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Microvascular complications of diabetes, susceptibility to, 1(MVCD1)

MedGen UID:
382957
•Concept ID:
C2676832
•
Finding
Synonym: Microvascular complications of diabetes 1
 
Gene (location): VEGFA (6p21.1)
 
Monarch Initiative: MONDO:0011386
OMIM®: 603933

Definition

Any microvascular complications of diabetes, susceptibility in which the cause of the disease is a mutation in the VEGFA gene. [from MONDO]

Professional guidelines

PubMed

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294
Diabetes mellitus: novel insights, analysis and interpretation of pathophysiology and complications management with imidazole-containing peptidomimetic antioxidants.
Babizhayev MA, Lankin VZ, Savel'Yeva EL, Deyev AI, Yegorov YE
Recent Pat Drug Deliv Formul 2013 Dec;7(3):216-56. doi: 10.2174/1872211307666131117121058. PMID: 24236935

Recent clinical studies

Etiology

Association of metabolic syndrome and chronic kidney disease.
Scurt FG, Ganz MJ, Herzog C, Bose K, Mertens PR, Chatzikyrkou C
Obes Rev 2024 Jan;25(1):e13649. Epub 2023 Oct 2 doi: 10.1111/obr.13649. PMID: 37783465
Genetics of diabetes-associated microvascular complications.
Lyssenko V, Vaag A
Diabetologia 2023 Sep;66(9):1601-1613. Epub 2023 Jul 14 doi: 10.1007/s00125-023-05964-x. PMID: 37452207Free PMC Article
Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy.
Dewanjee S, Vallamkondu J, Kalra RS, John A, Reddy PH, Kandimalla R
Ageing Res Rev 2021 Jul;68:101338. Epub 2021 Apr 7 doi: 10.1016/j.arr.2021.101338. PMID: 33838320
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
Haplotype specific alteration of diabetes MHC risk by olfactory receptor gene polymorphism.
Jahromi MM
Autoimmun Rev 2012 Dec;12(2):270-4. Epub 2012 May 8 doi: 10.1016/j.autrev.2012.05.001. PMID: 22579560

Diagnosis

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Association between the vitamin D receptor gene polymorphisms and diabetic nephropathy risk: A meta-analysis.
Yin F, Liu J, Fan MX, Zhou XL, Zhang XL
Nephrology (Carlton) 2018 Feb;23(2):107-116. doi: 10.1111/nep.13111. PMID: 28703918
Association of prediabetes-associated single nucleotide polymorphisms with microalbuminuria.
Choi JW, Moon S, Jang EJ, Lee CH, Park JS
PLoS One 2017;12(2):e0171367. Epub 2017 Feb 3 doi: 10.1371/journal.pone.0171367. PMID: 28158221Free PMC Article
Diabetic nephropathy--emerging epigenetic mechanisms.
Kato M, Natarajan R
Nat Rev Nephrol 2014 Sep;10(9):517-30. Epub 2014 Jul 8 doi: 10.1038/nrneph.2014.116. PMID: 25003613Free PMC Article

Therapy

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
Intracellular adhesion molecule-1 K469E gene polymorphism and risk of diabetic microvascular complications: a meta-analysis.
Su X, Chen X, Liu L, Chang X, Yu X, Sun K
PLoS One 2013;8(7):e69940. Epub 2013 Jul 26 doi: 10.1371/journal.pone.0069940. PMID: 23922864Free PMC Article
Host defenses and susceptibility to infection in patients with diabetes mellitus.
McMahon MM, Bistrian BR
Infect Dis Clin North Am 1995 Mar;9(1):1-9. PMID: 7769211

Prognosis

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Factors associated with higher falling risk in elderly diabetic patients with lacunar stroke.
Jin J, Wen S, Li Y, Zhou M, Duan Q, Zhou L
BMC Endocr Disord 2022 Aug 8;22(1):198. doi: 10.1186/s12902-022-01122-3. PMID: 35941681Free PMC Article
Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy.
Hsieh AR, Huang YC, Yang YF, Lin HJ, Lin JM, Chang YW, Wu CM, Liao WL, Tsai FJ
BMJ Open Diabetes Res Care 2020 Jan;8(1) doi: 10.1136/bmjdrc-2019-000727. PMID: 31958309Free PMC Article

Clinical prediction guides

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Alterations in pro- and anti-inflammatory mediators are involved in microvascular dysfunction in postmenopausal women with type 2 diabetes mellitus.
Jarrete AP, Giollo-Junior LT, Vilela-Martin JF, Novais IP, Delbin MA, Zanesco A
Braz J Med Biol Res 2022;55:e11821. Epub 2022 Feb 28 doi: 10.1590/1414-431X2021e11821. PMID: 35239779Free PMC Article
Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy.
Hsieh AR, Huang YC, Yang YF, Lin HJ, Lin JM, Chang YW, Wu CM, Liao WL, Tsai FJ
BMJ Open Diabetes Res Care 2020 Jan;8(1) doi: 10.1136/bmjdrc-2019-000727. PMID: 31958309Free PMC Article
CXCL5 gene polymorphism association with diabetes mellitus.
Hasani Ranjbar S, Amiri P, Zineh I, Langaee TY, Namakchian M, Heshmet R, Sajadi M, Mirzaee M, Rezazadeh E, Balaei P, Tavakkoly Bazzaz J, Gonzalez-Gay MA, Larijani B, Amoli MM
Mol Diagn Ther 2008;12(6):391-4. doi: 10.1007/BF03256304. PMID: 19035625

Recent systematic reviews

(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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