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Susceptibility to HIV infection

MedGen UID:
332156
•Concept ID:
C1836230
•
Finding
Synonyms: HIV-1, SUSCEPTIBILITY TO; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, RESISTANCE TO; Human immunodeficiency virus type 1, susceptibility to
 
Genes (locations): CCL11 (17q12); CCL2 (17q12); CCL3 (17q12); CCL3L1; CCL5 (17q12); CCR2 (3p21.31); CCR5 (3p21.31); CD209 (19p13.2); CX3CR1 (3p22.2); CXCL12 (10q11.21); CXCR1 (2q35); HLA-C (6p21.33); IFNG (12q15); IL10 (1q32.1); KIR3DL1 (19q13.42); TLR3 (4q35.1)
 
Monarch Initiative: MONDO:0004951
OMIM®: 609423

Definition

The pathogenesis of HIV infection and the progression from infection to AIDS vary significantly between exposed individuals. Infection occurs after the virus, which has macrophage (M)- and T lymphocyte (T)-tropic strains and more than 12 subtypes, survives an array of nonspecific, nongenetic environmental and host factors. [from OMIM]

Professional guidelines

PubMed

Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point.
Alsulami K, Bolastig N, Dupuy FP, Mabanga T, Gilbert L, Kiani Z, Routy JP, Bruneau J, Thomas R, Tremblay C, Tsoukas CM, Szabo J, Côté P, Trottier B, LeBlanc R, Rouleau D, Bernard NF; investigators in the Montreal Primary HIV Infection cohort
J Virol 2021 Jul 26;95(16):e0041721. doi: 10.1128/JVI.00417-21. PMID: 34076484Free PMC Article
Protective Effect of the Combination of Wild-Type Genotypes (G/G and G/G) of CCR2-64V and SDF1-3A' Genes in Serodiscordant Couples in Yaounde-Cameroon.
Nkenfou CN, Tchakounté C, Nkenfou-Tchinda CN, Ngoufack MN, Yatchou LG, Elong E, Kamgaing R, Tiga A, Ambada G, Kuiate JR, Ndjolo A
Curr HIV Res 2021;19(4):342-351. doi: 10.2174/1570162X19666210412121143. PMID: 33845725
Homozygous and heterozygous CCR5-Delta32 genotypes are associated with resistance to HIV infection.
Marmor M, Sheppard HW, Donnell D, Bozeman S, Celum C, Buchbinder S, Koblin B, Seage GR 3rd; HIV Network for Prevention Trials Vaccine Preparedness Protocol Team
J Acquir Immune Defic Syndr 2001 Aug 15;27(5):472-81. doi: 10.1097/00126334-200108150-00009. PMID: 11511825

Recent clinical studies

Etiology

High level of plasma TILRR protein is associated with faster HIV seroconversion.
Kashem MA, Lischynski J, Stojak B, Li L, Yuan XY, Liang B, Kimani J, Plummer FA, Luo M
EBioMedicine 2022 Apr;78:103955. Epub 2022 Mar 24 doi: 10.1016/j.ebiom.2022.103955. PMID: 35339895Free PMC Article
Fc-gamma receptor IIA and IIIA variants in two African cohorts: Lack of consistent impact on heterosexual HIV acquisition, viral control, and disease progression.
Connolly S, Wall KM, Tang J, Yu T, Kilembe W, Kijak G, Allen S, Hunter E
Virology 2018 Dec;525:132-142. Epub 2018 Oct 1 doi: 10.1016/j.virol.2018.09.015. PMID: 30278383Free PMC Article
CCR2, CX3CR1, RANTES and SDF1 genetic polymorphisms influence HIV infection in a Zimbabwean pediatric population.
Mhandire K, Duri K, Kandawasvika G, Chandiwana P, Chin'ombe N, Kanyera RB, Stray-Pedersen B, Dandara C
J Infect Dev Ctries 2014 Oct 15;8(10):1313-21. doi: 10.3855/jidc.4599. PMID: 25313609
The role of sexually transmitted diseases in HIV transmission.
Galvin SR, Cohen MS
Nat Rev Microbiol 2004 Jan;2(1):33-42. doi: 10.1038/nrmicro794. PMID: 15035007
AIDS knowledge and attitudes among injection drug users: the issue of reliability.
Longshore D, Hsieh SC, Anglin MD
AIDS Educ Prev 1992 Spring;4(1):29-40. PMID: 1543642

Diagnosis

Influence of sickle cell disease on susceptibility to HIV infection.
Kelly S, Jacobs ES, Stone M, Keating SM, Lee TH, Chafets D, Heitman J, Dimapasoc M, Operskalski E, Hagar W, Vichinsky E, Busch MP, Norris PJ, Custer B; Recipient Epidemiology and Donor Evaluation Study (REDS-III)
PLoS One 2020;15(4):e0218880. Epub 2020 Apr 8 doi: 10.1371/journal.pone.0218880. PMID: 32267841Free PMC Article
Facilitators, Barriers, and Outcomes of Self-Initiated HIV Testing: An Integrative Literature Review.
Adebayo OW, Salerno JP
Res Theory Nurs Pract 2019 Aug 1;33(3):275-291. doi: 10.1891/1541-6577.33.3.275. PMID: 31615946
Addressing the structural drivers of HIV: a luxury or necessity for programmes?
Seeley J, Watts CH, Kippax S, Russell S, Heise L, Whiteside A
J Int AIDS Soc 2012;15 Suppl 1(Suppl 1):1-4. doi: 10.7448/IAS.15.3.17397. PMID: 22905346Free PMC Article
Immunogenetics of HIV and HIV associated tuberculosis.
Raghavan S, Alagarasu K, Selvaraj P
Tuberculosis (Edinb) 2012 Jan;92(1):18-30. Epub 2011 Sep 22 doi: 10.1016/j.tube.2011.08.004. PMID: 21943869
Bacterial vaginosis and susceptibility to HIV infection in South African women: a nested case-control study.
Myer L, Denny L, Telerant R, Souza Md, Wright TC Jr, Kuhn L
J Infect Dis 2005 Oct 15;192(8):1372-80. Epub 2005 Sep 9 doi: 10.1086/462427. PMID: 16170754

Therapy

Influence of sickle cell disease on susceptibility to HIV infection.
Kelly S, Jacobs ES, Stone M, Keating SM, Lee TH, Chafets D, Heitman J, Dimapasoc M, Operskalski E, Hagar W, Vichinsky E, Busch MP, Norris PJ, Custer B; Recipient Epidemiology and Donor Evaluation Study (REDS-III)
PLoS One 2020;15(4):e0218880. Epub 2020 Apr 8 doi: 10.1371/journal.pone.0218880. PMID: 32267841Free PMC Article
Gene Expression Profiling of Human Vaginal Cells In Vitro Discriminates Compounds with Pro-Inflammatory and Mucosa-Altering Properties: Novel Biomarkers for Preclinical Testing of HIV Microbicide Candidates.
Zalenskaya IA, Joseph T, Bavarva J, Yousefieh N, Jackson SS, Fashemi T, Yamamoto HS, Settlage R, Fichorova RN, Doncel GF
PLoS One 2015;10(6):e0128557. Epub 2015 Jun 8 doi: 10.1371/journal.pone.0128557. PMID: 26052926Free PMC Article
The genetic basis of resistance to HIV infection and disease progression.
Biasin M, De Luca M, Gnudi F, Clerici M
Expert Rev Clin Immunol 2013 Apr;9(4):319-34. doi: 10.1586/eci.13.16. PMID: 23557268
Distribution of CCR-5Δ32, CCR2-64I, and SDF-1-3'A alleles among Jordanians.
Khabour OF, Abu-Haweleh LJ, Alzoubi KH
AIDS Res Hum Retroviruses 2013 Jan;29(1):151-5. Epub 2012 Jul 31 doi: 10.1089/AID.2012.0107. PMID: 22770415Free PMC Article
Immunogenetics of HIV and HIV associated tuberculosis.
Raghavan S, Alagarasu K, Selvaraj P
Tuberculosis (Edinb) 2012 Jan;92(1):18-30. Epub 2011 Sep 22 doi: 10.1016/j.tube.2011.08.004. PMID: 21943869

Prognosis

High level of plasma TILRR protein is associated with faster HIV seroconversion.
Kashem MA, Lischynski J, Stojak B, Li L, Yuan XY, Liang B, Kimani J, Plummer FA, Luo M
EBioMedicine 2022 Apr;78:103955. Epub 2022 Mar 24 doi: 10.1016/j.ebiom.2022.103955. PMID: 35339895Free PMC Article
Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point.
Alsulami K, Bolastig N, Dupuy FP, Mabanga T, Gilbert L, Kiani Z, Routy JP, Bruneau J, Thomas R, Tremblay C, Tsoukas CM, Szabo J, Côté P, Trottier B, LeBlanc R, Rouleau D, Bernard NF; investigators in the Montreal Primary HIV Infection cohort
J Virol 2021 Jul 26;95(16):e0041721. doi: 10.1128/JVI.00417-21. PMID: 34076484Free PMC Article
Distribution of CCR-5Δ32, CCR2-64I, and SDF-1-3'A alleles among Jordanians.
Khabour OF, Abu-Haweleh LJ, Alzoubi KH
AIDS Res Hum Retroviruses 2013 Jan;29(1):151-5. Epub 2012 Jul 31 doi: 10.1089/AID.2012.0107. PMID: 22770415Free PMC Article
Genetic determinants of HIV-1 infection and progression to AIDS: susceptibility to HIV infection.
Kaur G, Mehra N
Tissue Antigens 2009 Apr;73(4):289-301. doi: 10.1111/j.1399-0039.2009.01220.x. PMID: 19317737Free PMC Article
AIDS knowledge and attitudes among injection drug users: the issue of reliability.
Longshore D, Hsieh SC, Anglin MD
AIDS Educ Prev 1992 Spring;4(1):29-40. PMID: 1543642

Clinical prediction guides

High level of plasma TILRR protein is associated with faster HIV seroconversion.
Kashem MA, Lischynski J, Stojak B, Li L, Yuan XY, Liang B, Kimani J, Plummer FA, Luo M
EBioMedicine 2022 Apr;78:103955. Epub 2022 Mar 24 doi: 10.1016/j.ebiom.2022.103955. PMID: 35339895Free PMC Article
Human microglial models to study HIV infection and neuropathogenesis: a literature overview and comparative analyses.
Gumbs SBH, Kübler R, Gharu L, Schipper PJ, Borst AL, Snijders GJLJ, Ormel PR, van Berlekom AB, Wensing AMJ, de Witte LD, Nijhuis M
J Neurovirol 2022 Feb;28(1):64-91. Epub 2022 Feb 9 doi: 10.1007/s13365-021-01049-w. PMID: 35138593Free PMC Article
Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point.
Alsulami K, Bolastig N, Dupuy FP, Mabanga T, Gilbert L, Kiani Z, Routy JP, Bruneau J, Thomas R, Tremblay C, Tsoukas CM, Szabo J, Côté P, Trottier B, LeBlanc R, Rouleau D, Bernard NF; investigators in the Montreal Primary HIV Infection cohort
J Virol 2021 Jul 26;95(16):e0041721. doi: 10.1128/JVI.00417-21. PMID: 34076484Free PMC Article
The polymorphisms in DC-SIGNR affect susceptibility to HIV type 1 infection.
Wichukchinda N, Kitamura Y, Rojanawiwat A, Nakayama EE, Song H, Pathipvanich P, Auwanit W, Sawanpanyalert P, Iwamoto A, Shioda T, Ariyoshi K
AIDS Res Hum Retroviruses 2007 May;23(5):686-92. doi: 10.1089/aid.2006.0212. PMID: 17530994
AIDS knowledge and attitudes among injection drug users: the issue of reliability.
Longshore D, Hsieh SC, Anglin MD
AIDS Educ Prev 1992 Spring;4(1):29-40. PMID: 1543642

Recent systematic reviews

HIV vaccine acceptability: a systematic review and meta-analysis.
Newman PA, Logie C
AIDS 2010 Jul 17;24(11):1749-56. doi: 10.1097/qad.0b013e32833adbe8. PMID: 20597165
Intravaginal practices, vaginal infections and HIV acquisition: systematic review and meta-analysis.
Hilber AM, Francis SC, Chersich M, Scott P, Redmond S, Bender N, Miotti P, Temmerman M, Low N
PLoS One 2010 Feb 9;5(2):e9119. doi: 10.1371/journal.pone.0009119. PMID: 20161749Free PMC Article

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    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
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      Related literature resources in PubMed

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