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Nasopharyngeal carcinoma, susceptibility to, 2(NPCA2)

MedGen UID:
413336
•Concept ID:
C2750548
•
Neoplastic Process
Synonym: Nasopharyngeal carcinoma 2
 
Monarch Initiative: MONDO:0008067
OMIM®: 161550

Definition

Nasopharyngeal carcinoma is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx (summary by Tse et al., 2009). For a general phenotypic description and a discussion of genetic heterogeneity of susceptibility to nasopharyngeal carcinoma, see NPCA1 (607107). [from OMIM]

Clinical features

From HPO
Neoplasm
MedGen UID:
10294
•Concept ID:
C0027651
•
Neoplastic Process
An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor).
See: Feature record | Search on this feature

Professional guidelines

PubMed

Association of Matrix Metalloproteinase-9 Genotypes With Nasopharyngeal Carcinoma Risk.
Chen CH, Shih LC, Hsu SW, Tien HC, Liu YF, Wang YC, Tsai CW, Bau DT, Chang WS
In Vivo 2024 Jul-Aug;38(4):1731-1739. doi: 10.21873/invivo.13623. PMID: 38936920Free PMC Article
Host genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation.
Xu M, Feng R, Liu Z, Zhou X, Chen Y, Cao Y, Valeri L, Li Z, Liu Z, Cao SM, Liu Q, Xie SH, Chang ET, Jia WH, Shen J, Yao Y, Cai YL, Zheng Y, Zhang Z, Huang G, Ernberg I, Tang M, Ye W, Adami HO, Zeng YX, Lin X
Cell Genom 2024 Feb 14;4(2):100474. Epub 2024 Jan 9 doi: 10.1016/j.xgen.2023.100474. PMID: 38359790Free PMC Article
Current understanding and management of nasopharyngeal carcinoma.
Yoshizaki T, Ito M, Murono S, Wakisaka N, Kondo S, Endo K
Auris Nasus Larynx 2012 Apr;39(2):137-44. Epub 2011 May 17 doi: 10.1016/j.anl.2011.02.012. PMID: 21592702

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Therapy

A Phase II Randomized Clinical Trial and Mechanistic Studies Using Improved Probiotics to Prevent Oral Mucositis Induced by Concurrent Radiotherapy and Chemotherapy in Nasopharyngeal Carcinoma.
Xia C, Jiang C, Li W, Wei J, Hong H, Li J, Feng L, Wei H, Xin H, Chen T
Front Immunol 2021;12:618150. Epub 2021 Mar 24 doi: 10.3389/fimmu.2021.618150. PMID: 33841399Free PMC Article
Medical History, Medication Use, and Risk of Nasopharyngeal Carcinoma.
Xiao X, Zhang Z, Chang ET, Liu Z, Liu Q, Cai Y, Chen G, Huang QH, Xie SH, Cao SM, Shao JY, Jia WH, Zheng Y, Liao J, Chen Y, Lin L, Ernberg I, Huang G, Zeng Y, Zeng YX, Adami HO, Ye W
Am J Epidemiol 2018 Oct 1;187(10):2117-2125. doi: 10.1093/aje/kwy095. PMID: 29701753Free PMC Article
Quantitative assessment of the association between interleukin-10 promoter gene polymorphisms and nasopharyngeal carcinoma susceptibility.
Huang H, Wu Y, Liao D, Zhang H
Minerva Med 2016 Apr;107(2):92-100. Epub 2016 Feb 3 PMID: 26842763
Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis.
Yu YF, Han ZG, Guo WB, Zhang GJ, Yang JK, Wu FL, Ou QY, Li YH, Cai XY, Zhan ZN, Chen JH, Xie WL, Tang L, Liu CD
Genet Mol Res 2015 Dec 29;14(4):18945-57. doi: 10.4238/2015.December.29.1. PMID: 26782544
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article

Prognosis

Epidemiology of nasopharyngeal carcinoma: current insights and future outlook.
Su ZY, Siak PY, Lwin YY, Cheah SC
Cancer Metastasis Rev 2024 Sep;43(3):919-939. Epub 2024 Mar 2 doi: 10.1007/s10555-024-10176-9. PMID: 38430391
Correlation between COX-2 gene polymorphism and susceptibility to nasopharyngeal carcinoma.
Sun N, Wang XQ
Eur Rev Med Pharmacol Sci 2019 Jul;23(13):5770-5778. doi: 10.26355/eurrev_201907_18315. PMID: 31298328
Targeting Jab1/CSN5 in nasopharyngeal carcinoma.
Pan Y, Claret FX
Cancer Lett 2012 Dec 30;326(2):155-60. Epub 2012 Aug 4 doi: 10.1016/j.canlet.2012.07.033. PMID: 22867945Free PMC Article
Unlocking the Rosetta Stone enigma for nasopharyngeal carcinoma: genetics, viral infection, and epidemiological factors.
Lung ML
Semin Cancer Biol 2012 Apr;22(2):77-8. Epub 2012 Jan 14 doi: 10.1016/j.semcancer.2012.01.006. PMID: 22266061
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article

Clinical prediction guides

Selective Organ-Targeting Hafnium Oxide Nanoparticles with Multienzyme-Mimetic Activities Attenuate Radiation-Induced Tissue Damage.
Liu D, Cao F, Xu Z, Zhao C, Liu Z, Pang J, Liu ZX, Moghiseh M, Butler A, Liang S, Fan W, Yang J
Adv Mater 2024 May;36(19):e2308098. Epub 2024 Jan 25 doi: 10.1002/adma.202308098. PMID: 37777858
Genetic variants in NKG2D axis and susceptibility to Epstein-Barr virus-induced nasopharyngeal carcinoma.
Viet NH, Trung NQ, Dong LT, Trung LQ, Espinoza JL
J Cancer Res Clin Oncol 2021 Mar;147(3):713-723. Epub 2021 Jan 3 doi: 10.1007/s00432-020-03475-5. PMID: 33392659
Correlation between COX-2 gene polymorphism and susceptibility to nasopharyngeal carcinoma.
Sun N, Wang XQ
Eur Rev Med Pharmacol Sci 2019 Jul;23(13):5770-5778. doi: 10.26355/eurrev_201907_18315. PMID: 31298328
Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis.
Yu YF, Han ZG, Guo WB, Zhang GJ, Yang JK, Wu FL, Ou QY, Li YH, Cai XY, Zhan ZN, Chen JH, Xie WL, Tang L, Liu CD
Genet Mol Res 2015 Dec 29;14(4):18945-57. doi: 10.4238/2015.December.29.1. PMID: 26782544
Epstein-Barr virus-associated malignancies.
Richtsmeier WJ, Wittels EG, Mazur EM
Crit Rev Clin Lab Sci 1987;25(2):105-36. doi: 10.3109/10408368709105879. PMID: 3038469

Recent systematic reviews

The Relationship Between the hOGG1 rs1052133 Polymorphism and the Occurrence of Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis.
Li G, Yao J, Zhang F, Xu X, Wang S
Technol Cancer Res Treat 2024 Jan-Dec;23:15330338241246457. doi: 10.1177/15330338241246457. PMID: 38836311Free PMC Article
The Epstein-Barr virus latent membrane protein-1 (LMP1) 30-bp deletion and XhoI-polymorphism in nasopharyngeal carcinoma: a meta-analysis of observational studies.
da Costa VG, Marques-Silva AC, Moreli ML
Syst Rev 2015 Apr 13;4:46. doi: 10.1186/s13643-015-0037-z. PMID: 25927427Free PMC Article
Non-viral environmental risk factors for nasopharyngeal carcinoma: a systematic review.
Jia WH, Qin HD
Semin Cancer Biol 2012 Apr;22(2):117-26. Epub 2012 Jan 30 doi: 10.1016/j.semcancer.2012.01.009. PMID: 22311401

Supplemental Content

Table of contents

    Clinical resources

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    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

    Reviews

    Related information

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