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Bone mineral density quantitative trait locus 15(BMND15)

MedGen UID:
462030
•Concept ID:
C3150680
•
Finding
Synonyms: BMND15; COMPRESSION FRACTURE, SUSCEPTIBILITY TO; METAPHYSEAL FRACTURE, SUSCEPTIBILITY TO
 
Gene (location): MIR2861 (9q34.11)
 
OMIM®: 613418

Recent clinical studies

Etiology

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.
Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS, Mook-Kanamori DO, Ham A, Hartwig FP, Evans DS, Joro R, Nedeljkovic I, Zheng HF, Zhu K, Atalay M, Liu CT, Nethander M, Broer L, Porleifsson G, Mullin BH, Handelman SK, Nalls MA, Jessen LE, Heppe DHM, Richards JB, Wang C, Chawes B, Schraut KE, Amin N, Wareham N, Karasik D, Van der Velde N, Ikram MA, Zemel BS, Zhou Y, Carlsson CJ, Liu Y, McGuigan FE, Boer CG, Bønnelykke K, Ralston SH, Robbins JA, Walsh JP, Zillikens MC, Langenberg C, Li-Gao R, Williams FMK, Harris TB, Akesson K, Jackson RD, Sigurdsson G, den Heijer M, van der Eerden BCJ, van de Peppel J, Spector TD, Pennell C, Horta BL, Felix JF, Zhao JH, Wilson SG, de Mutsert R, Bisgaard H, Styrkársdóttir U, Jaddoe VW, Orwoll E, Lakka TA, Scott R, Grant SFA, Lorentzon M, van Duijn CM, Wilson JF, Stefansson K, Psaty BM, Kiel DP, Ohlsson C, Ntzani E, van Wijnen AJ, Forgetta V, Ghanbari M, Logan JG, Williams GR, Bassett JHD, Croucher PI, Evangelou E, Uitterlinden AG, Ackert-Bicknell CL, Tobias JH, Evans DM, Rivadeneira F
Am J Hum Genet 2018 Jan 4;102(1):88-102. doi: 10.1016/j.ajhg.2017.12.005. PMID: 29304378Free PMC Article
Using GWAS to identify novel therapeutic targets for osteoporosis.
Sabik OL, Farber CR
Transl Res 2017 Mar;181:15-26. Epub 2016 Oct 27 doi: 10.1016/j.trsl.2016.10.009. PMID: 27837649Free PMC Article
Genetics of osteoporosis.
Ralston SH, Uitterlinden AG
Endocr Rev 2010 Oct;31(5):629-62. Epub 2010 Apr 29 doi: 10.1210/er.2009-0044. PMID: 20431112
Quantitative trait locus on chromosome 1q influences bone loss in young Mexican American adults.
Shaffer JR, Kammerer CM, Bruder JM, Cole SA, Dyer TD, Almasy L, Maccluer JW, Blangero J, Bauer RL, Mitchell BD
Calcif Tissue Int 2009 Feb;84(2):75-84. Epub 2008 Dec 9 doi: 10.1007/s00223-008-9197-3. PMID: 19067020Free PMC Article
A close examination of genes within quantitative trait loci of bone mineral density in whole mouse genome.
Xiong Q, Han C, Beamer WG, Gu W
Crit Rev Eukaryot Gene Expr 2008;18(4):323-43. doi: 10.1615/critreveukargeneexpr.v18.i4.20. PMID: 18652562

Diagnosis

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.
Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS, Mook-Kanamori DO, Ham A, Hartwig FP, Evans DS, Joro R, Nedeljkovic I, Zheng HF, Zhu K, Atalay M, Liu CT, Nethander M, Broer L, Porleifsson G, Mullin BH, Handelman SK, Nalls MA, Jessen LE, Heppe DHM, Richards JB, Wang C, Chawes B, Schraut KE, Amin N, Wareham N, Karasik D, Van der Velde N, Ikram MA, Zemel BS, Zhou Y, Carlsson CJ, Liu Y, McGuigan FE, Boer CG, Bønnelykke K, Ralston SH, Robbins JA, Walsh JP, Zillikens MC, Langenberg C, Li-Gao R, Williams FMK, Harris TB, Akesson K, Jackson RD, Sigurdsson G, den Heijer M, van der Eerden BCJ, van de Peppel J, Spector TD, Pennell C, Horta BL, Felix JF, Zhao JH, Wilson SG, de Mutsert R, Bisgaard H, Styrkársdóttir U, Jaddoe VW, Orwoll E, Lakka TA, Scott R, Grant SFA, Lorentzon M, van Duijn CM, Wilson JF, Stefansson K, Psaty BM, Kiel DP, Ohlsson C, Ntzani E, van Wijnen AJ, Forgetta V, Ghanbari M, Logan JG, Williams GR, Bassett JHD, Croucher PI, Evangelou E, Uitterlinden AG, Ackert-Bicknell CL, Tobias JH, Evans DM, Rivadeneira F
Am J Hum Genet 2018 Jan 4;102(1):88-102. doi: 10.1016/j.ajhg.2017.12.005. PMID: 29304378Free PMC Article
Genetic epidemiology of osteoporosis: past, present, and future.
Zmuda JM, Sheu YT, Moffett SP
Curr Osteoporos Rep 2005 Sep;3(3):111-5. doi: 10.1007/s11914-005-0019-5. PMID: 16131431

Therapy

Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus.
Oei L, Estrada K, Duncan EL, Christiansen C, Liu CT, Langdahl BL, Obermayer-Pietsch B, Riancho JA, Prince RL, van Schoor NM, McCloskey E, Hsu YH, Evangelou E, Ntzani E, Evans DM, Alonso N, Husted LB, Valero C, Hernandez JL, Lewis JR, Kaptoge SK, Zhu K, Cupples LA, Medina-Gómez C, Vandenput L, Kim GS, Hun Lee S, Castaño-Betancourt MC, Oei EH, Martinez J, Daroszewska A, van der Klift M, Mellström D, Herrera L, Karlsson MK, Hofman A, Ljunggren Ö, Pols HA, Stolk L, van Meurs JB, Ioannidis JP, Zillikens MC, Lips P, Karasik D, Uitterlinden AG, Styrkarsdottir U, Brown MA, Koh JM, Richards JB, Reeve J, Ohlsson C, Ralston SH, Kiel DP, Rivadeneira F
Bone 2014 Feb;59:20-7. PMID: 24516880Free PMC Article
A unified approach to modelling linkage to quantitative and qualitative traits.
Houwing-Duistermaat JJ, Bijkerk C, Hsu L, Stijnen T, Slagboom EP, van Duijn CM
Ann Hum Genet 2003 Sep;67(Pt 5):457-63. doi: 10.1046/j.1469-1809.2003.00033.x. PMID: 12940918

Prognosis

Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass.
Mesner LD, Calabrese GM, Al-Barghouthi B, Gatti DM, Sundberg JP, Churchill GA, Godfrey DA, Ackert-Bicknell CL, Farber CR
PLoS Genet 2019 May;15(5):e1008123. Epub 2019 May 1 doi: 10.1371/journal.pgen.1008123. PMID: 31042701Free PMC Article
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.
Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS, Mook-Kanamori DO, Ham A, Hartwig FP, Evans DS, Joro R, Nedeljkovic I, Zheng HF, Zhu K, Atalay M, Liu CT, Nethander M, Broer L, Porleifsson G, Mullin BH, Handelman SK, Nalls MA, Jessen LE, Heppe DHM, Richards JB, Wang C, Chawes B, Schraut KE, Amin N, Wareham N, Karasik D, Van der Velde N, Ikram MA, Zemel BS, Zhou Y, Carlsson CJ, Liu Y, McGuigan FE, Boer CG, Bønnelykke K, Ralston SH, Robbins JA, Walsh JP, Zillikens MC, Langenberg C, Li-Gao R, Williams FMK, Harris TB, Akesson K, Jackson RD, Sigurdsson G, den Heijer M, van der Eerden BCJ, van de Peppel J, Spector TD, Pennell C, Horta BL, Felix JF, Zhao JH, Wilson SG, de Mutsert R, Bisgaard H, Styrkársdóttir U, Jaddoe VW, Orwoll E, Lakka TA, Scott R, Grant SFA, Lorentzon M, van Duijn CM, Wilson JF, Stefansson K, Psaty BM, Kiel DP, Ohlsson C, Ntzani E, van Wijnen AJ, Forgetta V, Ghanbari M, Logan JG, Williams GR, Bassett JHD, Croucher PI, Evangelou E, Uitterlinden AG, Ackert-Bicknell CL, Tobias JH, Evans DM, Rivadeneira F
Am J Hum Genet 2018 Jan 4;102(1):88-102. doi: 10.1016/j.ajhg.2017.12.005. PMID: 29304378Free PMC Article
A methodology for multivariate phenotype-based genome-wide association studies to mine pleiotropic genes.
Park SH, Lee JY, Kim S
BMC Syst Biol 2011;5 Suppl 2(Suppl 2):S13. Epub 2011 Dec 14 doi: 10.1186/1752-0509-5-S2-S13. PMID: 22784570Free PMC Article
Association of a single-nucleotide variation (A1330V) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density in adult Japanese women.
Ezura Y, Nakajima T, Urano T, Sudo Y, Kajita M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Emi M
Bone 2007 Apr;40(4):997-1005. Epub 2007 Feb 15 doi: 10.1016/j.bone.2005.06.025. PMID: 17306638
A novel locus on the X chromosome regulates post-maturity bone density changes in mice.
Szumska D, Benes H, Kang P, Weinstein RS, Jilka RL, Manolagas SC, Shmookler Reis RJ
Bone 2007 Mar;40(3):758-66. Epub 2006 Dec 19 doi: 10.1016/j.bone.2006.10.012. PMID: 17185055Free PMC Article

Clinical prediction guides

Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass.
Mesner LD, Calabrese GM, Al-Barghouthi B, Gatti DM, Sundberg JP, Churchill GA, Godfrey DA, Ackert-Bicknell CL, Farber CR
PLoS Genet 2019 May;15(5):e1008123. Epub 2019 May 1 doi: 10.1371/journal.pgen.1008123. PMID: 31042701Free PMC Article
Bone mineral density is linked to 1p36 and 7p15-13 in a southern Chinese population.
Li HY, Kung WC, Huang QY
J Bone Miner Metab 2011 Jan;29(1):80-7. Epub 2010 Jul 6 doi: 10.1007/s00774-010-0195-y. PMID: 20607328
Quantitative trait locus on chromosome 1q influences bone loss in young Mexican American adults.
Shaffer JR, Kammerer CM, Bruder JM, Cole SA, Dyer TD, Almasy L, Maccluer JW, Blangero J, Bauer RL, Mitchell BD
Calcif Tissue Int 2009 Feb;84(2):75-84. Epub 2008 Dec 9 doi: 10.1007/s00223-008-9197-3. PMID: 19067020Free PMC Article
A novel locus on the X chromosome regulates post-maturity bone density changes in mice.
Szumska D, Benes H, Kang P, Weinstein RS, Jilka RL, Manolagas SC, Shmookler Reis RJ
Bone 2007 Mar;40(3):758-66. Epub 2006 Dec 19 doi: 10.1016/j.bone.2006.10.012. PMID: 17185055Free PMC Article
Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains.
Koller DL, Alam I, Sun Q, Liu L, Fishburn T, Carr LG, Econs MJ, Foroud T, Turner CH
Mamm Genome 2005 Aug;16(8):578-86. Epub 2005 Sep 14 doi: 10.1007/s00335-004-2459-0. PMID: 16180139

Supplemental Content

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    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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