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Chronic rejection of renal transplant

MedGen UID:
98337
•Concept ID:
C0403592
•
Disease or Syndrome
Synonyms: Chronic Allograft Nephropathy; Chronic transplant nephropathy
SNOMED CT: Chronic rejection of renal transplant (236578006); Chronic transplant nephropathy (236578006)

Definition

Gradual loss of donor kidney function occurring months to years after transplantation. It is characterized by renal tubular atrophy, interstitial fibrosis, and arterial wall thickening. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic rejection of renal transplant

Professional guidelines

PubMed

Long-Term Immunosuppression Management: Opportunities and Uncertainties.
Wojciechowski D, Wiseman A
Clin J Am Soc Nephrol 2021 Aug;16(8):1264-1271. Epub 2021 Apr 14 doi: 10.2215/CJN.15040920. PMID: 33853841Free PMC Article
Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association.
Rangaswami J, Bhalla V, Blair JEA, Chang TI, Costa S, Lentine KL, Lerma EV, Mezue K, Molitch M, Mullens W, Ronco C, Tang WHW, McCullough PA; American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Clinical Cardiology
Circulation 2019 Apr 16;139(16):e840-e878. doi: 10.1161/CIR.0000000000000664. PMID: 30852913
KDIGO clinical practice guideline for the care of kidney transplant recipients.
Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group
Am J Transplant 2009 Nov;9 Suppl 3:S1-155. doi: 10.1111/j.1600-6143.2009.02834.x. PMID: 19845597

Recent clinical studies

Therapy

Emphysematous cystitis as complication in chronic rejection of renal transplant.
Lang EK, Zhang K, Thorner D, Nguyen QD
Int Braz J Urol 2011 Jan-Feb;37(1):113-4. doi: 10.1590/s1677-55382011000100015. PMID: 21385488

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