U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Toxic megacolon

MedGen UID:
9940
Concept ID:
C0025162
Disease or Syndrome
Synonyms: Megacolon, Toxic; Toxic Megacolon
SNOMED CT: Toxic megacolon (1269214001); Toxic state due to colonic dilatation (1269214001)
 
Monarch Initiative: MONDO:0002105

Definition

An acute form of megacolon, severe pathological dilatation of the colon. It is associated with clinical conditions such as ulcerative colitis; crohn disease; amebic dysentery; or clostridium enterocolitis. [from MONDO]

Professional guidelines

PubMed

Iqbal T, DuPont HL
Curr Opin Gastroenterol 2021 Jan;37(1):66-75. doi: 10.1097/MOG.0000000000000693. PMID: 33105253
Mounsey A, Lacy Smith K, Reddy VC, Nickolich S
Am Fam Physician 2020 Feb 1;101(3):168-175. PMID: 32003951
Abreu Y Abreu AT, Velarde-Ruiz Velasco JA, Zavala-Solares MR, Remes-Troche JM, Carmona-Sánchez RI, Aldana-Ledesma JM, Camacho-Ortiz A, Contreras-Omaña R, Díaz-Seoane R, Elizondo-Vázquez CT, Garza-González E, Grajales-Figueroa G, Gómez-Escudero O, Jacobo-Karam JS, Morales-Arámbula M, Olivares-Guzmán LO, Sifuentes-Osornio J, Siu-Moguel AG, Soto-Solís R, Valdovinos-García LR, Valdovinos-Díaz MA, Vázquez-Elizondo G, Lazo-de la Vega Jasso SA
Rev Gastroenterol Mex (Engl Ed) 2019 Apr-Jun;84(2):204-219. Epub 2019 Apr 12 doi: 10.1016/j.rgmx.2018.12.001. PMID: 30987771

Recent clinical studies

Etiology

Abad CLR, Safdar N
Gastroenterol Clin North Am 2021 Jun;50(2):323-340. doi: 10.1016/j.gtc.2021.02.010. PMID: 34024444
Liu D, Zeng L, Yan Z, Jia J, Gao J, Wei Y
Expert Rev Anti Infect Ther 2020 Oct;18(10):967-975. Epub 2020 Jun 16 doi: 10.1080/14787210.2020.1778464. PMID: 32520637
Mounsey A, Lacy Smith K, Reddy VC, Nickolich S
Am Fam Physician 2020 Feb 1;101(3):168-175. PMID: 32003951
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Settle CD
Br J Hosp Med 1996 Oct 16-Nov 5;56(8):398-400. PMID: 8909713

Diagnosis

Abad CLR, Safdar N
Gastroenterol Clin North Am 2021 Jun;50(2):323-340. doi: 10.1016/j.gtc.2021.02.010. PMID: 34024444
Mounsey A, Lacy Smith K, Reddy VC, Nickolich S
Am Fam Physician 2020 Feb 1;101(3):168-175. PMID: 32003951
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Mullish BH, Williams HR
Clin Med (Lond) 2018 Jun;18(3):237-241. doi: 10.7861/clinmedicine.18-3-237. PMID: 29858434Free PMC Article
Martin JS, Monaghan TM, Wilcox MH
Nat Rev Gastroenterol Hepatol 2016 Apr;13(4):206-16. Epub 2016 Mar 9 doi: 10.1038/nrgastro.2016.25. PMID: 26956066

Therapy

Abad CLR, Safdar N
Gastroenterol Clin North Am 2021 Jun;50(2):323-340. doi: 10.1016/j.gtc.2021.02.010. PMID: 34024444
Iqbal T, DuPont HL
Curr Opin Gastroenterol 2021 Jan;37(1):66-75. doi: 10.1097/MOG.0000000000000693. PMID: 33105253
Mounsey A, Lacy Smith K, Reddy VC, Nickolich S
Am Fam Physician 2020 Feb 1;101(3):168-175. PMID: 32003951
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Mullish BH, Williams HR
Clin Med (Lond) 2018 Jun;18(3):237-241. doi: 10.7861/clinmedicine.18-3-237. PMID: 29858434Free PMC Article

Prognosis

Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Alcalá Hernández L, Reigadas Ramírez E, Bouza Santiago E
Med Clin (Barc) 2017 May 23;148(10):456-463. Epub 2017 Apr 8 doi: 10.1016/j.medcli.2017.01.033. PMID: 28396132
Cheung O, Regueiro MD
Gastroenterol Clin North Am 2003 Dec;32(4):1269-88. doi: 10.1016/s0889-8553(03)00095-5. PMID: 14696307
Sheth SG, LaMont JT
Lancet 1998 Feb 14;351(9101):509-13. doi: 10.1016/S0140-6736(97)10475-5. PMID: 9482465
Present DH
Med Clin North Am 1993 Sep;77(5):1129-48. doi: 10.1016/s0025-7125(16)30214-0. PMID: 8371619

Clinical prediction guides

Lesniak NA, Schubert AM, Flynn KJ, Leslie JL, Sinani H, Bergin IL, Young VB, Schloss PD
mBio 2022 Aug 30;13(4):e0118322. Epub 2022 Jul 20 doi: 10.1128/mbio.01183-22. PMID: 35856563Free PMC Article
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Tapani MJ, Olavi KH
Hepatogastroenterology 2014 May;61(131):638-41. PMID: 26176049
Benchimol EI, Turner D, Mann EH, Thomas KE, Gomes T, McLernon RA, Griffiths AM
Am J Gastroenterol 2008 Jun;103(6):1524-31. Epub 2008 May 28 doi: 10.1111/j.1572-0241.2008.01807.x. PMID: 18510624
Hull MW, Beck PL
Can Fam Physician 2004 Nov;50:1536-40, 1543-5. PMID: 15597970Free PMC Article

Recent systematic reviews

Hembree AE, Scherl E
Dis Colon Rectum 2022 Dec 1;65(S1):S85-S91. Epub 2022 Aug 25 doi: 10.1097/DCR.0000000000002593. PMID: 36399769
Eghbali E, Akhavi Milani A, Shirmohamadi M, Hosseinifard H
Radiography (Lond) 2021 May;27(2):716-720. Epub 2020 Nov 12 doi: 10.1016/j.radi.2020.10.019. PMID: 33189537
Bazerbachi F, Haffar S, Szarka LA, Wang Z, Prokop LJ, Murad MH, Camilleri M
Neurogastroenterol Motil 2017 Nov;29(11) Epub 2017 Jun 5 doi: 10.1111/nmo.13120. PMID: 28580600
Moura FA, de Andrade KQ, Dos Santos JCF, Araújo ORP, Goulart MOF
Redox Biol 2015 Dec;6:617-639. Epub 2015 Oct 23 doi: 10.1016/j.redox.2015.10.006. PMID: 26520808Free PMC Article
Kazanowski M, Smolarek S, Kinnarney F, Grzebieniak Z
Tech Coloproctol 2014 Mar;18(3):223-32. Epub 2013 Nov 1 doi: 10.1007/s10151-013-1081-0. PMID: 24178946Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...