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Psoriasis

MedGen UID:
10997
•Concept ID:
C0033860
•
Disease or Syndrome
Synonym: Psoriases
SNOMED CT: Psoriasis (9014002)
 
Monarch Initiative: MONDO:0005083
OMIM® Phenotypic series: PS177900

Definition

An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp. [from NCI]

Professional guidelines

PubMed

Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article
Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics.
Menter A, Strober BE, Kaplan DH, Kivelevitch D, Prater EF, Stoff B, Armstrong AW, Connor C, Cordoro KM, Davis DMR, Elewski BE, Gelfand JM, Gordon KB, Gottlieb AB, Kavanaugh A, Kiselica M, Korman NJ, Kroshinsky D, Lebwohl M, Leonardi CL, Lichten J, Lim HW, Mehta NN, Paller AS, Parra SL, Pathy AL, Rupani RN, Siegel M, Wong EB, Wu JJ, Hariharan V, Elmets CA
J Am Acad Dermatol 2019 Apr;80(4):1029-1072. Epub 2019 Feb 13 doi: 10.1016/j.jaad.2018.11.057. PMID: 30772098
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

Recent clinical studies

Etiology

Psoriasis.
Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker JNWN
Lancet 2021 Apr 3;397(10281):1301-1315. doi: 10.1016/S0140-6736(20)32549-6. PMID: 33812489
Management of psoriasis as a systemic disease: what is the evidence?
Korman NJ
Br J Dermatol 2020 Apr;182(4):840-848. Epub 2019 Oct 15 doi: 10.1111/bjd.18245. PMID: 31225638Free PMC Article
Risk Factors for the Development of Psoriasis.
Kamiya K, Kishimoto M, Sugai J, Komine M, Ohtsuki M
Int J Mol Sci 2019 Sep 5;20(18) doi: 10.3390/ijms20184347. PMID: 31491865Free PMC Article
Stress and psoriasis.
Rousset L, Halioua B
Int J Dermatol 2018 Oct;57(10):1165-1172. Epub 2018 May 4 doi: 10.1111/ijd.14032. PMID: 29729012
Psoriasis: epidemiology, clinical features, and quality of life.
Langley RG, Krueger GG, Griffiths CE
Ann Rheum Dis 2005 Mar;64 Suppl 2(Suppl 2):ii18-23; discussion ii24-5. doi: 10.1136/ard.2004.033217. PMID: 15708928Free PMC Article

Diagnosis

Challenges and Future Trends in the Treatment of Psoriasis.
Lee HJ, Kim M
Int J Mol Sci 2023 Aug 28;24(17) doi: 10.3390/ijms241713313. PMID: 37686119Free PMC Article
Psoriasis Pathogenesis and Treatment.
Rendon A, Schäkel K
Int J Mol Sci 2019 Mar 23;20(6) doi: 10.3390/ijms20061475. PMID: 30909615Free PMC Article
Childhood psoriasis.
Mahé E
Eur J Dermatol 2016 Dec 1;26(6):537-548. doi: 10.1684/ejd.2016.2932. PMID: 27900946
Psoriasis.
Boehncke WH, Schön MP
Lancet 2015 Sep 5;386(9997):983-94. Epub 2015 May 27 doi: 10.1016/S0140-6736(14)61909-7. PMID: 26025581
Psoriasis: epidemiology, clinical features, and quality of life.
Langley RG, Krueger GG, Griffiths CE
Ann Rheum Dis 2005 Mar;64 Suppl 2(Suppl 2):ii18-23; discussion ii24-5. doi: 10.1136/ard.2004.033217. PMID: 15708928Free PMC Article

Therapy

Role of nutritional supplements in selected dermatological disorders: A review.
Sardana K, Sachdeva S
J Cosmet Dermatol 2022 Jan;21(1):85-98. Epub 2021 Sep 26 doi: 10.1111/jocd.14436. PMID: 34564936
Home-based devices in dermatology: a systematic review of safety and efficacy.
Cohen M, Austin E, Masub N, Kurtti A, George C, Jagdeo J
Arch Dermatol Res 2022 Apr;314(3):239-246. Epub 2021 May 3 doi: 10.1007/s00403-021-02231-0. PMID: 33938981Free PMC Article
IL-23 blockade with guselkumab potentially modifies psoriasis pathogenesis: rationale and study protocol of a phase 3b, randomised, double-blind, multicentre study in participants with moderate-to-severe plaque-type psoriasis (GUIDE).
Eyerich K, Weisenseel P, Pinter A, Schäkel K, Asadullah K, Wegner S, Muñoz-Elias EJ, Bartz H, Taut FJH, Reich K
BMJ Open 2021 Sep 13;11(9):e049822. doi: 10.1136/bmjopen-2021-049822. PMID: 34518264Free PMC Article
Long-term safety of secukinumab in patients with moderate-to-severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis: integrated pooled clinical trial and post-marketing surveillance data.
Deodhar A, Mease PJ, McInnes IB, Baraliakos X, Reich K, Blauvelt A, Leonardi C, Porter B, Das Gupta A, Widmer A, Pricop L, Fox T
Arthritis Res Ther 2019 May 2;21(1):111. doi: 10.1186/s13075-019-1882-2. PMID: 31046809Free PMC Article
Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI): the correlation between disease severity and psychological burden in patients treated with biological therapies.
Mattei PL, Corey KC, Kimball AB
J Eur Acad Dermatol Venereol 2014 Mar;28(3):333-7. Epub 2013 Feb 21 doi: 10.1111/jdv.12106. PMID: 23425140

Prognosis

Temporal trends in the prevalence of autoimmune diseases from 1990 to 2019.
Cao F, Liu YC, Ni QY, Chen Y, Wan CH, Liu SY, Tao LM, Jiang ZX, Ni J, Pan HF
Autoimmun Rev 2023 Aug;22(8):103359. Epub 2023 May 16 doi: 10.1016/j.autrev.2023.103359. PMID: 37201621
Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial.
Hahn J, Cook NR, Alexander EK, Friedman S, Walter J, Bubes V, Kotler G, Lee IM, Manson JE, Costenbader KH
BMJ 2022 Jan 26;376:e066452. doi: 10.1136/bmj-2021-066452. PMID: 35082139Free PMC Article
National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study.
Parisi R, Iskandar IYK, Kontopantelis E, Augustin M, Griffiths CEM, Ashcroft DM; Global Psoriasis Atlas
BMJ 2020 May 28;369:m1590. doi: 10.1136/bmj.m1590. PMID: 32467098Free PMC Article
A systematic review of worldwide epidemiology of psoriasis.
Michalek IM, Loring B, John SM
J Eur Acad Dermatol Venereol 2017 Feb;31(2):205-212. Epub 2016 Aug 30 doi: 10.1111/jdv.13854. PMID: 27573025
Global epidemiology of psoriasis: a systematic review of incidence and prevalence.
Parisi R, Symmons DP, Griffiths CE, Ashcroft DM; Identification and Management of Psoriasis and Associated ComorbidiTy (IMPACT) project team
J Invest Dermatol 2013 Feb;133(2):377-85. Epub 2012 Sep 27 doi: 10.1038/jid.2012.339. PMID: 23014338

Clinical prediction guides

Artificial Intelligence-Based Psoriasis Severity Assessment: Real-world Study and Application.
Huang K, Wu X, Li Y, Lv C, Yan Y, Wu Z, Zhang M, Huang W, Jiang Z, Hu K, Li M, Su J, Zhu W, Li F, Chen M, Chen J, Li Y, Zeng M, Zhu J, Cao D, Huang X, Huang L, Hu X, Chen Z, Kang J, Yuan L, Huang C, Guo R, Navarini A, Kuang Y, Chen X, Zhao S
J Med Internet Res 2023 Mar 16;25:e44932. doi: 10.2196/44932. PMID: 36927843Free PMC Article
Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article
Nail Psoriasis: Diagnosis, Assessment, Treatment Options, and Unmet Clinical Needs.
Kaeley GS, Eder L, Aydin SZ, Rich P, Bakewell CJ
J Rheumatol 2021 Aug;48(8):1208-1220. Epub 2021 Feb 15 doi: 10.3899/jrheum.201471. PMID: 33589557
The skin in psoriasis: assessment and challenges.
Oji V, Luger TA
Clin Exp Rheumatol 2015 Sep-Oct;33(5 Suppl 93):S14-9. Epub 2015 Oct 15 PMID: 26472560
Grading of chronic synovitis--a histopathological grading system for molecular and diagnostic pathology.
Krenn V, Morawietz L, Häupl T, Neidel J, Petersen I, König A
Pathol Res Pract 2002;198(5):317-25. doi: 10.1078/0344-0338-5710261. PMID: 12092767

Recent systematic reviews

Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis.
Formisano E, Proietti E, Borgarelli C, Pisciotta L
Nutrients 2023 Jul 30;15(15) doi: 10.3390/nu15153387. PMID: 37571324Free PMC Article
Paradoxical eruptions to targeted therapies in dermatology: A systematic review and analysis.
Murphy MJ, Cohen JM, Vesely MD, Damsky W
J Am Acad Dermatol 2022 May;86(5):1080-1091. Epub 2020 Dec 8 doi: 10.1016/j.jaad.2020.12.010. PMID: 33307146
National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study.
Parisi R, Iskandar IYK, Kontopantelis E, Augustin M, Griffiths CEM, Ashcroft DM; Global Psoriasis Atlas
BMJ 2020 May 28;369:m1590. doi: 10.1136/bmj.m1590. PMID: 32467098Free PMC Article
A systematic review of worldwide epidemiology of psoriasis.
Michalek IM, Loring B, John SM
J Eur Acad Dermatol Venereol 2017 Feb;31(2):205-212. Epub 2016 Aug 30 doi: 10.1111/jdv.13854. PMID: 27573025
Global epidemiology of psoriasis: a systematic review of incidence and prevalence.
Parisi R, Symmons DP, Griffiths CE, Ashcroft DM; Identification and Management of Psoriasis and Associated ComorbidiTy (IMPACT) project team
J Invest Dermatol 2013 Feb;133(2):377-85. Epub 2012 Sep 27 doi: 10.1038/jid.2012.339. PMID: 23014338

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