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Abnormal circulating enzyme concentration

MedGen UID:
869169
•Concept ID:
C4023591
•
Finding
Synonym: Abnormality of circulating enzyme level
 
HPO: HP:0011021

Definition

The concentration or activity of an enzyme in the blood circulation is outside of the limits of the normal range. [from HPO]

Professional guidelines

PubMed

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Effect of Growth Hormone Treatment on the Concentration of Selected Metabolic Markers in Girls With Turner Syndrome.
Błaszczyk E, Gawlik J, Gieburowska J, Tokarska A, Kimsa-Furdzik M, Hibner G, Francuz T, Gawlik A
Front Endocrinol (Lausanne) 2022;13:818735. Epub 2022 Jun 13 doi: 10.3389/fendo.2022.818735. PMID: 35769087Free PMC Article
Congenital blood coagulation factor XIII deficiency and perinatal management.
Ichinose A, Asahina T, Kobayashi T
Curr Drug Targets 2005 Aug;6(5):541-9. doi: 10.2174/1389450054545953. PMID: 16026274

Recent clinical studies

Etiology

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Angiogenic Biomarkers for Risk Stratification in Women with Preeclampsia.
Docheva N, Arenas G, Nieman KM, Lopes-Perdigao J, Yeo KJ, Rana S
Clin Chem 2022 Jun 1;68(6):771-781. doi: 10.1093/clinchem/hvab281. PMID: 35092286
Premature adrenarche: etiology, clinical findings, and consequences.
Voutilainen R, Jääskeläinen J
J Steroid Biochem Mol Biol 2015 Jan;145:226-36. Epub 2014 Jun 9 doi: 10.1016/j.jsbmb.2014.06.004. PMID: 24923732
Eryptosis in lead-exposed workers.
Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684
Angiogenic factors and preeclampsia.
Tjoa ML, Levine RJ, Karumanchi SA
Front Biosci 2007 Jan 1;12:2395-402. doi: 10.2741/2241. PMID: 17127249

Diagnosis

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Angiogenic Biomarkers for Risk Stratification in Women with Preeclampsia.
Docheva N, Arenas G, Nieman KM, Lopes-Perdigao J, Yeo KJ, Rana S
Clin Chem 2022 Jun 1;68(6):771-781. doi: 10.1093/clinchem/hvab281. PMID: 35092286
Multifunctional Liposomes.
Aryasomayajula B, Salzano G, Torchilin VP
Methods Mol Biol 2017;1530:41-61. doi: 10.1007/978-1-4939-6646-2_3. PMID: 28150195
Angiogenic factors and preeclampsia.
Tjoa ML, Levine RJ, Karumanchi SA
Front Biosci 2007 Jan 1;12:2395-402. doi: 10.2741/2241. PMID: 17127249
The pharmacology of letrozole.
Haynes BP, Dowsett M, Miller WR, Dixon JM, Bhatnagar AS
J Steroid Biochem Mol Biol 2003 Oct;87(1):35-45. doi: 10.1016/s0960-0760(03)00384-4. PMID: 14630089

Therapy

Organokines and liver enzymes in adolescent girls with polycystic ovary syndrome during randomized treatments.
Garcia-Beltran C, Peyrou M, Navarro-Gascon A, López-Bermejo A, de Zegher F, Villarroya F, Ibáñez L
Front Endocrinol (Lausanne) 2024;15:1325230. Epub 2024 May 16 doi: 10.3389/fendo.2024.1325230. PMID: 38818508Free PMC Article
Multifunctional Liposomes.
Aryasomayajula B, Salzano G, Torchilin VP
Methods Mol Biol 2017;1530:41-61. doi: 10.1007/978-1-4939-6646-2_3. PMID: 28150195
Eryptosis in lead-exposed workers.
Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684
Obstructive nephropathy.
Klahr S
Intern Med 2000 May;39(5):355-61. doi: 10.2169/internalmedicine.39.355. PMID: 10830173
Dichloroacetate.
Stacpoole PW, Greene YJ
Diabetes Care 1992 Jun;15(6):785-91. doi: 10.2337/diacare.15.6.785. PMID: 1600837

Prognosis

Angiogenic Biomarkers for Risk Stratification in Women with Preeclampsia.
Docheva N, Arenas G, Nieman KM, Lopes-Perdigao J, Yeo KJ, Rana S
Clin Chem 2022 Jun 1;68(6):771-781. doi: 10.1093/clinchem/hvab281. PMID: 35092286
Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis.
Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG
Hepatology 2022 Apr;75(4):968-982. Epub 2021 Dec 7 doi: 10.1002/hep.32203. PMID: 34662439Free PMC Article
Trimethylamine oxide: a potential target for heart failure therapy.
Lv S, Wang Y, Zhang W, Shang H
Heart 2022 May 25;108(12):917-922. doi: 10.1136/heartjnl-2021-320054. PMID: 34611047
Urinary renin-angiotensin markers in polycystic kidney disease.
Salih M, Bovée DM, Roksnoer LCW, Casteleijn NF, Bakker SJL, Gansevoort RT, Zietse R, Danser AHJ, Hoorn EJ
Am J Physiol Renal Physiol 2017 Oct 1;313(4):F874-F881. Epub 2017 Jul 26 doi: 10.1152/ajprenal.00209.2017. PMID: 28747358
Angiogenic factors and preeclampsia.
Tjoa ML, Levine RJ, Karumanchi SA
Front Biosci 2007 Jan 1;12:2395-402. doi: 10.2741/2241. PMID: 17127249

Clinical prediction guides

Organokines and liver enzymes in adolescent girls with polycystic ovary syndrome during randomized treatments.
Garcia-Beltran C, Peyrou M, Navarro-Gascon A, López-Bermejo A, de Zegher F, Villarroya F, Ibáñez L
Front Endocrinol (Lausanne) 2024;15:1325230. Epub 2024 May 16 doi: 10.3389/fendo.2024.1325230. PMID: 38818508Free PMC Article
SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells.
Iida H, Kono T, Lee CC, Krishnan P, Arvin MC, Weaver SA, Jarvela TS, Branco RCS, McLaughlin MR, Bone RN, Tong X, Arvan P, Lindberg I, Evans-Molina C
Diabetologia 2023 Nov;66(11):2042-2061. Epub 2023 Aug 4 doi: 10.1007/s00125-023-05979-4. PMID: 37537395Free PMC Article
Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Angiogenic Biomarkers for Risk Stratification in Women with Preeclampsia.
Docheva N, Arenas G, Nieman KM, Lopes-Perdigao J, Yeo KJ, Rana S
Clin Chem 2022 Jun 1;68(6):771-781. doi: 10.1093/clinchem/hvab281. PMID: 35092286
Angiogenic factors and preeclampsia.
Tjoa ML, Levine RJ, Karumanchi SA
Front Biosci 2007 Jan 1;12:2395-402. doi: 10.2741/2241. PMID: 17127249

Recent systematic reviews

Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis.
Murri M, Luque-Ramírez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF
Hum Reprod Update 2013 May-Jun;19(3):268-88. Epub 2013 Jan 9 doi: 10.1093/humupd/dms059. PMID: 23303572

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