U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acquired idiopathic inflammatory myopathy

MedGen UID:
989441
•Concept ID:
CN305781
•
Disease or Syndrome
Synonyms: acquired idiopathic inflammatory myopathy; idiopathic inflammatory myopathies; Idiopathic inflammatory myopathy; idiopathic inflammatory myopathy, familial; Idiopathic inflammatory myositis; idiopathic inflammatory myositis; IIm; IMM
 
Monarch Initiative: MONDO:0020122
Orphanet: ORPHA98482

Definition

An umbrella term for diseases which have chronic muscle inflammation and weakness of unknown etiology. The types of idiopathic inflammatory myopathy are further defined by either clinicopathologic criteria or by the presence of certain autoantibodies. [from MONDO]

Professional guidelines

PubMed

Inclusion Body Myositis: Update on Pathogenesis and Treatment.
Naddaf E, Barohn RJ, Dimachkie MM
Neurotherapeutics 2018 Oct;15(4):995-1005. doi: 10.1007/s13311-018-0658-8. PMID: 30136253Free PMC Article
Diagnosis and Management of Immune-Mediated Myopathies.
Milone M
Mayo Clin Proc 2017 May;92(5):826-837. doi: 10.1016/j.mayocp.2016.12.025. PMID: 28473041
Inclusion body myositis: diagnosis, pathogenesis, and treatment options.
Solorzano GE, Phillips LH 2nd
Rheum Dis Clin North Am 2011 May;37(2):173-83, v. doi: 10.1016/j.rdc.2011.01.003. PMID: 21444018

Recent clinical studies

Etiology

Autoimmune inflammatory myopathies.
Dalakas MC
Handb Clin Neurol 2023;195:425-460. doi: 10.1016/B978-0-323-98818-6.00023-6. PMID: 37562881
Contemporary perspectives on heterotopic ossification.
Hwang CD, Pagani CA, Nunez JH, Cherief M, Qin Q, Gomez-Salazar M, Kadaikal B, Kang H, Chowdary AR, Patel N, James AW, Levi B
JCI Insight 2022 Jul 22;7(14) doi: 10.1172/jci.insight.158996. PMID: 35866484Free PMC Article
The five major autoimmune diseases increase the risk of cancer: epidemiological data from a large-scale cohort study in China.
Zhou Z, Liu H, Yang Y, Zhou J, Zhao L, Chen H, Fei Y, Zhang W, Li M, Zhao Y, Zeng X, Zhang F, Yang H, Zhang X
Cancer Commun (Lond) 2022 May;42(5):435-446. Epub 2022 Mar 31 doi: 10.1002/cac2.12283. PMID: 35357093Free PMC Article
Myositis Mimics.
Michelle EH, Mammen AL
Curr Rheumatol Rep 2015 Oct;17(10):63. doi: 10.1007/s11926-015-0541-0. PMID: 26290112
Polymyositis and dermatomyositis.
Dalakas MC, Hohlfeld R
Lancet 2003 Sep 20;362(9388):971-82. doi: 10.1016/S0140-6736(03)14368-1. PMID: 14511932

Diagnosis

Autoimmune inflammatory myopathies.
Dalakas MC
Handb Clin Neurol 2023;195:425-460. doi: 10.1016/B978-0-323-98818-6.00023-6. PMID: 37562881
The five major autoimmune diseases increase the risk of cancer: epidemiological data from a large-scale cohort study in China.
Zhou Z, Liu H, Yang Y, Zhou J, Zhao L, Chen H, Fei Y, Zhang W, Li M, Zhao Y, Zeng X, Zhang F, Yang H, Zhang X
Cancer Commun (Lond) 2022 May;42(5):435-446. Epub 2022 Mar 31 doi: 10.1002/cac2.12283. PMID: 35357093Free PMC Article
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases.
de Jesus AA, Hou Y, Brooks S, Malle L, Biancotto A, Huang Y, Calvo KR, Marrero B, Moir S, Oler AJ, Deng Z, Montealegre Sanchez GA, Ahmed A, Allenspach E, Arabshahi B, Behrens E, Benseler S, Bezrodnik L, Bout-Tabaku S, Brescia AC, Brown D, Burnham JM, Caldirola MS, Carrasco R, Chan AY, Cimaz R, Dancey P, Dare J, DeGuzman M, Dimitriades V, Ferguson I, Ferguson P, Finn L, Gattorno M, Grom AA, Hanson EP, Hashkes PJ, Hedrich CM, Herzog R, Horneff G, Jerath R, Kessler E, Kim H, Kingsbury DJ, Laxer RM, Lee PY, Lee-Kirsch MA, Lewandowski L, Li S, Lilleby V, Mammadova V, Moorthy LN, Nasrullayeva G, O'Neil KM, Onel K, Ozen S, Pan N, Pillet P, Piotto DG, Punaro MG, Reiff A, Reinhardt A, Rider LG, Rivas-Chacon R, Ronis T, Rösen-Wolff A, Roth J, Ruth NM, Rygg M, Schmeling H, Schulert G, Scott C, Seminario G, Shulman A, Sivaraman V, Son MB, Stepanovskiy Y, Stringer E, Taber S, Terreri MT, Tifft C, Torgerson T, Tosi L, Van Royen-Kerkhof A, Wampler Muskardin T, Canna SW, Goldbach-Mansky R
J Clin Invest 2020 Apr 1;130(4):1669-1682. doi: 10.1172/JCI129301. PMID: 31874111Free PMC Article
Myositis Mimics.
Michelle EH, Mammen AL
Curr Rheumatol Rep 2015 Oct;17(10):63. doi: 10.1007/s11926-015-0541-0. PMID: 26290112
Polymyositis and dermatomyositis.
Dalakas MC, Hohlfeld R
Lancet 2003 Sep 20;362(9388):971-82. doi: 10.1016/S0140-6736(03)14368-1. PMID: 14511932

Therapy

Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP): Results of a Randomized, Placebo-Controlled, Double-Blind Phase 2 Trial.
Pignolo RJ, Baujat G, Hsiao EC, Keen R, Wilson A, Packman J, Strahs AL, Grogan DR, Kaplan FS
J Bone Miner Res 2022 Oct;37(10):1891-1902. Epub 2022 Aug 17 doi: 10.1002/jbmr.4655. PMID: 35854638Free PMC Article
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases.
de Jesus AA, Hou Y, Brooks S, Malle L, Biancotto A, Huang Y, Calvo KR, Marrero B, Moir S, Oler AJ, Deng Z, Montealegre Sanchez GA, Ahmed A, Allenspach E, Arabshahi B, Behrens E, Benseler S, Bezrodnik L, Bout-Tabaku S, Brescia AC, Brown D, Burnham JM, Caldirola MS, Carrasco R, Chan AY, Cimaz R, Dancey P, Dare J, DeGuzman M, Dimitriades V, Ferguson I, Ferguson P, Finn L, Gattorno M, Grom AA, Hanson EP, Hashkes PJ, Hedrich CM, Herzog R, Horneff G, Jerath R, Kessler E, Kim H, Kingsbury DJ, Laxer RM, Lee PY, Lee-Kirsch MA, Lewandowski L, Li S, Lilleby V, Mammadova V, Moorthy LN, Nasrullayeva G, O'Neil KM, Onel K, Ozen S, Pan N, Pillet P, Piotto DG, Punaro MG, Reiff A, Reinhardt A, Rider LG, Rivas-Chacon R, Ronis T, Rösen-Wolff A, Roth J, Ruth NM, Rygg M, Schmeling H, Schulert G, Scott C, Seminario G, Shulman A, Sivaraman V, Son MB, Stepanovskiy Y, Stringer E, Taber S, Terreri MT, Tifft C, Torgerson T, Tosi L, Van Royen-Kerkhof A, Wampler Muskardin T, Canna SW, Goldbach-Mansky R
J Clin Invest 2020 Apr 1;130(4):1669-1682. doi: 10.1172/JCI129301. PMID: 31874111Free PMC Article
Systematic Review of Safety and Efficacy of Rituximab in Treating Immune-Mediated Disorders.
Kaegi C, Wuest B, Schreiner J, Steiner UC, Vultaggio A, Matucci A, Crowley C, Boyman O
Front Immunol 2019;10:1990. Epub 2019 Sep 6 doi: 10.3389/fimmu.2019.01990. PMID: 31555262Free PMC Article
Acquired and congenital forms of heterotopic ossification: new pathogenic insights and therapeutic opportunities.
Pacifici M
Curr Opin Pharmacol 2018 Jun;40:51-58. Epub 2018 Mar 31 doi: 10.1016/j.coph.2018.03.007. PMID: 29614433Free PMC Article
Acquired necrotizing myopathies.
Allenbach Y, Benveniste O
Curr Opin Neurol 2013 Oct;26(5):554-60. doi: 10.1097/WCO.0b013e328364e9d9. PMID: 23995277

Prognosis

Autoimmune inflammatory myopathies.
Dalakas MC
Handb Clin Neurol 2023;195:425-460. doi: 10.1016/B978-0-323-98818-6.00023-6. PMID: 37562881
Identification of key biomarkers associated with immune cells infiltration for myocardial injury in dermatomyositis by integrated bioinformatics analysis.
Zhang Y, Shan L, Li D, Tang Y, Qian W, Dai J, Du M, Sun X, Zhu Y, Wang Q, Zhou L
Arthritis Res Ther 2023 Apr 28;25(1):69. doi: 10.1186/s13075-023-03052-4. PMID: 37118825Free PMC Article
Inflammatory myopathies in childhood.
Stenzel W, Goebel HH, Bader-Meunier B, Gitiaux C
Neuromuscul Disord 2021 Oct;31(10):1051-1061. Epub 2021 Oct 9 doi: 10.1016/j.nmd.2021.08.007. PMID: 34736626
Neuromuscular disorders in pregnancy.
Weimer LH
Handb Clin Neurol 2020;172:201-218. doi: 10.1016/B978-0-444-64240-0.00012-X. PMID: 32768089Free PMC Article
Polymyositis and dermatomyositis.
Dalakas MC, Hohlfeld R
Lancet 2003 Sep 20;362(9388):971-82. doi: 10.1016/S0140-6736(03)14368-1. PMID: 14511932

Clinical prediction guides

Identification of key biomarkers associated with immune cells infiltration for myocardial injury in dermatomyositis by integrated bioinformatics analysis.
Zhang Y, Shan L, Li D, Tang Y, Qian W, Dai J, Du M, Sun X, Zhu Y, Wang Q, Zhou L
Arthritis Res Ther 2023 Apr 28;25(1):69. doi: 10.1186/s13075-023-03052-4. PMID: 37118825Free PMC Article
The five major autoimmune diseases increase the risk of cancer: epidemiological data from a large-scale cohort study in China.
Zhou Z, Liu H, Yang Y, Zhou J, Zhao L, Chen H, Fei Y, Zhang W, Li M, Zhao Y, Zeng X, Zhang F, Yang H, Zhang X
Cancer Commun (Lond) 2022 May;42(5):435-446. Epub 2022 Mar 31 doi: 10.1002/cac2.12283. PMID: 35357093Free PMC Article
COVID-19 and the clinical course of rheumatic manifestations.
Ahmed S, Zimba O, Gasparyan AY
Clin Rheumatol 2021 Jul;40(7):2611-2619. Epub 2021 Mar 17 doi: 10.1007/s10067-021-05691-x. PMID: 33733315Free PMC Article
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases.
de Jesus AA, Hou Y, Brooks S, Malle L, Biancotto A, Huang Y, Calvo KR, Marrero B, Moir S, Oler AJ, Deng Z, Montealegre Sanchez GA, Ahmed A, Allenspach E, Arabshahi B, Behrens E, Benseler S, Bezrodnik L, Bout-Tabaku S, Brescia AC, Brown D, Burnham JM, Caldirola MS, Carrasco R, Chan AY, Cimaz R, Dancey P, Dare J, DeGuzman M, Dimitriades V, Ferguson I, Ferguson P, Finn L, Gattorno M, Grom AA, Hanson EP, Hashkes PJ, Hedrich CM, Herzog R, Horneff G, Jerath R, Kessler E, Kim H, Kingsbury DJ, Laxer RM, Lee PY, Lee-Kirsch MA, Lewandowski L, Li S, Lilleby V, Mammadova V, Moorthy LN, Nasrullayeva G, O'Neil KM, Onel K, Ozen S, Pan N, Pillet P, Piotto DG, Punaro MG, Reiff A, Reinhardt A, Rider LG, Rivas-Chacon R, Ronis T, Rösen-Wolff A, Roth J, Ruth NM, Rygg M, Schmeling H, Schulert G, Scott C, Seminario G, Shulman A, Sivaraman V, Son MB, Stepanovskiy Y, Stringer E, Taber S, Terreri MT, Tifft C, Torgerson T, Tosi L, Van Royen-Kerkhof A, Wampler Muskardin T, Canna SW, Goldbach-Mansky R
J Clin Invest 2020 Apr 1;130(4):1669-1682. doi: 10.1172/JCI129301. PMID: 31874111Free PMC Article
Acquired necrotizing myopathies.
Allenbach Y, Benveniste O
Curr Opin Neurol 2013 Oct;26(5):554-60. doi: 10.1097/WCO.0b013e328364e9d9. PMID: 23995277

Recent systematic reviews

Myositis and acute kidney injury in bacterial atypical pneumonia: Systematic literature review.
Simoni C, Camozzi P, Faré PB, Bianchetti MG, Kottanattu L, Lava SAG, Milani GP
J Infect Public Health 2020 Dec;13(12):2020-2024. Epub 2020 Nov 1 doi: 10.1016/j.jiph.2020.10.007. PMID: 33139236
Systematic Review of Safety and Efficacy of Rituximab in Treating Immune-Mediated Disorders.
Kaegi C, Wuest B, Schreiner J, Steiner UC, Vultaggio A, Matucci A, Crowley C, Boyman O
Front Immunol 2019;10:1990. Epub 2019 Sep 6 doi: 10.3389/fimmu.2019.01990. PMID: 31555262Free PMC Article
Muscle and nerve inflammation in intensive care unit-acquired weakness: a systematic translational review.
Witteveen E, Wieske L, Verhamme C, Schultz MJ, van Schaik IN, Horn J
J Neurol Sci 2014 Oct 15;345(1-2):15-25. Epub 2014 Jul 16 doi: 10.1016/j.jns.2014.07.014. PMID: 25128472
Creatine for treating muscle disorders.
Kley RA, Tarnopolsky MA, Vorgerd M
Cochrane Database Syst Rev 2013 Jun 5;2013(6):CD004760. doi: 10.1002/14651858.CD004760.pub4. PMID: 23740606Free PMC Article
Creatine for treating muscle disorders.
Kley RA, Tarnopolsky MA, Vorgerd M
Cochrane Database Syst Rev 2011 Feb 16;(2):CD004760. doi: 10.1002/14651858.CD004760.pub3. PMID: 21328269

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...