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Autoimmune thyroid disease, susceptibility to, 3(AITD3)

MedGen UID:
374932
•Concept ID:
C1842444
•
Finding
Synonym: Autoimmune thyroid disease 3
 
Genes (locations): TG (8q24.22); ZFAT (8q24.22)
 
Monarch Initiative: MONDO:0011982
OMIM®: 608175

Clinical features

From HPO
Thyroiditis
MedGen UID:
21548
•Concept ID:
C0040147
•
Disease or Syndrome
Inflammation of the thyroid gland.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Autoimmune and inflammatory thyroid diseases following vaccination with SARS-CoV-2 vaccines: from etiopathogenesis to clinical management.
Caron P
Endocrine 2022 Dec;78(3):406-417. Epub 2022 Jun 28 doi: 10.1007/s12020-022-03118-4. PMID: 35763241Free PMC Article
Hashimoto thyroiditis: an evidence-based guide to etiology, diagnosis and treatment.
Klubo-Gwiezdzinska J, Wartofsky L
Pol Arch Intern Med 2022 Mar 30;132(3) Epub 2022 Mar 3 doi: 10.20452/pamw.16222. PMID: 35243857Free PMC Article
Autoimmune diseases and celiac disease which came first: genotype or gluten?
Diamanti A, Capriati T, Bizzarri C, Ferretti F, Ancinelli M, Romano F, Perilli A, Laureti F, Locatelli M
Expert Rev Clin Immunol 2016;12(1):67-77. Epub 2015 Oct 16 doi: 10.1586/1744666X.2016.1095091. PMID: 26471843

Curated

UK NICE Guideline NG145, Thyroid disease: assessment and management, 2023

Recent clinical studies

Etiology

Identification of multiple novel susceptibility genes associated with autoimmune thyroid disease.
Liu X, Miao Y, Liu C, Lu W, Feng Q, Zhang Q
Front Immunol 2023;14:1161311. Epub 2023 May 1 doi: 10.3389/fimmu.2023.1161311. PMID: 37197658Free PMC Article
Hashimoto thyroiditis: an evidence-based guide to etiology, diagnosis and treatment.
Klubo-Gwiezdzinska J, Wartofsky L
Pol Arch Intern Med 2022 Mar 30;132(3) Epub 2022 Mar 3 doi: 10.20452/pamw.16222. PMID: 35243857Free PMC Article
Autoinmune polyendocrinopathy.
Fernández Miró M, Colom Comí C, Godoy Lorenzo R
Med Clin (Barc) 2021 Sep 10;157(5):241-246. Epub 2021 May 3 doi: 10.1016/j.medcli.2021.02.004. PMID: 33958142
Thyroid disease in the time of COVID-19.
Dworakowska D, Grossman AB
Endocrine 2020 Jun;68(3):471-474. Epub 2020 Jun 7 doi: 10.1007/s12020-020-02364-8. PMID: 32507963Free PMC Article
The Impact of Obesity on Thyroid Autoimmunity and Dysfunction: A Systematic Review and Meta-Analysis.
Song RH, Wang B, Yao QM, Li Q, Jia X, Zhang JA
Front Immunol 2019;10:2349. Epub 2019 Oct 1 doi: 10.3389/fimmu.2019.02349. PMID: 31681268Free PMC Article

Diagnosis

Hashimoto thyroiditis: an evidence-based guide to etiology, diagnosis and treatment.
Klubo-Gwiezdzinska J, Wartofsky L
Pol Arch Intern Med 2022 Mar 30;132(3) Epub 2022 Mar 3 doi: 10.20452/pamw.16222. PMID: 35243857Free PMC Article
Autoinmune polyendocrinopathy.
Fernández Miró M, Colom Comí C, Godoy Lorenzo R
Med Clin (Barc) 2021 Sep 10;157(5):241-246. Epub 2021 May 3 doi: 10.1016/j.medcli.2021.02.004. PMID: 33958142
The Impact of Obesity on Thyroid Autoimmunity and Dysfunction: A Systematic Review and Meta-Analysis.
Song RH, Wang B, Yao QM, Li Q, Jia X, Zhang JA
Front Immunol 2019;10:2349. Epub 2019 Oct 1 doi: 10.3389/fimmu.2019.02349. PMID: 31681268Free PMC Article
Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders.
Biondi B, Kahaly GJ, Robertson RP
Endocr Rev 2019 Jun 1;40(3):789-824. doi: 10.1210/er.2018-00163. PMID: 30649221Free PMC Article
Autoimmune endocrine diseases.
Ruggeri RM, Giuffrida G, Campennì A
Minerva Endocrinol 2018 Sep;43(3):305-322. Epub 2017 Oct 9 doi: 10.23736/S0391-1977.17.02757-2. PMID: 28990742

Therapy

Autoimmune thyroid disease and myasthenia gravis: a study bidirectional Mendelian randomization.
Wang S, Wang K, Chen X, Chen D, Lin S
Front Endocrinol (Lausanne) 2024;15:1310083. Epub 2024 Feb 9 doi: 10.3389/fendo.2024.1310083. PMID: 38405140Free PMC Article
Periodontitis and thyroid function: A bidirectional Mendelian randomization study.
Gao Y, Huang D, Liu Y, Qiu Y, Lu S
J Periodontal Res 2024 Jun;59(3):491-499. Epub 2024 Jan 9 doi: 10.1111/jre.13240. PMID: 38193661
Identification of multiple novel susceptibility genes associated with autoimmune thyroid disease.
Liu X, Miao Y, Liu C, Lu W, Feng Q, Zhang Q
Front Immunol 2023;14:1161311. Epub 2023 May 1 doi: 10.3389/fimmu.2023.1161311. PMID: 37197658Free PMC Article
Hashimoto thyroiditis: an evidence-based guide to etiology, diagnosis and treatment.
Klubo-Gwiezdzinska J, Wartofsky L
Pol Arch Intern Med 2022 Mar 30;132(3) Epub 2022 Mar 3 doi: 10.20452/pamw.16222. PMID: 35243857Free PMC Article
Iodine excess.
Bürgi H
Best Pract Res Clin Endocrinol Metab 2010 Feb;24(1):107-15. doi: 10.1016/j.beem.2009.08.010. PMID: 20172475

Prognosis

DNA Methylation in Autoimmune Thyroid Disease.
Lafontaine N, Wilson SG, Walsh JP
J Clin Endocrinol Metab 2023 Feb 15;108(3):604-613. doi: 10.1210/clinem/dgac664. PMID: 36420742
Autoinmune polyendocrinopathy.
Fernández Miró M, Colom Comí C, Godoy Lorenzo R
Med Clin (Barc) 2021 Sep 10;157(5):241-246. Epub 2021 May 3 doi: 10.1016/j.medcli.2021.02.004. PMID: 33958142
Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity.
McLachlan SM, Rapoport B
Endocr Rev 2014 Feb;35(1):59-105. Epub 2013 Dec 4 doi: 10.1210/er.2013-1055. PMID: 24091783Free PMC Article
Hashimoto's Thyroiditis.
Lorini R, Gastaldi R, Traggiai C, Perucchin PP
Pediatr Endocrinol Rev 2003 Dec;1 Suppl 2:205-11; discussion 211. PMID: 16444160
Interferon-alpha and autoimmune thyroid disease.
Prummel MF, Laurberg P
Thyroid 2003 Jun;13(6):547-51. doi: 10.1089/105072503322238809. PMID: 12930598

Clinical prediction guides

Autoinmune polyendocrinopathy.
Fernández Miró M, Colom Comí C, Godoy Lorenzo R
Med Clin (Barc) 2021 Sep 10;157(5):241-246. Epub 2021 May 3 doi: 10.1016/j.medcli.2021.02.004. PMID: 33958142
Distinct clinical features and prognosis between persistent and temporary thyroid dysfunctions by immune-checkpoint inhibitors.
Inaba H, Ariyasu H, Iwakura H, Kurimoto C, Takeshima K, Morita S, Furuta H, Hotomi M, Akamizu T
Endocr J 2021 Feb 28;68(2):231-241. Epub 2020 Oct 3 doi: 10.1507/endocrj.EJ20-0371. PMID: 33012745
Genetic predictors of the development and recurrence of Graves' disease.
Vejrazkova D, Vcelak J, Vaclavikova E, Vankova M, Zajickova K, Duskova M, Vrbikova J, Bendlova B
Physiol Res 2018 Nov 28;67(Suppl 3):S431-S439. doi: 10.33549/physiolres.934018. PMID: 30484670
Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity.
McLachlan SM, Rapoport B
Endocr Rev 2014 Feb;35(1):59-105. Epub 2013 Dec 4 doi: 10.1210/er.2013-1055. PMID: 24091783Free PMC Article
Hashimoto's Thyroiditis.
Lorini R, Gastaldi R, Traggiai C, Perucchin PP
Pediatr Endocrinol Rev 2003 Dec;1 Suppl 2:205-11; discussion 211. PMID: 16444160

Recent systematic reviews

The Association Between Foxp3 Polymorphisms and Risk of Graves' Disease: A Systematic Review and Meta-Analysis of Observational Studies.
Li HN, Li XR, Du YY, Yang ZF, Lv ZT
Front Endocrinol (Lausanne) 2020;11:392. Epub 2020 Jun 16 doi: 10.3389/fendo.2020.00392. PMID: 32612577Free PMC Article
The Impact of Obesity on Thyroid Autoimmunity and Dysfunction: A Systematic Review and Meta-Analysis.
Song RH, Wang B, Yao QM, Li Q, Jia X, Zhang JA
Front Immunol 2019;10:2349. Epub 2019 Oct 1 doi: 10.3389/fimmu.2019.02349. PMID: 31681268Free PMC Article
Association of TNF-α promoter polymorphism and Graves' disease: an updated systematic review and meta-analysis.
Tu Y, Fan G, Zeng T, Cai X, Kong W
Biosci Rep 2018 Apr 27;38(2) Epub 2018 Mar 21 doi: 10.1042/BSR20180143. PMID: 29440561Free PMC Article
A systematic review of genetic studies of thyroid disorders in Taiwan.
Huang CJ, Jap TS
J Chin Med Assoc 2015 Mar;78(3):145-53. Epub 2014 Nov 11 doi: 10.1016/j.jcma.2014.09.010. PMID: 25455162
Frequency of autoimmune diseases in myasthenia gravis: a systematic review.
Mao ZF, Yang LX, Mo XA, Qin C, Lai YR, He NY, Li T, Hackett ML
Int J Neurosci 2011 Mar;121(3):121-9. Epub 2010 Dec 13 doi: 10.3109/00207454.2010.539307. PMID: 21142828

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG145, Thyroid disease: assessment and management, 2023

    Consumer resources

    Reviews

    Related information

    • ClinVar
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    • Gene
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    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
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    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
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