jun 30;72(3):307-12. doi: 10.1177/030089168607200312. PMID: 3739009

Clinical prediction guides

Oral Leukoplakia: Clinicopathological Correlation and Its Relevance to Regional Tobacco-related Habit Index.
Shetty P, Hegde S, Vinod KS, Kalra S, Goyal P, Patel M
J Contemp Dent Pract 2016 Jul 1;17(7):601-8. PMID: 27595730
Premalignant oral mucosal diseases.
Melrose RJ
J Calif Dent Assoc 2001 Aug;29(8):593-600. PMID: 11577670
Topical application of vitamin A to oral leukoplakia: A clinical case series.
Epstein JB, Gorsky M
Cancer 1999 Sep 15;86(6):921-7. doi: 10.1002/(sici)1097-0142(19990915)86:6<921::aid-cncr5>3.0.co;2-6. PMID: 10491516
Scanning electron microscopy of different types of oral leukoplakia: comparison with normal and malignant oral mucosa.
Pillai KR, Kannan S, Koshy P, Mathew B, Thampi BS, Nalinakumari KR, Nair MK, Menon VP
Eur J Cancer B Oral Oncol 1994 Nov;30B(6):400-4. doi: 10.1016/0964-1955(94)90019-1. PMID: 7719223
A critical evaluation of epithelial dysplasia in oral mucosal lesions using the Smith-Pindborg method of standardization.
Katz HC, Shear M, Altini M
J Oral Pathol 1985 Jul;14(6):476-82. doi: 10.1111/j.1600-0714.1985.tb00519.x. PMID: 3926973

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