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Cervical cancer

MedGen UID:
890252
Concept ID:
C4048328
Neoplastic Process
Synonyms: Cancer of cervix; Cervical cancer, somatic; Cervix cancer
SNOMED CT: Cancer of cervix (363354003)
 
Gene (location): FGFR3 (4p16.3)
 
HPO: HP:0030079
Monarch Initiative: MONDO:0002974
OMIM®: 603956

Definition

A tumor of the uterine cervix. [from HPO]

Clinical features

From HPO
Neoplasm
MedGen UID:
10294
Concept ID:
C0027651
Neoplastic Process
An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor).
Cervical cancer
MedGen UID:
890252
Concept ID:
C4048328
Neoplastic Process
A tumor of the uterine cervix.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical cancer

Conditions with this feature

Cervical cancer
MedGen UID:
890252
Concept ID:
C4048328
Neoplastic Process
A tumor of the uterine cervix.
Mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition
MedGen UID:
1824057
Concept ID:
C5774284
Disease or Syndrome
Mosaic variegated aneuploidy syndrome-7 with inflammation and tumor predisposition (MVA7) is an autosomal recessive disorder characterized by increased susceptibility to benign and malignant neoplasms beginning in early childhood. Affected individuals show dysmorphic facies and may have early developmental delay. Patient cells show a high level of aneuploidy due to defects in cell division (Villarroya-Beltri et al., 2022). For a discussion of genetic heterogeneity of MVA, see MVA1 (257300).

Professional guidelines

PubMed

Small W Jr, Bosch WR, Harkenrider MM, Strauss JB, Abu-Rustum N, Albuquerque KV, Beriwal S, Creutzberg CL, Eifel PJ, Erickson BA, Fyles AW, Hentz CL, Jhingran A, Klopp AH, Kunos CA, Mell LK, Portelance L, Powell ME, Viswanathan AN, Yacoub JH, Yashar CM, Winter KA, Gaffney DK
Int J Radiat Oncol Biol Phys 2021 Feb 1;109(2):413-424. Epub 2020 Sep 6 doi: 10.1016/j.ijrobp.2020.08.061. PMID: 32905846Free PMC Article
Perkins RB, Guido RS, Castle PE, Chelmow D, Einstein MH, Garcia F, Huh WK, Kim JJ, Moscicki AB, Nayar R, Saraiya M, Sawaya GF, Wentzensen N, Schiffman M; 2019 ASCCP Risk-Based Management Consensus Guidelines Committee
J Low Genit Tract Dis 2020 Apr;24(2):102-131. doi: 10.1097/LGT.0000000000000525. PMID: 32243307Free PMC Article
Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A, Galazios G
J BUON 2016 Mar-Apr;21(2):320-5. PMID: 27273940

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Cervical Cancer, 2024

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

Recent clinical studies

Etiology

Gavinski K, DiNardo D
Med Clin North Am 2023 Mar;107(2):259-269. Epub 2022 Dec 26 doi: 10.1016/j.mcna.2022.10.006. PMID: 36759096
Ferrall L, Lin KY, Roden RBS, Hung CF, Wu TC
Clin Cancer Res 2021 Sep 15;27(18):4953-4973. Epub 2021 Apr 22 doi: 10.1158/1078-0432.CCR-20-2833. PMID: 33888488Free PMC Article
Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F
Lancet Glob Health 2020 Feb;8(2):e191-e203. Epub 2019 Dec 4 doi: 10.1016/S2214-109X(19)30482-6. PMID: 31812369Free PMC Article
Bedell SL, Goldstein LS, Goldstein AR, Goldstein AT
Sex Med Rev 2020 Jan;8(1):28-37. Epub 2019 Nov 30 doi: 10.1016/j.sxmr.2019.09.005. PMID: 31791846
Johnson CA, James D, Marzan A, Armaos M
Semin Oncol Nurs 2019 Apr;35(2):166-174. Epub 2019 Mar 14 doi: 10.1016/j.soncn.2019.02.003. PMID: 30878194

Diagnosis

Mayadev JS, Ke G, Mahantshetty U, Pereira MD, Tarnawski R, Toita T
Int J Gynecol Cancer 2022 Mar;32(3):436-445. doi: 10.1136/ijgc-2021-003001. PMID: 35256434Free PMC Article
Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F
Lancet Glob Health 2020 Feb;8(2):e191-e203. Epub 2019 Dec 4 doi: 10.1016/S2214-109X(19)30482-6. PMID: 31812369Free PMC Article
Bedell SL, Goldstein LS, Goldstein AR, Goldstein AT
Sex Med Rev 2020 Jan;8(1):28-37. Epub 2019 Nov 30 doi: 10.1016/j.sxmr.2019.09.005. PMID: 31791846
Johnson CA, James D, Marzan A, Armaos M
Semin Oncol Nurs 2019 Apr;35(2):166-174. Epub 2019 Mar 14 doi: 10.1016/j.soncn.2019.02.003. PMID: 30878194
Vu M, Yu J, Awolude OA, Chuang L
Curr Probl Cancer 2018 Sep;42(5):457-465. Epub 2018 Jun 25 doi: 10.1016/j.currproblcancer.2018.06.003. PMID: 30064936

Therapy

Pothuri B, Eskander RN, Randall LM, O'Malley DM, Slomovitz B, Moore KN, Herzog TJ, Coleman RL, Copeland LJ, Monk BJ
Gynecol Oncol 2022 Jun;165(3):410-412. Epub 2022 Apr 20 doi: 10.1016/j.ygyno.2022.03.004. PMID: 35461731
Wang R, Pan W, Jin L, Huang W, Li Y, Wu D, Gao C, Ma D, Liao S
Cancer Lett 2020 Feb 28;471:88-102. Epub 2019 Dec 5 doi: 10.1016/j.canlet.2019.11.039. PMID: 31812696
Koh WJ, Greer BE, Abu-Rustum NR, Apte SM, Campos SM, Chan J, Cho KR, Cohn D, Crispens MA, DuPont N, Eifel PJ, Gaffney DK, Giuntoli RL 2nd, Han E, Huh WK, Lurain JR 3rd, Martin L, Morgan MA, Mutch D, Remmenga SW, Reynolds RK, Small W Jr, Teng N, Tillmanns T, Valea FA, McMillian NR, Hughes M; National Comprehensive Cancer Network
J Natl Compr Canc Netw 2013 Mar 1;11(3):320-43. doi: 10.6004/jnccn.2013.0043. PMID: 23486458
Billich A
Curr Opin Investig Drugs 2003 Feb;4(2):210-3. PMID: 12669384
Gibbons SK, Keys HM
Curr Treat Options Oncol 2000 Jun;1(2):157-60. doi: 10.1007/s11864-000-0060-7. PMID: 12057053

Prognosis

Lei J, Ploner A, Elfström KM, Wang J, Roth A, Fang F, Sundström K, Dillner J, Sparén P
N Engl J Med 2020 Oct 1;383(14):1340-1348. doi: 10.1056/NEJMoa1917338. PMID: 32997908
Buskwofie A, David-West G, Clare CA
J Natl Med Assoc 2020 Apr;112(2):229-232. Epub 2020 Apr 8 doi: 10.1016/j.jnma.2020.03.002. PMID: 32278478
Siegel RL, Miller KD, Jemal A
CA Cancer J Clin 2019 Jan;69(1):7-34. Epub 2019 Jan 8 doi: 10.3322/caac.21551. PMID: 30620402
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A
CA Cancer J Clin 2018 Nov;68(6):394-424. Epub 2018 Sep 12 doi: 10.3322/caac.21492. PMID: 30207593
Torre LA, Siegel RL, Ward EM, Jemal A
Cancer Epidemiol Biomarkers Prev 2016 Jan;25(1):16-27. Epub 2015 Dec 14 doi: 10.1158/1055-9965.EPI-15-0578. PMID: 26667886

Clinical prediction guides

Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501
Yao S, Zhao L, Chen S, Wang H, Gao Y, Shao NY, Dai M, Cai H
Front Immunol 2023;14:1135657. Epub 2023 Mar 10 doi: 10.3389/fimmu.2023.1135657. PMID: 36969161Free PMC Article
Lehtinen M, Pimenoff VN, Nedjai B, Louvanto K, Verhoef L, Heideman DAM, El-Zein M, Widschwendter M, Dillner J
Int J Cancer 2023 Mar 15;152(6):1060-1068. Epub 2022 Oct 10 doi: 10.1002/ijc.34286. PMID: 36093582Free PMC Article
Musto A, Grassetto G, Marzola MC, Chondrogiannis S, Maffione AM, Rampin L, Fuster D, Giammarile F, Colletti PM, Rubello D
Yonsei Med J 2014 Nov;55(6):1467-72. doi: 10.3349/ymj.2014.55.6.1467. PMID: 25323881Free PMC Article
Schneider A
J Surg Oncol 2007 Sep 15;96(4):337-41. doi: 10.1002/jso.20864. PMID: 17726665

Recent systematic reviews

Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501
Yimer NB, Mohammed MA, Solomon K, Tadese M, Grutzmacher S, Meikena HK, Alemnew B, Sharew NT, Habtewold TD
Public Health 2021 Jun;195:105-111. Epub 2021 May 31 doi: 10.1016/j.puhe.2021.04.014. PMID: 34082174
Saei Ghare Naz M, Kariman N, Ebadi A, Ozgoli G, Ghasemi V, Rashidi Fakari F
Asian Pac J Cancer Prev 2018 Apr 25;19(4):875-884. doi: 10.22034/APJCP.2018.19.4.875. PMID: 29693331Free PMC Article
Shrestha AD, Neupane D, Vedsted P, Kallestrup P
Asian Pac J Cancer Prev 2018 Feb 26;19(2):319-324. doi: 10.22034/APJCP.2018.19.2.319. PMID: 29479954Free PMC Article
Peirson L, Fitzpatrick-Lewis D, Ciliska D, Warren R
Syst Rev 2013 May 24;2:35. doi: 10.1186/2046-4053-2-35. PMID: 23706117Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Cervical Cancer, 2024
    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

    Consumer resources

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